Melatonin vs. Magnesium: Which Works Best for Sleep?

https://www.news-medical.net/health/Melatonin-vs-Magnesium-Which-Works-Best-for-Sleep.aspx

New drug combination shows promise in treating melanoma brain metastasis

https://www.news-medical.net/news/20250321/New-drug-combination-shows-promise-in-treating-melanoma-brain-metastasis.aspx

Study reveals how virtual body pain disrupts sense of ownership

https://www.news-medical.net/news/20250321/Study-reveals-how-virtual-body-pain-disrupts-sense-of-ownership.aspx

Groundbreaking study unveils key mechanism for neuronal identity regulation

https://www.news-medical.net/news/20250322/Groundbreaking-study-unveils-key-mechanism-for-neuronal-identity-regulation.aspx

New video-based method enhances detection of infantile spasms syndrome

https://www.news-medical.net/news/20250321/New-video-based-method-enhances-detection-of-infantile-spasms-syndrome.aspx

The forgotten social and emotional toll of rare diseases

https://www.re-solveglobalhealth.com/post/the-forgotten-social-and-emotional-toll-of-rare-diseases

Rare Diseases: Betting on the pharma package for timely and equitable access, still awaiting an EU Action Plan

https://www.euractiv.com/section/health-consumers/news/rare-diseases-betting-on-the-pharma-package-for-timely-and-equitable-access-still-awaiting-an-eu-action-plan/ In this recent Euractiv article, Valentina Bottarelli, our Head of Policy and Public Affairs, called for a European Action Plan for Rare Diseases to unify existing efforts and create a coherent strategy that ensures health equity, faster diagnoses, and better access to treatments. She also elaborated on the ongoing reforms to the EU's pharmaceutical legislation and their centrality to strengthening patient engagement, securing medicine supply, and fostering innovation.

Podcast: Rare on Air

https://www.eurordis.org/rare-on-air/ Rare on Air Stories Don't forget to listen to our bonus podcast series marking Rare Disease Day! Hosted by Julien Poulain, the Rare on Air Stories series presents the striking personal stories of individuals living with a rare disease across the globe. From Australia to Mexico, Nepal to Nigeria and the U.S. to the U.K., each episode shares deeply moving personal experiences. Listen now to our latest episode, where we follow the journey of Noah from the United States! Listen to the podcast by subscribing to Spotify, Apple Podcasts, Amazon Music, or YouTube.

39th Workshop of the EURORDIS Round Table of Companies (ERTC): Addressing systemic inequalities through patient-driven innovation & research

https://www.eurordis.org/39th-ertc/ ERTC Workshop Last month, our 39th EURORDIS Round Table of Companies (ERTC) Workshop in Brussels focused on patient-driven innovation to address systemic health inequalities. The workshop focused on integrating patients' priorities into future EU research policies and funding. The discussions explored the need to enhance clinical trials, leveraging public-private investments, corroborating healthcare systems, and promoting fairness in newborn screening.

EURORDIS Membership Meeting (EMM) 2025 March 2025

https://www.eurordis.org/eurordis-membership-meeting-emm-2025/ This year’s EURORDIS Membership Meeting will be held in Riga, Latvia, on 22-24 May. This event represents an invaluable opportunity for the members of the rare disease community to meet while sharing knowledge and building partnerships. Participants will explore topics such as advocacy at national and EU levels, volunteer involvement in healthcare, and leveraging Rare Barometer findings for advocacy. https://www.eurordis.org/rare-barometer/english/

SANT launches public consultation on rare diseases

https://www.europarl.europa.eu/news/en/press-room/20250227IPR27074/sant-launches-public-consultation-on-rare-diseases The European Parliament Committee on Public Health (SANT) has opened a public Consultation on Rare Diseases to identify the challenges faced by those living with a rare disease and the potential EU actions to address them. With SANT now a fully-fledged parliamentary committee, the consultation presents a key moment to advocate for better funding, cooperation, and recognition of our community's unmet needs. EURORDIS' response highlights policy priorities, and you can submit your own response by 31 March! For questions or feedback, contact valentina.bottarelli@eurordis.org. Have your say: Help shape the future of rare disease policy in Europe The European Parliament’s Committee on Public Health (SANT), newly established as a fully-fledged committee, is responsible for shaping EU policies on healthcare, pharmaceutical legislation, and public health. It has now launched a Consultation on Rare Diseases, seeking input from patients, caregivers, researchers, healthcare professionals, and organisations working in the field. https://www.eurordis.org/publications/eurordis-submission-sant-consultation/

Decreasing the invasiveness of deep brain stimulation

Decreasing the invasiveness of deep brain stimulation: Researchers are developing a preclinical method to stimulate the brain without drilling into the skull by guiding a catheter through the cerebrospinal fluid. Deep brain stimulation—the application of electricity to specific deep brain regions to modulate their function—has been used clinically for over 25 years. This technique is used to monitor and treat neurological conditions, especially movement disorders, such as Parkinson’s disease and epilepsy. Yet many of these interfaces are highly invasive, as they require removing part of the skull to implant electrodes in the brain. Finding a way to monitor and stimulate the central nervous system in a less intrusive way has been a holy grail for those in the neuromodulation field. Now, a collaborative team of NIH-funded researchers at Rice University and The University of Texas are developing a method to access and stimulate deep brain regions without drilling into the skull. They engineered a tiny pulse generator that can be implanted in the spine following a lumbar puncture. This pulse generator is connected to a stimulating catheter, which can be guided through the cerebrospinal fluid to the surface of the brain. After preliminary experiments in human cadavers, the team successfully used the device to record and stimulate brain activity in sheep with the aid of a wireless interface. Their work was recently published in Nature Biomedical Engineering.

Seasonal Allergies at a Glance

https://www.nccih.nih.gov/health/seasonal-allergies-at-a-glance?nav=govd As spring approaches, seasonal allergic rhinitis—also called hay fever—becomes a problem for some people. Symptoms may include sneezing, coughing, a runny or stuffy nose, and itching in the eyes, nose, mouth, and throat. Many complementary health approaches have been studied for allergic rhinitis, and there’s evidence that a few may help. Rinsing the sinuses with a neti pot (a device that comes from the Ayurvedic tradition) or other devices may be a useful addition to conventional treatment for seasonal allergies. Make sure to use only distilled, sterile, or boiled and cooled water; tap water may not be safe for use as a nasal rinse. There’s evidence that acupuncture may be helpful for seasonal allergy symptoms. Some studies of probiotics for allergies have had promising results, but others have not. It’s possible that only some types of probiotics are helpful.

Posttraumatic Stress Disorder Learning Hub: Improving Recognition and Management

https://www.medscape.org/sites/advances/ptsd-learning-hub?sso=true&uac=148436CN&src=mkmcmr_driv_clinad_mscpedu

IMPACT EBC: IMPlementing Advances in Cancer Treatment for Patients With HR+/HER2- Early Breast Cancer Moving Patient Care Forward

https://www.medscape.org/sites/advances/early-breast-cancer?sso=true&uac=148436CN&src=mkmcmr_driv_clinad_mscpedu#ca-section-2

Withdrawal of life sustaining therapies in patients with or without acute brain injury +++

COMMENTS Withdrawal of life sustaining therapies in patients with or without acute brain injury Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00008-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz--rQN6km016zetaUjkoDznhldhX3grKw1VNNzDreQ25CnzsSWHhX25e-wN4Twkwf9ejc7mPjv2aGMqaNhhRh3GplxcJMQ&_hsmi=352808851&utm_content=352808851&utm_source=hs_email Preoxygenation for tracheal intubation in adults who are critically ill: time to abandon the facemask? Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00056-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-9FptrEp4QRM1yekX7fB2o1JwzC59KdPyEtMt0qhIDwd-xO3Rb6OKrWDWAkiWNXISUvnyQUyCg7YvGs_NrOzHPb5PDb6Q&_hsmi=352808851&utm_content=352808851&utm_source=hs_email Nasal high-flow oxygen for apnoeic oxygenation during emergency endotracheal intubation of children Free with registration until Mar 29, 2025 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00085-2/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-8ysi4xFSEa7P680VqjRTHyMLr8p9fBZqqTjhXgC9ZiPAH_53o6OX9XPklbv0LTgdritcdmAixx-rG-DpySoqeTCVXycA&_hsmi=352808851&utm_content=352808851&utm_source=hs_email

Effectiveness of nasal high-flow oxygen during apnoea on hypoxaemia and intubation success in paediatric emergency and ICU settings: a randomised, controlled, open-label trial

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00074-8/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-9BvqpDR6w1vAKeZmjDzcorixmAGUr0folT6HThKVikGSuK81ccogy33IlD9UmAuYYzhfZh4gLe7KHWAZvkk44qyTaObQ&_hsmi=352808851&utm_content=352808851&utm_source=hs_email

Preoxygenation strategies for intubation of patients who are critically ill: a systematic review and network meta-analysis of randomised trials

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00029-3/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz--aMHhxzEMmhwa4WgcpXr_o714uRJxbe02_r_0Sj1zl6A07W_Pq61pRdLsUQTBeWBIi7BROPO1acTSaI5VqDSjem5ybdA&_hsmi=352808851&utm_content=352808851&utm_source=hs_email

Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00404-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-97FuvpYCVh_SueJbF9im7HoEwZjywyMv_Zk32uiYKyFYfYB6npxVMpyhHoFzXBmgImzxgUKH203xhqt14PddcH5-UCYg&_hsmi=352808851&utm_content=352808851&utm_source=hs_email

NIH researchers develop eye drops that slow vision loss in animals Treatment shows potential to slow the progression of human degenerative eye diseases, including retinitis pigmentosa.

https://www.nih.gov/news-events/news-releases/nih-researchers-develop-eye-drops-slow-vision-loss-animals

Study reveals gaps in lung cancer screening despite updated guidelines

https://www.news-medical.net/news/20250320/Study-reveals-gaps-in-lung-cancer-screening-despite-updated-guidelines.aspx

Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein

https://www.news-medical.net/news/20250320/Natural-compounds-identified-as-potential-inhibitors-of-SARS-CoV-2-spike-protein.aspx

Endometriosis Breakthroughs: New Treatments and Research

https://www.news-medical.net/health/Endometriosis-Breakthroughs-New-Treatments-and-Research.aspx

Researchers dig deep into cancer with magnetic nanoparticles Science Highlights March 21, 2025

https://www.nibib.nih.gov/news-events/newsroom/researchers-dig-deep-cancer-magnetic-nanoparticles

Intensive Program Helps People Being Screened for Lung Cancer Quit Smoking

https://www.cancer.gov/news-events/cancer-currents-blog/2025/lung-cancer-screening-helping-people-quit-smoking?cid=eb_govdel

Precision T-Cell Therapy Improves Blood Cancer Outcomes Edited by Susan Ruel, PhD March 21, 2025 +++++

Precision T-Cell Therapy Improves Blood Cancer Outcomes Edited by Susan Ruel, PhD March 21, 2025 https://www.medscape.com/viewarticle/precision-t-cell-therapy-improves-blood-cancer-outcomes-2025a10006rv 3D Total Body Photography Shown to Decrease Biopsies, Improve Dx of Nonmelanoma Skin Cancers Richard Mark Kirkner March 21, 2025 https://www.medscape.com/viewarticle/3d-total-body-photography-shown-decrease-biopsies-improve-dx-2025a10006r7 CA-125 Shows Less Accuracy in Black and American Indian Patients with Ovarian Cancer Edited by Katie Lennon March 21, 2025 https://www.medscape.com/viewarticle/ca-125-shows-less-accuracy-black-and-american-indian-2025a10006rk Do Patients With Intermediate-Risk Cervical Cancer Need Adjuvant Chemotherapy? Whitney McKnight March 20, 2025 https://www.medscape.com/viewarticle/do-patients-intermediate-risk-cervical-cancer-need-adjuvant-2025a10006q4 Can Adjuvant Immunotherapy Boost Survival Outcomes in Advanced Nasopharyngeal Cancer? Edited by Gargi Mukherjee March 20, 2025 https://www.medscape.com/viewarticle/can-adjuvant-immunotherapy-boost-survival-outcomes-advanced-2025a10006o6

OK to Skip Pelvic Lymph Node Dissection in Cervical Cancer? Megan Brooks March 21, 2025

https://www.medscape.com/viewarticle/ok-skip-pelvic-lymph-node-dissection-cervical-cancer-2025a10006s3

Projected Cancer Trends Highlight Urgent Need for Prevention Maurie Markman, MD

https://www.medscape.com/viewarticle/projected-cancer-trends-highlight-urgent-need-prevention-2025a10005lr

Encapsulation of a Single-Stranded Form of DNA Impurities into the Capsid of a Recombinant Adeno-Associated Virus

https://www.liebertpub.com/doi/10.1089/hum.2024.264?utm_campaign=MAL_HUM&utm_medium=email&_hsenc=p2ANqtz-8iXI7dSloS6J_pZvH0Om8Np3gdmU7z_JfPtlgF9Df1-IsCiO8RmrWHSt89dd8QhGuOUGtewNJF1u_wWkpOb2ZtWaNEWA&_hsmi=352880154&utm_content=352880154&utm_source=hs_email Evaluating DNA Impurities in Recombinant Adeno-Associated Virus New Rochelle, NY, March 20, 2025—A new study in the peer-reviewed journal Human Gene Therapy indicates that DNA impurities derived from plasmid and host cell DNA are encapsulated into recombinant adeno-associated virus (rAAV) capsids as single-stranded DNA. Click here to read the article now. rAAVs are widely used viral vectors in human gene therapy, but contamination from DNA impurities, such as plasmid and host cell DNA, remains a significant quality control concern for their manufacture. In this study, Kazuhisa Uchida, from Kobe University, and coauthors examined several purifies rAAV samples and found that they contained DNA derived from three plasmids. They determined that the impurities were encapsulated into the rAAV capsids as single-stranded DNA. The investigators suggest that when rAAVs are used in gene therapy, the adverse effects of the single-stranded form of DNA impurities may differ from those of double-stranded DNA. “It may be necessary to reconsider or evaluate the effects of single-strand form of DNA impurities independently,” stated the investigators. “Studies like this are incredibly important to better understand how DNA impurities are generated and what sources they come from during the production process in order to improve the efficiency of manufacturing and purity of the final rAAV product, which will help make the therapy more effective and reduce adverse events for patients,” says Managing Editor of Human Gene Therapy Thomas Gallagher, PhD, from the University of Massachusetts Chan Medical School.

We empower, partner, and advocate for people living with a rare disease in Europe

https://www.eurordis.org/

Breaking Barriers: Advancing accessibility and inclusion for cerebral palsy in Milan March 2025

https://www.eurordis.org/breaking-barriers-advancing-accessibility-and-inclusion-for-cerebral-palsy-in-milan/

More Than You Can Imagine: A recap of our conference at the European Parliament March 2025

https://www.eurordis.org/recap-conference-european-parliament/

European Parliament Event on Rare Disease Day +++

https://www.eurordis.org/european-parliament-rare-disease-day/ Impactofrarediseases: https://download2.eurordis.org/REPORT_European_Parliament_event_on_RDD.pdf Patient organisations warn against EU rollback on patient involvement in medicines regulation https://www.eurordis.org/epf-eurordis-joint-statement-patient-involvement/

Most Read Papers - Cancer Science & Oncogenesis

https://read.qxmd.com/collection/1133?ecd=wnl_readmost_250321

Hesitating to take the final step? “They made me feel so welcome here.”

https://news.va.gov/138878/hesitating-to-take-the-final-step/

Out of the shadows: One Veteran’s journey through trauma, substance use and renewal Brian Treasure didn’t realize the weight of his past until it started pulling him under

https://news.va.gov/139012/shadows-journey-trauma-substance-use-renewal/

New breast cancer screening recommendations Mammogram costs are covered for Veterans receiving care at VA

https://news.va.gov/138863/new-breast-cancer-screening-recommendations/

FDA approves pembrolizumab for HER2 positive gastric or gastroesophageal junction adenocarcinoma expressing PD-L1 (CPS ≥1)

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pembrolizumab-her2-positive-gastric-or-gastroesophageal-junction-adenocarcinoma

FDA approves first treatment for adults with complement 3 glomerulopathy, a rare kidney disease, to reduce proteinuria

https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-first-treatment-adults-complement-3-glomerulopathy-rare-kidney-disease-reduce?utm_medium=email&utm_source=govdelivery FDA Approves First Treatment for Adults with Complement 3 Glomerulopathy, a Rare Kidney Disease, to Reduce Proteinuria FDA approved Fabhalta (iptacopan) for the treatment of adults with complement 3 glomerulopathy (C3G) to reduce proteinuria. Fabhalta is an oral capsule, taken twice daily. Recommended dosing is available in the prescribing information. C3G is a rare disease that causes inflammation and damage to the kidney glomeruli, which are responsible for filtering blood and producing urine. In C3G, the complement system (proteins in the blood that play a critical role in the immune system) becomes abnormally activated. Complement products can become lodged in the glomeruli causing them to become leaky and harming their ability to filter blood. Waste products and toxins then build up in the blood, which decreases the kidneys’ ability to balance salts and minerals, decreases urine production, and causes continued kidney damage. Fabhalta increases the risk of serious and life-threatening infections caused by encapsulated bacteria, including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b. Patients should complete or update vaccination for encapsulated bacteria at least 2 weeks before the first dose of Fabhalta, unless the risks of delaying treatment outweigh the risks of developing a serious infection. Health care providers should monitor patients for early signs and symptoms of serious infections and evaluate immediately if infection is suspected. Fabhalta may increase total cholesterol, LDL-cholesterol, and serum triglycerides. Health care providers should monitor patients’ serum lipid parameters periodically during treatment with Fabhalta and initiate cholesterol-lowering medication, if indicated. Fabhalta is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS). The most common adverse reactions (reported in at least 10% of patients) to Fabhalta were nasopharyngitis (common cold) and viral infections.

Study Illuminates the Structural Features of Memory Formation at the Cellular and Subcellular Levels NIH-funded study uses cutting-edge imaging techniques to reconstruct features underlying learning and memory in the mouse brain March 20, 2025 • Media Advisory

https://www.nimh.nih.gov/news/science-updates/2025/study-illuminates-the-structural-features-of-memory-formation-at-the-cellular-and-subcellular-levels In a recent study funded by the National Institutes of Health (NIH), researchers shed new light on memory encoding. The researchers exposed mice to a conditioning task and examined their hippocampus about one week later using cutting-edge technology such as 3-D electron microscopy and artificial intelligence. Researchers discovered that neurons involved in memory formation were not preferentially connected. They also found that these neurons reorganized their connections through an atypical connection called a multi-synaptic bouton. This study sheds new light on the fundamentally flexible nature of memory encoding and raises new questions and ideas for future exploration. Read More Study Findings

Zain Verjee is no longer hiding from psoriasis Long-time international TV news anchor shares her story

https://magazine.medlineplus.gov/article/zain-verjee-is-no-longer-hiding-from-psoriasis/

Breast cancer at 33: Telemundo host Adamari López leads with laughter López credits early detection to self-exam and regular checkups

https://magazine.medlineplus.gov/article/breast-cancer-at-33-telemundo-host-adamari-lopez-leads-with-laughter

Starting the conversation to improve mental health Actress Taraji P. Henson is starting the conversation to improve mental health using her platform, Henson is working to de-stigmatize depression and anxiety

https://magazine.medlineplus.gov/article/starting-the-conversation-to-improve-mental-health

Kristin Chenoweth wants to put migraine awareness center stage The Tony Award winner lets others with the condition know they’re not alone

https://magazine.medlineplus.gov/article/kristin-chenoweth-wants-to-put-migraine-awareness-center-stage

The power of music Soprano Renée Fleming teams with NIH on Sound Health Initiative

https://magazine.medlineplus.gov/article/the-power-of-music

Several kinds of acne products recalled over cancer risk, FDA says The recalled items include La Roche-Posay, Proactiv and Walgreens products Brie Stimson By Brie Stimson Fox News Published March 14, 2025 3:58pm EDT

Several kinds of acne products recalled over cancer risk, FDA says The recalled items include La Roche-Posay, Proactiv and Walgreens products Brie Stimson By Brie Stimson Fox News Published March 14, 2025 3:58pm EDT https://www.foxnews.com/health/several-kinds-acne-products-recalled-cancer-risk-fda-says

Deadly cancer type linked to obesity and high stress levels Healthy diet, exercise and mindfulness could reduce pancreatic cancer risk, study finds Melissa Rudy By Melissa Rudy Fox News Published March 15, 2025 5:17pm EDT

Deadly cancer type linked to obesity and high stress levels Healthy diet, exercise and mindfulness could reduce pancreatic cancer risk, study finds Melissa Rudy By Melissa Rudy Fox News Published March 15, 2025 5:17pm EDT https://www.foxnews.com/health/deadly-cancer-type-linked-obesity-high-stress-levels

Pain could be reduced by watching nature scenes, new study suggests Exposure to outdoor environments affects brain's pain centers, researchers say By Khloe Quill Fox News Published March 18, 2025 12:51pm EDT

Pain could be reduced by watching nature scenes, new study suggests Exposure to outdoor environments affects brain's pain centers, researchers say By Khloe Quill Fox News Published March 18, 2025 12:51pm EDT https://www.foxnews.com/health/pain-could-reduced-watching-nature-scenes-new-study-suggests

New outbreak of deadly bird flu strain confirmed for first time in 8 years The H7N9 strain was detected on a poultry farm in Mississippi Angelica Stabile By Angelica Stabile Fox News Published March 19, 2025 5:05pm EDT

New outbreak of deadly bird flu strain confirmed for first time in 8 years The H7N9 strain was detected on a poultry farm in Mississippi Angelica Stabile By Angelica Stabile Fox News Published March 19, 2025 5:05pm EDT https://www.foxnews.com/health/outbreak-deadly-bird-flu-strain-confirmed-first-time-8-years

Traveling amid measles, plus pet food recalls and cancer risk factors And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published March 19, 2025 9:55pm EDT

Traveling amid measles, plus pet food recalls and cancer risk factors And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published March 19, 2025 9:55pm EDT https://www.foxnews.com/health/traveling-amid-measles-outbreak-bird-flu-product-recalls-plus-cancer-linked-high-stress

Jillian Michaels reveals simple workout to extend your lifespan 'up to 7 years' 'Fitness is the No. 1 form of preventative medicine,' Michaels says Ashley J. DiMella By Ashley J. DiMella Fox News Published March 19, 2025 5:00am EDT

Jillian Michaels reveals simple workout to extend your lifespan 'up to 7 years' 'Fitness is the No. 1 form of preventative medicine,' Michaels says Ashley J. DiMella By Ashley J. DiMella Fox News Published March 19, 2025 5:00am EDT https://www.foxnews.com/health/jillian-michaels-reveals-simple-workout-extend-lifespan-7-years

4 troubling cancer trends you must know about in 2025 Oncologists reveal the warning signs that most concern them this year Angelica Stabile By Angelica Stabile Fox News Published March 17, 2025 3:19pm EDT

4 troubling cancer trends you must know about in 2025 Oncologists reveal the warning signs that most concern them this year Angelica Stabile By Angelica Stabile Fox News Published March 17, 2025 3:19pm EDT https://www.foxnews.com/health/4-troubling-cancer-trends-you-must-know-about-2025

Mother with rare ALS touts 'miracle drug' that has stopped her disease Since starting a clinical trial more than 7 years ago, Raziel Green says her symptoms have not gotten any worse Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 5:00am EDT

Mother with rare ALS touts 'miracle drug' that has stopped her disease Since starting a clinical trial more than 7 years ago, Raziel Green says her symptoms have not gotten any worse Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 5:00am EDT https://www.foxnews.com/health/mother-rare-als-touts-miracle-drug-has-stopped-her-disease

Cannabis use endangers heart health for certain group Marijuana impacts cardiac risk as soon as one hour after use, study finds Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 4:58pm EDT

Cannabis use endangers heart health for certain group Marijuana impacts cardiac risk as soon as one hour after use, study finds Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 4:58pm EDT https://www.foxnews.com/health/cannabis-use-endangers-heart-health-certain-group

Just 1 in 10 back pain treatments work, study says — what to do instead Pain is 'complex condition' that requires individual solutions, experts say Melissa Rudy By Melissa Rudy Fox News Published March 20, 2025 5:00am EDT

Just 1 in 10 back pain treatments work, study says — what to do instead Pain is 'complex condition' that requires individual solutions, experts say Melissa Rudy By Melissa Rudy Fox News Published March 20, 2025 5:00am EDT https://www.foxnews.com/health/just-1-10-back-pain-treatments-work-study-says-what-do-instead

A new vaccine is here to protect you and your loved ones from RSV this winter FDA approved a new vaccine for older adults and expanded approval for others

https://magazine.medlineplus.gov/article/a-new-vaccine-is-here-to-protect-you-and-your-loved-ones-from-rsv-this-winter December and January are peak months for respiratory syncytial virus (RSV) infections. While anyone can get RSV, severe infections are more common in young children and older adults. Fortunately, new vaccine approvals by the U.S. Food and Drug Administration (FDA) mean there are more options to avoid getting sick this winter.

Parkinson’s disease explained What you need to know about this movement disorder

https://magazine.medlineplus.gov/article/parkinsons-disease-explained/ Parkinson's disease (PD) is a progressive movement disorder of the nervous system. PD is one of the most common nervous system disorders, especially among older adults. It’s estimated to affect between 500,000 and 1 million Americans.

IBS: What you need to know

Irritable bowel syndrome (IBS) refers to a group of symptoms that occur together and cause pain in the abdomen. They also cause changes in your bowel movements. The type of IBS you have depends on whether you have constipation, diarrhea, or both. Other symptoms may include abdominal cramping, bloating, or whitish mucus in your stool. You also may feel like you haven't finished a bowel movement. https://magazine.medlineplus.gov/article/ibs-what-you-need-to-know/

Meet the Director: Griffin P. Rodgers, M.D., National Institute of Diabetes and Digestive and Kidney Diseases

https://magazine.medlineplus.gov/article/meet-the-director-griffin-p-rodgers-m.d-national-institute-of-diabetes-and-digestive-and-kidney-diseases How does an expert on blood diseases become the head of a “diabetes institute”? That’s a question Griffin P. Rodgers, M.D., Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hears a lot. Since 2007, he has led NIDDK’s staff of nearly 600 people. He also made his own monumental contributions to sickle cell disease research. NIH MedlinePlus Magazine asked Dr. Rodgers about entering medicine and addressing health disparities, and he told us what advice he would give young researchers starting in the field today.

Pancreatic cancer: What you need to know

https://magazine.medlineplus.gov/article/pancreatic-cancer-what-you-need-to-know?utm_medium=email&utm_source=govdelivery The pancreas is a gland behind your stomach and in front of your spine. It produces enzymes that help break down food and hormones that control blood sugar levels. Pancreatic cancer usually begins in these cells. It forms when cells grow out of control and create a tumor. Tumors may be malignant (cancerous) or benign (not cancerous). Two kinds of pancreatic cancer About 95% of pancreatic cancers begin in the cells After pancreatic cancer, Maria Menounos makes health her focus https://magazine.medlineplus.gov/article/after-pancreatic-cancer-maria-menounos-makes-health-her-focus?utm_medium=email&utm_source=govdelivery Maria Menounos has held many jobs and many titles. She is an Emmy Award-winning TV host, reporter, author, podcaster, and sometimes professional wrestler. You may recognize her as host of Entertainment Tonight, Access Hollywood, and E! News and as a reporter for The Today Show. Menounos has faced two major health challenges in recent years: a brain tumor in 2017 and a rare form of pancreatic cancer in 2023. For the pancreatic

NIST Releases Reference Material to Aid Gut Microbiome Research March 17, 2025

https://www.nist.gov/news-events/news/2025/03/nist-releases-reference-material-aid-gut-microbiome-research

Study explores the link between diet, blood glucose, and cancer risk

https://www.news-medical.net/news/20250319/Study-explores-the-link-between-diet-blood-glucose-and-cancer-risk.aspx

Oropouche virus: Emerging threats, symptoms, and prevention

https://www.news-medical.net/news/20250319/Oropouche-virus-Emerging-threats-symptoms-and-prevention.aspx

Australian scientists redefine dietary fiber classification for better health benefits

https://www.news-medical.net/news/20250319/Australian-scientists-redefine-dietary-fiber-classification-for-better-health-benefits.aspx

The Unexpected Effects of GLP-1 Medications on Women’s Health

https://www.news-medical.net/health/The-Unexpected-Effects-of-GLP-1-Medications-on-Womene28099s-Health.aspx

Research shows decline in risky behaviors and rise in depression among adolescents

https://www.news-medical.net/news/20250319/Research-shows-decline-in-risky-behaviors-and-rise-in-depression-among-adolescents.aspx

Comparing mental health trajectories of teenagers in London and Tokyo

https://www.news-medical.net/news/20250319/Comparing-mental-health-trajectories-of-teenagers-in-London-and-Tokyo.aspx

Electronic cigarettes may pose lower cardiovascular risks for people with HIV

https://www.news-medical.net/news/20250319/Electronic-cigarettes-may-pose-lower-cardiovascular-risks-for-people-with-HIV.aspx

Older immigrants and immigrants with dementia face interconnected barriers to social and medical services in Finland

https://www.news-medical.net/news/20250319/Older-immigrants-and-immigrants-with-dementia-face-interconnected-barriers-to-social-and-medical-services-in-Finland.aspx

Altered knee joint movement after ACL surgery could contribute to early-onset knee osteoarthritis

https://www.news-medical.net/news/20250319/Altered-knee-joint-movement-after-ACL-surgery-could-contribute-to-early-onset-knee-osteoarthritis.aspx

The brain scans its surroundings in a steady rhythm and only turns off during deep sleep Eldrid Borgan | Science Norway | March 19, 2025

https://geneticliteracyproject.org/2025/03/19/the-brain-scans-its-surroundings-in-a-steady-rhythm-and-only-turns-off-during-deep-sleep/?mc_cid=d787e7d5f8&mc_eid=b73600b7ac

Guided by RFK Jr.’s scientifically illiterate advice, many Texas families with measles-infected children avoid going to the doctor, sometimes until it’s too late Teddy Rosenbluth | New York Times | March 19, 2025

https://geneticliteracyproject.org/2025/03/19/guided-by-rfk-jr-s-scientifically-illiterate-advice-many-texas-families-with-measles-infected-children-avoid-going-to-the-doctor-sometimes-until-its-too-late/?mc_cid=d787e7d5f8&mc_eid=b73600b7ac

Missing teeth? A drug that that spurs regrowth shows promise March 19, 2025

https://geneticliteracyproject.org/2025/03/19/missing-teeth-a-drug-that-that-spurs-regrowth-shows-promise/?mc_cid=d787e7d5f8&mc_eid=b73600b7ac

Bacterial biosensors eavesdrop on the gut Genetically engineered bacteria could help diagnose or monitor gut diseases.

https://www.drugdiscoverynews.com/bacterial-biosensors-eavesdrop-on-the-gut-15641?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8MbRvKz92_DgTzkvEPDW-uyYvmccNWOxFXYw8AfY9GMG6D-9Fu-Ai4mdfPpBexuea3KdHkjsk_1BVNJ7wBEjSpeZC1LQ&_hsmi=352612159&utm_content=352612159&utm_source=hs_email

Engineering bacteria for drug delivery Researchers investigated the feasibility of microbiome-based drug delivery as a longer-lasting alternative to current topical formulations.

https://www.drugdiscoverynews.com/engineering-bacteria-for-drug-delivery-15978?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_BQ0CjDh4so3nFh2-kRcekMAg1tS4jj8-iR9mHQwEw75ua40dL1Y-sBtRH2jAf8K4XB6bok-5T1glbBLTQOtJvfcjGPw&_hsmi=352612159&utm_content=352612159&utm_source=hs_email

A live bacteria treatment for acne Microbiome researcher Sarah Lebeer studies how beneficial bacteria can help treat inflammatory skin conditions such as acne and atopic dermatitis.

https://www.drugdiscoverynews.com/a-live-bacteria-treatment-for-acne-15924?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_X63nF3tUsVvpJz3ltadw1IhFDKeqsUJ7PUT9B_Ds0W0S26eAao1XtqAhW_QIYYqiOsQ_CHn52-VmH9kdE9f2XyyK7EA&_hsmi=352612159&utm_content=352612159&utm_source=hs_email

Phages return CRISPR to its microbial roots Virus-inspired delivery methods enable gene editing of dysregulated microbes.

https://www.drugdiscoverynews.com/phages-return-crispr-to-its-microbial-roots-16270

Teenager who received Elevidys, Sarepta’s Duchenne gene therapy, dies The therapy was approved amid intense debate at the FDA, though mostly around its efficacy

https://www.statnews.com/2025/03/18/elevidys-sarepta-duchenne-death/?utm_campaign=daily_recap&utm_medium=email&_hsenc=p2ANqtz-9GVb4cgn_m-M7MQeZmy8u6e65s9p7yb3TvaW2-nHAYlnZXNnmrEWjoxnPhuidFaJyYbcao_bm-tRv8HtvZTq4KFPrKgA&_hsmi=352511346&utm_content=352511346&utm_source=hs_email

The biggest challenge to forcing change in America’s diet: making it taste good Banning junk food from SNAP and school lunches is only half the battle

https://www.statnews.com/2025/03/19/snap-candy-soda-ban-school-lunches-ultra-processed-food-rfk-jr/

Immunovant and Roivant report success in autoimmune drug’s Phase 3 trial Myasthenia gravis patients showed improvement with both low and high doses of batoclimab

https://www.statnews.com/2025/03/19/immunovant-roivant-batoclimab-myasthenia-gravis-autoimmune-trial-success/

45% of Americans will develop osteoporosis of the knee in their lifetime. How did evolution botch this? Michael Berthaume | March 17, 2025

https://geneticliteracyproject.org/2025/03/17/45-of-americans-will-develop-osteoporosis-of-the-knee-in-their-lifetime-how-did-evolution-botch-this/

Viewpont: MACA—Make America Contagious Again. As the COVID pandemic turns 5, with Trump and RFK, Jr.’s health team in place, we’re less prepared for a crisis than ever before Simon Williams | Time | March 17, 2025

https://geneticliteracyproject.org/2025/03/17/veiewpont-maca-make-america-contagious-again-as-the-covid-pandemic-turns-5-with-trump-and-rfk-jr-s-health-team-in-place-were-less-prepared-for-a-crisis-than-ever-before/?mc_cid=1c0653b3c3&mc_eid=b73600b7ac

Viewpoint: Here’s why almost all sports supplements are a risky scam Christopher Labos | Montreal Gazette | March 17, 2025

https://geneticliteracyproject.org/2025/03/17/viewpoint-heres-why-almost-all-sports-supplements-are-a-risky-scam/?mc_cid=1c0653b3c3&mc_eid=b73600b7ac

‘Biological rewind button’: Eye treatment on the horizon that some scientists believe literally turns back the clock on age-related health conditions Alice Park | Time | March 18, 2025

https://geneticliteracyproject.org/2025/03/18/biological-rewind-button-eye-treatment-on-the-horizon-that-some-scientists-believe-literally-turns-back-the-clock-on-age-related-health-conditions/?mc_cid=1c0653b3c3&mc_eid=b73600b7ac

Honing in on the difference between chronological and biological age Charlie De Mar | CBS News | March 18, 2025

https://geneticliteracyproject.org/2025/03/18/honing-in-on-the-difference-between-chronological-and-biological-age/?mc_cid=1c0653b3c3&mc_eid=b73600b7ac

A gene therapy for chronic pain Researchers identified a peptide that selectively blocks pain signaling in sensory neurons and packaged it into a viral-based gene therapy in a step towards treating chronic pain without the risk for addiction.

https://www.drugdiscoverynews.com/a-gene-therapy-for-chronic-pain-15866?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8WayVKS-FUBEXNrc5xsz9zTqlEogfVcwRLfIsIQomQXDVL5dl7UUgNqjN8A9A4LIA8oLEiXCmDm98LFUJTfnWwFV3-eA&_hsmi=352430543&utm_content=352430543&utm_source=hs_email

Activating a brain circuit relieves pain in male mice, but not in female mice Scientists identified a new sex-specific pain circuit in the brain, laying the groundwork for developing better pain-relieving drugs for both sexes.

https://www.drugdiscoverynews.com/activating-a-brain-circuit-relieves-pain-in-male-mice-but-not-in-female-mice-15193?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9UgK5P06QO1MEikyAaiEWX4YkJeqglJ6KGBqpUshlkPQO-41dAtGINXEnwjkmzRQX0vqtNFE67M9B2385tIsHVel4btg&_hsmi=352430543&utm_content=352430543&utm_source=hs_email

A dual-threat cancer drug takes aim at resistance mechanisms Judy Sebolt-Leopold and her team at MEKanistic Therapeutics developed a single molecule targeting two kinase enzymes that drive resistance to cancer therapies.

https://www.drugdiscoverynews.com/a-dual-threat-cancer-drug-takes-aim-at-resistance-mechanisms-16267

What’s next for the first non-opioid pain drug in 20 years Vertex Pharmaceuticals’ drug, Journavx, blocks a sodium channel outside of the brain. Experts hope that this non-addictive pain drug may be the first of many.

https://www.drugdiscoverynews.com/what-s-next-for-the-first-non-opioid-pain-drug-in-20-years-16269

Revolutionising cancer treatment access in low-income and middle-income countries: a sustainable approach

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00071-3/abstract?utm_campaign=update-lanonc&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanonc&_hsenc=p2ANqtz-_xLDn-Iisc8WM4tOeyWHc8pt0BBlEY8cpE-65Sj0M8ppCY2c2WHjMyTGZu-9LyMG3NXNJ-K2LzbRP9vBNeh0MUHP11lg&_hsmi=352273015&utm_content=351420884&utm_source=hs_email

Personalised cancer vaccines and new regulatory struggles The Lancet Oncology

https://www.thelancet.com/journals/lanonc/issue/vol26no3/PIIS1470-2045(25)X0003-6

Overall survival and quality of life with [177Lu]Lu-PSMA-617 plus enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer (ENZA-p): secondary outcomes from a multicentre, open-label, randomised, phase 2 trial

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00009-9/abstract?utm_campaign=update-lanonc&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanonc&_hsenc=p2ANqtz-8Y-cIRsp4vSXZfOTRUqSGbEcW-NwLc2hj-7HODar5Kuv3TgK852QD_0PfWJQSD-bQI2AjR6VU4OecNSKMA_PtsHE6jiA&_hsmi=352273015&utm_content=351420884&utm_source=hs_email

Cancer surveillance in the Eastern Mediterranean region: a 10-year International Agency for Research on Cancer–WHO Regional Office for the Eastern Mediterranean collaboration

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(24)00624-7/abstract?utm_campaign=update-lanonc&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanonc&_hsenc=p2ANqtz-_lCuQCEVFY8VD9D6zyT6N63UdIPShgs0f9O4vscurlmmMAeoE4NQw5VzGNL7mqBbTlgZaEI965yH7d2WJglTzFGxeEmQ&_hsmi=352273015&utm_content=351420884&utm_source=hs_email

Defining obesity to improve ageing The Lancet Healthy Longevity

https://www.thelancet.com/journals/lanhl/issue/vol6no2/PIIS2666-7568(25)X0003-9

Moving beyond the prevalent exposure design for causal inference in dementia research

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00201-0/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz-8Xk4qEO_pbg6m0Ah1UQuNdkOjNxuKgZn7PkhbKW46sk7AN7HmfQ84hSuF_NmbK-4tQSbwquQuXwowl0e3m2oaL3_pYPQ&_hsmi=352137268&utm_content=351421695&utm_source=hs_email

Clinical and cost-effectiveness of a home-based health promotion intervention for older people with mild frailty in England: a multicentre, parallel-group, randomised controlled trial

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00196-X/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz-_yg4uEksZkMJMXM4Zos_qLzU7kS2r1CKKDNBwcBFwlBK1vNofzavs8LIifqH1BPDxUUa3LrjS0tWPT2bnMXMo9qdZGmQ&_hsmi=352137268&utm_content=351421695&utm_source=hs_email

Cost-utility of a new psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: an economic evaluation embedded within a randomised controlled trial

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00202-2/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz--Ozvtpbdy677tvQoV0J80VGX4hsadc3y9OKVwYU7mwkchPWDG8dsxmaWcr5feXDn9-mElu-6np90q7UyCdC-lP7FWMRg&_hsmi=352137268&utm_content=351421695&utm_source=hs_email

NIH-funded study identifies potential new stroke treatment Preclinical study in rodents suggests that uric acid is ready for human clinical testing.

https://www.nih.gov/news-events/news-releases/nih-funded-study-identifies-potential-new-stroke-treatment

NIH-Sponsored Trial of Lassa Vaccine Opens

https://www.niaid.nih.gov/news-events/nih-sponsored-trial-lassa-vaccine-opens?utm_campaign=+64446275&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=

Surgery in kids with mild sleep-disordered breathing tied to fewer doctor visits, meds NIH-funded study supports use of adenotonsillectomy in this at-risk patient group.

https://www.nih.gov/news-events/news-releases/surgery-kids-mild-sleep-disordered-breathing-tied-fewer-doctor-visits-meds

Rectal Cancer Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/colorectal/hp/rectal-treatment-pdq?cid=eb_govdel#top

Prostate Cancer Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/prostate/hp/prostate-treatment-pdq?cid=eb_govdel#top

Pancreatic Cancer Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/pancreatic/hp/pancreatic-treatment-pdq?cid=eb_govdel#top

Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/ovarian/hp/ovarian-epithelial-treatment-pdq?cid=eb_govdel#top

Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq?cid=eb_govdel#top

Aggressive B-Cell Non-Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version

https://www.cancer.gov/types/lymphoma/hp/aggressive-b-cell-lymphoma-treatment-pdq?cid=eb_govdel#top

Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00559-X/fulltext?dgcid=hubspot_update_feature_updatealerts_langlo&utm_campaign=update-langlo&utm_medium=email&_hsenc=p2ANqtz--rSEbPwbfBr3AR_sqaM6f4ToJKqssQg8SO2G4wC5158plS3iR-N8_UJwi9aV3wkryiovWaB6qOkYqqq-RnJpIiJTrlyA&_hsmi=350996327&utm_content=350942355&utm_source=hs_email

Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D)

https://www.fda.gov/about-fda/accelerating-rare-disease-cures-arc-program/learning-and-education-advance-and-empower-rare-disease-drug-developers-leader-3d?utm_medium=email&utm_source=govdelivery#case-studies

Social Bonds | Multiple Sclerosis | Peanut Allergy | NIH Clinical Center Research | Stomach Flu

https://content.govdelivery.com/accounts/USNIH/bulletins/3d507f9?reqfrom=share

Adding Online Group Mindfulness Sessions to Medication Treatment Reduces Opioid Craving in People With Opioid Use Disorder

https://www.nccih.nih.gov/research/research-results/adding-online-group-mindfulness-sessions-to-medication-treatment-reduces-opioid-craving-in-people-with-opioid-use-disorder?nav=govd

Scientists develop improved mouse model for studying systemic aging-related health decline

https://www.nia.nih.gov/news/scientists-develop-improved-mouse-model-studying-systemic-aging-related-health-decline?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250317

Senolytic therapy shows subtle impact on age-related bone health in women

https://www.nia.nih.gov/news/senolytic-therapy-shows-subtle-impact-age-related-bone-health-women?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250317

A mother’s X chromosome affects learning and memory in later life

https://www.nia.nih.gov/news/mothers-x-chromosome-affects-learning-and-memory-later-life?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250317

Timeframe of 8-hour restricted eating irrelevant to weight loss

https://www.nia.nih.gov/news/timeframe-8-hour-restricted-eating-irrelevant-weight-loss?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250317

Updated Guideline on the Treatment of Locally Advanced Esophageal and Esophageal Junction Adenocarcinoma and Metastatic SCC (ESMO, 2025) European Society for Medical Oncology March 10, 2025

https://reference.medscape.com/viewarticle/updated-guideline-treatment-locally-advanced-esophageal-and-2025a10004z7?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

Clinical Practice Guidelines on the Management of Vascular Trauma (ESVS, 2025) European Society for Vascular Surgery March 10, 2025

https://reference.medscape.com/viewarticle/clinical-practice-guidelines-management-vascular-trauma-esvs-2025a10004z8?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

Preferred Practice Pattern for Diabetic Retinopathy (AAO, 2025) American Academy of Ophthalmology March 10, 2025

https://reference.medscape.com/viewarticle/preferred-practice-pattern-diabetic-retinopathy-aao-2025-2024a1000kxp?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

Updated Guideline on the Treatment of Drug-Susceptible and Drug-Resistant TB (ATA/CDC/ERS/IDSA, 2025) American Thoracic Society, US Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America March 10, 2025

https://reference.medscape.com/viewarticle/updated-guideline-treatment-drug-susceptible-and-drug-2025a10004yx?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

Guideline for Outpatient Pharmacologic Prevention of Episodic Migraine Headache (ACP, 2025) American College of Physicians March 10, 2025

https://reference.medscape.com/viewarticle/guideline-outpatient-pharmacologic-prevention-episodic-2025a10004zp?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

Pharmacologic Management of Adults With Dyslipidemia Clinical Practice Guideline (AACE, 2025) American Association of Clinical Endocrinology March 10, 2025

https://reference.medscape.com/viewarticle/pharmacologic-management-adults-dyslipidemia-clinical-2025a10004yy?ecd=WNL_drugguidelines_250317_MSCPREF_traf_etid7291826&uac=148436CN&impID=7291826

U.S. consumers still unaware of raw milk risks despite bird flu findings

https://www.news-medical.net/news/20250314/US-consumers-still-unaware-of-raw-milk-risks-despite-bird-flu-findings.aspx

New scientific clue could unlock key cellular pathway leading to neurodegenerative diseases

https://www.news-medical.net/news/20250314/New-scientific-clue-could-unlock-key-cellular-pathway-leading-to-neurodegenerative-diseases.aspx

Blood-brain barrier dysfunction and inflammation linked to Down syndrome Regression Disorder

https://www.news-medical.net/news/20250314/Blood-brain-barrier-dysfunction-and-inflammation-linked-to-Down-syndrome-Regression-Disorder.aspx

Wildland-urban interface fires are far more dangerous to health than remote wildfires

https://www.news-medical.net/news/20250314/Wildland-urban-interface-fires-are-far-more-dangerous-to-health-than-remote-wildfires.aspx

Adding chemotherapy to radiotherapy does not improve outcomes for cervical cancer patients

https://www.news-medical.net/news/20250314/Adding-chemotherapy-to-radiotherapy-does-not-improve-outcomes-for-cervical-cancer-patients.aspx

Targeting aneuploidy to treat cancer Most cancer cells have the wrong number of chromosomes, known as aneuploidy. Scientists are finding ways to target this flaw with new treatments.

https://www.drugdiscoverynews.com/targeting-aneuploidy-to-treat-cancer-16262?utm_campaign=DDN_Newsletter_Science%20Spotlight&utm_medium=email&_hsenc=p2ANqtz-8BELVscoiQd7RZelWMjtcTBb-SGbiiwb6ok8vCkOsTSPwWJyZFYKgo6-3BON0oC-nKZ7JTHae2E388RJbArwjSkeIXUw&_hsmi=352063753&utm_content=351951369&utm_source=hs_email

Weekly Rundown: Report of first in vivo base editing DDN editors break down a surprising connection between microplastics and antimicrobial resistance, vitamin D for multiple sclerosis, obesity drugs updates, and more news from this week.

https://www.drugdiscoverynews.com/weekly-rundown-report-of-first-in-vivo-base-editing-16266?utm_campaign=DDN_Newsletter_Science%20Spotlight&utm_medium=email&_hsenc=p2ANqtz-9J1mFFU7izAUGKeUMcytu3AubxWT4tjclewxNwOKJQUSqixwDDncjuZqbGXyQB8mgcYzSUVWqdkiKVyLeE7VlBkMYN9w&_hsmi=352063753&utm_content=351951369&utm_source=hs_email

Illuminating the full side effect profile of GLP-1 drugs GLP-1 agonists have transformed the treatment of type 2 diabetes and obesity, but they come with side effects. Physicians say the benefits outweigh the risks.

https://www.drugdiscoverynews.com/illuminating-the-full-side-effect-profile-of-glp-1-drugs-16259?utm_campaign=DDN_Newsletter_Science%20Spotlight&utm_medium=email&_hsenc=p2ANqtz-9Z4EEmxwDfFjzewMqLLqKtsom2XQEfqYa4uSlCiKbvuwpotaSeN4q0R0I64G1iANY9hn_zFSN0g7uk75CliXWEsIme6Q&_hsmi=352063753&utm_content=351951369&utm_source=hs_email

Ensitrelvir Shows Promise for COVID-19 Prevention Following Exposure Heidi Splete March 14, 2025

https://www.medscape.com/viewarticle/ensitrelvir-shows-promise-covid-19-prevention-following-2025a100068j

Ovarian Cancer Highlights From ESGO 2025 Kathleen N. Moore, MD | March 14, 2025

https://www.medscape.com/viewarticle/esgo-2025-ovarian-cancer-2025a10001ze

ASCO Updates Treatment Guidance for Newly Diagnosed, Advanced Ovarian Cancer Christos Evangelou, MSc, PhD February 24, 2025 +++++ ++ +++

TRENDING IN WOMEN’S HEALTH Tirzepatide & Birth Control: What to Know Tirzepatide Plus Contraceptives: What You Need to Know Clare J. Spencer, DM https://www.medscape.com/viewarticle/tirzepatide-plus-contraceptives-what-you-need-know-2025a10005dj?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 Is Nutrition a Missing Link in Infertility? 1 in 6 Face Infertility: Is Nutrition the Missing Link? Caroline Guignot March 04, 2025 https://www.medscape.com/viewarticle/1-6-face-infertility-nutrition-missing-link-2025a10005ac?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 LARC Effectiveness and the Limits of Long-Term Use Systematic Review Demonstrates Prolonged LARC Efficacy Louise Gagnon March 02, 2025 https://www.medscape.com/viewarticle/systematic-review-demonstrates-prolonged-larc-efficacy-2025a1000572?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 Ob/Gyns Under Pressure: Mental Health & Burnout Striving for Balance in Your Specialty: Medscape Ob/Gyn Mental Health & Well-Being Report 2025 Mary Lyn Koval | March 7, 2025 | https://www.medscape.com/slideshow/2025-mentalhealth-obgyn-6018057?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 Rising Burden of Postmenopausal OA Global Osteoarthritis Burden Shows Dramatic Rise in Postmenopausal Women Edited by Javed Choudhury March 10, 2025 https://www.medscape.com/viewarticle/global-osteoarthritis-burden-shows-dramatic-rise-2025a10005r1?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 OVARIAN CANCER New Ovarian Cancer Guidelines: What’s Changing? ASCO Updates Treatment Guidance for Newly Diagnosed, Advanced Ovarian Cancer Christos Evangelou, MSc, PhD February 24, 2025 https://www.medscape.com/viewarticle/asco-updates-treatment-guidance-newly-diagnosed-advanced-2025a10004ox?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 Ovarian Cancer Risk: Does ‘The Pill’ Help? Does Taking ‘The Pill’ Reduce Ovarian Cancer Risk? Tara Haelle February 21, 2025 https://www.medscape.com/viewarticle/does-taking-pill-reduce-ovarian-cancer-risk-2025a10004kg?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 PREGNANCY & POSTPARTUM Before Pregnancy – Are GLP-1s a Cause for Concern? GLP-1 Exposure Before and During Pregnancy Linked to Contradictory Outcomes Tara Haelle February 27, 2025 https://www.medscape.com/viewarticle/glp-1-exposure-before-and-during-pregnancy-linked-2025a100050l?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 Gestational Hypertension: BP Patterns Predict Risk BP Patterns and Adverse Outcomes in Gestational Hypertension Edited by Satish Kumar M March 11, 2025 https://www.medscape.com/viewarticle/bp-patterns-and-adverse-outcomes-gestational-hypertension-2025a10005n6?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321 GLP-1s in Pregnancy: Benefits & Risks GLP-1 Therapies and Pregnancy: Navigating Risks and Optimizing Outcomes Ambarish Pandey, MD, MSCS; Jaime Almandoz, MD, MBA; Sarah Ro, MD DISCLOSURES | March 03, 2025 https://www.medscape.com/viewarticle/glp-1-therapies-and-pregnancy-navigating-risks-and-2025a10004z6?ecd=mkm_ret_250316_mscpmrk_obgyn_women_etid7296321&uac=148436CN&impID=7296321

Mohs Surgery Demonstrates Superior Margin Control and Reconstruction Times in Melanoma March 14, 2025

https://www.medscape.com/viewarticle/mohs-surgery-demonstrates-superior-margin-control-and-2025a100068i

Is Butter Consumption Linked to Increased Risk of Cancer Death? Will Pass March 14, 2025

https://www.medscape.com/viewarticle/butter-consumption-linked-increased-risk-cancer-death-2025a100069z

Cryotherapy for Chemotherapy Neuropathy: Does It Work? M. Alexander Otto, PA, MMS March 14, 2025

https://www.medscape.com/viewarticle/cryotherapy-chemotherapy-neuropathy-does-it-work-2025a100069v

Depression

https://emedicine.medscape.com/article/286759-overview?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441

Seasonal Affective Disorder (SAD)

https://emedicine.medscape.com/article/2500054-overview?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441

Trump Administration Review of Psychiatric Meds Raises Concerns Kelli Whitlock Burton February 20, 2025 +++++

TRENDING Psych Med Review Raises Concerns Trump Administration Review of Psychiatric Meds Raises Concerns Kelli Whitlock Burton February 20, 2025 https://www.medscape.com/viewarticle/trump-administration-review-psychiatric-meds-raises-concerns-2025a10004hu?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 Do Antidepressants Worsen Dementia? Do Antidepressants Speed Cognitive Decline in Dementia? Megan Brooks February 25, 2025 https://www.medscape.com/viewarticle/do-antidepressants-speed-cognitive-decline-dementia-2025a10004tq?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 MAJOR DEPRESSION UPDATES New Hope for Treatment-Resistant Depression Rethinking Treatment-Resistant Depression: New Hope Ahead? Megan Brooks February 26, 2025 https://www.medscape.com/viewarticle/rethinking-treatment-resistant-depression-new-hope-ahead-2025a10004wb?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 MDD Tied to This Risky Behavior in Seniors Major Depression in Older Adults Tied to Risky Driving Behaviors Megan Brooks January 06, 2025 https://www.medscape.com/viewarticle/major-depression-older-adults-tied-risky-driving-behaviors-2025a100006k?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 Novel Protocol Promising for Treatment-Resistant Depression Novel Accelerated Theta-Burst Stimulation Protocol Shows Promise for Treatment-Resistant Depression Megan Brooks March 07, 2025 https://www.medscape.com/viewarticle/novel-accelerated-theta-burst-stimulation-protocol-shows-2025a10005ns?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441

KEY INSIGHTS ON DEPRESSION: Can Walking More Steps Per Day Help Keep Depression Away? Edited by Anushree Chaphalkar January 17, 2025 ++++

KEY INSIGHTS ON DEPRESSION The Simple Activity to Keep Depression Away Can Walking More Steps Per Day Help Keep Depression Away? Edited by Anushree Chaphalkar January 17, 2025 https://www.medscape.com/viewarticle/can-walking-more-steps-day-help-keep-depression-away-2025a100015f?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 How Nutrients Affect Depression Risk in Older Adults Nutrient Patterns and Depression Risk in Older Adults Edited by Anushree Chaphalkar February 21, 2025 https://www.medscape.com/viewarticle/nutrient-patterns-and-depression-risk-older-adults-2025a100049d?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 Psych Disorder May Speed Physical Decline Depression May Speed Up Physical Health Decline Edited by Anushree Chaphalkar March 06, 2025 https://www.medscape.com/viewarticle/depression-may-speed-physical-health-decline-2025a10005ii?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 Can You Identify Seasonal Affective Disorder? Fast Five Quiz: Seasonal Affective Disorder Yasmine S. Ali, MD https://reference.medscape.com/viewarticle/1001923?ecd=mkm_ret_250316_mscpmrk_psych_depress_etid7296441&uac=148436CN&impID=7296441 March 10, 2025

Evolving Strategies for Metastatic Breast Cancer: A Deep Dive Into Recent Progress Authors: Fatima Cardoso, MD; Nicola Fusco, MD; Komal Jhaveri, MD, FACP

https://www.medscape.org/viewarticle/1001849?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250316-OUS-HONC-1001849-cta

The uncertainties of monitoring progress towards achieving global nutrition targets

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02180-9/abstract?utm_campaign=gbdalerts&utm_medium=email&dgcid=hubspot_email_gbdalerts&_hsenc=p2ANqtz-8VYUAf9uTVZlJaWEOdjvuCoFO9urroRvLXVRagqMsGBwWzaCRk_OgoDw0ZESacsMQ6sBIXrQdMZdKBcPdinNDfsLIumQ&_hsmi=351974507&utm_content=351927943&utm_source=hs_email

Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01821-X/fulltext?dgcid=hubspot_email_gbdalerts&utm_campaign=gbdalerts&utm_medium=email&_hsenc=p2ANqtz-8p87_UFDBrbWoOJVlmqNdJ29CFSqY-MIHc9KsjnApqc4NfNEiXELaOES4Br5qwRxq1VFsvuN5x_uM5gfk8vYwrV5zSNA&_hsmi=351974507&utm_content=351927943&utm_source=hs_email

Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease Study 2021

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00577-7/fulltext?dgcid=hubspot_email_gbdalerts&utm_campaign=gbdalerts&utm_medium=email&_hsenc=p2ANqtz--TYaWvR8uK4JdWAcE7buEsaY5TnSFTtMBlpMh3cQ-OwjJNoMDzvpKtaYCvcefD58T5a5DmXhnf9rAQ8YzPfOqVT6e6Dg&_hsmi=351974507&utm_content=351927943&utm_source=hs_email

Global prevalence of autism in changing times

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00412-7/abstract?utm_campaign=gbdalerts&utm_medium=email&dgcid=hubspot_email_gbdalerts&_hsenc=p2ANqtz-8bpboXe8JYeEG4WjkJAgUSh7tJ9OzxNE9WVayjH_ia9vn6qezyvizIZ-1-o4qeg75tvz5bAIJUta2_1KZzOn3dOyIbyA&_hsmi=351974507&utm_content=351927943&utm_source=hs_email

The global epidemiology and health burden of the autism spectrum: findings from the Global Burden of Disease Study 2021

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00363-8/fulltext?dgcid=hubspot_email_gbdalerts&utm_campaign=gbdalerts&utm_medium=email&_hsenc=p2ANqtz-_d2C0NHMTXavrv5ZJL7jOFVYpqMqiyfwQ02Q6Xh_VVw0sy7vndXBEn66ewcPM_jpOzsLnj7UKDTxkp_qJTm0YlE1X20g&_hsmi=351974507&utm_content=351927943&utm_source=hs_email

STRESS-PROOF KIDS: THE POWER OF ACTIVE HOPE

Stress-Proof Kids: The Power of Active Hope By Ivanhoe Broadcast News on March 22, 2025 https://www.ivanhoe.com/?p=35174&preview=1&_ppp=06bea8c1ff

FRUGAL FORMULA: HOW TO SPEND LESS AND SAVE MORE!

Frugal Formula: How To Spend Less And Save More! By Ivanhoe Broadcast News on March 21, 2025 https://www.ivanhoe.com/?p=35189&preview=1&_ppp=b2ee0232f4

PROTECTING YOUR DIGITS: KEEPING YOUR SOCIAL SECURITY NUMBER SAFE

Protecting Your Digits: Keeping Your Social Security Number Safe By Ivanhoe Broadcast News on March 20, 2025 https://www.ivanhoe.com/?p=35186&preview=1&_ppp=1940d1ce94

BETTING ON HER! THE RISE OF WOMEN’S NCAA

Betting On Her! The Rise Of Women’s NCAA By Ivanhoe Broadcast News on March 19, 2025 https://www.ivanhoe.com/?p=35183&preview=1&_ppp=a1a4ee1521

BUYER BEWARE: SIGNS OF HIDDEN WATER DAMAGE IN USED VEHICLES

Buyer Beware Signs Of Hidden Water Damage In Used Vehicles By Ivanhoe Broadcast News on March 18, 2025 https://www.ivanhoe.com/?p=35180&preview=1&_ppp=9ab9d6bd45

Busting Burnout: Recharging with mini retirements

Busting Burnout: Taking Mini Retirements To Recharge By Ivanhoe Broadcast News on March 17, 2025 https://www.ivanhoe.com/?p=35177&preview=1&_ppp=070a8261bf

New Israeli tech doubles IVF success rates The new method accurately identifying high-quality sperm cells without using potentially harmful chemical dyes.

https://www.israel21c.org/new-israeli-tech-doubles-ivf-success-rates/

Treating clogged arteries will soon be safer and faster Pylon Medical offers a first-of-its-kind method to clean clogged neck arteries in the least invasive way possible, reducing complications.

https://www.israel21c.org/treating-clogged-arteries-will-soon-be-safer-and-faster/

Israeli researcher to lead new EU cardiometabolic care program The CAREPATH program aims to help heart disease patients take their medication correctly and consistently.

https://www.israel21c.org/eu-invests-in-israeli-heart-disease-care-program/

New drug-delivery method promises revolution in IBD treatment By adjusting the fat levels in mRNA-based drugs, researchers have found a way to bypass the liver and go straight to the intestine.

https://www.israel21c.org/new-drug-delivery-method-promises-revolution-in-ibd-treatment/

Artificial breastmilk could form basis for future oral meds and vaccines Israelis develop ‘milkosomes,’ artificial particles based on human milk that can deliver drugs across the intestinal barrier to the bloodstream.

https://www.israel21c.org/artificial-breastmilk-could-form-basis-for-future-oral-meds-and-vaccines/

Scientists find how to avoid contamination of lab-grown meat Evolving cultivated meat industry aims to avoid the use of antibiotics but will need to ensure the meat does not become infected with bacteria.

https://www.israel21c.org/scientists-find-how-to-avoid-contamination-of-lab-grown-meat/

Topical steroid withdrawal (TSW) results in dermatitis that is distinct from eczema and is caused by an excess of an essential chemical compound in the body, according to a new study from researchers at the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID). Scientists identified treatments that could be studied in clinical trials for the condition based on their potential to lower levels of the chemical compound—called nicotinamide adenine dinucleotide (NAD+), a form of vitamin B3. The findings were published today in the Journal of Investigative Dermatology.

https://www.israel21c.org/diagnosing-rare-diseases-could-soon-get-much-simpler/

Topical steroid withdrawal diagnostic criteria defined by NIH researchers Criteria may help guide treatment of dermatitis.

https://www.nih.gov/news-events/news-releases/topical-steroid-withdrawal-diagnostic-criteria-defined-nih-researchers Topical steroid withdrawal (TSW) results in dermatitis that is distinct from eczema and is caused by an excess of an essential chemical compound in the body, according to a new study from researchers at the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID). Scientists identified treatments that could be studied in clinical trials for the condition based on their potential to lower levels of the chemical compound—called nicotinamide adenine dinucleotide (NAD+), a form of vitamin B3. The findings were published today in the Journal of Investigative Dermatology.

Can Comfort Foods Be Healthy?

https://dpcpsi.nih.gov/onr/blog/march-2025-onr-directors-blog Comfort foods—like ice cream, cookies, and pizza—help you feel good because they tap into your emotions and memories and even your brain. But can they be good for your body, too? Dr. Drew Bremer, director of the Office of Nutrition Research at the National Institutes of Health, says that the answer to this question is yes—if you choose healthy versions or smaller portions. In a blog post for National Nutrition Month®, Dr. Bremer explains that leaning into healthy comfort eating can have benefits for both physical and mental health and be part of a positive strategy for wellness. And although there’s much more to be learned, research is beginning to suggest that diet may even help to improve symptoms of some mental health conditions.

AI and Immunotherapy | Breast Reconstruction | Multiple Myeloma Research, 03/12/2025

https://content.govdelivery.com/accounts/USNIHNCI/bulletins/3d65890?reqfrom=share

Facial Paralysis: Is This Stroke, Botox, or Bell’s Palsy? Matthew F Watto, MD; Paul N Williams, MD

https://www.medscape.com/viewarticle/facial-paralysis-this-stroke-botox-or-bells-palsy-2025a100056m

Chronic Skin Effects Persist After Cancer Immunotherapy Edited by Deepa Varma March 12, 2025

https://www.medscape.com/viewarticle/chronic-skin-effects-persist-after-cancer-immunotherapy-2025a100061e

Diabetes Drug Cuts Blood Cancer Risk Edited by Susan Ruel, PhD March 13, 2025

https://www.medscape.com/viewarticle/diabetes-drug-cuts-blood-cancer-risk-2025a100063x

Increasing, Persistent PSA Levels Linked to Higher All-Cause Mortality Edited by Katie Lennon March 13, 2025

https://www.medscape.com/viewarticle/increasing-persistent-psa-levels-linked-higher-all-cause-2025a1000654

Chemotherapy Linked to Long-Lasting Health Decline in Breast Cancer Survivors Edited by Gargi Mukherjee March 11, 2025

https://www.medscape.com/viewarticle/chemotherapy-linked-long-lasting-health-decline-breast-2025a10005w5

Adding Online Group Mindfulness Sessions to Medication Treatment Reduces Opioid Craving in People With Opioid Use Disorder

Adding Online Group Mindfulness Sessions to Medication Treatment Reduces Opioid Craving in People With Opioid Use Disorder https://www.nccih.nih.gov/research/research-results/adding-online-group-mindfulness-sessions-to-medication-treatment-reduces-opioid-craving-in-people-with-opioid-use-disorder?nav=govd Adding an online group mindfulness intervention to a standard treatment for opioid use disorder was similar to adding an online evidence-based recovery support program when it came to reducing illicit opioid use, other substance use, and anxiety, but the mindfulness intervention resulted in greater reductions in opioid craving, according to a new study published in JAMA Network Open. The study was conducted by researchers at the Cambridge Health Alliance, McLean Hospital, Harvard University, and Tufts University and partially funded by the National Center for Complementary and Integrative Health through the Helping to End Addiction Long-term® Initiative or NIH HEAL Initiative® Behavioral Research to Improve Medication-Based Treatment (BRIM) program. Treatment with the medication buprenorphine in people with opioid use disorder reduces illicit opioid use and the risk for opioid overdose, but research shows that most patients stop buprenorphine treatment—considered the first-line treatment for opioid use disorder—within 6 months. Risk factors for treatment dropout or opioid relapse in people receiving buprenorphine include an additional substance use disorder, anxiety, and residual opioid craving. The findings from the new study suggest that group mindfulness training sessions may help people who are receiving buprenorphine maintenance therapy and struggling with residual opioid craving.

Digital Shareables on Bipolar Disorder

https://www.nimh.nih.gov/get-involved/digital-shareables/shareable-resources-on-bipolar-disorder?utm_campaign=WBD25&utm_medium=email&utm_source=govd

Bipolar Disorder

https://www.nimh.nih.gov/health/topics/bipolar-disorder?utm_campaign=WBD25&utm_medium=email&utm_source=govd

Digital Toolkit for World Bipolar Day

https://www.nimh.nih.gov/get-involved/digital-toolkit-for-world-bipolar-day?utm_campaign=WBD25&utm_medium=email&utm_source=govd

Tecovirimat is safe but ineffective as treatment for clade II mpox NIH-sponsored trial data offer further evidence to help inform mpox treatment decisions.

https://www.nih.gov/news-events/news-releases/tecovirimat-safe-ineffective-treatment-clade-ii-mpox

Excessive phone and screen use tied to manic symptoms for one group, study finds Experts share key tips for safe and healthy tech use today Angelica Stabile By Angelica Stabile Fox News Published March 8, 2025 4:44pm EST

Excessive phone and screen use tied to manic symptoms for one group, study finds Experts share key tips for safe and healthy tech use today Angelica Stabile By Angelica Stabile Fox News Published March 8, 2025 4:44pm EST https://www.foxnews.com/health/excessive-phone-screen-use-tied-manic-symptoms-group-study

This diet plan helped man lose nearly 200 pounds for son's graduation Maine father says he also saves thousands per month on food expenses By Khloe Quill Fox News Published March 11, 2025 1:19pm EDT

This diet plan helped man lose nearly 200 pounds for son's graduation Maine father says he also saves thousands per month on food expenses By Khloe Quill Fox News Published March 11, 2025 1:19pm EDT https://www.foxnews.com/health/diet-plan-helped-man-lose-nearly-200-pounds-sons-graduation

Teen with ‘werewolf syndrome’ breaks world record for hairiest face Rare medical condition causes abnormal hair growth Melissa Rudy By Melissa Rudy Fox News Published March 11, 2025 5:12pm EDT

Teen with ‘werewolf syndrome’ breaks world record for hairiest face Rare medical condition causes abnormal hair growth Melissa Rudy By Melissa Rudy Fox News Published March 11, 2025 5:12pm EDT https://www.foxnews.com/health/teen-werewolf-syndrome-breaks-world-record-hairiest-face

Measles updates, plus medication that could reduce cancer spread And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published March 12, 2025 8:21pm EDT

Measles updates, plus medication that could reduce cancer spread And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published March 12, 2025 8:21pm EDT https://www.foxnews.com/health/measles-outbreak-updates-plus-medication-could-reduce-cancer-spread

Five years since initial response to coronavirus spread in the United States COVID-19 outbreak roiled the 2020 presidential campaign, and Trump said, 'We cannot let the cure be worse than the problem itself' Bret Baier By Bret Baier , Amy Munneke Fox News Published March 12, 2025 9:12pm EDT

Five years since initial response to coronavirus spread in the United States COVID-19 outbreak roiled the 2020 presidential campaign, and Trump said, 'We cannot let the cure be worse than the problem itself' Bret Baier By Bret Baier , Amy Munneke Fox News Published March 12, 2025 9:12pm EDT https://www.foxnews.com/health/five-years-since-initial-response-coronavirus-spread-united-states

Higher dementia risk seen in women with common health issue Number of menopause symptoms may be indicator of future cognitive decline: study Melissa Rudy By Melissa Rudy Fox News Published March 13, 2025 10:49am EDT

Higher dementia risk seen in women with common health issue Number of menopause symptoms may be indicator of future cognitive decline: study Melissa Rudy By Melissa Rudy Fox News Published March 13, 2025 10:49am EDT https://www.foxnews.com/health/higher-dementia-risk-seen-women-common-health-issue

US measles outbreak: See the states where cases have been reported Texas has documented the vast majority of US cases, with more than 220 confirmed Melissa Rudy By Melissa Rudy Fox News Published March 12, 2025 4:34pm EDT

US measles outbreak: See the states where cases have been reported Texas has documented the vast majority of US cases, with more than 220 confirmed Melissa Rudy By Melissa Rudy Fox News Published March 12, 2025 4:34pm EDT https://www.foxnews.com/health/us-measles-outbreak-see-states-where-cases-have-been-reported

Federal dietary guidelines will soon change for Americans, HHS and USDA announce USDA Secretary Rollins and HHS Secretary Kennedy to release new report before December Ashley J. DiMella By Ashley J. DiMella Fox News Published March 12, 2025 12:59pm EDT

Federal dietary guidelines will soon change for Americans, HHS and USDA announce USDA Secretary Rollins and HHS Secretary Kennedy to release new report before December Ashley J. DiMella By Ashley J. DiMella Fox News Published March 12, 2025 12:59pm EDT https://www.foxnews.com/health/federal-dietary-guidelines-soon-change-americans-hhs-usda-announce

Popular frozen drink linked to children’s illness, study finds Glycerol, a sweetener in slush drinks, led to acute symptoms within an hour Melissa Rudy By Melissa Rudy Fox News Published March 13, 2025 5:51pm EDT

Popular frozen drink linked to children’s illness, study finds Glycerol, a sweetener in slush drinks, led to acute symptoms within an hour Melissa Rudy By Melissa Rudy Fox News Published March 13, 2025 5:51pm EDT https://www.foxnews.com/health/popular-frozen-drink-linked-childrens-illness-study-finds

Fly safely amid measles outbreak with these important travel tips Measles is ‘more contagious than COVID,’ warns chief medical officer Angelica Stabile By Angelica Stabile Fox News Published March 14, 2025 5:00am EDT

Fly safely amid measles outbreak with these important travel tips Measles is ‘more contagious than COVID,’ warns chief medical officer Angelica Stabile By Angelica Stabile Fox News Published March 14, 2025 5:00am EDT https://www.foxnews.com/health/fly-safely-measles-outbreak-important-travel-tips

Detection of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease using home monitoring in the Netherlands (DecreaSSc): a prospective, observational study

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00236-4/abstract?utm_campaign=update-lanrhe&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanrhe&_hsenc=p2ANqtz-8VJBPeenZ46Wr5Q7kYLz4H0pHL6gluCi-Q1bKPdNLhxG2MUNf5KgTvb71qBFpC1AWywP9j1fZHP25KiuqiewdnvkChvg&_hsmi=351497352&utm_content=351151680&utm_source=hs_email

A new era of non-opioid analgesics? The Lancet Rheumatology

https://www.thelancet.com/journals/lanrhe/issue/vol7no3/PIIS2665-9913(25)X0003-5

The projected burden of arthritis among adults and children in Australia to the year 2040: a population-level forecasting study

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00247-9/abstract?utm_campaign=update-lanrhe&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanrhe&_hsenc=p2ANqtz--hZV5BPw2kIvLvd_kCGzxmPsBPy9nU89SF353TEkvF7B4cDkaHWeG2TkwAO-6G_DkVx2VYypGdUzPNoYIHb-54gqSl1A&_hsmi=351497352&utm_content=351151680&utm_source=hs_email

New on NCI’s Websites for March 2025

https://www.cancer.gov/news-events/cancer-currents-blog/2025/new-online-march-2025?cid=eb_govdel

Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season

https://www.fda.gov/vaccines-blood-biologics/influenza-vaccine-composition-2025-2026-us-influenza-season?utm_medium=email&utm_source=govdelivery

Low carb diet danger alert: It increases the risk of colorectal cancer Erika Watts | Medical News Today | March 13, 2025

https://geneticliteracyproject.org/2025/03/13/low-carb-diet-danger-alert-it-increases-the-risk-of-colorectal-cancer/?mc_cid=d550fdc791&mc_eid=b73600b7ac

Cancer rates are falling around the world, especially for men—except for among younger people. Here is the best guess as to why Jamie Ducharme | Time | March 12, 2025

https://geneticliteracyproject.org/2025/03/12/cancer-rates-are-falling-around-the-world-especially-for-men-except-for-among-younger-people-here-is-the-best-guess-as-to-why/?mc_cid=d550fdc791&mc_eid=b73600b7ac

Women really do live longer — here’s why Mohana Ravindranath | New York Times | March 13, 2025

https://geneticliteracyproject.org/2025/03/13/women-really-do-live-longer-heres-why/?mc_cid=d550fdc791&mc_eid=b73600b7ac

Engineered T cells turn cancer’s strength against itself Researchers mix gene editing with the principles of martial arts to boost T cell therapies.

https://www.drugdiscoverynews.com/engineered-t-cells-turn-cancer-s-strength-against-itself-15893?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9BzhNuqq7S_7cWBfI3A3QqqKuq0pwTukfrZ1F8Ac-TYXOqDlg2TV-GnYy-60iUfkxwbZ8vDgTmj83miUxzxeKnDeP2rw&_hsmi=351518776&utm_content=351518776&utm_source=hs_email

CRISPR strategy could restore delayed-onset hearing loss Previous genome editing techniques only work when delivered early in life. This approach could help preserve hearing that is lost later on.

https://www.drugdiscoverynews.com/crispr-strategy-could-restore-delayed-onset-hearing-loss-16116?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_zyN5BHczJAsal_0PtyKTaGXCd9kgDNMwID0RkGtluHJUnJKxqZ3DJkvog6EfhZ4Q7pTc2m_DVAq9MB6vK2jwpZLDBnw&_hsmi=351518776&utm_content=351518776&utm_source=hs_email

Tapping into tRNAs to treat rare diseases Michelle Werner and her team at Alltrna are developing novel tRNA therapeutics to overwrite mutations shared by hundreds of rare genetic diseases.

https://www.drugdiscoverynews.com/tapping-into-trnas-to-treat-rare-diseases-16260

Targeting aneuploidy to treat cancer Most cancer cells have the wrong number of chromosomes, known as aneuploidy. Scientists are finding ways to target this flaw with new treatments.

https://www.drugdiscoverynews.com/targeting-aneuploidy-to-treat-cancer-16262

Resurrected ancient enzyme could transform gene editing An enzyme reconstructed from a three-billion-year-old bacterium widens gene editing capabilities to even more regions of the genome.

https://www.drugdiscoverynews.com/resurrected-ancient-enzyme-could-transform-gene-editing-16263

MEDIA CALL: Front of Package Nutrition Labels – 1/14/2025

Cervical Cancer Treatment Innovation: A Collaborative Discussion

Striving for Balance in Your Specialty: Medscape Oncologist Mental Health & Well-Being Report 2025 Mary Lyn Koval | March 7, 2025

https://www.medscape.com/slideshow/2025-mentalhealth-oncologist-6018054?ecd=WNL_physrep_250312_MSCPEDIT_mental-health-spec_etid7286607&uac=148436CN&impID=7286607

Serious liver injury being observed in patients without cirrhosis taking...

FDA D.I.S.C.O. Burst Edition: FDA approval of Ryoncil (remestemcel-L-rkn...

Sexually Transmitted Infections in Women – OWH Speaker Series

Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D) Case Study User Guide

https://www.fda.gov/media/185425/download?attachment=&utm_medium=email&utm_source=govdelivery

Olipudase alfa-rpcp (Xenpozyme) A Clinical Dose Escalation Strategy for a Rare Disease Drug Program

https://www.fda.gov/media/185753/download?attachment=&utm_medium=email&utm_source=govdelivery

Fosdenopterin (Nulibry) Use of a Single Adequate and Well-Controlled Clinical Investigation and Confirmatory Evidence to Demonstrate Substantial Evidence of Effectiveness for a Rare Disease

https://www.fda.gov/media/185752/download?attachment=&utm_medium=email&utm_source=govdelivery

Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D)

https://www.fda.gov/about-fda/accelerating-rare-disease-cures-arc-program/learning-and-education-advance-and-empower-rare-disease-drug-developers-leader-3d?utm_medium=email&utm_source=govdelivery#case-studies

LEADER 3D: Challenges, Strategies & Regulatory Considerations for Rare D...

LEADER 3D: Announcing New Rare Disease Drug Development Educational Materials

https://content.govdelivery.com/accounts/USFDA/bulletins/3d6b88b LEADER 3D: Announcing New Rare Disease Drug Development Educational Materials Today, the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research (CDER) published two case studies and a case study user guide, developed as part of the Accelerating Rare disease Cures (ARC) Program’s Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D) initiative. These case studies highlight approaches successfully used by sponsors when designing and conducting rare disease drug development programs. The cases include: Fosdenopterin (Nulibry), which demonstrates the use of a single adequate and well-controlled investigation and confirmatory evidence to support substantial evidence of effectiveness, and Olipudase alfa-rpcp (Xenpozyme), which illustrates a clinical dose escalation strategy, informed by multiple data sources, for a rare disease drug program. To accompany the case studies, a user guide was also published to assist with navigating the case studies, provide key concepts, and additional resources on key regulatory topics. Note: Case studies are not intended or designed to provide specific strategies for obtaining product approval. Rare disease drug development is not one-size-fits-all. The type and quantity of data in each rare disease application will be different based on the unique considerations of each development program and must therefore be assessed on a case-by-case basis. [READ THE CASE STUDIES] The ARC Program launched LEADER 3D to better understand and address the unique challenges in bringing rare disease products to market. As part of the initiative, CDER’s Rare Diseases Team worked with an independent contractor to conduct interviews with the rare disease drug development community and performed a review of public docket comments to identify educational opportunities across topics of interest in rare disease drug development. These case studies and the other materials on the LEADER 3D website are reflective of the needs and priorities heard from our valuable partners in the rare disease drug development community. Additional Information Visit the LEADER 3D website to learn more about the program. https://www.fda.gov/about-fda/accelerating-rare-disease-cures-arc-program/learning-and-education-advance-and-empower-rare-disease-drug-developers-leader-3d?utm_medium=email&utm_source=govdelivery Visit CDER’s ARC website for an overview and information about the ARC Program. https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/accelerating-rare-disease-cures-arc-program?utm_medium=email&utm_source=govdelivery Watch the recently published video, “Challenges, Strategies & Regulatory Considerations for Rare Disease Clinical Trial Design”.