martes, 31 de marzo de 2020

COVID-19 and Sepsis, Charité Hot Topics, ESA Event, Hadley, GSA Awards, More...

Dear Friends, Colleagues, and Supporters,
Welcome to World Sepsis Day News - March Edition.

As always, if you want to delve deeper into a particular topic, the link below the picture will take you directly to the article on our website.
To stay up to date on our activities, please join us on TwitterInstagram, or Facebook, and visit the news section on our WSD website regularly.

Here we go:

Can COVID-19 Cause Sepsis? Explaining the Relationship Between the Coronavirus Disease and Sepsis

The COVID-19 Pandemic has the world in its grip, with new developments by the hour. But what is the relationship between COVID-19 and sepsis? Can SARS-CoV-2 actually cause sepsis? Read on to find out...

Video Recap from the 3rd Annual Meeting of the European Sepsis Alliance Now Available

On March 23rd, the 3rd Annual Meeting of the European Sepsis Alliance took place online, with speakers from the European Commission, the WHO, researchers, sepsis survivors, clinicians, and more, including presentations on national sepsis plans and COVID-19 (again). Watch the video here...

Deadline for Applications and Nominations for the 2020 GSA Awards Extended to June 30th, 2020

Due to the current situation worldwide, we are extending the deadline for applications and nominations for the 2020 GSA Awards to June 30th, 2020. Please share this call with your colleagues, friends, and other interested parties - $2,500 prize money, a beautiful trophy, and eternal glory await...

Free Video – Global Burden, Diagnosis, and Adjunctive Therapies of Sepsis and COVID-19 – Charité Hot Topics

On March 16th, the Sepsis Comprehensive Center Charité (SCCC) hosted another Charité Hot Topic Event, supported by the Global Sepsis Alliance. The video recap is available here...

Hadley's Sepsis Story – Casting Down Her Rae's of Sunshine

"Hadley Rae was the sweetest little baby you could ever meet. She would light up the room with her laugh and smile from the day she was born. Our beautiful “Haddie” provided 8 months and 13 days of joy, love, smiles, and sunshine to her family and two big sisters – until March 2019…"

Sepsis Awareness Posters, Pocket Cards, and WSD Flyer Now Updated with New Data from GBD Sepsis Study

In January, the Global Burden of Disease Sepsis Study revealed staggering new data on the incidence and mortality of sepsis globally. We are now happy to report that our Sepsis Awareness Posters, our Pocket Cards, and our WSD Flyer have been updated with the new numbers and are available for you to download...

Calling International Pediatric Nurses to Apply for Erin’s Campaign for Kids Nursing Awards

Until April 10th, 2020, you can nominate or apply for the Erin's Campaign for Kids Nursing Awards, including in the category of international nurse. Learn more here...

Study: Predictive Accuracy of the Quick Sepsis-Related Organ Failure Assessment Score in Brazil: A Prospective Multicenter Study

When the Sepsis-3 definition was published, a new retrospectively-derived tool was proposed to help identify patients with infection at higher risk of deterioration – the 'quick-SOFA' or qSOFA score. Although it was intended only as a risk prediction score, many institutions are now incorrectly using it as a screening tool for sepsis...

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Getting Closer to a Blood Test for Alzheimer’s Disease? – NIH Director's Blog

Getting Closer to a Blood Test for Alzheimer’s Disease? – NIH Director's Blog

Getting Closer to a Blood Test for Alzheimer’s Disease?

Posted on  by 

Blood Test

As research on Alzheimer’s disease (AD) advances, a desperate need remains for an easy blood test to help diagnose the condition as early as possible. Ideally, such a test could also distinguish AD from other forms of dementia that produce similar symptoms. As published recently in Nature Medicine, an NIH-funded research team has designed a simple blood test that is on course to meet these criteria [1].
The latest work builds on a large body of work showing that one secret to predicting a person’s cognitive decline and treatment response in AD lies in a protein called tau. Using the powerful, but expensive, approach of PET scan imaging, we know that tau builds up in the brain as Alzheimer’s disease progresses. We also know that some tau spills from the brain into the bloodstream.
The trouble is that the circulating tau protein breaks down far too quickly for a blood test to offer a reliable measure of what’s happening in a person’s brain. A few years ago, researchers discovered a possible solution: test for blood levels of a slightly different and more stable version of the protein called pTau181 [2]. (The “p” in its name comes from the addition of phosphorus in a particular part of the protein’s structure.)
In the latest study, researchers in the lab of Adam Boxer, University of California, San Francisco, followed up further on this compelling lead. Boxer’s team measured pTau181 levels in blood samples from 362 people between the ages of 58 and 70. Those samples included 56 people with an Alzheimer’s diagnosis, along with 47 people with mild cognitive impairment and 69 healthy controls.
The researchers also included another 190 people diagnosed with frontotemporal lobar degeneration (FTLD). It is a relatively rare form of dementia that leads to a gradual decline in behavior, language, and movement, often in connection with a buildup of tau in the brain.
The study found that levels of pTau181 were roughly 3.5-times higher in the blood of people with AD compared to people without AD. Those with mild cognitive impairment due to underlying AD also showed an intermediate increase in blood levels of pTau181.
Importantly, people with FLTD had normal blood levels of pTau181. As a result, the blood test could reliably distinguish between a person with AD and a person with FLTD. That’s important because, while FLTD is a relatively rare condition, its prevalence is similar to AD in people under the age of 65. But both conditions have similar symptoms, making it often challenging to distinguish them.
The findings add to evidence that the new blood test can help in diagnosing AD and in distinguishing it from other neurodegenerative conditions. In fact, it does so with an accuracy that often rivals more expensive PET scans and more invasive cerebrospinal fluid tests, which are now the only reliable ways to measure tau.
There’s still plenty of work to do before this blood test is ready for a doctor’s office. But these initial findings are very promising in helping to simplify the diagnosis of this devastating condition that now affects an estimated 5.5 million Americans [3].
[1] Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration. Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL; Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators. Nat Med. 2020 Mar 2.
[2] Plasma phospho-tau181 increases with Alzheimer’s disease clinical severity and is associated with tau- and amyloid-positron emission tomography. Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL. Alzheimers Dement. 2018 Aug;14(8):989-997.
[3] Alzheimer’s Disease Fact Sheet. National Institute on Aging, May 22, 2019.
Alzheimer’s Disease & Related Dementias (National Institute on Aging/NIH)
Adam Boxer  (University of California, San Francisco)
NIH Support: National Institute on Aging; National Institute of Neurological Disorders and Stroke

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MARCH 2020
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