miércoles, 16 de julio de 2025

New review identifies promising and under-researched OTC depression aids

https://www.news-medical.net/news/20250716/New-review-identifies-promising-and-under-researched-OTC-depression-aids.aspx

A million veterans gave DNA to aid health research. Scientists worry the data will be wasted.

https://www.news-medical.net/news/20250716/A-million-veterans-gave-DNA-to-aid-health-research-Scientists-worry-the-data-will-be-wasted.aspx One of the world's biggest genetic databases comprises DNA data donated over the years by more than a million retired military service members. It's part of a project run by the Department of Veterans Affairs.

Study reveals key social factors that support preterm children's mental health

https://www.news-medical.net/news/20250716/Study-reveals-key-social-factors-that-support-preterm-childrens-mental-health.aspx

Extracellular vesicle RNA reveals clues about obesity and metabolic disease

https://www.news-medical.net/news/20250715/Extracellular-vesicle-RNA-reveals-clues-about-obesity-and-metabolic-disease.aspx

New insights into depressive symptoms in premature ovarian insufficiency

https://www.news-medical.net/news/20250716/New-insights-into-depressive-symptoms-in-premature-ovarian-insufficiency.aspx

Study reveals stigma causes more distress than disease itself

https://www.news-medical.net/news/20250716/Study-reveals-stigma-causes-more-distress-than-disease-itself.aspx

Understanding resistance to EGFR targeted therapies in head and neck cancers and breast cancer ++++++

Understanding resistance to EGFR targeted therapies in head and neck cancers and breast cancer Understanding resistance to EGFR targeted therapies in head and neck cancers and breast cancerA new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms." https://www.news-medical.net/news/20250710/Understanding-resistance-to-EGFR-targeted-therapies-in-head-and-neck-cancers-and-breast-cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Watch: She’s at high risk of breast cancer. She moved, and her screening costs soared. https://www.news-medical.net/news/20250710/Watch-Shee28099s-at-high-risk-of-breast-cancer-She-moved-and-her-screening-costs-soared.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Watch: She’s at high risk of breast cancer. She moved, and her screening costs soared.Kelli Reardon undergoes an MRI twice a year to screen for breast cancer, a measure she said she must take to protect her health. Her mother died of the disease at age 48, putting Reardon at higher risk, and Reardon has dense breast tissue, which makes it harder to detect a growth through a mammogram. Metabolic enzyme PHGDH found to play a surprising role in breast cancer immunity https://www.news-medical.net/news/20250707/Metabolic-enzyme-PHGDH-found-to-play-a-surprising-role-in-breast-cancer-immunity.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Metabolic enzyme PHGDH found to play a surprising role in breast cancer immunityMacrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most macrophages fall into the latter camp—dubbed M2-like—fueling tumor progression and dampening immune responses. Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness https://www.news-medical.net/news/20250709/Energy-waves-on-cancer-cell-surfaces-linked-to-tumor-growth-and-aggressiveness.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power-generating waves on the covering, or membrane, of these cells. KAIST scientists develop tool to fight drug resistance in cancer https://www.news-medical.net/news/20250708/KAIST-scientists-develop-tool-to-fight-drug-resistance-in-cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 KAIST scientists develop tool to fight drug resistance in cancerOne of the biggest obstacles in cancer treatment is drug resistance in cancer cells. Conventional efforts have focused on identifying new drug targets to eliminate these resistant cells, but such approaches can often lead to even stronger resistance. Preeclampsia in pregnancy reduces risk of some cancers but raises endometrial cancer odds https://www.news-medical.net/news/20250707/Preeclampsia-in-pregnancy-reduces-risk-of-some-cancers-but-raises-endometrial-cancer-odds.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Preeclampsia in pregnancy reduces risk of some cancers but raises endometrial cancer oddsWomen with preeclampsia in their first pregnancy had a lower risk of developing breast, cervical, and lung cancer later in life, but a higher risk of endometrial cancer. The large Nordic cohort study also found that siblings of women with PE had a modestly reduced risk of cancer, particularly lung cancer.

Confusion persists over breast cancer screening guidelines +++++

https://www.news-medical.net/news/20250703/Confusion-persists-over-breast-cancer-screening-guidelines.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Mammograms can find cancer early before symptoms appear. Regular screening decreases the risk of dying from breast cancer. But a recent survey question by the Annenberg Public Policy Center shows that some Americans appear to be confused about when women with an average risk of breast cancer should begin a regimen of regular mammograms. Artificial intelligence enhances radiologists’ accuracy in breast cancer detection https://www.news-medical.net/news/20250708/Artificial-intelligence-enhances-radiologistse28099-accuracy-in-breast-cancer-detection.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Excess weight linked to breast cancer risk in postmenopausal women with cardiovascular disease https://www.news-medical.net/news/20250707/Excess-weight-linked-to-breast-cancer-risk-in-postmenopausal-women-with-cardiovascular-disease.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Amino acid metabolism in breast cancer as a driver of disease and therapeutic target https://www.news-medical.net/news/20250707/Amino-acid-metabolism-in-breast-cancer-as-a-driver-of-disease-and-therapeutic-target.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025 Evolutionary mutation weakens human immune response to solid tumors https://www.news-medical.net/news/20250703/Evolutionary-mutation-weakens-human-immune-response-to-solid-tumors.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=breast_cancer_newsletter_11_july_2025

Gut-brain axis in eating disorders offers new treatment potential

https://www.news-medical.net/news/20250716/Gut-brain-axis-in-eating-disorders-offers-new-treatment-potential.aspx

Exploring the changing intensity of opioid use

https://www.news-medical.net/news/20250716/Exploring-the-changing-intensity-of-opioid-use.aspx

FINRISK population-based study investigates factors associated with prevalence of antibiotic resistance

https://www.news-medical.net/news/20250716/FINRISK-population-based-study-investigates-factors-associated-with-prevalence-of-antibiotic-resistance.aspx

Targeting amino acid networks could lead to more precise medicines

https://www.news-medical.net/news/20250716/Targeting-amino-acid-networks-could-lead-to-more-precise-medicines.aspx

Circadian Disruption: The Hidden Cancer Link? Maria Weiss July 16, 2025

https://www.medscape.com/viewarticle/circadian-disruption-hidden-cancer-link-2025a1000ir1

MCED Screening: What Patients Need to Know Katie Lennon July 11, 2025

https://www.medscape.com/viewarticle/mced-screening-what-patients-need-know-2025a1000iei

Advancing Patient-Centered Care in mCRPC: Exploring PARP Inhibitor Combinations Authors: Neeraj Agarwal, MD, FASCO; Karim Fizazi, MD, PhD

https://www.medscape.org/viewarticle/1002353?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250715-OUS-HONC-1002353-cta

Hormone Therapy Unlocked: Case Studies in Diagnosing and Managing Hypoactive Sexual Desire Disorder and Menopausal Hormone Therapy Wednesday, Aug. 13, from 11:10 a.m. to 2:30 p.m. ET

https://www.dhaj7-cepo.com/content/hormone-therapy-special-feature?utm_source=newsletter&utm_medium=email&utm_campaign=july2025 Watch the discussion on timely approaches to menopause and perimenopause care from February’s Clinical Communities Speaker Series, then join the panelists live to dissect real-world case studies on the complexities of diagnosing and managing hypoactive sexual desire disorder and menopausal symptoms in women.

Measuring aging with brain scans

https://www.nih.gov/news-events/nih-research-matters/measuring-aging-brain-scans

Engineering immune cells within the body

https://www.nih.gov/news-events/nih-research-matters/engineering-immune-cells-within-body

Factors linked to lung cancer in never-smokers

https://www.nih.gov/news-events/nih-research-matters/factors-linked-lung-cancer-never-smokers

Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial +...

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(25)00092-0/abstract?dgcid=raven_jbs_etoc_feature_landia Editorial p635 Reassessing driving safety in diabetes The Lancet Diabetes & Endocrinology https://www.thelancet.com/journals/landia/issue/vol13no8/PIIS2213-8587(25)X0008-5

martes, 15 de julio de 2025

Hepatitis E virus also attacks organs other than the liver, study finds

https://www.news-medical.net/news/20250703/Hepatitis-E-virus-also-attacks-organs-other-than-the-liver-study-finds.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_7_july_2025

Researchers find gut bacteria rapidly soak up ‘forever chemicals’

https://www.news-medical.net/news/20250701/Researchers-find-gut-bacteria-rapidly-soak-up-e28098forever-chemicalse28099.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_7_july_2025 Can our gut bacteria help clear dangerous ‘forever chemicals’ from our bodies? New research reveals certain microbes rapidly sequester PFAS, offering hope for microbiome-based solutions against toxic environmental exposures.

Study explores how a familiar spice tackles the toughest cancer cells

https://www.news-medical.net/news/20250627/Study-explores-how-a-familiar-spice-tackles-the-toughest-cancer-cells.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_7_july_2025 Could a kitchen spice help stop colorectal cancer before it starts? New research shows curcumin selectively attacks the stem-like cells that fuel early tumors, pointing to a promising, low-risk addition to current prevention strategies.

Cabozantinib plus atezolizumab in metastatic prostate cancer (CONTACT-02): final analyses from a phase 3, open-label, randomised trial

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00209-8/abstract?utm_campaign=update-lanonc&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanonc&_hsenc=p2ANqtz-_pK1rMKRU_vMqovSxowWmCDtJXQrdE8g1EEQfy8By2UAS8ZaQD24nx93FxrE_enTglT5nPLamtn91j1GR6_R7ZnxIiYg&_hsmi=371230603&utm_content=371146860&utm_source=hs_email Editorial p817 Politics and pharma: hurdles in UK science ambitions The Lancet Oncology +... https://www.thelancet.com/journals/lanonc/issue/vol26no7/PIIS1470-2045(25)X0007-3

Weight loss drugs can boost testosterone in men with obesity or diabetes

https://www.news-medical.net/news/20250714/Weight-loss-drugs-can-boost-testosterone-in-men-with-obesity-or-diabetes.aspx

Study finds no increased risk from vaccine aluminum exposure

https://www.news-medical.net/news/20250715/Study-finds-no-increased-risk-from-vaccine-aluminum-exposure.aspx

Insomnia may be the missing link between ADHD and low life satisfaction

https://www.news-medical.net/news/20250715/Insomnia-may-be-the-missing-link-between-ADHD-and-low-life-satisfaction.aspx

Light-activated drug discovery identifies broad-spectrum antivirals

https://www.news-medical.net/news/20250715/Light-activated-drug-discovery-identifies-broad-spectrum-antivirals.aspx

Americans divided on how to manage neck and back pain, survey reveals

https://www.news-medical.net/news/20250715/Americans-divided-on-how-to-manage-neck-and-back-pain-survey-reveals.aspx

Study highlights dangers of vascular injuries in young gunshot victims

https://www.news-medical.net/news/20250715/Study-highlights-dangers-of-vascular-injuries-in-young-gunshot-victims.aspx

Person-focused approach explains distinct autism genetic subtypes

https://www.news-medical.net/news/20250715/Person-focused-approach-explains-distinct-autism-genetic-subtypes.aspx New study shows that autism is not one condition, but four, each driven by different genes and brain development patterns, helping to reshape diagnosis and care.

Microplastics found to trigger cancer-linked changes in lung cells

https://www.news-medical.net/news/20250715/Microplastics-found-to-trigger-cancer-linked-changes-in-lung-cells.aspx

Survey highlights widespread emotional impact of cancer on patients and their families

https://www.news-medical.net/news/20250715/Survey-highlights-widespread-emotional-impact-of-cancer-on-patients-and-their-families.aspx

GLP-1 and Diet: Evidence-Based Strategies for Better Weight Loss +++

https://www.news-medical.net/health/GLP-1-and-Diet-Evidence-Based-Strategies-for-Better-Weight-Loss.aspx What Happens to Your Body When You Skip Meals? https://www.news-medical.net/health/What-Happens-to-Your-Body-When-You-Skip-Meals.aspx Saffron’s Evolving Place in Modern Medicine - From Tradition to Evidence https://www.news-medical.net/health/Saffrone28099s-Evolving-Place-in-Modern-Medicinee28094From-Tradition-to-Evidence.aspx

Reports of young children accidentally eating nicotine pouches rose 763% in three years: Study Nicotine pouch ingestions were 1.5 times more likely to lead to a serious medical outcome in young kids compared to other nicotine products.

https://www.statnews.com/2025/07/14/reports-of-young-children-accidentally-eating-nicotine-pouches-rose-763-percent-study/

Study finds no evidence aluminum salts in vaccines are tied to higher risk of asthma, other childhood diseases Aluminum increases some shots’ effectiveness and should be seen as safe, researchers say

https://www.statnews.com/2025/07/14/aluminum-in-vaccines-large-danish-study-finds-no-link-to-autism-asthma-allergies/

Ozempic for addiction: How an elite rehab center is using GLP-1s to ‘obliterate’ all kinds of cravings By Lev Facher Photos by Rachel Wisniewski for STAT July 14, 2025

https://www.statnews.com/2025/07/14/glp1-drugs-addiction-treatment-rehab-center-uses-weight-loss-drugs-to-reduce-cravings/?utm_campaign=daily_recap&utm_medium=email&_hsenc=p2ANqtz-_d52ttZwNTqX2j7mKY6Vywu0ZrFjKpTAsExYIMR53KxmEM7q-AqAYjFC2peIwH96b27COcH81aPABxzymRakWZwa01bQ&_hsmi=371264737&utm_content=371264737&utm_source=hs_email

Do We Really Need New Antihypertensives? The Experts Analyze Why Authors: Bryan Williams, MD, FRCP, FESC, FMedSci; Vivek Bhalla, MD, FASN, FAHA

https://www.medscape.org/viewarticle/1002613_sidebar3

Multiomics Platform May Guide Melanoma Treatment Edited by Gargi Mukherjee July 15, 2025

https://www.medscape.com/viewarticle/multiomics-platform-may-guide-melanoma-treatment-2025a1000ioy

Adjuvant Triple Therapy Boosts Survival in Biliary Cancers Edited by Gargi Mukherjee July 15, 2025

https://www.medscape.com/viewarticle/adjuvant-triple-therapy-boosts-survival-biliary-cancers-2025a1000ina

Obesity-Related Cancer Deaths More Than Triple Megan Brooks July 15, 2025 + +...

https://www.medscape.com/viewarticle/obesity-related-cancer-deaths-more-than-triple-2025a1000iou ENDO 2025: The Endocrine Society Annual Meeting https://www.medscape.com/viewcollection/37856

Myelofibrosis-Associated Anemia: Burden, Management, and Future Directions Authors: Francesca Palandri, MD; Jean-Jacques Kiladjian, MD, PhD; Jon Mathias

https://www.medscape.org/viewarticle/1002370?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250715-OUS-HONC-1002370-cta

lunes, 14 de julio de 2025

Treating spinal muscular atrophy before birth An injection of an antisense oligonucleotide in utero improved outcomes for mice with the neurogenetic disease.

https://www.drugdiscoverynews.com/treating-spinal-muscular-atrophy-before-birth-16495

Editorial e483 Much to hope for in blood donation The Lancet Haematology +...

https://www.thelancet.com/journals/lanhae/issue/vol12no7/PIIS2352-3026(25)X0007-7

Intergenerational association of adverse childhood experiences and perinatal mental health in adult female offspring: evidence from the longitudinal grandmothers, mothers, and their Children's health study in China +...

https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(25)00116-6/fulltext?dgcid=hubspot_update_feature_updatealerts_lanwpc&utm_campaign=update-lanwpc&utm_medium=email&_hsenc=p2ANqtz-9jGcRbrCjK8wkg_d0fEtgd6eQywVAIUSppgWPfLBj0M7Az9tYPUF2QN_WYoaRMUUGY7Rr3sgV8B98gbleUNee2BiFVNw&_hsmi=371100144&utm_content=370502769&utm_source=hs_email Editorial +... Menstrual reform: cultural roots of delayed endometriosis diagnosis in the Asia–Pacific region The Lancet Regional Health – Western Pacific https://www.thelancet.com/journals/lanwpc/issue/vol59nonull/PIIS2666-6065(25)X0007-9

Management of Early Alzheimer's Disease: Merging Clinical Data and Clinical Decision-Making Authors: Ronald C. Petersen, MD, PhD; Sharon Cohen, MD, FRCPC

https://www.medscape.org/viewarticle/1002541_sidebar9?sso=true&uac=148436CN&src=mkmcmr_driv_il_mscpedu_250713_1002541_ES_LANG_NEUR

Rarity Life: Some highlights from Issue 13 of Rarity Life

https://www.samebutdifferentcic.org.uk/raritylife

Is the American Academy of Pediatrics a stalwart defender of science and vaccines or a biotechnology science rejectionist? Sadly, it’s both Jon Entine, Kevin Folta | July 14, 2025

https://geneticliteracyproject.org/2025/07/14/is-the-american-academy-of-pediatrics-a-stalwart-defender-of-science-and-vaccines-or-a-biotechnology-science-rejectionist-sadly-its-both/

Digital therapies for smartphone addicts Arielle Pardes | Wired | July 14, 2025

https://geneticliteracyproject.org/2025/07/14/digital-therapies-for-smartphone-addicts/

Sustainable drugs: Your pain killer pills may soon be made from plastic waste Fernanda Gonzalez | Wired | July 14, 2025

https://geneticliteracyproject.org/2025/07/14/sustainable-drugs-your-pain-killer-pills-may-soon-be-made-from-plastic-waste/

US measles cases hit highest level in more than 30 years, CDC data shows By Greg Norman Fox News Published July 9, 2025 1:05pm EDT

US measles cases hit highest level in more than 30 years, CDC data shows The last time measles cases in the US were this high was in 1992, according to CDC Greg Norman By Greg Norman Fox News Published July 9, 2025 1:05pm EDT https://www.foxnews.com/health/us-measles-cases-hit-highest-level-more-than-30-years-cdc-data-shows

‘I’m a cardiologist – here’s how the summer heat could damage your heart’ By Angelica Stabile Fox News Published July 12, 2025 5:00am EDT | Updated July 11, 2025 5:00am EDT

‘I’m a cardiologist – here’s how the summer heat could damage your heart’ Recognizing key warning signs can help prevent heat-related cardiac events, expert says Angelica Stabile By Angelica Stabile Fox News Published July 12, 2025 5:00am EDT | Updated July 11, 2025 5:00am EDT https://www.foxnews.com/health/im-cardiologist-heres-how-summer-heat-could-damage-your-heart

Arizona resident dies of pneumonic plague, the first deadly case in area in nearly 20 years By Brie Stimson Fox News Published July 12, 2025 10:19pm EDT

Arizona resident dies of pneumonic plague, the first deadly case in area in nearly 20 years The disease, once responsible for killing millions during the Black Death of the 14th century, is now rare in the US and treatable with antibiotics By Brie Stimson Fox News Published July 12, 2025 10:19pm EDT https://www.foxnews.com/health/arizona-resident-dies-from-pneumonic-plague-first-deadly-case-area-nearly-20-years

Always running late? A mental health condition could be to blame, experts say By Khloe Quill Fox News Published July 14, 2025 5:00am EDT

Always running late? A mental health condition could be to blame, experts say Time blindness may be culprit behind chronic lateness — how to handle it By Khloe Quill Fox News Published July 14, 2025 5:00am EDT https://www.foxnews.com/health/always-running-late-mental-health-condition-could-blame-experts-say

Just In Case: How To Build An Emergency Fund By Ivanhoe Broadcast News on July 10, 2025

https://www.ivanhoe.com/smart-living/just-in-case-how-to-build-an-emergency-fund/

Minority Mental Health Month: Bridging The Gap By Ivanhoe Broadcast News on July 7, 2025

https://www.ivanhoe.com/smart-living/minority-mental-health-month-bridging-the-gap/

Fighting Loneliness: Small Steps, Big Impact By Ivanhoe Broadcast News on July 11, 2025

https://www.ivanhoe.com/smart-living/fighting-loneliness-small-steps-big-impact/

Tough Times, Tough Cuts: Smart Spending & Thrifting By Ivanhoe Broadcast News on July 14, 2025

https://www.ivanhoe.com/smart-living/tough-times-tough-cuts-smart-spending-thrifting/

The Great Unsub: Beat Subscription Fatigue & Save By Ivanhoe Broadcast News on July 15, 2025

https://www.ivanhoe.com/?p=35694&preview=1&_ppp=c7eab6dfc9

The Longevity Divide: Living Longer Vs. Better By Ivanhoe Broadcast News on June 16, 2025

https://www.ivanhoe.com/smart-living/the-longevity-divide-living-longer-vs-better/

Esophageal Cancer: 3-Minute Life Saver! By Ivanhoe Broadcast News on July 17, 2025

https://www.ivanhoe.com/?p=35716&preview=1&_ppp=37ce20d87c

Roman’s Second Chance: A Pancreas Pak! By Ivanhoe Broadcast News on July 18, 2025

https://www.ivanhoe.com/?p=35719&preview=1&_ppp=a61446242a

domingo, 13 de julio de 2025

Maternal depression found to disrupt key parenting behaviors

https://www.news-medical.net/news/20250711/Maternal-depression-found-to-disrupt-key-parenting-behaviors.aspx

Teclistamab shows promising results in heavily pretreated multiple myeloma

https://www.news-medical.net/news/20250712/Teclistamab-shows-promising-results-in-heavily-pretreated-multiple-myeloma.aspx

Global project measures true cost of healthy diets

https://www.news-medical.net/news/20250712/Global-project-measures-true-cost-of-healthy-diets.aspx

Study shines new light on how harmful industries shape scientific narratives

https://www.news-medical.net/news/20250712/Study-shines-new-light-on-how-harmful-industries-shape-scientific-narratives.aspx

Design strategies and therapeutic applications of smart materials in diabetes care

https://www.news-medical.net/news/20250712/Design-strategies-and-therapeutic-applications-of-smart-materials-in-diabetes-care.aspx

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

https://www.news-medical.net/news/20250712/Melatonin-receptor-signaling-counters-sleep-fragmentation-mediated-infertility-in-T2DM.aspx

ALKBH3 regulates glycolysis and doxorubicin resistance in triple negative breast cancer

https://www.news-medical.net/news/20250712/ALKBH3-regulates-glycolysis-and-doxorubicin-resistance-in-triple-negative-breast-cancer.aspx

Social media analysis reveals emotional burden of children with multiple health conditions

https://www.news-medical.net/news/20250712/Social-media-analysis-reveals-emotional-burden-of-children-with-multiple-health-conditions.aspx

Mapping how major organs communicate during physiological stress in humans

https://www.news-medical.net/news/20250712/Mapping-how-major-organs-communicate-during-physiological-stress-in-humans.aspx

HPV16 and 18 nearly eliminated in vaccinated Danish women but other high risk types persist

https://www.news-medical.net/news/20250712/HPV16-and-18-nearly-eliminated-in-vaccinated-Danish-women-but-other-high-risk-types-persist.aspx

Study reveals dopamine sends precise signals rather than broad brainwide messages

https://www.news-medical.net/news/20250712/Study-reveals-dopamine-sends-precise-signals-rather-than-broad-brainwide-messages.aspx

Tirzepatide reduces obesity-associated breast cancer growth in mouse model

https://www.news-medical.net/news/20250712/Tirzepatide-reduces-obesity-associated-breast-cancer-growth-in-mouse-model.aspx

Combining tirzepatide and hormone therapy boosts weight loss in postmenopausal women

https://www.news-medical.net/news/20250712/Combining-tirzepatide-and-hormone-therapy-boosts-weight-loss-in-postmenopausal-women.aspx

Improving parent well-being may directly benefit the health of children with chronic conditions

https://www.news-medical.net/news/20250712/Improving-parent-well-being-may-directly-benefit-the-health-of-children-with-chronic-conditions.aspx

IMPACT CLL & MCL: IMPlementing Advances in Cancer Treatment for Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

https://www.medscape.org/advances/impact-cll-mcl-2025a1000ar6?sso=true&uac=148436CN&src=mkmcmr_driv_32025_mscpedu_421115.01_ace_launch

Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial

https://www.thelancet.com/events/conferences/american-society-clinical-oncology?dgcid=hubspot_email_infocusalerts-oncology_feature_asco25&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz-91LlyGdMVA9CGoGipJfoLokKPcRi1nAFNr0fMv7JOL0JpI51xpsPycw_hFnIo8oGygQybEB4PewG04EoSY_oj9MEIByg&_hsmi=371012952&utm_content=370484992&utm_source=hs_email

The EORTC QLQ-F17 as a shortened version of the EORTC QLQ-C30 to assess self-reported functioning in cancer patients: investigating equivalence and psychometric properties in a randomized cross-over trial

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(25)00194-4/fulltext?dgcid=hubspot_email_infocusalerts-oncology_feature&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz-9rrUpyLCK9epzmlEQpJ6aS0MlInoxOmvSrganIMzt-MPyx6JuT6Kcdr5KuDM3_Or375946wWOb5rBiQUqd3dwV017UFw&_hsmi=371012952&utm_content=370484992&utm_source=hs_email

Cancer Control in the Middle East

https://www.thelancet.com/video-do/cancer-control-middle-east?dgcid=hubspot_email_infocusalerts-oncology_feature_lanonccanceremro25&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz-_0fWRs9XzE593Icp8zSCsLh8fqB5XGJphcJ-lfIsIV84Gg_bKlsvjLakI5gIPquvZ9MyY8I8jzuAV6bt9jCz7t2Jz7Bw&_hsmi=371012952&utm_content=370484992&utm_source=hs_email

Efficacy and safety of HBM4003 combined with toripalimab in refractory neuroendocrine neoplasms: a multicenter, phase II study Neuro-oncology

https://www.thelancet.com/collections/neuro-oncology?dgcid=hubspot_email_infocusalerts-oncology_feature&parent=001611&startPage=&ContentItemType=fla&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz-8kURv7eJHLoU-wRARfiYAYMfMp47K3LDU7cpKgR7-MjTt7JRqVwo95L5Ya33-YCideWP9ABvavd1p1UrwSORvawLcIZw&_hsmi=371012952&utm_content=370484992&utm_source=hs_email

Designing the Optimal Care Plan for the Patient With Metastatic Castration-Resistant Prostate Cancer Authors: Bertrand Tombal, MD, PhD; Jonathan D. Tward, MD, PhD, FASTRO

https://www.medscape.org/viewarticle/1002397?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250712-OUS-HONC-1002397-cta

sábado, 12 de julio de 2025

Oral Semaglutide: By Year’s End, a GLP-1 Weight-Loss Pill? Kathleen Doheny July 08, 2025

https://www.medscape.com/viewarticle/oral-semaglutide-years-end-glp-1-weight-loss-pill-2025a1000i2f?ecd=wnl_tp10_daily_250708_MSCPEDIT_etid7553205&uac=148436CN&impID=7553205

Key Updates in Axial Spondyloarthritis From EULAR 2025 Philip Mease, MD

https://www.medscape.com/viewarticle/axial-spondyloarthritis-ankylosing-spondylitis-eular-2025-2025a10002jk?ecd=wnl_tp10_daily_250708_MSCPEDIT_etid7553205&uac=148436CN&impID=7553205

Antidepressants Can Cause Weight Gain. Help Patients Manage Erica Lamberg July 08, 2025

https://www.medscape.com/viewarticle/antidepressants-can-cause-weight-gain-help-patients-manage-2025a1000i0p?ecd=wnl_tp10_daily_250708_MSCPEDIT_etid7553205&uac=148436CN&impID=7553205

New Obesity Definition Raises the Number Who Have It Miriam E. Tucker July 08, 2025

https://www.medscape.com/viewarticle/new-obesity-definition-raises-number-who-have-it-2025a1000i1u?ecd=wnl_tp10_daily_250708_MSCPEDIT_etid7553205&uac=148436CN&impID=7553205

GLP-1s May Ease Symptom Burden in Patients With Fibromyalgia Lucy Hicks July 08, 2025

https://www.medscape.com/viewarticle/glp-1s-may-ease-symptom-burden-patients-fibromyalgia-2025a1000i16?ecd=wnl_tp10_daily_250708_MSCPEDIT_etid7553205&uac=148436CN&impID=7553205

Drug Combo Outpaces Standard Chemo in R/R LBCL Randy Dotinga July 09, 2025 B-cell lymphoma (R/R LBCL)

https://www.medscape.com/viewarticle/drug-combo-outpaces-standard-chemo-r-r-lbcl-2025a1000i58?ecd=wnl_edit_tpal_etid7556706&uac=148436CN&impID=7556706

Burning Up? A Guide To Recognizing And Managing Heat Illness Zina Semenovskaya, MD, FAWM; Sage Wiener, MD | June 20, 2025 ++++

https://reference.medscape.com/slideshow/heat-illness-6004448?ecd=wnl_critimg_250711_mscpref_etid7557978&uac=148436CN&impID=7557978#1 Heat Stroke https://emedicine.medscape.com/article/166320-overview?ecd=wnl_critimg_250711_mscpref_etid7557978&uac=148436CN&impID=7557978 Heat-Related Deaths in Europe Will Skyrocket by 2099 Ute Eppinger https://www.medscape.com/viewarticle/heat-related-deaths-europe-will-skyrocket-2099-2025a10003r6?ecd=wnl_critimg_250711_mscpref_etid7557978&uac=148436CN&impID=7557978 February 13, 2025 Higher Heat Index Tied to Adverse Kidney Transplant Outcomes Nancy A. Melville https://www.medscape.com/viewarticle/higher-heat-index-tied-adverse-kidney-transplant-outcomes-2025a100090r?ecd=wnl_critimg_250711_mscpref_etid7557978&uac=148436CN&impID=7557978 April 16, 2025

California stem cell agency shutting down unique human tissue biobank Scientists have six days left to buy CIRM patient samples at fire sale prices

https://www.statnews.com/2025/07/11/stem-cell-research-cirm-biobank-shutting-down-launches-human-tissue-closeout-sale/

Ending the federal LGBTQ+ suicide prevention line is a public health failure In the middle of a mental health crisis, stopping this service is dangerous

https://www.statnews.com/2025/07/12/ending-988-federal-lgbtq-suicide-prevention-line-public-health/

A patient told me that I hadn’t listened closely enough. I’m glad she did Patients who express concern can receive better medical care

https://www.statnews.com/2025/07/11/psychological-safety-doctors-office-trust-patients-communication/

3 ways AI is delivering for unmet cardiology needs

https://www.statnews.com/sponsor/2025/06/30/3-ways-ai-is-delivering-for-unmet-cardiology-needs/

FDA rejects Capricor’s cell therapy for Duchenne muscular dystrophy The decision follows the ouster of the agency’s chief regulator of cell and gene therapies

https://www.statnews.com/2025/07/11/fda-rejects-capricors-cell-therapy-for-duchenne-muscular-dystrophy/

Bionic knee developed by MIT researchers gives amputees a new world of motion ‘If you just tap the toe in a really modest way, the person can feel it exquisitely,’ says MIT’s Hugh Herr

https://www.statnews.com/2025/07/11/bionic-knee-mit-researchers-amputees-new-motion/

Prevalence and severity of chronic kidney disease in a population with type 1 diabetes from a United States health system: a real-world cohort study +...

https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(25)00140-1/fulltext?dgcid=raven_jbs_etoc_feature_lanam Editorial No safe line: the human cost of dismantling LGBTQ+ youth support services The Lancet Regional Health – Americas https://www.thelancet.com/journals/lanam/issue/vol47nonull/PIIS2667-193X(25)X0006-5

Satellite Symposia in conjunction with the Society of Hematologic Oncology (SOHO) 2025 Annual Meeting CME/CNE/CPE Houston, TX

https://events.medscapelive.org/website/87553/ Join us in Houston this September for 3 dynamic, live symposia. These activities are planned and provided by Medical Learning Institute Inc and Medscape Oncology. Engage with leading experts as they explore the latest research and treatments in hematologic malignancies. Each session offers interactive discussions, lively panel debates, and audience Q&A. Browse the sessions below and reserve your spot today.

Toxic PFAS Contaminate Eggs, Meat, and Milk Caroline Guignot Medscape UK July 11, 2025

https://www.medscape.com/viewarticle/toxic-pfas-contaminate-eggs-meat-and-milk-2025a1000idj?ecd=wnl_edit_tpal_etid7561995&uac=148436CN&impID=7561995

Transforming Gastric and GEJ Cancer Care With Perioperative Immunotherapy: Latest Updates From Chicago Authors: Yelena Y. Janjigian, MD; Zev A. Wainberg, MD

https://www.medscape.org/viewarticle/transforming-gastric-and-gej-cancer-care-perioperative-2025a1000i7e?page=1

Navigating the Storm of Heavily Pretreated Multiple Myeloma: Calming the Waters With Bispecific Antibodies Authors: Hermann C. Einsele, MD, PhD; Xavier Leleu, MD, PhD; Naresh Bumma, MD

https://www.medscape.org/viewarticle/1002692?sso=true&impID=7561169&uac=148436CN&src=wnl_tpal_250711_mscpedu

Virtual Simulations: Managing the Patient With HR+/HER2- Early Breast Cancer Through a Multidisciplinary Approach Authors: Manali Bhave, MD; Jane Meisel, MD

https://www.medscape.org/viewarticle/1002474?sso=true&uac=148436CN&src=mkmcmr_driv_psims_mscpedu_250711-OUS-HONC-1002474-cta

Hormone Therapy Unlocked Wednesday, August 13, 2025 11:10 a.m. to 2:30 p.m. ET

https://www.dhaj7-cepo.com/content/hormone-therapy-special-feature?utm_source=adobe&utm_medium=email&utm_campaign=july092025 Join expert panelists for a two-part discussion on unlocking the benefits of hormone therapy After a replay of the exciting session on the latest approaches to menopause and perimenopause care from the Clinical Communities Speaker Series event held earlier this year, join the panelists live for an exploration of real-world case studies on navigating the complexities of diagnosing and managing hypoactive sexual desire disorder and menopausal symptoms in women.

viernes, 11 de julio de 2025

Understanding resistance to EGFR targeted therapies in head and neck cancers and breast cancer

https://www.news-medical.net/news/20250710/Understanding-resistance-to-EGFR-targeted-therapies-in-head-and-neck-cancers-and-breast-cancer.aspx

PREVENT equations accurately predict heart disease in diverse Asian and Hispanic groups

https://www.news-medical.net/news/20250710/PREVENT-equations-accurately-predict-heart-disease-in-diverse-Asian-and-Hispanic-groups.aspx

Weekly injectable drug offers hope for Parkinson's patients

https://www.news-medical.net/news/20250711/Weekly-injectable-drug-offers-hope-for-Parkinsons-patients.aspx

Who’s policing opioid settlement spending? A crowdsourced database might help

https://www.news-medical.net/news/20250711/Whoe28099s-policing-opioid-settlement-spending-A-crowdsourced-database-might-help.aspx

Insecticide exposure could impair mental function in older adults

https://www.news-medical.net/news/20250711/Insecticide-exposure-could-impair-mental-function-in-older-adults.aspx

Fasting triggers neuroprotective changes that could delay dementia

https://www.news-medical.net/news/20250711/Fasting-triggers-neuroprotective-changes-that-could-delay-dementia.aspx

Bacterial warriors fight mosquito-borne diseases Scientists weaponize the symbiotic bacteria in mosquitoes against the deadly diseases they transmit.

https://www.drugdiscoverynews.com/bacterial-warriors-fight-mosquito-borne-diseases-15896?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9aCXc2kINFa1j-sAJJFBCAsNdEe53BmCd1wjJ2ObG1OjO0N5LeF69PCe_gtBPiLsqAlgW533OQDeZ3ah04Gjy_ynLaeQ&_hsmi=370883314&utm_content=370883314&utm_source=hs_email

To block dengue, humans and mosquitoes could share antivirals A compound that inhibits replication of the dengue virus in mammals was similarly effective in mosquitoes consuming it via blood, reducing transmissibility.

https://www.drugdiscoverynews.com/to-block-dengue-humans-and-mosquitoes-could-share-antivirals-16207?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz--zBUv9ePN3h1FmBgcyGjoeKcl3HtRNyxkDFrh0UTpsukCEAGoFjd1QgCR9XEAl5wS7Xqwica4twdmiob-jNZT9s3Fecw&_hsmi=370883314&utm_content=370883314&utm_source=hs_email

Weekly Rundown: First malaria drug for babies approved A new CRISPR center for kids, Trump threatens 200 percent tariffs on foreign-made drugs, the first malaria treatment for babies, and more led this week’s news.

https://www.drugdiscoverynews.com/weekly-rundown-first-malaria-drug-for-babies-approved-16494?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz--kCmhS-L_5gbhe0gN4b60sPMkRb5xfKKIZ5OWvM9RYhatbPlecuN78SM6QKu6JIoF2O3RreCS0r7CIwSrGdAp-yXWsBw&_hsmi=370883314&utm_content=370883314&utm_source=hs_email

Common Pain Drug Gabapentin Linked To Dementia Diagnoses In Adults

https://kffhealthnews.org/morning-breakout/common-pain-drug-gabapentin-linked-to-dementia-diagnoses-in-adults/

Nearly 1 in 3 US Teens Has Prediabetes, CDC Data Indicate

https://kffhealthnews.org/morning-breakout/nearly-1-in-3-us-teens-has-prediabetes-cdc-data-indicate/

Most Read Papers - Cancer Science & Oncogenesis; Novel immunotargets in multiple myeloma: biological relevance and therapeutic potential.

https://read.qxmd.com/collection/1133?ecd=wnl_readmost_250711

Mini-Invasive Surgery Eases Hemorrhoid Pain Fast Jean-Bernard Gervais July 11, 2025

https://www.medscape.com/viewarticle/mini-invasive-surgery-eases-hemorrhoid-pain-fast-2025a1000idr

MCED Screening: What Patients Need to Know Katie Lennon July 11, 2025 + +...

https://www.medscape.com/viewarticle/mced-screening-what-patients-need-know-2025a1000iei American Society of Clinical Oncology (ASCO) 2025 https://www.medscape.com/viewcollection/37796

Witness to a Revolution: A Blood Cancer Expert’s Long View Randy Dotinga July 11, 2025 + +...

https://www.medscape.com/viewarticle/witness-revolution-blood-cancer-experts-long-view-2025a1000ie8 European Hematology Association (EHA) 2025 Annual Meeting https://www.medscape.com/viewcollection/37800

Artificial Intelligence Outperforms Humans in Mammography Analysis Edited by Anushree Chaphalkar Medscape UK July 11, 2025

https://www.medscape.com/viewarticle/artificial-intelligence-outperforms-humans-mammography-2025a1000i6g

Cerebral palsy + + +...

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00686-5/abstract?dgcid=raven_jbs_etoc_feature_lancet Social prescribing: bringing community back to health? The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01435-7/fulltext?dgcid=raven_jbs_etoc_email Jul 12, 2025 Volume 406Number 10499p103-202 https://www.thelancet.com/journals/lancet/issue/vol406no10499/PIIS0140-6736(25)X0028-3

The Rise of Protein Degraders for Hematologic Malignancies: Exploring the Latest Data From ASH 2024 Authors: Sagar Lonial, MD, FACP; Constatine Tam, MBBS, MD, FRACP, FRCPath; Julio Chavez, MD, MS

https://www.medscape.org/viewarticle/1002295?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250710-OUS-HONC-1002295-cta

Eating Disorder Awareness for School Providers Thursday, July 24, 1–2 p.m. ET

https://guidehouse.zoom.us/webinar/register/WN_2MLRyFEHSr-lSMPfPoG9-A?utm_source=SAMHSA&utm_campaign=34aab51d6d-EMAIL_CAMPAIGN_2025_07_03_02_30&utm_medium=email&utm_term=0_-34aab51d6d-167840245#/registration

Palliative Care | Kidney Disease | Cervical Cancer | Juvenile Arthritis | Sleep & Older Adults

https://content.govdelivery.com/accounts/USNIH/bulletins/3e8c199?reqfrom=share

Patient-Centered Paroxysmal Nocturnal Hemoglobinuria Treatment and the Role of Terminal Complement Inhibitors Authors: Regis Peffault de Latour, MD, PhD; Talha Munir, MBChB, PhD; Rachel Paine; Richard Kelly, MBChB, PhD; Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath

https://www.medscape.org/viewarticle/1002332?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250711-OUS-HONC-1002332-cta

jueves, 10 de julio de 2025

The Proteoform Puzzle: Unlocking the Next Frontier

https://www.news-medical.net/news/20250710/The-Proteoform-Puzzle-Unlocking-the-Next-Frontier.aspx

Can what we eat shape how we feel?

https://www.news-medical.net/news/20250710/Can-what-we-eat-shape-how-we-feel.aspx

Watch: She’s at high risk of breast cancer. She moved, and her screening costs soared.

https://www.news-medical.net/news/20250710/Watch-Shee28099s-at-high-risk-of-breast-cancer-She-moved-and-her-screening-costs-soared.aspx

Most baby foods are sweet, smooth, and poorly aligned with health advice, review finds

Despite their popularity and promises, commercial baby foods are often packed with sugar and lack the diversity infants need, raising concerns for parents who trust the packaging over public health advice. https://www.news-medical.net/news/20250709/Most-baby-foods-are-sweet-smooth-and-poorly-aligned-with-health-advice-review-finds.aspx

How plant-based meats are made Jacinta Bowler | Cosmos | July 10, 2025

https://geneticliteracyproject.org/2025/07/10/how-plant-based-meats-are-made/

RFK, Jr., other vaccine skeptics claim children get too many shots too soon. Here are the facts Jake Scott | STAT News | July 10, 2025

https://geneticliteracyproject.org/2025/07/10/rfk-jr-other-vaccine-skeptics-claim-children-get-too-many-shots-too-soon-here-are-the-facts/

States Expand Access to Ivermectin as Cancer Myths Continue, and Abortion Pill Faces False Water Supply Claim Irving Washington, Hagere Yilma, and Joel Luther

https://www.kff.org/the-monitor/states-expand-access-to-ivermectin-as-cancer-myths-continue-and-abortion-pill-faces-false-water-supply-claim/?utm_campaign=KFF-Misinformation-Trust&utm_medium=email&_hsenc=p2ANqtz--EBmK2r1vCNgBXHHI_b4N72ohQ0TTgMes5JhtheTk5mVixuPCo1F9gMjXLbEUibJ8UL0GA0EI9ZZucLrRh9DoU36huqA&_hsmi=370612761&utm_content=370612761&utm_source=hs_email

Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lost +...

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00174-4/fulltext?dgcid=raven_jbs_etoc_feature_ebiom The careful use of opioids and alternatives for pain management eBioMedicine https://www.thelancet.com/journals/ebiom/issue/vol117nonull/PIIS2352-3964(25)X0006-2

Science side-by-side 9 July 2025 Written by Paul Kidwell

https://rarerevolutionmagazine.com/science-side-by-side/

MAHA’s European food envy is full of contradictions RFK Jr. and his allies say Europe’s food policies help explain its lower rates of chronic disease — but experts say they’re overlooking policies with more impact

https://www.statnews.com/2025/07/10/maha-movement-vs-european-food-standards-make-america-healthy-again/

U.S. sees most single-year measles cases since it declared disease eliminated As anti-vaccine sentiment rises, experts predict country is on dangerous course

https://www.statnews.com/2025/07/09/measles-america-breaks-33-year-record-anti-vaccine-sentiment-key-factor-behind-outbreaks/?utm_campaign=breaking_news&utm_medium=email&_hsenc=p2ANqtz--hKwbn4DEjEQ__YdFYEaC3BI9gH7b3dfXuxn7QgDy23Iao4GPlytcSjPa1b7qekqGP3v8mwImy_LBL_Iz33Jd513wfGQ&_hsmi=370521008&utm_content=370521008&utm_source=hs_email

Precision Meets Collaboration: Advancing Personalized Multidisciplinary Care for mHSPC Authors: Fred Saad, MD, FRCS, FCAHS; Alberto Bossi, MD; Elena Castro, MD, PhD; Axel Merseburger, MD, PhD

https://www.medscape.org/viewarticle/1002563_sidebar8?sso=true&uac=148436CN&src=mkmcmr_driv_il_mscpedu_250709-1002563_EN_LANG_HONC

Safety and efficacy of the anti-TL1A monoclonal antibody tulisokibart for Crohn's disease: a phase 2a induction trial The Lancet Gastroenterology & Hepatology

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00071-8/abstract?dgcid=raven_jbs_etoc_feature_langas

Exercise for colon cancer: from supportive care to therapy The Lancet Gastroenterology & Hepatology +...

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00206-7/fulltext?dgcid=raven_jbs_etoc_email Volume 10, Issue 8 Aug 2025 Volume 10Number 8p701-778, e10 vhttps://www.thelancet.com/journals/langas/issue/vol10no8/PIIS2468-1253(25)X0007-8

Is pneumococcal vaccination required for new residents of care facilities for older adults? The Lancet Healthy Longevity +...

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00056-X/fulltext?dgcid=raven_jbs_etoc_email Jun 2025 Volume 6Number 6 https://www.thelancet.com/journals/lanhl/issue/vol6no6/PIIS2666-7568(25)X0007-6

Risk of cardiovascular disease among cancer survivors: systematic review and meta-analysis +...

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(25)00206-8/fulltext?dgcid=hubspot_update_feature_updatealerts_eclinm&utm_campaign=update-eclinm&utm_medium=email&_hsenc=p2ANqtz-9I8W3kkTJPjHtC9GQaa1T1wDPlp_bl6ogw38I86GJXT3nSBSLg0hGYW7fmyBMF-m95AFjOg0--INDJSjKMgCsWD2BUrA&_hsmi=370561096&utm_content=370499787&utm_source=hs_email The bloom and the breathless: the rising burden of pollen allergy eClinicalMedicine https://www.thelancet.com/journals/eclinm/issue/vol84nonull/PIIS2589-5370(25)X0005-5

ASCO | American Society of Clinical Oncology

https://www.thelancet.com/events/conferences/american-society-clinical-oncology?dgcid=hubspot_update_feature_asco25_eclinm&utm_campaign=update-eclinm&utm_medium=email&_hsenc=p2ANqtz-8wpLr_aiN_5ZUGv8TGici3cSYMICvmNsCRd7ESUpDDlXdFYxg8njDTay5NUN4eZZVq-BnMNOtlXFTNQDf10VKogEajCg&_hsmi=370561096&utm_content=370499787&utm_source=hs_email

A Year in Review of Antibody-Drug Conjugates for Breast Cancer: Trends, Practice, and Outlook Authors: Peter Schmid, MD, PhD, FRCP; Shanu Modi, MD; Erika P. Hamilton, MD; Nicola Fusco, MD

https://www.medscape.org/viewarticle/1002233?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250709-OUS-HONC-1002233-cta

Exploring Novel Combinations in mCRPC Care: Radioligands and Beyond Authors: Alison Birtle, MD, MBBS, FRCR, FRCP; Tony Collier, BEM; Ray McDermott, MD, PhD; Kambiz Rahbar, MD

https://www.medscape.org/viewarticle/1001854_sidebar10?sso=true&uac=148436CN&src=mkmcmr_driv_il_mscpedu_250710-ES_LANG-HONC-1001854-cta

Journal Club: Latest Advances in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Authors: Claudia Sommer, MD; Jeffrey Allen, MD; Anna Kostera-Pruszczyk, MD, PhD

https://www.medscape.org/viewarticle/1002373_sidebar6?sso=true&uac=148436CN&src=mkmcmr_driv_il_mscpedu_250710-ES_LANG-NEUR-1002373-cta

miércoles, 9 de julio de 2025

New study identifies factors linked to successful weight loss using GLP-1RAs

https://www.news-medical.net/news/20250709/New-study-identifies-factors-linked-to-successful-weight-loss-using-GLP-1RAs.aspx

Healthy plant-based diet ilinked with reduced risk of inflammatory bowel disease

https://www.news-medical.net/news/20250709/Healthy-plant-based-diet-ilinked-with-reduced-risk-of-inflammatory-bowel-disease.aspx

Many Americans misunderstand the health impact of processed foods

https://www.news-medical.net/news/20250709/Many-Americans-misunderstand-the-health-impact-of-processed-foods.aspx

How context shapes the mental health benefits of exercise

https://www.news-medical.net/news/20250709/How-context-shapes-the-mental-health-benefits-of-exercise.aspx

At-home HPV test offers a more accessible alternative to Pap test The self-collection test detects HPV, the virus linked to cervical cancer, and expands screening access for those unable or unwilling to visit a clinic.

https://www.drugdiscoverynews.com/at-home-hpv-test-offers-a-more-accessible-alternative-to-pap-test-16485?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8PgWqJA-RP8eBKZFeDhU1y5DCxgdkkF-b1UQe5VhMds5akujKZastvRiBPXqzKEow4N-C_K1wwC9I4MiysH9KAXhGbhQ&_hsmi=370500226&utm_content=370500226&utm_source=hs_email

Research-driven neonatology for equitable neonatal health The Lancet Child & Adolescent Health +...

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00189-0/fulltext?dgcid=raven_jbs_etoc_email Aug 2025 Volume 9Number 8p519-612, e16 https://www.thelancet.com/journals/lanchi/issue/vol9no8/PIIS2352-4642(25)X0008-0

Clearing the Air: How an Air Quality Researcher Takes Care of the Air Her Family Breathes July 9, 2025 By: Lisa Ng

https://www.nist.gov/blogs/taking-measure/clearing-air-how-air-quality-researcher-takes-care-air-her-family-breathes

Redefining Alzheimer’s development by mapping disease sequences

https://www.news-medical.net/news/20250709/Redefiningc2a0-Alzheimere28099s-development-by-mapping-disease-sequences.aspx By mapping millions of real patient health records, UCLA scientists have uncovered four unique and predictable routes to Alzheimer’s, reshaping how we detect, understand, and potentially prevent the condition.

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

https://www.news-medical.net/news/20250709/Energy-waves-on-cancer-cell-surfaces-linked-to-tumor-growth-and-aggressiveness.aspx

Is Spirulina the Next Anti-Aging Superfood?

https://www.news-medical.net/health/Is-Spirulina-the-Next-Anti-Aging-Superfood.aspx

Thimerosal in Vaccines: Myths vs. Medical Facts

https://www.news-medical.net/health/Thimerosal-in-Vaccines-Myths-vs-Medical-Facts.aspx

More fiber, fewer health risks: evidence for this easy diet fix

https://www.news-medical.net/news/20250709/More-fibre-fewer-health-risks-evidence-for-this-easy-diet-fix.aspx

Efficacy and safety of onradivir in adults with acute uncomplicated influenza A infection in China: a multicentre, double-blind, randomised, placebo-controlled and oseltamivir-controlled, phase 3 trial

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00046-3/abstract?utm_campaign=update-lanres&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanres&_hsenc=p2ANqtz-9w9tpPdthNdthDdYGcc1Eu3qfo7q2_6bhaCU-PjPnONCKG9ReBCI_gtg2uab4DOAYPLt_5GIL0QEfxMm2JYlM4nBhAfw&_hsmi=370165620&utm_content=370130586&utm_source=hs_email Jul 2025 Volume 13Number 7p569-654, e33-e37 https://www.thelancet.com/journals/lanres/issue/vol13no7/PIIS2213-2600(25)X0007-2

Global burden of vision impairment due to age-related macular degeneration, 1990–2021, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Global burden of vision impairment due to age-related macular degeneration, 1990–2021, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021 https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(25)00143-3/fulltext?dgcid=hubspot_update_feature_updatealerts_langlo&utm_campaign=update-langlo&utm_medium=email&_hsenc=p2ANqtz-9TNFSp1HIJxTgimp0cPIWBwuIDNvdCt97AxKh4tFvjrPrNdobf0YJUe6NmMDRoGo8bysa7D7DI4cQeLjqXVXp9NALrNg&_hsmi=370151790&utm_content=370131563&utm_source=hs_email Jul 2025 Volume 13Number 7e1151-e1326 https://www.thelancet.com/journals/langlo/issue/vol13no7/PIIS2214-109X(25)X0007-3

Primary Biliary Cholangitis: Setting Higher Expectations Authors: Maria-Carlota Londoño, MD, PhD; Marlyn J. Mayo, MD; Mark G. Swain, MD

https://www.medscape.org/viewarticle/1002582_sidebar9

Shared Decision-Making in Epilepsy Today Authors: Bettina Schmitz, MD, PhD; Jakob Christensen, MD, PhD; Elinor Ben-Menachem, MD, PhD; Antonio Gil-Nagel, MD, PhD

https://www.medscape.org/viewarticle/1002600_sidebar9

ESMO Gynecological (ESMO Gyn) Cancers Congress 2025 +... June 19 - 21, 2025 Vienna, Austria and Virtual

https://www.medscape.com/viewcollection/37812

18th International Conference on Malignant Lymphoma (ICML) 2025 +... June 17 - 21, 2025 Lugano, Switzerland

https://www.medscape.com/viewcollection/37821

The science of seed oils: Healthy or harmful Lucy Stitzer | July 9, 2025

https://geneticliteracyproject.org/2025/07/09/the-science-of-seed-oils-healthy-or-harmful/

Myelofibrosis-Associated Anemia: Burden, Management, and Future Directions Authors: Francesca Palandri, MD; Jean-Jacques Kiladjian, MD, PhD; Jon Mathias

https://www.medscape.org/viewarticle/1002370?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250708-OUS-HONC-1002370-cta

COVID-19 and Oral Antivirals: How to Define an Eligible Patient Authors: Marta Boffito, MD, PhD, FRSP, MBA; Jörg Schelling, MD, FESPCH

https://www.medscape.org/viewarticle/1002037?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250709-OUS-HONC-1002037-cta

Early Lyme Disease as Manifested by Erythema Migrans: Developing Drugs for Treatment June 2025

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/early-lyme-disease-manifested-erythema-migrans-developing-drugs-treatment?utm_medium=email&utm_source=govdelivery

martes, 8 de julio de 2025

Morning workouts can boost weight loss if one key habit is followed, experts say By Angelica Stabile Fox News Published July 7, 2025 5:00am EDT

Morning workouts can boost weight loss if one key habit is followed, experts say Trainers reveal critical balance between early exercise and proper sleep Angelica Stabile By Angelica Stabile Fox News Published July 7, 2025 5:00am EDT https://www.foxnews.com/health/morning-workouts-can-boost-weight-loss-one-key-habit-followed-experts-say

Miley Cyrus reveals the 'powerful' therapy that helped her conquer stage fright By Reem Amro Fox News Published July 6, 2025 5:00am EDT

Miley Cyrus reveals the 'powerful' therapy that helped her conquer stage fright The pop icon credits EMDR for her confident stage presence: "Saved my life' By Reem Amro Fox News Published July 6, 2025 5:00am EDT https://www.foxnews.com/health/miley-cyrus-reveals-powerful-therapy-helped-her-conquer-stage-fright

Stanford scientists 'totally surprised' by potential Parkinson's treatment discovery By Khloe Quill Fox News Published July 7, 2025 5:20pm EDT

Stanford scientists 'totally surprised' by potential Parkinson's treatment discovery Experimental treatment could improve patient condition, not just stabilize symptoms, researchers say By Khloe Quill Fox News Published July 7, 2025 5:20pm EDT https://www.foxnews.com/health/stanford-scientists-totally-surprised-potential-parkinsons-treatment-discovery

Children's health declines in last 17 years, study finds By Stephen Sorace Fox News Published July 8, 2025 8:00am EDT

Children's health declines in last 17 years, study finds Research shows American kids more likely to die than children in comparable countries By Stephen Sorace Fox News Published July 8, 2025 8:00am EDT https://www.foxnews.com/health/childrens-health-declines-last-17-years-study-finds

Never smoked? You could still be at risk of developing lung cancer, doctors warn By Melissa Rudy Fox News Published July 8, 2025 5:00am EDT | Updated July 8, 2025 5:51am EDT

Never smoked? You could still be at risk of developing lung cancer, doctors warn Medical experts note concerning trend in patients without traditional smoking history Melissa Rudy By Melissa Rudy Fox News Published July 8, 2025 5:00am EDT | Updated July 8, 2025 5:51am EDT https://www.foxnews.com/health/never-smoked-you-could-still-risk-developing-lung-cancer-doctors-warn

How the U.S. health care system fails cancer patients like former MTV VJ Ananda Lewis People are turning to alternative medicine out of fear and a sense of disorientation

https://www.statnews.com/2025/07/07/ananda-lewis-breast-cancer-natural-therapies-oncology-navigation/

Apogee reports first data on long-acting eczema drug Skin-clearance rates were similar to currently marketed drugs from Sanofi, Regeneron, and Eli Lilly

https://www.statnews.com/2025/07/07/apogee-therapeutics-eczema-drug-study-results/

Cogent Biosciences drug improves symptoms of chronic immune disorder, study results show A comparison of the therapy to a rival treatment from Blueprint Medicines remains muddled

https://www.statnews.com/2025/07/07/cogent-biosciences-bezuclastinib-indolent-systemic-mastocytosis-blueprint-comparison/

Survival rates for cancer patients on immunotherapy depend on insurance coverage, study finds Those on private insurance or Medicaid had higher survival rates compared to uninsured

https://www.statnews.com/2025/07/07/cancer-odds-better-with-health-insurance-coverage-jama-open-network-study-finds/

Leading medical groups sue Kennedy over changed Covid-19 vaccine recommendations Suit argues HHS changed federal guidance outside of established processes, undermining trust

https://www.statnews.com/2025/07/07/doctors-groups-sue-rfk-jr-over-vaccine-policy-changes/

I work in drug law enforcement and policy. Maybe pharma companies should develop ‘safe’ recreational drugs Right now, it’s a thought experiment, but the day is probably coming

https://www.statnews.com/2025/07/08/pharmaceutical-companies-recreational-drugs-safe-legal-high-dea-expert/

ER docs are too quick to assume cannabis users are experiencing this rare side effect Cannabis hyperemesis syndrome is real — but overdiagnosed

https://www.statnews.com/2025/07/08/cannabis-hyperemsis-syndrome-marijuana-vomiting-emergency-room-overdiagnosis/

Male and female athletes have different hearts, and that can have serious consequences Biological questions and delays in CPR leave women potentially at risk

https://www.statnews.com/2025/07/08/cardiovascular-health-female-athlete-conference-boston-how-gender-differences-play-out-in-sports-medicine/

GLP podcast: Has MAHA made vaccine denial a right-wing cause? Cameron English, Liza Dunn | July 8, 2025

https://geneticliteracyproject.org/2025/07/08/glp-podcast-has-maha-made-vaccine-denial-a-right-wing-cause/

Why evolution hasn’t eliminated human susceptibility to depression as it has for other diseases Sam Goldstein | Psychology Today | July 8, 2025

https://geneticliteracyproject.org/2025/07/08/why-evolution-hasnt-eliminated-human-susceptibility-to-depression-as-it-has-for-other-diseases/

Around the Web Today’s Daily Digest of stories culled from the Internet and excerpted +++

‘Designer baby’ startup: Controversal germline editing company Bootstrap Bio raising money for germline gene editing launch https://geneticliteracyproject.org/2025/07/07/designer-baby-startup-controversal-germline-editing-company-bootstrap-bio-raising-money-for-germline-gene-editing-launch/?mc_cid=f2630965f0&mc_eid=b73600b7ac Hyper-communication: How our phones, emails and social media are reshaping evolution https://geneticliteracyproject.org/2025/07/07/hyper-communication-how-our-phones-emails-and-social-media-are-reshaping-evolution/?mc_cid=f2630965f0&mc_eid=b73600b7ac Olympics on Steroids: The juiced enhanced games are coming in 2026. But that’s not the most bizarre gimmick https://geneticliteracyproject.org/2025/07/07/olympics-on-steroids-the-juiced-enhanced-games-are-coming-in-2026-but-thats-not-the-most-bizarre-gimmick/?mc_cid=f2630965f0&mc_eid=b73600b7ac

Conditioning Regimens for HSCT in AML/MDS: Importance of Individualization in Your Adult Patients Authors: Domenico Russo, MD, PhD; Daniele Avenoso, MD, PhD; Matthias Stelljes, MD

https://www.medscape.org/viewarticle/1002516_sidebar9?sso=true&uac=148436CN&src=mkmcmr_driv_il_mscpedu_250707-1002516_ES_LANG_HONC

Palliative Care | Worms in Research | Personalized Gene Therapy | Tooth Grinding | Risky Drinking

https://newsinhealth.nih.gov/2025/07-0

Clinical Trials in CLL and MCL: Expert In-Depth Analysis Authors: Chan Cheah, MBBS, DMSc; Nirav N. Shah, MD; Jennifer A. Woyach, MD

https://www.medscape.org/viewarticle/1002400?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250707-OUS-HONC-1002400-cta

Hormone Receptor-Positive, HER2-Negative Early Breast Cancer: The Adjuvant Clinical Trial Populations Explained Authors: Erika Hamilton, MD; Nadia Harbeck, MD, PhD

https://www.medscape.org/viewarticle/1002403?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250708-OUS-HONC-1002403-cta

lunes, 7 de julio de 2025

ADA2 regulates inflammation through lysosomal and extracellular mechanisms

https://www.news-medical.net/news/20250707/ADA2-regulates-inflammation-through-lysosomal-and-extracellular-mechanisms.aspx

UCLA Health researchers discover four pathways leading to Alzheimer’s disease

https://www.news-medical.net/news/20250707/UCLA-Health-researchers-discover-four-pathways-leading-to-Alzheimere28099s-disease.aspx

Twin study reveals genetic influence on infant crying and sleep

https://www.news-medical.net/news/20250707/Twin-study-reveals-genetic-influence-on-infant-crying-and-sleep.aspx

Side of onset influences non-motor symptoms in Parkinson’s disease

https://www.news-medical.net/news/20250707/Side-of-onset-influences-non-motor-symptoms-in-Parkinsone28099s-disease.aspx

Excess weight linked to breast cancer risk in postmenopausal women with cardiovascular disease

https://www.news-medical.net/news/20250707/Excess-weight-linked-to-breast-cancer-risk-in-postmenopausal-women-with-cardiovascular-disease.aspx

Metabolic enzyme PHGDH found to play a surprising role in breast cancer immunity

https://www.news-medical.net/news/20250707/Metabolic-enzyme-PHGDH-found-to-play-a-surprising-role-in-breast-cancer-immunity.aspx

Neem - Evidence-Based Health Benefits +++

Neem - Evidence-Based Health Benefits https://www.news-medical.net/health/Neem-Evidence-Based-Health-Benefits.aspx What is the TLC Diet? https://www.news-medical.net/health/What-is-the-TLC-Diet.aspx Tridecanoic Acid (C13): The Odd-Chain Fatty Acid With Big Implications Tridecanoic acid (C13) is a rare, odd-chain saturated fatty acid produced mainly by gut and rumen microbes, entering metabolic pathways via β-oxidation to support gluconeogenesis and the TCA cycle. Although scarcely detected in plasma, emerging research suggests C13 could serve as a sensitive biomarker for diet-microbiome interactions and may have distinct metabolic and anti-inflammatory effects. https://www.news-medical.net/medical/articles

Do Popular Skincare Ingredients Like Niacinamide and Retinol Actually Work?

https://www.news-medical.net/health/Do-Popular-Skincare-Ingredients-Like-Niacinamide-and-Retinol-Actually-Work.aspx

Early exposure to plastics raises young children’s asthma risk

https://www.news-medical.net/news/20250706/Early-exposure-to-plastics-raises-young-childrene28099s-asthma-risk.aspx

Bioprinting a thick skin Researchers used 3D printing to create multi-layered skin grafts for deep wounds.

https://www.drugdiscoverynews.com/bioprinting-a-thick-skin-16013?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-94VSrWIttqxwc_R53QXAO-ZdC1dQ4f9VSksyRlMJ9c3crZViFPTmOlZKi3OTiYoK2PSAKUox2-UQGRIMxfFgZoXPRUaw&_hsmi=369863556&utm_content=369863556&utm_source=hs_email

A smart bandage fights bacteria with precision A new wound dressing monitors infections in real time and administers timely treatment using metal ions.

https://www.drugdiscoverynews.com/a-smart-bandage-fights-bacteria-with-precision-15980?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9m2zo0sa9gzQlpnoPw03mWBF-qZUPHIJqVtJu9sxYEHfHARwELBcQYzZjY5uOvQC_JnTEdOcidERH7NZPEKRBoFMFjJQ&_hsmi=369863556&utm_content=369863556&utm_source=hs_email

New smart bandage detects real-time biomarkers in chronic wounds To help clinicians monitor slow-healing chronic wounds, researchers created the iCares device and tested it in 20 people with a variety of wounds.New smart bandage detects real-time biomarkers in chronic wounds To help clinicians monitor slow-healing chronic wounds, researchers created the iCares device and tested it in 20 people with a variety of wounds.

https://www.drugdiscoverynews.com/new-smart-bandage-detects-real-time-biomarkers-in-chronic-wounds-16481?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9GmWjFzGhDSBp5dv--xBokraRudaJgvpcW4GsEw-d_BzM1kkJrqsFiBJ_zG4X5STCw7vyxf_LmvGpuQnYODodnm7VnBQ&_hsmi=369863556&utm_content=369863556&utm_source=hs_email

The cellular players that enable wound healing A coordinated effort between the stroma, the immune system, and the skin microbiome restores damaged skin.

https://www.drugdiscoverynews.com/the-cellular-players-that-enable-wound-healing-15739?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8a9pAQKm16XDm_o4jsE1sutQZYg9jfkHb5vhvVdI3wbJDcDwsyGHBR9fs5CMT1ap5tmUmcB4Pfz7Di8TC-F7wmgsCWwQ&_hsmi=369863556&utm_content=369863556&utm_source=hs_email

Viewpoint: Food as medicine — with obesity and medical-related issues growing, we need to refocus our perspective on fruits and vegetables Meredith Bauer | University of Florida | July 7, 2025

https://geneticliteracyproject.org/2025/07/07/viewpoint-food-as-medicine-with-obesity-and-medical-related-issues-growing-we-need-to-refocus-our-perspective-on-fruits-and-vegetables/

Hyper-communication: How our phones, emails and social media are reshaping evolution Eric Haseltine | Psychology Today | July 7, 2025

https://geneticliteracyproject.org/2025/07/07/hyper-communication-how-our-phones-emails-and-social-media-are-reshaping-evolution/

Designing the Optimal Care Plan for the Patient With Metastatic Castration-Resistant Prostate Cancer Authors: Bertrand Tombal, MD, PhD; Jonathan D. Tward, MD, PhD, FASTRO

https://www.medscape.org/viewarticle/1002397?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_250706-OUS-HONC-1002397-cta

Patient-Attributable Delays in Breast Cancer Care Linked to Increased Risk for 2-Year Mortality Edited by Gargi Mukherjee Medscape UK July 07, 2025

https://www.medscape.com/viewarticle/patient-attributable-delays-breast-cancer-care-linked-2025a1000had

Paclitaxel Matches Cisplatin HIPEC in Ovarian Cancer Edited by Gargi Mukherjee July 07, 2025

https://www.medscape.com/viewarticle/paclitaxel-matches-cisplatin-hipec-ovarian-cancer-2025a1000hv8

MHRA Approves New Immunotherapy for Bladder Cancer Zeel Mehta Medscape UK July 07, 2025

https://www.medscape.com/viewarticle/mhra-approves-new-immunotherapy-bladder-cancer-2025a1000hw6

Are Breast Cancer Survivors Vulnerable to Alzheimer’s Disease? Megan Brooks | July 07, 2025

https://www.medscape.com/viewarticle/are-breast-cancer-survivors-vulnerable-alzheimers-disease-2025a1000hv0

Navigating the complexities of the rare glomerular diseases C3G and primary IC-MPGN

https://us02web.zoom.us/webinar/register/WN_fG5Gj5r8QQadimusIa8Awg#/registration Join Our Glomerular Diseases RARE Rev-inar on July 8th! We are thrilled to invite you to our 20th RARE Rev-inar, focusing on glomerular diseases, specifically C3G and primary IC-MPGN. This vital discussion, supported by Apellis Pharmaceuticals, promises to be highly informative and engaging. Date: Tuesday, 8th July 2025 Time: 3.30 PM BST | 10:30 AM EST | Where: Online – register here: https://bit.ly/GlomerularDiseasesWebinar Our expert panel includes: Dr. Bradley Dixon: Professor of paediatrics-nephrology specialising in kidney diseases linked to complement system abnormalities. Lexi Pencis: Mother of Collette, diagnosed with C3 Glomerulopathy (C3G) at age six, offering a parent's perspective on managing intensive care pathways. Christina Gilchrist ("BLIND CHICK LIVING"): With over 20 years of experience navigating dialysis and two kidney transplants, co-manages a popular dialysis support group and hosts a podcast. Michael Gilchrist: Christina's husband and primary caregiver, co-managing their dialysis kidney support group. Michelle Williams: Diagnosed with plasma cell neoplasm and primary IC-MPGN in September 2023. The webinar will cover: Understanding the Journey: Diagnosis and early experiences with glomerular diseases. Living with and Managing the Disease: Insights into daily life, care pathways, and unmet needs. Hope for the Future: Discussions on research, support, and necessary changes in healthcare. Don't miss this opportunity to gain valuable insights and participate in a live Q&A session with our esteemed panellists. A link to articles and experiences from our digital spotlight, including an educational infographic, will be shared in the chat during the webinar.

domingo, 6 de julio de 2025

Artificial Intelligence Applications in Breast Imaging

https://www.medscape.org/advances/imaging-2025-curriculum-2025a1000ayx?src=prt_vanity_250630_mscpedu_421597.01_ace

One Team, One Goal: The Key to Better Patient Outcomes in Early Breast Cancer Management Authors: Fatima Cardoso, MD, FESMO, ESCO; Nadia Harbeck, MD, PhD; Shani Paluch, MBBS, MSc

https://www.medscape.org/viewarticle/1002593?sso=true&uac=148436CN&src=mkmcmr_reeng_recap_mscpedu_activity One Team, One Goal: The Key to Better Patient Outcomes in Early Breast Cancer Management Below are some key learning points to help reinforce the impact of this activity. ☑ HR+/HER2- breast cancer • For a 28-year old woman with cT2 cN1 cM0, HR+/HER2-negative breast cancer with germline BRCA wild-type, therapy recommendations would be pre-operative endocrine therapy, based on data from the ADAPT trial • In this patient, considering that she was ypT2 ypN1 after neoadjuvant therapy and surgery, adjuvant therapy with either exemestane or tamoxifen, ovarian function suppression plus an aromatase inhibitor is warranted • These recommendations are supported by long-term data from the SOFT and TEXT trials, as well as monarchE and NATALEE • The ADAPTcycle trial which is ongoing will also serve to inform if chemotherapy can be substituted for endocrine therapy based on recurrence risk scores and response to endocrine therapy ☑ HER2-positive early breast cancer • For a 55-year-old patient with Grade 3, ER 80%, PR 30%, HER2 IHC3+, Ki-67 60% cT2 (2.5 cm) cN0 disease, ESMO currently recommends neoadjuvant therapy with trastuzumab + pertuzumab + chemotherapy • This recommendation is supported by long-term (11.3 years) follow-up data from APHINITY, which showed sustained improvement with this regimen vs trastuzumab + chemotherapy • If after surgery, the patient still has residual disease, the patient should continue to receive adjuvant T-DM1 (KATHERINE data), with the potential for also receiving neratinib (ExteNET data) • Current ongoing trials which could inform treatment decisions in the future include DESTINY-Breast05 (adjuvant T-DXd compared to T-DM1) and DESTINY-Breast11 (neoadjuvant T-DXd vs standard of care) ☑ Triple-negative early breast cancer • For a patient with Grade 3, ER-/PR-/HER2-negative, Ki-67 80%, with germline BRCA mutation, ESMO currently recommends neoadjuvant therapy with chemotherapy + pembrolizumab, followed by surgery, and if non-PCR, adjuvant pembrolizumab or olaparib • These recommendations are based on ◦ KEYNOTE-522 (phase 3), which showed significantly improved outcomes with pembrolizumab vs placebo, on a backbone of chemotherapy ◦ OlympiA (phase 3), which showed significantly improved outcomes with olaparib vs placebo • Multiple clinical trials with various antibody-drug conjugates are ongoing in this setting

Virtual Simulations: Managing the Patient With HR+/HER2- Early Breast Cancer Through a Multidisciplinary Approach Authors: Manali Bhave, MD; Jane Meisel, MD

https://www.medscape.org/viewarticle/1002474?sso=true&uac=148436CN&src=mkmcmr_reeng_recap_mscpedu_activity Virtual Simulations: Managing the Patient With HR+/HER2- Early Breast Cancer Through a Multidisciplinary Approach Below are some key learning points to help reinforce the impact of this activity. ☑ ASSESSING RISK OF RECURRENCE IN PATIENTS WITH EBC • Several factors must be considered when assessing a patient’s risk of recurrence. Key prognostic factors include age, tumor size, tumor grade, nodal involvement, and biomarker expression. • Gene expression profiling can also provide additional insight about an individual’s risk for recurrence. Multiple gene expression profiling assays are currently available for patients with early-stage, HR-positive/HER2-negative breast cancer. Each of these assays differs with respect to the type of information they provide and the specific patient populations used for assay validation. • Current guidelines from National Comprehensive Cancer Network® (NCCN®), ASCO, and the European Society for Medical Oncology (ESMO) should be followed when considering whether to test and which assay is most appropriate. ☑ GUIDELINE-BASED ADJUVANT TREATMENT OF HR-POSITIVE/HER2-NEGATIVE EBC • NCCN and ESMO guidelines recommend considering adjuvant radiation therapy for those undergoing breast conserving surgery. The use of adjuvant chemotherapy should be based on risk for recurrence, including use of genomic assays when appropriate to identify patients most likely to benefit. [NCCN,v6.2024;Loibl,2024] • NCCN guidelines recommend adjuvant endocrine therapy ± a CDK 4/6 inhibitor in HR-positive/HER2-negative EBC as follows [NCCN,v6.2024]: ◦ For patients who are premenopausal at diagnosis ▪ Tamoxifen for 5 years (± ovarian suppression or ablation) (both Category 1); consider adjuvant abemaciclib in eligible patients ∙ If considering extended endocrine therapy in a postmenopausal patient after 5 years of tamoxifen, then can switch to AI for 5 years (Category 1) or continue tamoxifen for an additional 5 years ∙ If considering extended endocrine therapy in a premenopausal patient after 5 years of tamoxifen, consider tamoxifen for an additional 5 years or no further endocrine therapy OR ▪ An aromatase inhibitor (AI) for 5 years plus ovarian suppression or ablation (Category 1); consider adjuvant abemaciclib or ribociclib in eligible patients; then consider an additional 3 to 5 years of AI with continuation of ovarian suppression or ablation if patient remains premenopausal • For patients who are postmenopausal at diagnosis ◦ An AI for 5 years (Category 1); consider adjuvant abemaciclib or ribociclib in eligible patients; consider additional 3 to 5 years of AI OR ◦ An AI for 2 to 3 years (Category 1); consider adjuvant abemaciclib or ribociclib in eligible patients; then follow with tamoxifen to complete 5 years of endocrine therapy total (Category 1) OR ◦ Tamoxifen for 2 to 3 years, followed by either an AI to complete 5 years of endocrine therapy total (Category 1) or an AI for 5 years (Category 2B) OR ◦ Tamoxifen for 4.5 to 6 years, followed by either an AI for 5 years (Category 1) or tamoxifen for an additional 5 years OR ◦ For patients with contraindication or intolerance to an AI, tamoxifen for 5 years (Category 1) with consideration to extend tamoxifen for 10 years total • Current breast cancer guidelines recommend consideration of 2 years of adjuvant abemaciclib (ASCO, ESMO, and NCCN) or 3 years of adjuvant ribociclib (ASCO and NCCN) in combination with endocrine therapy in patients with moderate-risk to high-risk disease. • Use of an adjuvant PARP inhibitor, olaparib, should be considered for patients with high-risk, early-stage HER2-negative breast cancer who also carry a germline BRCA1/2 mutation. ☑ ADDITION OF CDK-TARGETED THERAPY TO ADJUVANT ENDOCRINE THERAPY • Adjuvant CDK 4/6 inhibitors (eg, abemaciclib, ribociclib) have been shown to further reduce the risk of recurrence in high-risk, HR-positive/HER2-negative early breast cancer in combination with adjuvant endocrine therapy. • Abemaciclib ◦ Guidelines from NCCN, ASCO, and ESMO recommend abemaciclib for node-positive, high-risk, HR-positive/HER2-negative EBC. [NCCN,v6.2024;Freedman,2024;Loibl,2024] NCCN defines high risk as [NCCN,v6,2024]: ▪ 4 positive nodes OR ▪ 1-3 positive nodes AND grade 3 OR ▪ 1-3 positive nodes AND tumor size ≥5 cm ◦ ASCO guidelines also include a definition of high risk as 1 to 3 positive nodes and Ki-67 ≥20%. [Freedman,2024] ESMO guidelines recommend consideration of abemaciclib for patients with Stage III or high-risk Stage II disease. [Loibl,2024] • Ribociclib ◦ Ribociclib was evaluated in the phase 3 NATALEE trial comparing a nonsteroidal AI (with goserelin for premenopausal patients) with or without 3 years of ribociclib. ◦ Eligibility criteria differed from the monarchE trial and included patients with HR-positive/HER2-negative EBC with either Stage III, Stage II with positive nodes (N1), or Stage II node-negative disease that was Grade 3 or had a high Oncotype Dx score or high-risk Mammaprint and/or Ki-67 ≥20%. [Slamon,2024] ◦ Based on these data, 3 years of ribociclib therapy is currently approved by both the FDA and EMA in combination with adjuvant endocrine therapy for patients with HR-positive/HER2-negative, high-risk EBC. ASCO and NCCN guidelines recommend consideration of these therapies in patients who meet the eligibility criteria for the NATALEE trial, defining high-risk as: ▪ Node-positive OR ▪ Node-negative AND tumor size >5 cm OR ▪ Node-negative AND tumor size 2 to 5 cm AND Grade 3 OR ▪ Node-negative AND tumor size 2 to 5 cm AND Grade 2 AND high genomic risk OR Ki-67 ≥20% ☑ Monitoring and Management of AEs • Patients receiving CDK4/6 inhibitor therapy should be educated on potential AEs, as well as how and when to notify their healthcare teams when side effects do occur. Complete blood counts and liver function should be assessed at baseline and monitored during therapy or as clinically indicated. • Electrocardiograms (ECGs) should also be used to monitor for QTc prolongation with ribociclib. Patients should also be closely monitored for signs and symptoms of venous thromboembolism, interstitial lung disease, and pneumonitis (eg, hypoxia, cough, dyspnea).

New ACC guidance helps incorporate pharmacologic weight management strategies into cardiovascular care

https://www.news-medical.net/news/20250620/New-ACC-guidance-helps-incorporate-pharmacologic-weight-management-strategies-into-cardiovascular-care.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_1_july_2025

Heart scan study reveals low-fiber diets drive dangerous heart plaques

https://www.news-medical.net/news/20250618/Heart-scan-study-reveals-low-fiber-diets-drive-dangerous-heart-plaques.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_1_july_2025

America slashes heart attack deaths but faces surge in deadly heart failure and arrhythmias

https://www.news-medical.net/news/20250626/America-slashes-heart-attack-deaths-but-faces-surge-in-deadly-heart-failure-and-arrhythmias.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_1_july_2025

Can your athletic past raise your risk for atrial fibrillation?

https://www.news-medical.net/news/20250626/Can-your-athletic-past-raise-your-risk-for-atrial-fibrillation.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_1_july_2025

Teen drivers spend over one fifth of each trip distracted by phones

https://www.news-medical.net/news/20250704/Teen-drivers-spend-over-one-fifth-of-each-trip-distracted-by-phones.aspx

Early life exposure to PFHxA may impact male brain development

https://www.news-medical.net/news/20250704/Early-life-exposure-to-PFHxA-may-impact-male-brain-development.aspx

Ten-year study tracks trends in pediatric clavicle fractures across the U.S.

https://www.news-medical.net/news/20250704/Ten-year-study-tracks-trends-in-pediatric-clavicle-fractures-across-the-US.aspx

Research highlights an increase in informal use of doxyPEP/PrEP among key populations in the Netherlands

https://www.news-medical.net/news/20250704/Research-highlights-an-increase-in-informal-use-of-doxyPEPPrEP-among-key-populations-in-the-Netherlands.aspx

First large-scale stem cell bank created to investigate Alzheimer’s genetic risk factors

https://www.news-medical.net/news/20250704/First-large-scale-stem-cell-bank-created-to-investigate-Alzheimere28099s-genetic-risk-factors.aspx

Letting bird flu run its course could spark wider pandemic

https://www.news-medical.net/news/20250704/Letting-bird-flu-run-its-course-could-spark-wider-pandemic.aspx

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

https://www.news-medical.net/news/20250624/Once-monthly-obesity-injection-shows-double-digit-weight-loss-in-major-clinical-trial.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=gastroenterology_newsletter_1_july_2025

Do spicy foods help or hurt your gut health?

https://www.news-medical.net/news/20250626/Do-spicy-foods-help-or-hurt-your-gut-health.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=gastroenterology_newsletter_1_july_2025

Synbiotics May Lower Anxiety | Single Dose Psilocybin Treats Depression +++++ ++++ +++ +

INTEGRATIVE THERAPIES Prebiotics, Probiotics May Lower Anxiety, Depression https://www.medscape.com/viewarticle/probiotics-prebiotics-tied-decreased-depression-anxiety-2025a1000fec?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 How One Dose of Psilocybin Treats Depression https://www.medscape.com/viewarticle/how-one-dose-psilocybin-treats-depression-2025a1000g2w?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Novel Method Eases Pain, Anxiety in ED https://www.medscape.com/viewarticle/music-therapy-eases-pain-and-anxiety-emergency-department-2025a1000apm?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Program May Reduce Anxiety in COPD https://www.medscape.com/viewarticle/digital-mindfulness-program-may-reduce-anxiety-patients-2025a1000gmw?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 One Dose Eases Cancer Depression https://www.medscape.com/viewarticle/one-psilocybin-dose-eases-cancer-depression-over-long-term-2025a1000gd9?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 ANXIETY & CORMORBIDITIES Anxiety & Alcohol Use: The Complex Interplay https://www.medscape.com/viewarticle/two-diagnoses-one-patient-how-treat-alcohol-use-and-mental-2025a1000czn?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Depression, Anxiety Rates With Chronic Pain https://www.medscape.com/viewarticle/high-global-rates-comorbid-depression-anxiety-chronic-pain-2025a10007t1?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 The Therapy After Stroke Tied to Better Psych Outcome https://www.medscape.com/viewarticle/early-talk-therapy-after-stroke-tied-better-psych-outcome-2025a1000geo?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Leg Weakness, Fatigue, Cognitive Issues With Anxiety, Depression: What’s Your Dx? https://reference.medscape.com/viewarticle/1001934?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 TREATMENT ESSENTIALS Antidepressant Meds: How Much Do You Know? https://reference.medscape.com/viewarticle/986771?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Antidepressants Effective for GAD https://www.medscape.com/viewarticle/confirmed-antidepressants-effective-generalized-anxiety-2025a100032i?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 Anxiety Disorders: What to Know https://emedicine.medscape.com/article/286227-overview?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034 US DRUG SPOTLIGHT Risperidone https://reference.medscape.com/drug/perseris-risperdal-consta-risperidone-342986?ecd=mkm_ret_250705_mscpmrk_psych_anxiety_etid7538034&uac=148436CN&impID=7538034