domingo, 31 de marzo de 2024
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space StationGenomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
sábado, 30 de marzo de 2024
Borrowing an idea from cancer immunotherapy, scientists make old-mice immune systems youthful again Megan Molteni By Megan Molteni March 27, 2024
Scientists rejuvenate immune systems in old mice
https://www.statnews.com/2024/03/27/immune-system-rejuvenated-stanford-research-aging-stem-cells/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=300173672&_hsenc=p2ANqtz-9LdG7gS0Q3u_zaRNd_Ugi1rSDc4Ir4V1dpQSdFWM-MQAMo28haur2UIdSVQS9rJk2D1NM5dfr4C8LnJ5-AzXHrKLCkpQ&utm_content=300173672&utm_source=hs_email
The “twilight of immunity” has a much more poetic flavor than almost any other phrase describing our bodies’ deterioration with age. STAT’s Megan Motleni calls this to mind in today’s story about research seeking to explain how our aging immune systems leave us more vulnerable to infection. Reporting in Nature yesterday on their experiments in mice, scientists traced waning immune strength to the bone marrow where blood and immune cells originate from hematopoietic stem cells. The balance of immune memory cells, blood cells, and front-line defenders shifts over time depending on what kind of cells are produced, with an impact on how well they work against invaders.
When the scientists restored a youthful balance of these cells with injections of antibodies, they were able to rejuvenate the immune systems of older mice — allowing them to better fend off viral attacks. Megan has more on whether and how this might hold up in humans, plus the rich history behind the work.
The twilight of immunity: emerging concepts in aging of the immune system
https://www.nature.com/articles/s41590-017-0006-x?utm_campaign=morning_rounds&utm_medium=email&_hsmi=300173672&_hsenc=p2ANqtz-_8_7-bdRPRkAC9muXhMech-1XmROmeiGH-g9A3HMGcz-3P7-ltlXDTxVdIqrDQfqcz0TvkuOp46w75g-wENid4HA-3HQ&utm_content=300173672&utm_source=hs_email
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
https://www.nature.com/articles/s41586-024-07238-x?utm_campaign=morning_rounds&utm_medium=email&_hsmi=300173672&_hsenc=p2ANqtz-8CYY00ZS6n1GguktPXtSQiFvQi1geeKJa1vHJ4nRtYKBxQ1z6z_8R9UgfMYlCXhv92ef4zo0NQiPqy1oX1odOPdOPU4A&utm_content=300173672&utm_source=hs_email
Covid’s scientific silver lining: A chance to watch the human immune system respond in real time Helen Branswell By Helen Branswell March 28, 2024
https://www.statnews.com/2024/03/28/covid-immune-system-response/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=300173672&_hsenc=p2ANqtz-95Agty6VUArBCC-UeJ8eS99pwg_JSOIn8ZHfrhuj5IPCi1AshMiFzNAiHqZQjL5csjc6Wi7HyMqQ9ZjNndInDspvgUTg&utm_content=300173672&utm_source=hs_email
Immunologists would never deny Covid-19’s worldwide devastation, but if you look through their eyes back to 2020, when the disease still had no name but was spreading across the world, you’ll see a silver lining. For a window of time that has now closed, they could watch what happened when 8 billion people were exposed to a novel coronavirus. They had a front-row seat to witness how we developed immunity to the virus — and its variants — at a cellular level.
Pandemics have emerged before, but this time scientists had the tools to study how the immune system awakens to a new threat and develops defenses against it. “You see textbook immunology happening in real time,” said Marc Veldhoen, a professor of immunology at the University of Lisbon. “You couldn't have designed a better experiment,” said Stephen Deeks, an HIV researcher at the University of California, San Francisco. STAT’s Helen Branswell tells us what they did with this opportunity — and what they learned.
REGISTER FOR FREE CE/CMEs | April 04, 2024 DHA, CCSS, “Evidence-Based and Promising Practices in Pediatric Care for Military Children and Youth" Live Event | 6.5 FREE CE/CME Credits
Greetings,
https://content.govdelivery.com/attachments/USMHS/2024/03/28/file_attachments/2829365/DHA_J-7_CEPO_04APR24-CCSS-REGFlyer_vF_2024-3-27.pdf
Registration is OPEN for the upcoming Clinical Communities Speaker Series (CCSS), "Evidence-Based and Promising Practices in Pediatric Care for Military Children and Youth” occurring on April 4th, 2024, 8:55 a.m. - 5:30 p.m. (ET). This live event offers up to 6.5 Continuing Education/Continuing Medical Education (CE/CME) credits. Register here: https://www.dhaj7-cepo.com/content/2024-apr-ccss
https://www.dhaj7-cepo.com/content/2024-apr-ccss
Purpose
The Defense Health Agency (DHA), J-7, Continuing Education Program Office (CEPO) Clinical Communities Speaker Series (CCSS) events are designed to address the professional practice gaps of our learners to improve the care that our health care professionals deliver. This continuing education (CE)/continuing medical education (CME) event is conducted to achieve results that reflect a change in skills, competence, and performance of the health care team, and patient outcomes. Collaboration occurs with the Department of Defense, several government agencies, and other civilian experts for recruitment of academic subject matter experts (SMEs), clinicians, and researchers to present on current promising, evidence-based research and best practices, thus enhancing the overall educational experience. Participants are expected to apply what they learned in providing patient care individually and collaboratively as a team towards improved patient outcomes.
Target Audience
This activity is designed to meet the educational needs of Physicians, Nurses, Pharmacists, Pharmacy Technicians, Physician Assistants, Optometrists, Social Workers, Audiologists, Speech Language Pathologists, Psychologists, Dentists, Dental Hygienists, Dental Technicians, Registered Dieticians, Dietetic Technicians, Athletic Trainers, Case Managers, Certified Counselors, Occupational Therapists, Occupational Therapist Assistants, Physical Therapists/Physical Therapist Assistants, Kinesiotherapists, and Healthcare Executives. This activity is also approved for physicians who are board certified with the American Board of Pediatrics and other health care professionals who support/care for U.S. active-duty service members, reservists, Coast Guard, Public Health Service, National Guardsmen, military veterans, and their families.
Program Overview
This event will explore the evidence-based practices in the care of the pediatric patient through educational content created by military and civilian Subject Matter Experts specializing in bioethics, research, healthcare, and academia. Each session is designed to refine the quality of care, achieve the best outcomes, and improve population health in children and youth. Attending this continuing education opportunity will advance the practice, skills, and knowledge of the pediatric care provider in service to children and youth engaged in the military and civilian healthcare and education system.
Program Agenda
8:55 - 9:00 a.m. (ET) - Welcome Remarks
Lolita T. O’Donnell, Ph.D., M.S.N., R.N.
Division Chief
Leadership Education Analysis Development Sustainment (LEADS) Division
Academic Superintendent, Continuing Education Program Office (CEPO),
Education and Training (E&T) Directorate, J-7
Defense Health Agency (DHA)
Falls Church, Va.
9:00 – 9:10 a.m. (ET) - Opening Remarks
Gregory Leskin, Ph.D.
Director, The National Child Traumatic Stress Network Military and Veteran Families and Children & Academy on Child Traumatic Stress
University of California, Los Angeles/Duke University, National Center for Child Traumatic Stress
Los Angeles, Ca.
Moderator
Army Col. Joseph May, M.D., M.P.H., F.A.A.P., F.A.C.C.
Chief, Department of Pediatrics
Walter Reed National Military Medical Center
Associate Professor of Pediatrics
Uniform Services University of the Health Sciences
Bethesda, Md.
09:10 –10:10 a.m. (ET) - S01: "Overdiagnosis or Underdiagnosis? Considerations for Diagnosing and Treating ADHD and Autism"
Jennifer A. Ulbricht, Ph.D.
Behavioral Health Clinical Management Team
Medical Affairs
DHA
Falls Church, Va.
10:20 – 11:20 a.m. (ET) - S02: “Or At Least Do No Harm: The Complexities of Pediatric Healthcare Ethics”
Theophil A. Stokes, M.D.
Medical Director, Neonatology, Howard University Hospital
Associate Chief, Division of Regional Hospital Based Specialties
Children's National Hospital
Associate Professor of Pediatrics, The George Washington University
School of Medicine, and Health Sciences
Washington, DC
11:30 a.m. - 1:00 p.m. (ET) - S03: “Pediatric Immunizations: Current and Future
Considerations”
Cecilia Mikita, M.D., M.P.H., F.A.A.A.A.I.
Medical Director
North Atlantic Region Vaccine Safety Hub
DHA Public Health (DHA-PH)
Immunization Healthcare Division
Bethesda, Md.
Lakshmi Panagiotakopoulos, M.D., M.P.H.
Medical Officer
Center for Disease Control and Prevention
Division of Coronaviruses and Other Respiratory Viruses Division
Atlanta, Ga.
2:00 p.m. – 3:00 p.m. (ET) - S04: "Mental Health Needs Amongst Military Children
and Youth: Strategies to Improve Access and Outcomes”
Mary Acri, Ph.D.
Chief, Child and Adolescent Services Research
Program and Clinical Epidemiology Branch
Division of Services and Intervention Research
National Institute of Mental Health
Bethesda, Md.
3:10 – 4:10 p.m. (ET) - S05: "The Millennium Cohort Program: Understanding Risk and
Context in the Life Course of the Military Child”
Hope Seib McMaster, Ph.D.
Principal Investigator, Millennium Cohort Family Study and Study of Adolescent Resilience
Naval Health Research Center
San Diego, Ca.
Sabrina Richardson, Ph.D.
Research Psychologist for the Millennium Cohort Program
NHRC
San Diego, Ca.
4:20 – 5:20 p.m. (ET) - S06: "Addressing Problematic Technology Use in Children and
Youth”
Navy Lt. Cmdr. Nathan R. Moon, Psy.D., A.B.P.P.
Clinical Child Psychologist
Educational and Developmental Services
Navy Medicine Readiness and Training Center Okinawa
Okinawa, Japan
5:20 – 5:30 p.m. (ET) - Closing Remarks
Army Col. Maria Molina, M.D., F.A.C.O.G., F.A.C.S., C.H.S.E.
Acting Director, J-7, Education and Training
Defense Health Agency
Falls Church, Va.
This agenda is subject to change.
Please visit the following website to register: https://www.dhaj7-cepo.com/content/2024-apr-ccss
Continuing Education
This CE/CME activity is provided through the DHA J-7 CEPO and is approved for a total of 6.5 CE/CMEs.
Commercial Support
No commercial support was provided for this activity.
Participation Costs
There is no cost to participate in this activity.
CE/CME Inquiries
For all CE/CME related inquiries, please contact us at: dha.ncr.j7.mbx.cepo-cms-support@health.mil
V/r,
DHA, J-7, CEPO
Transforming Mental Health Implementation Research
The Lancet Psychiatry Commission on Transforming Mental Health Implementation Research
Published: March 26, 2024
Effective approaches exist to prevent and treat mental illness and to promote mental health but most people who could benefit from evidence-based interventions (policies, programmes, and individual-level practices or services) do not receive them. Too often, research produces interventions and implementation strategies that are difficult to scale owing to misalignment with the political, cultural, policy, system, community, provider, and individual realities of real-world settings. This Commission considers strategies for transforming how research is done to produce more actionable evidence. It examines how to integrate research and real-world implementation; centre equity in mental health intervention and implementation research; apply a complexity science lens to mental health research; expand designs beyond the randomised clinical trial; and value transdisciplinarity across endeavours. Most mental health implementation research has been done in high-income countries but the Commission’s recommendations incorporate research from low-income and middle-income countries and call for strategies to expand mental health implementation research globally.
https://www.thelancet.com/commissions/implementation-mental-health?dgcid=hubspot_update_feature_lanpsymentalhealthresearch24&utm_campaign=update-lanpsy&utm_medium=email&_hsmi=300103241&_hsenc=p2ANqtz--P4PPvZC_yPuG6DDEw6sPN4F2DHr58ub7bBvfoRMvgbFfgK0mumLs_F_6xL0CoD7UHhotVAi05rqeikPaj1kNovRZcnQ&utm_content=300031254&utm_source=hs_email
Decoding the Mind: Basic Science Revolutionizes Treatment of Mental Illnesses
https://www.nimh.nih.gov/about/director/messages/2024/decoding-the-mind-basic-science-revolutionizes-treatment-of-mental-illnesses?utm_campaign=75&utm_medium=email&utm_source=govd
The National Institute of Mental Health (NIMH) is committed to supporting research on basic neuroscience, genetics, and basic behavioral science. These are foundational pillars in the quest to decode the human mind and unravel the complexities of mental illnesses.
To learn about some of our greatest achievements conducting genomics research, read our guest-written Director's message from NIMH's Division of Neuroscience and Basic Behavioral Science.
They explain how their efforts connecting genes to cells to circuits to behavior have led to a wealth of discoveries and knowledge that can improve the diagnosis, treatment, and prevention of mental illnesses.
viernes, 29 de marzo de 2024
MIRRORED LUNGS: WHEN ORGANS ARE REVERSED
Mirrored Lungs: When Organs are Reversed
By Ivanhoe Broadcast News on March 27, 2024
https://www.ivanhoe.com/medical-breakthroughs/mirrored-lungs-when-organs-are-reversed/
MAKING A HARD CANCER DIAGNOSIS A LOT EASIER ON PATIENTS
Making a Hard Diagnosis a Lot Easier on Patients
By Ivanhoe Broadcast News on March 28, 2024
https://www.ivanhoe.com/medical-breakthroughs/making-a-hard-diagnosis-a-lot-easier-on-patients/
POSTAGE STAMP-SIZED TREATMENT FOR BRAIN TUMORS
Postage Stamp-Sized Treatment for Brain Tumors
By Ivanhoe Broadcast News on March 29, 2024
https://www.ivanhoe.com/medical-breakthroughs/postage-stamp-sized-treatment-for-brain-tumors/
KIDS AND THEIR BATTLES WITH KIDNEY STONES
Kids and Their Battles with Kidney Stones
By Ivanhoe Broadcast News on April 7, 2024
https://www.ivanhoe.com/?p=32892&preview=1&_ppp=64a1597253
FOLLOWING ‘LIFE’S ESSENTIAL 8’ COULD SLOW AGING BY 6 YEARS!
Following ‘Life’s Essential 8’ Could Slow Aging By 6 Years!
By Ivanhoe Broadcast News on April 7, 2024
https://www.ivanhoe.com/?p=32889&preview=1&_ppp=80c40ef554
PREVENTING PITCHING INJURIES: REWRITING THE HIGH SCHOOL RULEBOOK
Preventing Pitching Injuries: Rewriting the High School Rulebook
By Ivanhoe Broadcast News on April 6, 2024
https://www.ivanhoe.com/?p=32886&preview=1&_ppp=1bc175b1b0
BLACK VS. WHITE: 8 FACTORS THAT CAUSE EARLY DEATH
Race: 8 Factors That Cause Early Death
By Ivanhoe Broadcast News on April 6, 2024
https://www.ivanhoe.com/?p=32883&preview=1&_ppp=11f7d2b4b9
BACK TO BASICS TO BOOST BRAIN HEALTH
Your brain allows you to think, feel, communicate, make decisions, and live a productive life. That’s why it is important to keep it healthy. And that starts by adding some good brain habits to your normal daily routine
Back to Basics to Boost Brain Health
By Ivanhoe Broadcast News on April 5, 2024
https://www.ivanhoe.com/?p=32880&preview=1&_ppp=73e6da2e57
WALKING VS. RUNNING: WHICH IS BETTER?
Exercise is good for your body, but does it matter how you move? Before putting on those tennis shoes and hitting the trail, hear what research has to say on the topic.
Walking vs Running: Which Is Better?
By Ivanhoe Broadcast News on April 4, 2024
https://www.ivanhoe.com/?p=32877&preview=1&_ppp=cccec6f715
ROBOTIC PUPPIES ARE THERAPEUTIC ALSO!
Studies indicate children who spend more time with therapy dogs can lower stress even more than relaxation exercises. But what happens when there are not enough therapy dogs? One hospital may have the solution with the help of Otis, Max, and Stride.
Robotic Puppies Are Therapeutic Also!
By Ivanhoe Broadcast News on April 3, 2024
https://www.ivanhoe.com/?p=32873&preview=1&_ppp=bf5e0773fc
PDD: THE DEPRESSION YOU MAY NEVER HAVE HEARD OF
Do you have ongoing feeling of sadness? It could be linked to a mild form of depression that can last a long time. Now, with the right diagnoses, doctors are helping turn those frowns upside down.
PDD: The Depression You May Never Have Heard Of
By Ivanhoe Broadcast News on April 2, 2024
https://www.ivanhoe.com/?p=32871&preview=1&_ppp=bf762ec736
EARLY PANCREATIC CANCER DETECTION GIVES PATIENTS AN ADVANTAGE
It’s one of the deadliest cancers and it’s on the rise. It’s also increasing more rapidly in women than in men. Find out how a chance at survival could be lurking in your genes
Early Pancreatic Cancer Detection Gives Patients an Advantage
By Ivanhoe Broadcast News on April 1, 2024
https://www.ivanhoe.com/?p=32868&preview=1&_ppp=ca15a241e6
Wireless, light-powered pacemaker shines bright in animal study
Wireless, light-powered pacemaker shines bright in animal study: While pacemakers have treated many patients with heart rhythm disorders, their bulky design and use of wires limits their usefulness and poses a risk of heart damage or infection. Now, researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.
jueves, 28 de marzo de 2024
What are the health costs of air pollution, and what can we do about it?
https://magazine.medlineplus.gov/article/what-are-the-health-costs-of-air-pollution-and-what-can-we-do-about-it
Have you ever noticed the hazy smog that hangs over cities or the lingering smell of exhaust fumes from traffic? These are just a few noticeable signs of air pollution, a threat that can have a significant effect on our health and well-being.
Hotter days put human health at risk Climate change and rising temperatures can affect your body in many ways
https://magazine.medlineplus.gov/article/hotter-days-put-human-health-at-risk?utm_medium=email&utm_source=govdelivery
Extreme heat and unpredictable weather patterns are big news around the world. But did you know that climate change is not just a concern for scientists? It’s also worrying doctors. Warmer global temperatures cause many environmental changes. These include droughts, increased risk of wildfires, more extreme temperatures, warmer oceans, and stronger storms. These changes can contribute to water-borne illnesses, infectious diseases spread by animals—especially insects such as ticks and mosquitoes—and
Too loud and too bright! Noise and light pollution's effects on your health
https://magazine.medlineplus.gov/article/too-loud-and-too-bright?utm_medium=email&utm_source=govdelivery
Noise pollution Every day you are surrounded by sounds from your environment, including the TV, radio, appliances, and traffic. Noise pollution is unwanted or bothersome sound. In some cases, noise pollution can be loud enough to damage the ear and contribute to hearing loss. Noise pollution can also disrupt sleep and contribute to chronic stress. These issues have been associated with health conditions like high blood pressure, heart disease, and
Finding Forever Chemicals Wherever They’re Hiding
https://www.nist.gov/feature-stories/finding-forever-chemicals-wherever-theyre-hiding
They’re called per- and polyfluoroalkyl substances, or PFAS, a group of thousands of compounds that contain a chemical bond between fluorine and carbon. That bond has proved to be one of the most stable and unbreakable known to chemistry — a fact baked into the common nickname “forever chemicals,” because once PFAS are created, they last a very long time.
First manufactured in the 1940s, PFAS have seeped into our daily lives, and our bodies. In recent years, they have emerged as a serious public health concern. Scientists have reported evidence that certain PFAS, at high enough concentrations, may harm health by suppressing the immune system or causing cancers, obesity, thyroid problems and birth defects.
How Do You Measure Forever Chemicals?
https://www.nist.gov/how-do-you-measure-it/how-do-you-measure-forever-chemicals
Stem Cell Changes Rejuvenate Immune System in Aged Mice
https://www.niaid.nih.gov/news-events/immune-system?utm_campaign=+59960585&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
Stem Cell Changes Rejuvenate Immune System in Aged Mice
NIAID, Stanford Exploring Potential for Revitalizing Human Immunity
Aging is associated with a reduced ability to generate immune responses against novel infections, as was recently illustrated by the high mortality among older people during the COVID-19 pandemic. Using a mouse model of human aging and disease, NIAID scientists and Stanford University colleagues have shown that immune systems of aged laboratory mice can be made more youthful and effective at fighting disease by depleting a subset of haematopoietic stem cells (HSCs). The researchers think the method they developed may have potential for rejuvenating immunity in elderly people and are pursuing further study. Their findings are published in Nature.
Rare condition caused patient to see ‘demonic’ faces, says study on ‘visual disorder’ The patient, age 58, saw distorted facial features for 2½ years Melissa Rudy By Melissa Rudy Fox News Published March 26, 2024 6:00am EDT
Rare condition caused patient to see ‘demonic’ faces, says study on ‘visual disorder’
The patient, age 58, saw distorted facial features for 2½ years
Melissa Rudy By Melissa Rudy Fox News
Published March 26, 2024 6:00am EDT
https://www.foxnews.com/health/rare-condition-caused-patient-see-demonic-faces-study-visual-disorder
Abortion pill use has spiked in recent years, new report reveals: ‘Substantial increase’ Medication abortions make up 63% of all terminated pregnancies in the US right now Melissa Rudy By Melissa Rudy Fox News Published March 27, 2024 6:00am EDT
Abortion pill use has spiked in recent years, new report reveals: ‘Substantial increase’
Medication abortions make up 63% of all terminated pregnancies in the US right now
Melissa Rudy By Melissa Rudy Fox News
Published March 27, 2024 6:00am EDT
https://www.foxnews.com/health/abortion-pills-spiked-recent-years-new-report-reveals-substantial-increase
Sleep disorders and suicide: A mental health expert reveals the concerning link Lack of sleep can trigger a variety of mental and physical health issues, experts warn Melissa Rudy By Melissa Rudy Fox News Published March 24, 2024 6:00am EDT
Sleep disorders and suicide: A mental health expert reveals the concerning link
Lack of sleep can trigger a variety of mental and physical health issues, experts warn
Melissa Rudy By Melissa Rudy Fox News
Published March 24, 2024 6:00am EDT
https://www.foxnews.com/health/sleep-disorders-suicide-mental-health-expert-reveals-link
COVID pandemic led to thousands of missed prostate cancer cases, new study finds Amid the pandemic, patients’ healthcare-seeking behavior changed as the focus was almost entirely on COVID Melissa Rudy By Melissa Rudy Fox News Published March 22, 2024 7:52am EDT
COVID pandemic led to thousands of missed prostate cancer cases, new study finds
Amid the pandemic, patients’ healthcare-seeking behavior changed as the focus was almost entirely on COVID
Melissa Rudy By Melissa Rudy Fox News
Published March 22, 2024 7:52am EDT
https://www.foxnews.com/health/covid-pandemic-led-thousands-missed-prostate-cancer-cases-study-finds
Massachusetts man receives successful pig kidney transplant: ‘Uncharted territory’ Richard Slayman, 62, had end-stage kidney disease before receiving the life-saving transplant Melissa Rudy By Melissa Rudy Fox News Published March 21, 2024 3:47pm EDT
Massachusetts man receives successful pig kidney transplant: ‘Uncharted territory’
Richard Slayman, 62, had end-stage kidney disease before receiving the life-saving transplant
Melissa Rudy By Melissa Rudy Fox News
Published March 21, 2024 3:47pm EDT
https://www.foxnews.com/health/massachusetts-man-receives-successful-pig-kidney-transplant-uncharted-territory
Daily marijuana smokers face higher risk of heart attack, stroke, says American Heart Association study Marijuana is 'as bad as smoking tobacco cigarettes,' an expert said Angelica Stabile By Angelica Stabile Fox News Published March 25, 2024 5:00am EDT
Daily marijuana smokers face higher risk of heart attack, stroke, says American Heart Association study
Marijuana is 'as bad as smoking tobacco cigarettes,' an expert said
Angelica Stabile By Angelica Stabile Fox News
Published March 25, 2024 5:00am EDT
https://www.foxnews.com/health/daily-weed-smokers-higher-risk-heart-attack-stroke-american-heart-association-study
Intermittent fasting linked to higher risk of heart-related death in new study Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk Melissa Rudy By Melissa Rudy Fox News Published March 25, 2024 6:31pm EDT
Intermittent fasting linked to higher risk of heart-related death in new study
Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk
Melissa Rudy By Melissa Rudy Fox News
Published March 25, 2024 6:31pm EDT
https://www.foxnews.com/health/intermittent-fasting-linked-higher-risk-heart-related-death-study
Princess Kate Middleton undergoing ‘preventative chemotherapy’ after cancer diagnosis: ‘Stronger every day’ The Princess of Wales did not reveal what type of cancer was diagnosed, but said she is ‘focused on recovery’ Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News Published March 22, 2024 4:25pm EDT
Princess Kate Middleton undergoing ‘preventative chemotherapy’ after cancer diagnosis: ‘Stronger every day’
The Princess of Wales did not reveal what type of cancer was diagnosed, but said she is ‘focused on recovery’
Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News
Published March 22, 2024 4:25pm EDT
https://www.foxnews.com/health/princess-kate-middleton-undergoing-preventative-chemotherapy-after-cancer-diagnosis-stronger-every-day
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies
https://pubmed.ncbi.nlm.nih.gov/37024676/
From the abstract: "Recent advances in sequencing technologies and collaborative efforts have led to substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS). This momentum has, in turn, fostered the development of putative molecular therapies. In this Review, we outline the current genetic knowledge, emphasizing recent discoveries and emerging concepts such as the implication of distinct types of mutation, variability in mutated genes in diverse genetic ancestries and gene–environment interactions. "
Advancing Newborn Screening Long-Term Follow-Up: Integration of Epic-Based Registries, Dashboards, and Efficient Workflows
https://www.mdpi.com/2409-515X/10/2/27
From the abstract: "The Connecticut Newborn Screening (NBS) Network, in partnership with the Connecticut Department of Public Health, strategically utilized the Epic electronic health record (EHR) system to establish registries for tracking long-term follow-up (LTFU) of NBS patients. After launching the LTFU registry in 2019, the Network obtained funding from the Health Resources and Services Administration to address the slow adoption by specialty care teams. "
Applications of genome sequencing as a single platform for clinical constitutional genetic testing
https://www.sciencedirect.com/science/article/pii/S2949774424009865
From the abstract: "The number of human disease genes has dramatically increased over the past decade, largely fueled by ongoing advances in sequencing technologies. In parallel, the number of available clinical genetic tests has also increased, including exome sequencing for undiagnosed diseases. Although most clinical sequencing tests have been centered on enrichment-based multigene panels and exome sequencing, the continued improvements in performance and throughput of genome sequencing suggest that this technology is emerging as a potential platform for routine clinical genetic testing. "
Deep learning in cancer genomics and histopathology
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01315-6
From the abstract: " Histopathology and genomic profiling are cornerstones of precision oncology and are routinely obtained for patients with cancer. Traditionally, histopathology slides are manually reviewed by highly trained pathologists. Genomic data, on the other hand, is evaluated by engineered computational pipelines. In both applications, the advent of modern artificial intelligence methods, specifically machine learning (ML) and deep learning (DL), have opened up a fundamentally new way of extracting actionable insights from raw data, which could augment and potentially replace some aspects of traditional evaluation workflows. "
miércoles, 27 de marzo de 2024
Exercise could be the cure to your insomnia
https://www.news-medical.net/news/20240327/Exercise-could-be-the-cure-to-your-insomnia.aspx
In a recent study published in the journal BMJ Open, an international team of researchers conducted a longitudinal study over 10 years to understand the association between physical activity and sleep duration, daytime sleepiness, and current insomnia symptoms in adults.
“A randomized double-blinded trial to assess recurrence of systemic allergic reactions following COVID-19 mRNA vaccination”
https://www.sciencedirect.com/science/article/pii/S0091674924002367?utm_campaign=+59950531&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
A small NIAID clinical trial has found that receiving second and booster doses of a COVID-19 mRNA vaccine under medical supervision was safe for people who reported a systemic allergic reaction to their first dose. After revaccination, 12.5% of study participants had a systemic allergic reaction, while 62.5% had a non-allergic reaction that mimics anaphylaxis and is called Immunization Stress-Related Response (ISRR). These findings highlight the opportunity to assess and manage pre-vaccination anxiety to reduce ISRR. The results are published in the Journal of Allergy and Clinical Immunology.
Intermittent fasting linked to higher risk of heart-related death in new study Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk Melissa Rudy By Melissa Rudy Fox News Published March 25, 2024 6:31pm EDT
Intermittent fasting linked to higher risk of heart-related death in new study
Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk
Melissa Rudy By Melissa Rudy Fox News
Published March 25, 2024 6:31pm EDT
https://www.foxnews.com/health/intermittent-fasting-linked-higher-risk-heart-related-death-study
Drug overdoses have reached record high, per latest CDC report: ‘Grim statistics' Experts call for increases in treatment and support — ‘not enough is being done’ Melissa Rudy By Melissa Rudy Fox News Published March 26, 2024 4:13pm EDT
Drug overdoses have reached record high, per latest CDC report: ‘Grim statistics'
Experts call for increases in treatment and support — ‘not enough is being done’
Melissa Rudy By Melissa Rudy Fox News
Published March 26, 2024 4:13pm EDT
https://www.foxnews.com/health/drug-overdoses-reached-record-high-latest-cdc-report-grim-statistics
Cancer and Princess Kate: Important screenings to focus on for best health Amid Kate Middleton’s cancer announcement, here are screenings to know about Melissa Rudy By Melissa Rudy Fox News Published March 24, 2024 3:00pm EDT | Updated March 26, 2024 5:56pm EDT
Cancer and Princess Kate: Important screenings to focus on for best health
Amid Kate Middleton’s cancer announcement, here are screenings to know about
Melissa Rudy By Melissa Rudy Fox News
Published March 24, 2024 3:00pm EDT | Updated March 26, 2024 5:56pm EDT
https://www.foxnews.com/health/cancer-princess-kate-important-screenings-focus-best-health
Abortion pill use has spiked in recent years, new report reveals: ‘Substantial increase’ Medication abortions make up 63% of all terminated pregnancies in the US right now Melissa Rudy By Melissa Rudy Fox News Published March 27, 2024 6:00am EDTv
Abortion pill use has spiked in recent years, new report reveals: ‘Substantial increase’
Medication abortions make up 63% of all terminated pregnancies in the US right now
Melissa Rudy By Melissa Rudy Fox News
Published March 27, 2024 6:00am EDT
https://www.foxnews.com/health/abortion-pills-spiked-recent-years-new-report-reveals-substantial-increase
martes, 26 de marzo de 2024
New blood test shows high accuracy for colorectal cancer detection, study finds: ‘Not interchangeable’ Test offers an easy screening alternative, though some warn of a significant limitation Melissa Rudy By Melissa Rudy Fox News Published March 25, 2024 6:00am EDT
New blood test shows high accuracy for colorectal cancer detection, study finds: ‘Not interchangeable’
Test offers an easy screening alternative, though some warn of a significant limitation
Melissa Rudy By Melissa Rudy Fox News
Published March 25, 2024 6:00am EDT
https://www.foxnews.com/health/blood-test-shows-high-accuracy-colorectal-cancer-detection-study-not-interchangeable
Intermittent fasting linked to higher risk of heart-related death in new study Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk Melissa Rudy By Melissa Rudy Fox News Published March 25, 2024 6:31pm EDT
Intermittent fasting linked to higher risk of heart-related death in new study
Experts point out the limitations as those who restricted their eating to eight-hour windows saw the highest risk
Melissa Rudy By Melissa Rudy Fox News
Published March 25, 2024 6:31pm EDT
https://www.foxnews.com/health/intermittent-fasting-linked-higher-risk-heart-related-death-study
lunes, 25 de marzo de 2024
Drug Trials Snapshots: LETYBO (letibotulinumtoxinA)
LETYBO is a drug used in adults to temporarily improve the appearance of moderate to severe glabellar lines (wrinkles between the eyebrows).
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-letybo
Drug Trials Snapshots: POMBILITI (cipaglucosidase alfa-atga)
POMBILITI is an enzyme used for the treatment of adult patients with late-onset Pompe disease (LOPD) weighing ≥40 kg and who are not improving on their current enzyme replacement therapy. POMBILITI is approved for use in combination with Opfolda.
https://www.fda.gov/drugs/development-approval-process-drugs/drug-trials-snapshots-pombiliti
domingo, 24 de marzo de 2024
A window into placental development during pregnancy
A window into placental development during pregnancy: A multidisciplinary group of NIH-funded scientists have successfully captured real-time, high-resolution images of the developing mouse placenta during the course of pregnancy. Their technique, which combines a surgically implanted window with a next-generation imaging system, provides key insight into placental development under both healthy and pathological conditions.
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States. Vivienne Souter et al. Circ Genom Precis Med 2024 3 e004457 (Posted Mar 21, 2024 7AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=HLBS&query=home
From the abstract: "Familial hypercholesterolemia is a treatable genetic condition but remains underdiagnosed. We reviewed the frequency of pathogenic or likely pathogenic (P/LP) variants in the LDLR gene in female individuals receiving reproductive carrier screening. This retrospective observational study included samples from female patients (aged 18–55 years) receiving a 274-gene carrier screening panel. P/LP LDLR variants were identified in 283 samples (1 in 324). No patients were identified with >1 P/LP variant. LDLR carrier frequency was higher in Asian (1 in 191 [95% CI, 1 in 142–258]) compared with White (1 in 417 [95% CI, 1 in 326–533]; P<0.001) or Black groups (1 in 508 [95% CI, 1 in 284–910]; P=0.004). "
A call for increased inclusivity and global representation in pharmacogenetic testing. April Kennedy et al. NPJ Genom Med 2024 2 (1) 13 (Posted Feb 23, 2024 3PM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=fhh&query=home
From the abstract: "Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared variation in six pharmacogenes detected by whole genome sequencing (WGS) to a targeted commercial panel in a cohort of 308 individuals with family history of pediatric heart disease. In 1% of the cohort, WGS identified rare variants that altered the interpretation of metabolizer status and would thus prevent potential errors in gene-based dosing. "
Multi-ancestry polygenic mechanisms of type 2 diabetes K Smith et al, Nature Medicine, March 6, 2024 (Posted Mar 06, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=diabetes&query=home
From the abstract: "Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic clusters by analyzing genetic data from diverse populations in 37 published T2D genome-wide association studies representing more than 1.4 million individuals. We implemented soft clustering with 650 T2D-associated genetic variants and 110 T2D-related traits, capturing known and novel T2D clusters with distinct cardiometabolic trait associations across two independent biobanks. "
Lynch Syndrome Ups Risk for Colorectal, Other Cancers
https://thedacare.org/lynch-syndrome-ups-risk-for-colorectal-other-cancers/
From the article: "It’s impossible to change our genes, but with knowledge comes power. In the case of Lynch syndrome, a genetic condition that ups people’s risks for developing colorectal and other types of cancer, that’s especially true. Colorectal Cancer Awareness Month offers a reminder for everyone to examine their risk for colorectal cancer and to explore options for screening as well as genetic testing, when warranted. Lynch syndrome puts a person at a higher risk of developing colorectal, uterine, and ovarian cancer. It’s also associated with other cancers, including kidney, stomach, bladder, brain, prostate, and pancreatic cancer. "
Genomic analysis of 116 autism families strengthens known risk genes and highlights promising candidates
https://www.nature.com/articles/s41525-024-00411-1
From the abstract: "Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component in which rare variants contribute significantly to risk. We performed whole genome and/or exome sequencing (WGS and WES) and SNP-array analysis to identify both rare sequence and copy number variants (SNVs and CNVs) in 435 individuals from 116 ASD families. We identified 37 rare potentially damaging de novo SNVs (pdSNVs) in the cases (n?=?144). "
PARP Inhibitors for Breast Cancer Treatment: A Review
From the abstract: "Poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors have revolutionized the treatment of patients with germline BRCA1/2-associated breast cancer, representing the first targeted therapy capable of improving outcomes in patients with hereditary tumors. However, resistance to PARP inhibitors occurs in almost all patients. This narrative review summarizes the biological rationale behind the use of PARP inhibitors in breast cancer, as well as the available evidence, recent progress, and potential future applications of these agents. Recent studies have shown that the benefit of PARP inhibitors extends beyond patients with germline BRCA1/2-associated metastatic breast cancer to patients with somatic BRCA1/2 variants and to those with germline PALB2 alterations. "
https://pubmed.ncbi.nlm.nih.gov/38512229/
sábado, 23 de marzo de 2024
viernes, 22 de marzo de 2024
NEW DEVICE DESTROYS BRAIN ANEURYSMS
Brain Aneurysms: New Device Destroys
By Ivanhoe Broadcast News on March 19, 2024
https://www.ivanhoe.com/medical-breakthroughs/brain-aneurysms-new-device-destroys/
TOSS THE CUFF: A NEW BLOOD PRESSURE PATCH IS HERE
Toss the Cuff: A New Blood Pressure Patch is Here
By Ivanhoe Broadcast News on March 22, 2024
https://www.ivanhoe.com/medical-breakthroughs/toss-the-cuff-a-new-blood-pressure-patch-is-here/
SOLAR ECLIPSE COUNTDOWN: PREPPING FOR APRILE’S SOLAR SPECTACULAR
Solar Eclipse Countdown: Prepping for April’s Solar Spectacular
By Ivanhoe Broadcast News on March 31, 2024
https://www.ivanhoe.com/?p=32800&preview=1&_ppp=f5d6a3e423
HYPERSOMNIA: REDEFINING REST & DROWSY DAYS
Hypersomnia, Redefining Rest & Drowsy Days
By Ivanhoe Broadcast News on March 31, 2024
https://www.ivanhoe.com/?p=32797&preview=1&_ppp=c2cbceef88
TAX TACTICS: MISTAKES SENIORS MAKE
Tax Tactics: Mistakes Seniors Make
By Ivanhoe Broadcast News on March 30, 2024
https://www.ivanhoe.com/?p=32793&preview=1&_ppp=da68af5cd0
NEW SLANG & EMOJIS: WHAT’S IN AND WHAT’S OUT?
New Slang & Emojis: What’s In And What’s Out
By Ivanhoe Broadcast News on March 30, 2024
https://www.ivanhoe.com/?p=32790&preview=1&_ppp=f313ebca34
POSTAGE STAMP-SIZED TREATMENT FOR BRAIN TUMORS
Postage Stamp-Sized Treatment for Brain Tumors
By Ivanhoe Broadcast News on March 29, 2024
https://www.ivanhoe.com/?p=32836&preview=1&_ppp=26492522d5
MAKING A HARD CANCER DIAGNOSIS A LOT EASIER ON PATIENTS
Making a Hard Diagnosis a Lot Easier on Patients
By Ivanhoe Broadcast News on March 28, 2024
https://www.ivanhoe.com/?p=32829&preview=1&_ppp=75843185e8
MIRRORED LUNGS: WHEN ORGANS ARE REVERSED
Mirrored Lungs: When Organs are Reversed
By Ivanhoe Broadcast News on March 27, 2024
https://www.ivanhoe.com/?p=32822&preview=1&_ppp=ef518cfb8c
FINDING HARD-TO-FIND BREAST CANCER
Hard-to-Find Breast Cancer
By Ivanhoe Broadcast News on March 26, 2024
https://www.ivanhoe.com/?p=32818&preview=1&_ppp=dd36afbc9e
NEW HOPE FOR NON-HODGKIN’S LYMPHOMA PATIENTS
New Hope for Non-Hodgkin’s Lymphoma Patients
By Ivanhoe Broadcast News on March 25, 2024
https://www.ivanhoe.com/?p=32810&preview=1&_ppp=58d7e65bc5
Measles is surging. This doctor and mom wants you to know these five things right now Measles is not a harmless childhood illness. Serious health complications can occur from the disease. Here's what you need to know Nicole Saphier, M.D. By Nicole Saphier, M.D. Fox News Published March 22, 2024 5:00am EDT
Measles is surging. This doctor and mom wants you to know these five things right now
Measles is not a harmless childhood illness. Serious health complications can occur from the disease. Here's what you need to know
Nicole Saphier, M.D. By Nicole Saphier, M.D. Fox News
Published March 22, 2024 5:00am EDT
https://www.foxnews.com/opinion/measles-surging-doctor-mom-you-know-five-things
Congenital Heart Valve Repair Symposium Hosted by Yves d’Udekem, M.D., Ph.D and Children's National Heart Center. October 19, 2024 9:00 AM-6:00 PMET
https://web.cvent.com/event/fbaa76a8-43b1-4476-882a-7d10f7faed11/regProcessStep1
The Children's National Heart Center invites you to join us in Washington D.C. for an all-day Congenital Heart Valve Repair Symposium, centered on practical cases illustrated by intra-operative videos, echo and MRI imaging. The symposium is tailored for cardiac surgeons, imaging cardiologists, nurses and sonographers. Learn more and register here.
Q&A with Daniel J. Licht, M.D.: The future of medicine is in light February 14, 2024
https://innovationdistrict.childrensnational.org/qa-with-daniel-licht-the-future-of-medicine-is-in-light/
Pediatric neurologist Daniel J. Licht, M.D., joins Children’s National Hospital with a vision: He believes non-invasive devices built using biomedical optics – or instruments using light – can give clinicians invaluable information about how the brain and other organs are functioning.
Local context, health system integrations key to sustainable interventions after RHD diagnosis
https://innovationdistrict.childrensnational.org/sustainable-interventions-after-rhd-diagnosis/
A rheumatic heart disease (RHD) work group convened by the National Heart, Lung, and Blood Institute concluded that any priority intervention strategies to slow or stop late complications of RHD need to consider local contexts and should be integrated into health systems to meet the affected community’s needs in a sustainable way.
Babies with congenital heart disease display disrupted brain function before birth
https://innovationdistrict.childrensnational.org/babies-with-congenital-heart-disease-display-disrupted-brain-function-before-birth/
For the first time, researchers have found that babies born with congenital heart disease (CHD) have alterations to the emerging functional connectivity of their brains in utero. The changes are related to the subtype of their CHD and their oxygen status before having surgery to treat their cardiac malformation.
Earliest hybrid HLHS heart surgery kids thrive 5 years later February 1, 2024
https://innovationdistrict.childrensnational.org/earliest-hybrid-hlhs-heart-surgery-kids-thrive-5-years-later/
Five years ago, Cayden was born 6 weeks early weighing less than four pounds and at risk of dying from her critical congenital heart disease. Today, she’s a happy five-year-old who is excited to start kindergarten this fall.
Early diagnosis of her hypoplastic right ventricle, double inlet left ventricle and critical coarctation of the aorta allowed for the team at Children’s National Hospital to create a careful plan for safe delivery and to offer an innovative hybrid HLHS surgical approach at the hospital within 24 hours after she was born.
jueves, 21 de marzo de 2024
What are the health costs of air pollution, and what can we do about it?
https://magazine.medlineplus.gov/article/what-are-the-health-costs-of-air-pollution-and-what-can-we-do-about-it?utm_medium=email&utm_source=govdelivery
Have you ever noticed the hazy smog that hangs over cities or the lingering smell of exhaust fumes from traffic? These are just a few noticeable signs of air pollution, a threat that can have a significant effect on our health and well-being. What is air pollution? Air pollution is caused when harmful substances are released into the atmosphere. These pollutants can come from both natural and human-made sources. Natural
Researchers are exposing troubling consequences of air pollution Breathing clean air is important for everyone's health, but some communities face more risks than others
https://magazine.medlineplus.gov/article/researchers-are-exposing-troubling-consequences-of-air-pollution?utm_medium=email&utm_source=govdelivery
The air we breathe can sometimes contain tiny particles called particulate matter (PM). These particles come in different shapes and sizes and are made up of hundreds of different chemicals. Some are very small, smaller than 2.5 micrometers. They are referred to as PM2.5. You can't see these particles, but you can inhale them. As a group, PM2.5 is responsible for most pollution-related health problems in the United States.
Supercharge your immune system with these 10 foods These 10 immunity-boosting foods are easy to incorporate into simple recipes Associated Press Published March 19, 2024 1:05pm EDT
Supercharge your immune system with these 10 foods
These 10 immunity-boosting foods are easy to incorporate into simple recipes
Associated Press
Published March 19, 2024 1:05pm EDT
https://www.foxnews.com/health/supercharge-immune-system-10-foods
CDC issues measles alert as 2024 cases have already equaled all of 2023 CDC warns of ‘increase in global and US measles cases’ in 2024 Greg Norman By Greg Norman Fox News Published March 19, 2024 10:32am EDT
CDC issues measles alert as 2024 cases have already equaled all of 2023
CDC warns of ‘increase in global and US measles cases’ in 2024
Greg Norman By Greg Norman Fox News
Published March 19, 2024 10:32am EDT
https://www.foxnews.com/health/cdc-issues-measles-alert-2024-cases-already-equaled-all-2023
First patient implanted with Neuralink, plays chess with his mind Fox News contributor Dr. Marc Siegel joins ‘America’s Newsroom’ to discuss the ‘amazing’ brain-implant technology that uses thought to provide movement.
First patient implanted with Neuralink, plays chess with his mind
Fox News contributor Dr. Marc Siegel joins ‘America’s Newsroom’ to discuss the ‘amazing’ brain-implant technology that uses thought to provide movement.
https://www.foxnews.com/video/6349384909112
Artificial intelligence helps predict seniors’ long-term care needs: ‘Critical next steps’ Waterlily platform helps families determine when care will be needed — and how much it will cost Melissa Rudy By Melissa Rudy Fox News Published March 21, 2024 5:15am EDT
Artificial intelligence helps predict seniors’ long-term care needs: ‘Critical next steps’
Waterlily platform helps families determine when care will be needed — and how much it will cost
Melissa Rudy By Melissa Rudy Fox News
Published March 21, 2024 5:15am EDT
https://www.foxnews.com/health/artificial-intelligence-helps-predict-seniors-long-term-care-needs-critical-next-steps
Elon Musk reveals why he takes ketamine, denies abusing the drug: ‘I should keep taking it’ Tesla CEO said he gets the drug via a prescription from a medical doctor to combat 'chemical tides' Melissa Rudy By Melissa Rudy Fox News Published March 18, 2024 8:42pm EDT
Elon Musk reveals why he takes ketamine, denies abusing the drug: ‘I should keep taking it’
Tesla CEO said he gets the drug via a prescription from a medical doctor to combat 'chemical tides'
Melissa Rudy By Melissa Rudy Fox News
Published March 18, 2024 8:42pm EDT
https://www.foxnews.com/health/elon-musk-reveals-takes-ketamine-denies-abusing-drug-should-keep-taking-it
Tommy John surgery continues to save baseball careers 50 years after its debut: 'Revolutionary' First performed in 1974, the groundbreaking operation repairs a ligament essential for throwing Melissa Rudy By Melissa Rudy Fox News Published March 13, 2024 4:14pm EDT
Tommy John surgery continues to save baseball careers 50 years after its debut: 'Revolutionary'
First performed in 1974, the groundbreaking operation repairs a ligament essential for throwing
Melissa Rudy By Melissa Rudy Fox News
Published March 13, 2024 4:14pm EDT
https://www.foxnews.com/health/tommy-john-surgery-continues-save-baseball-careers-50-years-debut-revolutionary
Long COVID could be the cause of your bad hangovers, study finds: 'Bad reaction' Patient said hangovers feel like 'alcohol poisoning,' according to Stanford researchers Angelica Stabile By Angelica Stabile Fox News Published March 13, 2024 7:16pm EDT
Long COVID could be the cause of your bad hangovers, study finds: 'Bad reaction'
Patient said hangovers feel like 'alcohol poisoning,' according to Stanford researchers
Angelica Stabile By Angelica Stabile Fox News
Published March 13, 2024 7:16pm EDT
https://www.foxnews.com/health/long-covid-could-cause-bad-hangovers-study-finds-bad-reaction
Rescued therapy dog comforts families of fallen soldiers at Dover Air Force Base: 'Tremendous impact' Paws of War rescue dog, Blaze, supports soldiers and families at Dover's mortuary affairs unit Angelica Stabile By Angelica Stabile Fox News Published March 20, 2024 4:30am EDT
Rescued therapy dog comforts families of fallen soldiers at Dover Air Force Base: 'Tremendous impact'
Paws of War rescue dog, Blaze, supports soldiers and families at Dover's mortuary affairs unit
Angelica Stabile By Angelica Stabile Fox News
Published March 20, 2024 4:30am EDT
https://www.foxnews.com/lifestyle/rescued-therapy-dog-comforts-families-fallen-soldiers-dover-air-force-base-tremendous-impact
Actress Olivia Munn credits breast cancer risk-assessment score for saving her life Experts reveal how breast cancer risk-assessment score works and why it’s so important By Amy McGorry Fox News Published March 14, 2024 1:05pm EDT
Actress Olivia Munn credits breast cancer risk-assessment score for saving her life
Experts reveal how breast cancer risk-assessment score works and why it’s so important
By Amy McGorry Fox News
Published March 14, 2024 1:05pm EDT
https://www.foxnews.com/health/actress-olivia-munn-credits-breast-cancer-risk-assessment-score-saving-life
Ask a doc: ‘Do I need to wash my face every night?’ Two dermatologists reveal why it’s important to have a clean face before bed By Erica Lamberg Fox News Published March 19, 2024 6:05pm EDT
Ask a doc: ‘Do I need to wash my face every night?’
Two dermatologists reveal why it’s important to have a clean face before bed
By Erica Lamberg Fox News
Published March 19, 2024 6:05pm EDT
https://www.foxnews.com/health/ask-doc-need-wash-face-every-night
Woman’s life is saved when full-body scan detects deadly condition with no symptoms Patient and doctors reveal benefits and risks of advanced imaging tests Melissa Rudy By Melissa Rudy Fox News Published March 14, 2024 6:45am EDT
Woman’s life is saved when full-body scan detects deadly condition with no symptoms
Patient and doctors reveal benefits and risks of advanced imaging tests
Melissa Rudy By Melissa Rudy Fox News
Published March 14, 2024 6:45am EDT
https://www.foxnews.com/health/womans-life-saved-full-body-scan-detects-deadly-condition-no-symptoms
These medications could make driving dangerous, the FDA warns Medical professionals weigh in on potential side effects and how to prevent impaired driving Melissa Rudy By Melissa Rudy Fox News Published March 19, 2024 5:30am EDT
These medications could make driving dangerous, the FDA warns
Medical professionals weigh in on potential side effects and how to prevent impaired driving
Melissa Rudy By Melissa Rudy Fox News
Published March 19, 2024 5:30am EDT
https://www.foxnews.com/health/medications-could-make-driving-dangerous-fda-warns
High-school students are making strides in cancer research: ‘Gives me hope' 6 students working to fight cancer were finalists in the Regeneron Science Talent Search in Washington, DC Melissa Rudy By Melissa Rudy Fox News Published March 20, 2024 6:14am EDT
High-school students are making strides in cancer research: ‘Gives me hope'
6 students working to fight cancer were finalists in the Regeneron Science Talent Search in Washington, DC
Melissa Rudy By Melissa Rudy Fox News
Published March 20, 2024 6:14am EDT
https://www.foxnews.com/health/high-school-students-making-strides-cancer-research-gives-hope
miércoles, 20 de marzo de 2024
New gene therapy, to be priced at $4.25 million, has already transformed children’s lives Jason Mast Megan Molteni By Jason Mast and Megan Molteni March 20, 2024
https://www.statnews.com/2024/03/20/gene-therapy-orchard-therapeutics-metachromatic-leukodystrophy/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-8tWUeLuJO_3vtVtsaHYv4eQ3KUv7wnEMRphDDaOzd4JL4ymEsGPhafvNbAp7FvA2KD7IVxsyFVYW8Czv-H_h8-Kzulcw&utm_content=298983789&utm_source=hs_email
Victoria Rasberry sees the difference a gene therapy can make every morning. Her 8-year-old daughter Addi needs thick mucus sucked out of her airways so she can breathe. She eats breakfast from a feeding tube and must take 28 different medications to prevent pain, infections, and seizures. Her brother Oliver, age 3, is a typical giggling toddler. The children share a genetic mutation that causes a fatal neurodegenerative disease called metachromatic leukodystrophy, or MLD, but as a baby he was treated in Italy with what its maker said today will cost $4.25 million in the U.S., making it the most expensive drug in history.
“When Addi was this age she had lost the ability to speak and was already using a ventilator to sleep at night,” Raspberry said. “It’s amazing to see how well Ollie is doing in comparison. And it’s all because of the gene therapy.”
On Monday the U.S. FDA approved Orchard Therapeutics’ gene therapy Lenmeldy, an achievement decades in the making from parents’ efforts, researchers’ experiments, and a company’s experience with other gene therapies that failed. Now there’s the hurdle of that price. “It may take months sometimes to get those things worked out,” Paul Orchard of the University of Minnesota said about insurers. “And some of these kids aren't going to have months to screw around.” STAT’s Jason Mast and Megan Molteni have more on the complicated story.
https://www.statnews.com/2024/03/18/metachromatic-leukodystrophy-nerve-disease-children-gene-therapy-orchard-lenmeldy/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-_g-Yi4szim62kaksSiUY1SjB4RzZADinLA1bSfOgCEQqBFzAbOp3kHeGJg25GvfYOnIam6-J3QwLmrOeyLoaQxfXQS1Q&utm_content=298983789&utm_source=hs_email
Aspirin for Metabolic Dysfunction–Associated Steatotic Liver Disease Without Cirrhosis A Randomized Clinical Trial ++++
Aspirin for Metabolic Dysfunction–Associated Steatotic Liver Disease Without Cirrhosis
A Randomized Clinical Trial
https://jamanetwork.com/journals/jama/article-abstract/2816236?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-9jgcGdldbTPUIQE2oc2MPqb7qBN-GNGu49QvJuoutzKDe7tbQGgxyaES34BSvsow8hEjWr9M1WU4Vhpj8fwU9ev5K8lQ&utm_content=298983789&utm_source=hs_email
Renamed, common liver diseases might get fairer shake at treatment, researchers hope
Isabella Cueto
By Isabella Cueto Dec. 28, 2023
https://www.statnews.com/2023/12/28/liver-disease-masld-nafld-mash-nash-metald/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz--aSHVGmSgA9yjeh5Lr6msLxmLm6RkMbmHs33IQUoWUvnAtOSjgpRmlunfCUD3LHQPkSktLnpydD0TXFtzvAH2etFgCNg&utm_content=298983789&utm_source=hs_email
Madrigal wins first U.S. approval for drug to treat liver disease MASH
Adam Feuerstein
By Adam Feuerstein March 14, 2024
https://www.statnews.com/2024/03/14/madrigal-mash-drug-approval/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz--KpUT-TE1vRHkTA2ea9JqXI7BxsTEUT0pJXpwamA9GbxCpl662x8Z4P4UT1n7eVwRZDq2Mf2i4QWh-HytC-g5kynh61Q&utm_content=298983789&utm_source=hs_email
In small study, baby aspirin cuts fat buildup in liver disease patients
Isabella Cueto
By Isabella Cueto March 19, 2024
https://www.statnews.com/2024/03/19/baby-aspirin-liver-disease-masld/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-8Q4-OlUvcS2f6vmGWhy81yFEATh9I82rMfcP4C0d5UtFeiB8eMAtQCDcsiEe6-Um527z41MapyhUovvSpZdxl2UsnYAA&utm_content=298983789&utm_source=hs_email
A scientific mystery highlights the blind spots in genomics databases Andrew Joseph By Andrew Joseph March 20, 2024
https://www.statnews.com/2024/03/20/genomics-databases-scientific-mystery-gene-variant/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-8Vn6i2ybIpd0AhMcNXJwnwgY64YTMpmOTDGInUKZWXz3bhlTrtUvC23CU4gfO2rz71DtoFqS92a7r7n2HgyDFk9yvdFQ&utm_content=298983789&utm_source=hs_email
A medical mystery or a blind spot?
What does “rare” mean? It depends on the context. When that context is the world of genomic datasets dominated by European samples, it requires deeper sleuthing to determine what’s a mystery and what’s not. A preprint paper illustrates this point with the cases of two people who died young from heart problems and shared a particular variant of a gene that helps the heart beat. According to available datasets, the variant qualified as rare. And without knowing its meaning, one lab concluded it was likely disease-causing.
That was before looking harder. Researchers who authored the new report found that the two patients were of Oceanian ancestry, among the least represented populations in DNA databases, meaning their genetic variants likely aren’t reflected in rates saying how common they actually are. And it turned out the variant was not so rare after all. STAT’s Andrew Joseph explains.
https://www.medrxiv.org/content/10.1101/2024.02.08.24302375v1.full?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz-9S-9TWPtLUYA25irOtVBy4zIP1QIh06oYR3zKjD4q3tph0Hv-gRDqDUvg70RT7pgxK_wO_aNtECg5ZM0jciZBvm1RJLw&utm_content=298983789&utm_source=hs_email
Fetal tissue research gains in importance as roadblocks multiply Olivia Goldhill By Olivia Goldhill March 20, 2024
https://www.statnews.com/2024/03/20/fetal-tissue-research-scientists-roadblocks/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=298983789&_hsenc=p2ANqtz--PhSKgzKGn9XprsabNpoa-bjo84d8-Y20rKu3jCUovOz-SwqfE8Fr38S_GTgtj0jglrze0dV3XyvhsP12rS_0qQzTRcA&utm_content=298983789&utm_source=hs_email
Some pursuits of biomedical science can’t proceed without studying fetal tissue, which can help scientists learn about stem cells and understand cancer biology and brain development. But several scientists say fetal tissue research is increasingly untenable in the U.S. with the possible return of former president Donald Trump to office. His previous administration set up roadblocks that President Biden overturned, but federal funding of studies relying on fetal tissue has not fully rebounded.
“The U.S. is falling behind,” Dan Doherty, a pediatrics professor at the University of Washington, told STAT’s Olivia Goldhill. In one example, fetal tissue has gained importance thanks to advances leading to the creation of sophisticated human organoids — organ-like blobs of tissue grown in labs — to study the emergence of diseases and potential treatments. Fetal tissue is needed to validate results. Read more.
Doctors should intervene to help children with obesity, task force draft says, but it doesn’t recommend surgery or meds
https://edition.cnn.com/2023/12/12/health/uspstf-children-obesity-guidelines-wellness/index.html
Cloacal Malformations: Case Studies
Edited By Marc Levitt
Copyright 2024
https://www.routledge.com/Cloacal-Malformations-Case-Studies/Levitt/p/book/9781032215471
Children’s National to host Pediatric Inflammatory Bowel Disease Research Days Meeting March 5, 2024
https://innovationdistrict.childrensnational.org/childrens-national-to-host-pediatric-inflammatory-bowel-disease-research-days-meeting
The division of Gastroenterology, Hepatology and Nutrition at Children’s National Hospital is proud to host the Pediatric Inflammatory Bowel Disease Research Days (PIBDRD) Meeting from April 4-5, 2024.
This two-day event will review recent advances in pediatric Inflammatory Bowel Disease (IBD) research, identify gaps in knowledge in pediatric IBD and identify target areas for future pediatric IBD research.
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