Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology. - PubMed - NCBI
Cancer Inform. 2017 Mar 2;16:1176935117694349. doi: 10.1177/1176935117694349. eCollection 2017.
Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology.
Foran DJ1,2,
Chen W1,2,
Chu H1,2,
Sadimin E1,2,
Loh D1,
Riedlinger G1,2,
Goodell LA2,
Ganesan S1,
Hirshfield K1,
Rodriguez L1,
DiPaola RS3.
Abstract
Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes. KEYWORDS:
Clinical data warehouse; precision medicine; semantic interoperability; synoptic pathology reports
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