miércoles, 30 de abril de 2025
martes, 29 de abril de 2025
lunes, 28 de abril de 2025
domingo, 27 de abril de 2025
FO04 - Unlocking the Power of PROs to Assess Tolerability in Cancer Clinical Trials Add to My Itinerary April 29, 2025, 5:00 PM - 6:30 PM ++++
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/90
ADT05 - Bispecifics: The Case for Duality
Add to My Itinerary
April 29, 2025, 12:30 PM - 2:00 PM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/121
MS.BCS01.01. Artificial Intelligence and Machine Learning for Basic and Translational Research
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/sessions/@sessiontype=Minisymposium/1
PO.BCS01.04. Database Resources
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/sessions/@sessiontype=Poster%20Session/1
AACR Annual Meeting 2025
April 25-30, 2025
McCormick Place Convention Center
Chicago, Illinois
https://www.aacr.org/meeting/aacr-annual-meeting-2025/?cid=eb_govdel
PL03 - Innovative Technologies Driving Advances in Cancer Research Add to My Itinerary April 28, 2025, 8:00 AM - 10:00 AM +++ +++ +
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/5
SY45 - Harnessing the Microbiota to Transform Cancer Immunotherapy
Add to My Itinerary April 28, 2025, 10:15 AM - 11:45 AM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/113
SY01 - Presidential Select Symposium: Leveraging Science to Reduce the Cancer Burden Worldwide
Add to My Itinerary April 28, 2025, 10:15 AM - 12:00 PM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/13
ASD01 - Health Disparities across the Cancer Clinical Research Continuum: Emerging Opportunities and Challenges
Add to My Itinerary
April 28, 2025, 12:30 PM - 2:00
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/85
SY32 - Redefining Cancer Survivorship for People Living with Advanced and Metastatic Cancers
Add to My Itinerary
April 28, 2025, 12:30 PM - 2:00 PM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/94
SY14 - Synthetic Lethality: What Next?
April 28, 2025, 12:30 PM - 2:00 PM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/56
FO05 - The Role of Surgery in Modern Cancer Treatment: Opportunity for Patient-derived Models or Simply an Art of Diminishing Return
Add to My Itinerary
April 28, 2025, 5:00 PM - 6:30 PM
https://www.abstractsonline.com/pp8/?cid=eb_govdel#!/20273/session/104
Deep Intronic SVA_E Retrotransposition as a Novel Factor in Canavan Disease Pathogenesis
Weekly Rundown: HHS pulls COVID-19 vaccine funding mid-trials Landmark women’s health study loses funding, a promising antibody-drug conjugate for breast cancer, a schizophrenia drug setback, and more news from this week.
sábado, 26 de abril de 2025
Migraine: A Key Factor in Young Adults With Unexplained Stroke Megan Brooks April 21, 2025 ++
https://www.medscape.com/viewarticle/migraine-key-factor-young-adults-unexplained-stroke-2025a10009jj?ecd=WNL_mdpls_250425_mscpedit_wir_etid7381690&uac=148436CN&spon=17&impID=7381690
Heavy Drinking Tied to Risk for Brain Lesions
Edited by Anushree Chaphalkar
April 22, 2025
https://www.medscape.com/viewarticle/heavy-drinking-tied-risk-brain-lesions-2025a10009n1?ecd=WNL_mdpls_250425_mscpedit_wir_etid7381690&uac=148436CN&spon=17&impID=7381690
Repurposed Antidepressant Effective for Cataplexy in Narcolepsy Deborah Brauser April 16, 2025 +++
MORE FROM AAN 2025
Antidepressant Eases Narcolepsy Symptom
Repurposed Antidepressant Effective for Cataplexy in Narcolepsy
Deborah Brauser
April 16, 2025
https://www.medscape.com/viewarticle/repurposed-antidepressant-effective-cataplexy-narcolepsy-2025a100090d?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Nightmares Tied to Faster Aging, Death
Frequent Nightmares Linked to Faster Aging, Premature Death
Deborah Brauser
April 08, 2025
https://www.medscape.com/viewarticle/frequent-nightmares-linked-faster-aging-premature-death-2025a10008ea?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
OTC Pain Meds Aid in Concussion Recovery
Over-the-Counter Analgesics Improve Concussion Outcomes
Pauline Anderson
March 13, 2025
https://www.medscape.com/viewarticle/over-counter-analgesics-improve-concussion-outcomes-2025a100063h?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
NEURODEGENERATION NEWS ++++
NEURODEGENERATION NEWS
Alzheimer’s Agitation Drug Still Promising
Novel Agent for Alzheimer’s Agitation Continues to Show Promise
Megan Brooks
April 11, 2025
https://www.medscape.com/viewarticle/novel-agent-alzheimers-agitation-continues-show-promise-2025a10008os?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Drug Slows Huntington’s in Early Stages
Investigational Drug Slows Decline in Early Huntington
Pauline Anderson
April 14, 2025
https://www.medscape.com/viewarticle/investigational-drug-slows-decline-early-huntington-2025a10008s2?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Wearable Device Calms Essential Tremor
AI-Powered Wearable Calms Essential Tremor
Megan Brooks
April 10, 2025
https://www.medscape.com/viewarticle/ai-powered-wearable-calms-essential-tremor-2025a10008kp?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Inebilizumab Safe Long-Term in MG
Inebilizumab Safe, Effective Up to 52 Weeks in Myasthenia Gravis
Deborah Brauser
April 10, 2025
https://www.medscape.com/viewarticle/inebilizumab-safe-effective-52-weeks-myasthenia-gravis-2025a10008kk?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
HEADACHE & MIGRAINE UPDATES +++
HEADACHE & MIGRAINE UPDATES
First-in-Class Digital Tool Eases Episodic Migraine
First-in-Class Prescription Digital Therapeutic Effective for Episodic Migraine
Deborah Brauser
April 09, 2025
https://www.medscape.com/viewarticle/first-class-prescription-digital-therapeutic-effective-2025a10008h6?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Nasal Cooling Helps With Migraine Pain
Transnasal Cooling Promising for Migraine
Megan Brooks
April 08, 2025
https://www.medscape.com/viewarticle/transnasal-cooling-promising-migraine-2025a10008dh?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
New Hope for Hard-to-Treat Child Migraine
A New Option for Intractable Pediatric Migraine?
Pauline Anderson
March 10, 2025
https://www.medscape.com/viewarticle/new-option-intractable-pediatric-migraine-2025a10005r6?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
TOP AAN 2025 STORIES ++++
New Med Promising for Early Parkinson's
Novel Agent Shows Promise in Early Parkinson’s Disease
Pauline Anderson
April 15, 2025
https://www.medscape.com/viewarticle/novel-agent-shows-promise-early-parkinsons-disease-2025a10008yx?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
Fast Pain Relief for Trigeminal Neuralgia
Anticonvulsant Rapidly Reduces Pain in Acute Trigeminal Neuralgia
Deborah Brauser
April 17, 2025
https://www.medscape.com/viewarticle/anticonvulsant-rapidly-reduces-pain-acute-trigeminal-2025a100094e?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
New MS Drug Slows Disability Progression
Novel Drug Slows Disability Progression in Nonrelapsing Secondary Progressive MS
Pauline Anderson
April 14, 2025
https://www.medscape.com/viewarticle/novel-drug-slows-disability-progression-nonrelapsing-2025a10008u3?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
CPAP May Cut Parkinson’s Risk
CPAP for Sleep Apnea May Lower Risk for Parkinson’s Disease
Megan Brooks
March 10, 2025
https://www.medscape.com/viewarticle/cpap-sleep-apnea-may-lower-risk-parkinsons-disease-2025a10005ra?ecd=WNL_conf_neuro_AAN-SPON_250426_MSCPEDIT_etid7377172&uac=148436CN&impID=7377172
A simple lifesaver for hemorrhagic shock or cardiac arrest HemaShock exsanguination tourniquet squeezes the blood from the patient’s limbs and sends it to the core organs where it’s needed most.
https://www.israel21c.org/a-simple-lifesaver-for-hemorrhagic-shock-or-cardiac-arrest/
A young man was brought to the emergency room of Hadassah University Medical Center in Jerusalem in traumatic cardiac arrest after shrapnel tore his inferior vena cava, the big vein in the middle of the belly. The young trauma surgeon opened the young man’s chest to start internal cardiac massage.
By Abigail Klein Leichman
April 15
Muscle-loss concerns lead to new drug discovery platform ProFuse’s novel technology addresses the growing need to preserve muscle in the face of aging and the popularity of weight-loss drugs.
https://www.israel21c.org/muscle-loss-concerns-lead-to-new-drug-discovery-platform/
Israeli startup ProFuse Technology has launched a new drug discovery platform that seeks to prevent muscle mass loss caused by aging, cancer and the growing use of glucagon-like peptide-1 (GLP-1) weight-loss injections, such as Ozempic.
By Yulia Karra
April 17
Toxic masculinity is bad for men too, study says The new retreat towards more traditional gender roles will not only harm women, but also the men promoting it, warn social psychologists.
https://www.israel21c.org/toxic-masculinity-is-bad-for-men-too-study-says/
By Nicky Blackburn
April 23
As toxic masculinity rears its head once more with a new movement seeking a seeming return to more traditional gender roles, an Israeli social psychologist is warning that this behavior actually harms the men at the forefront of the change.
viernes, 25 de abril de 2025
New drug for Parkinson’s shown to be effective in clinical trials: 'Very encouraged' Tavapadon combats motor symptoms — largely without adverse side effects Melissa Rudy By Melissa Rudy Fox News Published April 18, 2025 5:00am EDT
New drug for Parkinson’s shown to be effective in clinical trials: 'Very encouraged'
Tavapadon combats motor symptoms — largely without adverse side effects
Melissa Rudy By Melissa Rudy Fox News
Published April 18, 2025 5:00am EDT
https://www.foxnews.com/health/new-drug-parkinsons-shown-effective-clinical-trials-very-encouraged
Blood pressure and dementia risk share surprising link, study suggests Patients who received ‘intensive blood pressure control’ were 15% less likely to get dementia Melissa Rudy By Melissa Rudy Fox News Published April 22, 2025 5:04pm EDTBlood pressure and dementia risk share surprising link, study suggests Patients who received ‘intensive blood pressure control’ were 15% less likely to get dementia Melissa Rudy By Melissa Rudy Fox News Published April 22, 2025 5:04pm EDT
Blood pressure and dementia risk share surprising link, study suggests
Patients who received ‘intensive blood pressure control’ were 15% less likely to get dementia
Melissa Rudy By Melissa Rudy Fox News
Published April 22, 2025 5:04pm EDT
https://www.foxnews.com/health/blood-pressure-dementia-risk-share-surprising-link-study-suggests
'I'm a neurologist — here's why dementia is rising and how to reduce your risk’ Cognitive decline is more prevalent than ever, but lifestyle changes can make a difference Melissa Rudy By Melissa Rudy Fox News Published April 23, 2025 5:00am EDT
'I'm a neurologist — here's why dementia is rising and how to reduce your risk’
Cognitive decline is more prevalent than ever, but lifestyle changes can make a difference
Melissa Rudy By Melissa Rudy Fox News
Published April 23, 2025 5:00am EDT
https://www.foxnews.com/health/neurologist-heres-why-dementia-rising-how-reduce-risk
Holding paper receipts for just 10 seconds can pose health risks, researchers warn The chemical BPS can disrupt regular bodily functioning, doctors say Andrea Margolis By Andrea Margolis Fox News Published April 24, 2025 11:00am EDT
Holding paper receipts for just 10 seconds can pose health risks, researchers warn
The chemical BPS can disrupt regular bodily functioning, doctors say
Andrea Margolis By Andrea Margolis Fox News
Published April 24, 2025 11:00am EDT
https://www.foxnews.com/health/holding-paper-receipts-just-10-seconds-can-pose-health-risks-researchers-warn
Woman says ChatGPT saved her life by helping detect cancer, which doctors missed Doctors told the mother of two she had arthritis when she actually had thyroid cancer Melissa Rudy By Melissa Rudy Fox News Published April 24, 2025 4:01pm EDT
Woman says ChatGPT saved her life by helping detect cancer, which doctors missed
Doctors told the mother of two she had arthritis when she actually had thyroid cancer
Melissa Rudy By Melissa Rudy Fox News
Published April 24, 2025 4:01pm EDT
https://www.foxnews.com/health/woman-says-chatgpt-saved-her-life-helping-detect-cancer-which-doctors-missed
Exposure to toxin increases colorectal cancer risk among younger adults, study finds Bacterial toxin linked to E. coli found to be ‘major contributor’ Melissa Rudy By Melissa Rudy Fox News Published April 25, 2025 8:36am EDT
Exposure to toxin increases colorectal cancer risk among younger adults, study finds
Bacterial toxin linked to E. coli found to be ‘major contributor’
Melissa Rudy By Melissa Rudy Fox News
Published April 25, 2025 8:36am EDT
https://www.foxnews.com/health/exposure-toxin-increases-colorectal-cancer-risk-younger-adults-study-finds
'I’m a spinal surgeon – here’s how your posture is killing your back' Humans are not 'designed to sit,' doctor says – here's what to do instead Angelica Stabile By Angelica Stabile Fox News Published April 25, 2025 5:00am EDT
'I’m a spinal surgeon – here’s how your posture is killing your back'
Humans are not 'designed to sit,' doctor says – here's what to do instead
Angelica Stabile By Angelica Stabile Fox News
Published April 25, 2025 5:00am EDT
https://www.foxnews.com/health/spinal-surgeon-heres-how-posture-killing-back
POPPING YOUR BRAIN BACK INTO FOCUS
Popping Your Brain Back Into Focus
By Ivanhoe Broadcast News on April 28, 2025
https://www.ivanhoe.com/?p=35376&preview=1&_ppp=9aba35588e
jueves, 24 de abril de 2025
Determining the Risk of Recurrence in HR+/HER2- Early Breast Cancer Without Axillary Dissection Authors: Sara M. Tolaney, MD, MPH; Elizabeth A. Mittendorf, MD, PhD, MHCM; Leah H. Portnow, MD
https://www.medscape.org/viewarticle/1002279?sso=true&uac=148436CN&src=mkmcmr_reeng_recap_mscpedu_activity
Determining the Risk of Recurrence in HR+/HER2- Early Breast Cancer Without Axillary Dissection
Below are some key learning points to help reinforce the impact of this activity.
☑ Lymph node involvement is a critical factor in determining the optimal management of patients with early-stage HR-positive, HER2-negative breast cancer.
• Along with tumor size, grade, and proliferation index, lymph node involvement serves as an important prognostic factor in the management of HR-positive, HER2-negative EBC.
• Escalated therapies, such as cyclin-dependent kinase (CDK) 4/6 inhibitors in the adjuvant setting, depend on understanding the degree of nodal involvement.
☑ Imaging techniques play a pivotal role in the assessment of the axilla.
• Breast magnetic resonance imaging (MRI), with its wide field of view, is useful for assessing the number of lymph nodes involved but is limited in its ability to provide detailed morphologic assessment.
• Ultrasound is preferred for evaluating lymph node morphology. Abnormal axillary lymph node characteristics include cortical thickness greater than 3 mm, loss of fatty hilum, non-hilar Doppler flow, and a round shape.
☑ Recent studies have provided evidence supporting the safety of omitting full ALND in select patients with EBC.
• The SOUND trial demonstrated that omitting axillary surgery was noninferior to sentinel lymph node biopsy (SLNB) in patients with small breast cancers and negative ultrasonography results.
• The INSEMA trial, with a median follow-up of 6 years, showed that in patients with clinically node-negative T1 or T2 invasive breast cancer, omission of surgical axillary staging was noninferior to SLNB.
☑ With expanding treatment options now available, a multidisciplinary approach to individualized treatment planning for patients with early-stage HR-positive, HER2-negative breast cancer is more important than ever.
New Study Advances Understanding of How Heat and Pain Are Sensed and How Touch Can Become Painful
https://www.nccih.nih.gov/research/research-results/new-study-advances-understanding-of-how-heat-and-pain-are-sensed-and-how-touch-can-become-painful?nav=govd
A study by investigators from the National Center for Complementary and Integrative Health and the National Institute of Dental and Craniofacial Research provides new insights into how the nervous system detects heat and touch and how inflammation modifies these processes to trigger pain. This research was conducted and supported by the National Institutes of Health (NIH) intramural research program and published in the journal Nature.
Nerve terminals in the skin allow us to make fine distinctions about our surroundings. However, after injury or inflammation, it has long been believed that these neurons must respond differently than they normally do since they now trigger pain. In fact, three types of inflammatory pain are clinically recognized: ongoing pain, heightened pain (hyperalgesia), and pain from normally innocuous stimuli (allodynia).
miércoles, 23 de abril de 2025
Childhood Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version // Childhood Astrocytomas, Other Gliomas, and Glioneuronal/Neuronal Tumors Treatment (PDQ®)–Health Professional Version
Childhood Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/lymphoma/hp/child-hodgkin-treatment-pdq?cid=eb_govdel#top
Childhood Astrocytomas, Other Gliomas, and Glioneuronal/Neuronal Tumors Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/brain/hp/child-astrocytoma-glioma-treatment-pdq?cid=eb_govdel#top
Childhood Vascular Tumors Treatment (PDQ®)–Health Professional Version // Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/soft-tissue-sarcoma/hp/child-vascular-tumors-treatment-pdq?cid=eb_govdel#top
Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/soft-tissue-sarcoma/hp/child-soft-tissue-treatment-pdq?cid=eb_govdel#top
Oral Cavity and Nasopharyngeal Cancers Screening (PDQ®)–Health Professional Version // Oral Cavity, Oropharyngeal, Hypopharyngeal, and Laryngeal Cancers Prevention (PDQ®)–Health Professional Version
Oral Cavity and Nasopharyngeal Cancers Screening (PDQ®)–Health Professional Version
https://www.cancer.gov/types/head-and-neck/hp/oral-screening-pdq?cid=eb_govdel#top
Oral Cavity, Oropharyngeal, Hypopharyngeal, and Laryngeal Cancers Prevention (PDQ®)–Health Professional Version
https://www.cancer.gov/types/head-and-neck/hp/oral-prevention-pdq?cid=eb_govdel#top
Lung Cancer Prevention (PDQ®)–Health Professional Version // Lung Cancer Screening (PDQ®)–Health Professional Version
https://www.cancer.gov/types/lung/hp/lung-prevention-pdq?cid=eb_govdel#top
Lung Cancer Screening (PDQ®)–Health Professional Version
https://www.cancer.gov/types/lung/hp/lung-screening-pdq?cid=eb_govdel#top
Cervical Cancer Prevention (PDQ®)–Health Professional Version // Cervical Cancer Screening (PDQ®)–Health Professional Version
https://www.cancer.gov/types/cervical/hp/cervical-prevention-pdq?cid=eb_govdel#top
Cervical Cancer Screening (PDQ®)–Health Professional Version
https://www.cancer.gov/types/cervical/hp/cervical-screening-pdq?cid=eb_govdel#top
NIH researchers supercharge ordinary clinical device to get a better look at the back of the eye New technique brings retina into sharper focus .
NIH researchers supercharge ordinary clinical device to get a better look at the back of the eye
New technique brings retina into sharper focus .
https://www.nih.gov/news-events/news-releases/nih-researchers-supercharge-ordinary-clinical-device-get-better-look-back-eye
martes, 22 de abril de 2025
The foretold Oropouche fever epidemic ++++
COMMENTS
Battling antimicrobial resistance: new guidance and insights
Free with registration
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00150-1/fulltext?dgcid=hubspot_email_conferencealerts_escmid25&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-8Bv4Tj-WrY9TX6YJH3o7X-x7xBSTNYZC5KBjCQtI2xyI6xcgCJCdA9_e6yt1Vd4zyKIYoWUq69Ht_ZHh_Ts2aSizj_ow&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
The foretold Oropouche fever epidemic
Free with registration
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00165-3/fulltext?dgcid=hubspot_email_conferencealerts_escmid25&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_Uc2AuPUoPhq5WjL3Txfln_KvJYV3NDDQKIxGR_edSHIbLSDiuM_vlu1_nsk7z1uXnhUCiTqYiBxOUCMaMWzI6EqJS0Q&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
The big five vexing questions of respiratory syncytial virus immunisation
Free with registration until Apr 23, 2025
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00093-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_escmid25&_hsenc=p2ANqtz--Qyx-LiBXWdFrQa4itpsuZVdsv5gTpCss4iA2kC488Uy25G93CSkJgORZsaTR4OVfC2gW1DuMgxuTx2eZBdk6tU9pUrQ&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
Gepotidacin shows promise for the treatment of uncomplicated gonorrhoea
Free with registration until Apr 23, 2025
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00680-4/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_escmid25&_hsenc=p2ANqtz-8fWZTq0Hkax74bx2XJw1cnzK5Q-tjncpQnPoD_Ukdatky1zNPsp5H6D57fUfiqXegeXHUOOt5eYTF9pV8tmhDB0oYbCw&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance ++++
ARTICLES
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
Open Access
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00118-5/fulltext?dgcid=hubspot_email_conferencealerts_escmid25&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-8xDRfUgjyNnhpFMSsoz-PA9GuTK6_moLgj_9DiPkDzqZFYh_NQMtdyF00UlOjGkZoFJkH3Gq0gRqUh_X9NTfcck3fxMw&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study
Open Access
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00110-0/fulltext?dgcid=hubspot_email_conferencealerts_escmid25&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-9AyDKjLumW64mKlAGLMVNxQ9CjNiO2GV3rL7HMCX0wFNGjjluyLoj6rEWVjwbTyWsQmojPbUdiCMu7h-KmRkPCyDi5Dw&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a multicentre, randomised, observer-blinded, placebo-controlled, phase 3 trial
Free with registration
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00048-7/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_escmid25&_hsenc=p2ANqtz-94cj1GOSr0sCRE7b8A4hUgMT7pRMTiWzHsn_yrU5cgIZ9CwNnH9_6QcfDEyN9jstRunZMaFPNapowgYbkpJDmb5HCQXQ&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study
Free with registration until Apr 23 20, 2025
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00628-2/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_escmid25&_hsenc=p2ANqtz-9cghVIFcXr7mhPgyjW45WhErq2lYAJ62Csjrh6oWz_UzFDW3cKnUOsCqJ60QoSsOGWFtTXdFvzGRhOqfLdAtll3R2xjg&_hsmi=356954167&utm_content=356954167&utm_source=hs_email
More Americans with mental health conditions are using psilocybin
More Americans with mental health conditions are using psilocybin
Use of psilocybin, the hallucinogenic compound found in numerous mushroom species, has sharply increased since 2019, according to a new study published Monday in the Annals of Internal Medicine.
The spike is particularly pronounced among Americans with mental health conditions, the study shows. The rate of adults 18-29 reporting psilocybin use in the past year jumped by 44%, according to the study, while adults over 30 showed a 188% increase. Perhaps unsurprisingly, poison control center calls related to psilocybin also skyrocketed among adults, teens, and even children.
“What really surprised us was how quickly these numbers changed and how many people using psilocybin had conditions like depression, anxiety or chronic pain,” Karilynn Rockhill, a researcher at the Colorado School of Public Health who co-led the study, said in a press release. “New laws or growing interest in its potential mental health benefits may be prompting people to seek psilocybin as a form of self-treatment.”More Americans with mental health conditions are using psilocybin
Use of psilocybin, the hallucinogenic compound found in numerous mushroom species, has sharply increased since 2019, according to a new study published Monday in the Annals of Internal Medicine.
The spike is particularly pronounced among Americans with mental health conditions, the study shows. The rate of adults 18-29 reporting psilocybin use in the past year jumped by 44%, according to the study, while adults over 30 showed a 188% increase. Perhaps unsurprisingly, poison control center calls related to psilocybin also skyrocketed among adults, teens, and even children.
“What really surprised us was how quickly these numbers changed and how many people using psilocybin had conditions like depression, anxiety or chronic pain,” Karilynn Rockhill, a researcher at the Colorado School of Public Health who co-led the study, said in a press release. “New laws or growing interest in its potential mental health benefits may be prompting people to seek psilocybin as a form of self-treatment.”
Leading Autism Organizations Release Joint Statement on Upholding Scientific Integrity and Supporting the Autism Community April 17, 2025
https://autisticadvocacy.org/2025/04/leading-autism-organizations-release-joint-statement-on-upholding-scientific-integrity-and-supporting-the-autism-community/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--yfXSJkOtBGRa7WzQ1BbssEL-8YspDGUtc7409bc9QkdQJ0v-NIAlB9OfNssiNM9O5oPSVnCbbnYdMKvYDp3Qcw41P2g&_hsmi=357740967&utm_content=357740967&utm_source=hs_email
Stances on autism are reshaping the advocacy landscape
Health Secretary Robert F. Kennedy Jr.'s repeated references to the autism “epidemic” and suggestions that it is fueled by an “environmental toxin” have provoked such intense outrage within the autism community that leading advocacy organizations have temporarily cast aside long-standing feuds.
More than 20 organizations penned a letter last week that brought together several unlikely bedfellows in the autism advocacy world, including Autism Speaks and the Autistic Self Advocacy Network. Those organizations’ beef stretches back decades to Autism Speaks’ infamous 2009 ad that compared autism to AIDS, cancer and diabetes. (See the recent graphic on ASAN’s website, titled “Before You Donate to Autism Speaks, Consider the Facts.”)
Before You Donate to Autism Speaks, Consider the Facts
https://autisticadvocacy.org/considerthefacts/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_J7Wk0fyaYpOnZlF7MA80EjVXjn5Q5U6-kzC1UHTYiZzcusSrPW6u5OKsOft_boSLPmiiWmDBAt3k1opH4bJesCUsw-w&_hsmi=357740967&utm_content=357740967&utm_source=hs_email
The signators write that rhetoric suggesting that autism is preventable will only deepen stigma and misunderstanding surrounding an already-marginalized population. It also ignores the robust scientific evidence that autism is mainly genetic. While it’s unclear how long this truce will last, the letter is a clear sign that Kennedy’s policies are changing how the autism community is advocating for itself. — O. Rose Broderick
RFK Jr. calls rising autism rate an ‘epidemic.’ Researchers call it a ‘good sign’
Experts attribute the uptick in autism prevalence to better diagnosis and care
https://www.statnews.com/2025/04/15/rfk-jr-says-rising-autism-rates-an-epidemic-researchers-disagree/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-94Y-6R8SPFrQ1XtKD2FkJLBGap_ZRxinuMz6Tx0wX2s6apKmCVx4ixJraBMlOaiVZPkTmrOpToRB8ou3DI1KdtIRoREA&_hsmi=357740967&utm_content=357740967&utm_source=hs_email
RFK Jr. promises autism answers by September. Prominent researchers and advocates have heard little
Nearly two dozen researchers and groups tell STAT they haven’t been approached about the project
https://www.statnews.com/2025/04/16/rfk-jr-cause-of-autism-study-by-september-prominent-scientists-not-involved-so-far/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_o8GvorZPi1b7g0hFwky-ZT2Iba7wuT0di_BDUMwdUzLW4EanUDq89OYcvW-Iu0eptZg2Rom8xTkksbML2nG1sP7ZXrA&_hsmi=357740967&utm_content=357740967&utm_source=hs_email
lunes, 21 de abril de 2025
Prediction of Adeno-Associated Virus Fitness with a Protein Language-Based Machine Learning Model
https://www.liebertpub.com/doi/10.1089/hum.2024.227?utm_campaign=MAL_HUM&utm_medium=email&_hsenc=p2ANqtz-9kGryx3OKOIJFIynFViEMH_tYRKYMLCnSRENlLTiU3gwCZYwyzfBqXIVSLZLL28t3V_LT1SRrc7rELLEp-igMDYP_whw&_hsmi=357188884&utm_content=357188884&utm_source=hs_email
Machine Learning Model to Predict the
Fitness of AAV Capsids for Gene Therapy
New Rochelle, NY, April 17, 2025—A new study in the peer-reviewed journal Human Gene Therapy describes a machine learning (ML) model that can be used as a surrogate for laborious in vitro experiments. This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients. Click here to read the article now.
Developing AAV capsids with improved yield, or fitness, is a key strategy for reducing manufacturing costs in order to make gene therapies more affordable.
Christian Mueller and coauthors from Sanofi describe a state-of-the-art ML model that predicts the fitness of AAV2 capsid mutants based on the amino acid sequence of the capsid monomer.
“By combining a protein language model (PLM) and classical ML techniques, our model achieved a significantly high prediction accuracy (Pearson correlation = 0.818) for capsid fitness,” stated the investigators. “Importantly, tests on completely independent datasets showed robustness and generalizability of our model, even for multi-mutant AAV capsids.”
“The emergence of artificial intelligence (AI)-based approaches is an exciting development in capsid engineering that has the potential to be more systematic, comprehensive, and cost-effective than traditional directed evolution- and rational design-based strategies. The study by Wu et al. is a great step forward in developing AI tools for the gene therapy field,” says Managing Editor of Human Gene Therapy Thomas Gallagher, PhD, from the University of Massachusetts Chan Medical School.
5th High-Performance Computing Security Workshop
https://www.nist.gov/news-events/events/2025/05/5th-high-performance-computing-security-workshop
High-performance computing (HPC) systems provide fundamental computing infrastructure and play a pivotal role in economic competitiveness and scientific discovery. Security is an essential component of HPC. NIST HPC Security Working Group (WG) has been leading the effort to create comprehensive and reliable security guidance for HPC systems. As part of the Working Group mission and to reach the greater HPC scientific community, NIST, in collaboration with the National Science Foundation (NSF), will host the 5th High-Performance Computing Security Workshop on May 7-8, 2025. The workshop aims to listen to the community’s needs and feedback, report and reflect on the ongoing activities at HPC Security WG, and define and discuss future directions with stakeholders from industry, academia, and government.
https://events.nist.gov/profile/web/index.cfm?PKwebID=0x10052abcd
In-Person Registration fee: $200/person.
Fee includes morning/afternoon snacks and lunch.
Virtual Registration fee: $46/person
In-Person Registration closes
NEXT WEDNESDAY, APRIL 30
Virtual attendee registration closes on May 8, 2025.
domingo, 20 de abril de 2025
Alcohol Now: The Latest Evidence Changes How You Deal with Patients Tue, Apr 29, 2025 8:00 PM - 9:00 PM -03
https://register.gotowebinar.com/register/3004750220688384352?source=email2
Emerging evidence is challenging long-held assumptions. Even light alcohol consumption may increase cancer risk, worsen mental health, and contribute to cognitive decline.
Join us live on April 29 at 7:00 PM ET for a free, expert-led event designed to help you better address alcohol use with your patients. Learn how the latest research is reshaping screening, counseling, and clinical decision-making.
You’ll gain insights on:
• Hidden cancer risks and chronic disease
• Rethinking 'moderate' drinking
• Improving screening and counseling strategies
Stress: A New Cancer Risk Factor? F. Perry Wilson, MD, MSCE | February 19, 2025 +++++
Stress: A New Cancer Risk Factor?
F. Perry Wilson, MD, MSCE
| February 19, 2025
Stress: A New Cancer Risk Factor?
https://www.medscape.com/viewarticle/stress-new-cancer-risk-factor-2025a10004b8?ecd=mkm_ret_250419_mscpmrk-OUS_InFocus_etid7364207&uac=148436CN&impID=7364207
How Comfort Foods Affect Patients’ Mood & Stress Levels
How Comfort Foods Affect Patients’ Mood and Stress Levels
Carolyn Crist
February 13, 2025
https://www.medscape.com/viewarticle/how-comfort-foods-affect-patients-mood-and-stress-levels-2025a10003si?ecd=mkm_ret_250419_mscpmrk-OUS_InFocus_etid7364207&uac=148436CN&impID=7364207
Stress Linked to Atopic Dermatitis Activity in Children
Early Childhood Stress Linked to Increased Atopic Dermatitis Activity
Edited by Deepa Varma
February 03, 2025
https://www.medscape.com/viewarticle/early-childhood-stress-linked-increased-atopic-dermatitis-2025a10002kl?ecd=mkm_ret_250419_mscpmrk-OUS_InFocus_etid7364207&uac=148436CN&impID=7364207
Dogs Helping Ease Staff & Patient Stress
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High Pay, Low Stress: The Dermatology Boom
High Pay, Low Stress: The Dermatology Boom
Lambeth Hochwald
January 30, 2025
https://www.medscape.com/viewarticle/high-pay-low-stress-dermatology-boom-2025a10002c4?ecd=mkm_ret_250419_mscpmrk-OUS_InFocus_etid7364207&uac=148436CN&impID=7364207
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