martes, 30 de junio de 2026
Memories Matter: Build A Better Brain at Any Age By Ivanhoe Broadcast News on July 3, 2026
RALEIGH, NC. (Ivanhoe Newswire) — More than seven million Americans 65 and older are living with Alzheimer’s and that number is expected to nearly double by 2050. But there’s a shift happening right now. Researchers are no longer just trying to treat decline. They’re trying to slow it — or stop it — before it starts. The latest Lancet Commission estimates that up to 45 percent of dementia cases could be prevented or delayed. In 2025, the FDA cleared the first blood test to help detect Alzheimer’s earlier. And new drugs like leqembi and kisunla are now available for early-stage patients. Ivanhoe looks at what the science says and what you can do at any age to protect your brain.
https://www.ivanhoe.com/?p=37261&preview=1&_ppp=4418bd663a
Children & Suicide: Five Years Old and Struggling By Ivanhoe Broadcast News on July 2, 2026
RALEIGH, NC. (Ivanhoe Newswire) — Suicide is now one of the leading causes of death for young people in the United States. For years, the focus has been on teens. But doctors say a disturbing shift is emerging. Some children are experiencing suicidal thoughts far earlier than many parents ever imagined.
https://www.ivanhoe.com/?p=37258&preview=1&_ppp=9640d5081c
Teen Mental Health Crisis: Can AI Help Save Lives? By Ivanhoe Broadcast News on July 1, 2026
RALEIGH, NC. (Ivanhoe Newswire) — Teen mental health in the US is reaching a critical point. According to the CDC, more than 40 percent of high school students reported feeling persistently sad or hopeless, and nearly one in five seriously considered suicide. At the same time, experts say many young people struggle for years before they ever see a mental health professional. Now researchers are using AI to help doctors identify which teens are at risk before a crisis begins.
https://www.ivanhoe.com/?p=37255&preview=1&_ppp=bfb901004d
Hurricane Prep: Keep Your Family Safe in the Storm By Ivanhoe Broadcast News on June 14, 2025
FALMOUTH, Mass. (Ivanhoe Newswire) — June 1st marks the official start of the Atlantic hurricane season, a five-month stretch where we keep a close eye on the tropical Atlantic. Forecasters are predicting 19 storms to form this season, nine of which will become hurricanes and four of which will reach category 3 status or stronger. That’s above the 30-year average for both hurricanes and storms. And while people who live on the coast are accustomed to preparing for these powerful weather events, it’s crucial to remember that the impact of a hurricane can extend far beyond the coastline. We saw that firsthand last year when hurricane Helene caused deadly flooding as far inland as the mountains of North Carolina. Today, we focus on how parents can take proactive steps to ensure their families are prepared, not panicked, for whatever this season may bring. Hurricane prep
https://www.ivanhoe.com/positive-parenting/hurricane-prep-keep-your-family-safe-in-the-storm/
The Heat Is On! Planning For a Cooler Future & Saving Money By Ivanhoe Broadcast News on June 21, 2025
ROCKVILLE, Md. (Ivanhoe Newswire) — Are you already feeling the sizzle? Last summer was the hottest summer on record and experts believe families will feel the heat this summer as well! It’s not just uncomfortable; for many families, the rising temperatures are hitting hard their health and their wallets. That’s why it’s important for us all to look at what we can do, and what our communities can do to tackle these problems head on.
https://www.ivanhoe.com/positive-parenting/the-heat-is-on-planning-for-a-cooler-future-saving-money/
Diagnosing Alpha-Gal Syndrome in Children Bethany Hodge, MD, MPH June 22, 2026
https://www.medscape.com/viewarticle/diagnosing-alpha-gal-syndrome-children-2026a1000kbq?ecd=wnl_conf_allergy_EAACI_NON-SPON_260630_mscpedit_etid8463659&uac=148436CN&impID=8463659
Hypothetical scenario: You are working at a pediatric urgent care office in your rural community and note that the next patient is an otherwise healthy 4-year-old with complaints of nausea, vomiting, and diarrhea. According to the child’s mother, the patient has had “weird episodes” for the past few weeks where he has woken up in the middle of the night on two occasions with severe stomach cramps, vomiting, and diarrhea that seem to improve by morning. Today she noted that although he woke up feeling well, he again developed stomach pain, looked pale, and vomited about two hours after breakfast.
Editorial p469 Global childhood cancer surveillance: too many left in the dark The Lancet Child & Adolescent Health +++ +...
Familial confounding and causal inference in child and adolescent neurodevelopment and mental health
Prof David Mataix-Cols, PhDa,b Send email to david.mataix.cols@ki.se ∙ Josep Pol-Fuster, PhDa ∙ Lorena Fernández de la Cruz, PhDa ∙ Prof Paul Lichtenstein, PhDc ∙ Prof Brian M D'Onofrio, PhDc,d ∙ Gustaf Brander, PhDa ∙ et al.
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00045-3/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz--W7-0T8nLi1DLS0uFiBWDcH73Ab6AqDzB_O1pJUCK6IWACgy-p7YPvO8ttcMNX8TtHBZTcgxEH6zmNoasmlEGZp_jVSg&_hsmi=425365236&utm_content=425294734&utm_source=hs_email
Global variation in injury patterns, interventions, and post-operative outcomes for children and adolescents undergoing trauma laparotomy: an international cohort study
Riaz Aziz, FFICMa ∙ Dr Michael F Bath, MRCSa Send email to mb2583@cam.ac.uk ∙Sarah M Abdelmohsen, MDb ∙ Isaac Chukwu, FWACSc ∙ Raoof Saleh, FRCSd ∙ Eder Cáceres, PhDe ∙ Carlos M Nuño-Guzmán, MDf,g ∙ Joachim Amoako, FWACSh,i ∙ Shobhana Nagraj, DPhilj ∙ Daphne K Karusoke, MBChBa,k ∙ Laura Hobbs, FRCAa,l,m ∙ Brandon G Smith, PhDa ∙ Katharina Kohler, PhDa,n ∙ Prof Timothy C Hardcastle, PhDo,p ∙ Zane B Perkins, PhDq,r ∙ Prof Thomas G Weiser, MDs ∙ Prof Kokila Lakhoo, PhDt ∙ Tom Bashford, PhDa,m,n on behalf of the GOAL-Trauma Collaborative
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00069-6/fulltext?dgcid=hubspot_update_feature_updatealerts_lanchi&utm_campaign=update-lanchi&utm_medium=email&_hsenc=p2ANqtz-8qDW2H8OVKrYj1F9ZjGFrMThrRMf8Dz6bTogYxtvHpTnpOXrgfP3cIqdHi9wbJ1QLIm2zExRXQ19QawrdRwDqC_Ikxdw&_hsmi=425365236&utm_content=425294734&utm_source=hs_email
Effectiveness of nirsevimab immunisation after birth versus RSVpreF maternal vaccination in preventing RSV-related hospitalisations in infants: a population-based retrospective cohort study
Zaba Valtuille, PhDa,† ∙ Inès Fafi, MDa,b,c,† ∙ Prof Florentia Kaguelidou, MD PhDb,d ∙ Corinne Levy, MDe,f,g ∙ Prof Robert Cohen, MD PhDe,f,g ∙ Prof Laurent Mandelbrot, MD PhDh,i ∙ et al.
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00075-1/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-8sONBGfA20iIOgMcggfx9wvHUhyHyExaUwJ0XKygjA2W3FAEIiR49NJW8ll0ESAPT2D5uXy0jRi5qTHJpyopiEJgcdJA&_hsmi=425365236&utm_content=425294734&utm_source=hs_email
Editorial
p469
Global childhood cancer surveillance: too many left in the dark
The Lancet Child & Adolescent Health
https://www.thelancet.com/journals/lanchi/issue/vol10no7/PIIS2352-4642(26)X2005-3
Antimicrobial resistance: the hidden pandemic we cannot ignore eClinicalMedicine ++... ++...
Antimicrobial resistance: the hidden pandemic we cannot ignore
eClinicalMedicine
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00306-8/fulltext?dgcid=raven_jbs_etoc_email
Jun 2026
Volume 96
https://www.thelancet.com/journals/eclinm/issue/vol96nonull/PIIS2589-5370(26)X2006-5
High-dose cannabidiol for chronic neuropathic pain associated with spinal cord injury: a randomised clinical trial
Rebecca V. Robertsona,b ∙ Anastasia Suraevb ∙ Danielle McCartneyb,c,d ∙ Allan Penga,b ∙ Noemi Meylakha,b ∙ Rebecca Gordona,e ∙ Fernando A. Tinoco-Mendozaa ∙ Callum Morsef ∙ Leana Sattarova,b ∙ Claire L. Boswell-Ruysf,g,h ∙ Kevin A. Keaya,b ∙ Elizabeth A. Cairnsb,c,e ∙ Sachin Shettyf ∙ Iain S. McGregorb,c,d,i ∙ Luke A. Henderson
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00234-8/fulltext?dgcid=raven_jbs_etoc_feature_eclinm
Transforming the Landscape of Gynaecological Cancer: Advances in Prevention, Precision Surgery, and Innovative Systemic Therapies
A three-paper Series examines how new strategies and technologies are transforming gynaecological cancer care, with a focus on prevention, precision surgery, and innovative systemic therapies. Paper 1 explores global efforts toward cervical cancer elimination, including progress in HPV vaccination and screening, alternative vaccine strategies, and WHO screening guidelines. Authors also propose targeted actions to accelerate elimination through innovation and more equitable strategies. Paper 2 discusses how computer-assisted and image-guided technologies are redefining surgical lymph node staging in gynaecological cancers. Paper 3 reviews the rapidly evolving field of antibody-drug conjugates (ADCs) in gynaecological cancers. The authors summarise mechanisms of action and findings from clinical trials, and address safety considerations, predictive biomarkers, and future directions for integrating ADCs into personalized treatment strategies.
https://www.thelancet.com/series-do/gynaecological-cancers-advances?dgcid=raven_jbs_etoc_feature_eclinmgyno26
Key facts about the Bundibugyo virus outbreak The Lancet Infectious Diseases ++... +...
Key facts about the Bundibugyo virus outbreak
The Lancet Infectious Diseases
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00293-8/fulltext?dgcid=raven_jbs_etoc_email
Jul 2026
Volume 26Number 7p651-750, e268-e336
https://www.thelancet.com/journals/laninf/issue/vol26no7/PIIS1473-3099(26)X2006-0
Ebola Collection
https://www.thelancet.com/ebola?dgcid=raven_jbs_etoc_feature_ebola26
A dynamic graph-based PU-learning approach for sequential recommendation in rare disease detection Guanhao Wei* [1] , Yunlong Wang [1] , Li Zhou [1]
https://www.academia.edu/3071-0286/2/2/10.20935/AcadAI8326
Introduction: Rare diseases affect over 300 million people globally; their low prevalence often leads to high misdiagnosis rates. While Electronic Health Record (EHR) data offers opportunities for early detection, existing predictive models struggle to capture the complex, time-sensitive sequence of patient journeys.
https://www.academia.edu/journals/academia-ai-and-applications/articles?source=journal-top-nav
Are Cancer Guidelines Hemming In Creativity? David Kerr, MD, DSc
https://www.medscape.com/viewarticle/are-cancer-guidelines-hemming-creativity-2026a1000k3y?ecd=wnl_edit_tpal_etid8458269&uac=148436CN&impID=8458269
Hello. I’m David Kerr, professor of cancer medicine at University of Oxford. Today, I’d like to talk a little about an excellent publication that’s popped up in Annals of Oncology, my old journal. This is a set of guidelines produced by the European Society for Medical Oncology (ESMO) guidelines group as to how to best, as they would recommend, manage metastatic colorectal cancer.
New diagnostic tool bypasses blood-brain barrier to detect autism early
https://www.news-medical.net/news/20260630/New-diagnostic-tool-bypasses-blood-brain-barrier-to-detect-autism-early.aspx
A study published in NeuroMarkers showed that a nanosensor can measure nitric oxide (NO) from patient-derived stem cells to distinguish autism spectrum disorder (ASD) from intellectual disability (ID), even when both conditions share the exact same genetic mutation.
The researchers, from the Department of Chemistry and Biochemistry at Ohio University, used a carbon-fiber nanosensor, originally developed to study cardiovascular and Alzheimer's disease to measure real-time NO production in induced pluripotent stem cells (iPSCs). The method bypasses the blood-brain barrier, which often makes blood-based biomarkers unreliable for brain conditions.
Foods That Help Lower Blood Sugar Naturally
https://www.news-medical.net/health/Foods-That-Help-Lower-Blood-Sugar-Naturally.aspx
Evidence shows that the right mix of whole grains, legumes, berries, fermented dairy, and fiber-rich foods may help steady glucose release and support long-term metabolic health.
Introduction
This article discusses how low-glycemic foods, dietary fiber, resistant starch, and balanced eating patterns can help moderate postprandial glucose excursions and support long-term metabolic health and diabetes prevention.1,2,3,4
What Are Neuropeptides and Why Are They Important?
https://www.news-medical.net/health/Neuropeptides-explained-How-brain-chemical-signals-affect-health.aspx
Introduction
Within the brain, neurons produce neuropeptides to regulate emotion, pain, metabolism, and the immune response. Rather than acting only locally, neuropeptides can signal through synapses, diffuse through extracellular space, or act as circulating hormone-like messengers, producing effects that often last from seconds to minutes.2,3
Fiber blend relieves constipation and improves stool consistency
https://www.news-medical.net/news/20260630/Fiber-blend-relieves-constipation-and-improves-stool-consistency.aspx
Adults with chronic functional constipation experienced more frequent bowel movements and better stool consistency after taking a blend of dietary fibers from multiple food sources in a placebo-controlled trial.
A recent study in the journal Food Science & Nutrition reports that a combination of dietary fibers from various foods significantly improved symptoms of functional constipation in a small randomized clinical trial compared with placebo.
Knee Distraction Shows Promise in Severe Osteoarthritis Ute Eppinger
https://www.medscape.com/viewarticle/knee-distraction-shows-promise-severe-osteoarthritis-2026a1000lxy?ecd=WNL_trdalrt_pos1_ous_260630_etid8465887&uac=148436CN&impID=8465887
Damaged knee cartilage has long been considered irreparable. Knee distraction may be changing that. The procedure is intended to stimulate tissue regeneration and help patients with severe osteoarthritis delay knee replacement for many years. Early studies have shown encouraging results, though experts caution that expectations should remain realistic.
lunes, 29 de junio de 2026
Results From the Phase 3 ElevAATe Clinical Trial in Alpha-1 Antitrypsin Deficiency by Madaline Spencer| Published on: Jun 19, 2026
Results From the Phase 3 ElevAATe Clinical Trial in Alpha-1 Antitrypsin Deficiency
by Madaline Spencer| Published on: Jun 19, 2026
Alaa Hamed, MD, Global Head of Medical Affairs Rare Diseases at Sanofi, discusses results from the phase 2 ElevAATe clinical trial of efdoralprin alfa in patients with alpha-1 antitrypsin deficiency (AATD).
https://checkrare.com/results-from-the-phase-3-elevaate-clinical-trial-in-alpha-1-antitrypsin-deficiency/
Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks by Madaline Spencer| Published on: Jun 25, 2026
https://checkrare.com/oral-deucrictibant-for-on-demand-treatment-of-hereditary-angioedema-attacks/
A study published in The Lancet Hematology evaluated the efficacy and safety of deucrictibant for the on-demand treatment of hereditary angioedema (HAE) attacks.
Hereditary angioedema (HAE) is a rare condition characterized by recurrent episodes of severe swelling of the skin and mucous membranes. These attacks generally become more frequent after puberty, and continue throughout life, often affecting the skin, gastrointestinal tract, and upper airway. Triggers for these episodic HAE attacks vary but may include emotional and physical stressors, including dental procedures. HAE may be caused by genetic changes in the SERPING1 gene (also called the C1NH gene) or in the F12 gene. In some cases, the genetic cause is not yet certain.
Effects of a SGLT2 inhibitor on Reducing Heart Failure in Carriers of Cardiomyopathy-Associated Genetic Variants by Madaline Spencer| Published on: Jun 24, 2026
Effects of a SGLT2 inhibitor on Reducing Heart Failure in Carriers of Cardiomyopathy-Associated Genetic Variants
by Madaline Spencer| Published on: Jun 24, 2026
https://checkrare.com/effects-of-a-sglt2-inhibitor-on-reducing-heart-failure-in-carriers-of-cardiomyopathy-associated-genetic-variants/
Results From the VISIONARY Clinical Trial of Sibeprenlimab in Patients With IgA Nephropathy by Madaline Spencer| Published on: Jun 29, 2026
Results From the VISIONARY Clinical Trial of Sibeprenlimab in Patients With IgA Nephropathy
by Madaline Spencer| Published on: Jun 29, 2026
https://checkrare.com/results-from-the-visionary-clinical-trial-of-sibeprenlimab-in-patients-with-iga-nephropathy/
Advancing Clinical Excellence IMPACT CLL & MCL: IMPlementing Advances in Cancer Treatment for Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma
Advancing Clinical Excellence
IMPACT CLL & MCL: IMPlementing Advances in Cancer Treatment for Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma
Welcome to our educational platform, where Medscape Oncology Global provides high-quality education specifically designed for hematologists/oncologists and members of the multidisciplinary team to identify and address the key barriers to effective patient care in...
https://www.medscape.org/advances/impact-cll-mcl-2025a1000ar6?src=mkmcmr_driv_32025_mscpedu_436318.01_ace_launch&uac=148436CN
Editorial p445 Maternal depression: improving estimates and care The Lancet Psychiatry +... ++
Editorial
p445
Maternal depression: improving estimates and care
The Lancet Psychiatry
https://www.thelancet.com/journals/lanpsy/issue/vol13no6/PIIS2215-0366(26)X2004-1
Pharmacological interventions for ADHD: a systematic review and dose–effect network meta-analysis
Mikail Nourredine, PhDa,b,c Send email to mikail.nourredine@chu-lyon.fr ∙ Lucie Jurek, PhDa,d,e ∙ Tasnim Hamza, PhDf ∙ Andrea Cipriani, PhDg,h,i ∙ Fabien Subtil, PhDb,c ∙ Valeria Parlatini, PhDj,k,l,m ∙ et al.
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(26)00091-X/fulltext?dgcid=hubspot_email_infocusalerts-psychiatry_feature&utm_campaign=infocusalerts-psychiatry&utm_medium=email&_hsenc=p2ANqtz-8A1JtLEF6TUj6R-Ov5kaERaQBzYJrY6f47wjRhm-Q5WuqClFECQA07hkqsPGr9qnIONiMoJ-OOREr4f-XNNkR_Pvuk4w&_hsmi=425864235&utm_content=425699340&utm_source=hs_email
Global mental health disparities among transgender women and transfeminine people living with HIV: a systematic review and meta-analysis of 63 studies
David R A Coelho, MDa,b Send email to daraujocoelho@mgh.harvard.edu ∙ Maria L R Defantec ∙ Rômulo da Silva Sanglardd ∙ Beatriz Ximenes Mendes, MDe ∙ Willians Fernando Vieira, PhDf,g ∙ Carrie G Wade, MLISh ∙ Arjee Javellana Restar, PhDi ∙ Lilia Maria Lima de Oliveira, MDj ∙ Joshua D Salvi, MDb,k,l ∙ Prof Alex S Keuroghlian, MD
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(26)00004-4/abstract?utm_campaign=infocusalerts-psychiatry&utm_medium=email&dgcid=hubspot_email_infocusalerts-psychiatry_feature&_hsenc=p2ANqtz-8RJ5HlRewHzKHWwpdYS_jxH-zDAeQXAPZiCfpJSc1fb9SDBD7o_bxUBlBBk7aWY_HlblfJBTaatotwAsrImwREiLbzgg&_hsmi=425864235&utm_content=425699340&utm_source=hs_email
A Graduate Student With Foot Pain and Stress Fractures Heidi Moawad, MD ++++
https://reference.medscape.com/viewarticle/graduate-student-foot-pain-and-stress-fractures-2026a1000i7k?ecd=WNL_casechlg_260628_MSCPREF_etid8458350&uac=148436CN&impID=8458350
Editor's Note:
The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians, but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please email us at ccsuggestions@medscape.com with the subject line "Case Challenge Suggestion." We look forward to hearing from you.
Hematemesis and Heartburn in a Woman With a History of Heavy NSAID Use
Sarah El-Nakeep, MD
https://reference.medscape.com/viewarticle/hematemesis-and-heartburn-woman-history-heavy-nsaid-use-2026a1000fiv?ecd=WNL_casechlg_260628_MSCPREF_etid8458350&uac=148436CN&impID=8458350
A 50-year-old woman presents with a 1-day history of hematemesis. She reports progressive episodes of vomiting over the preceding month, self-managed with over-the-counter (OTC) antiemetics, as well as severe epigastric pain of increasing intensity. She also reports severe heartburn for the past year, self-treated with milk and OTC antacids.
A 27-Year-Old Model With White Facial Macules and Graying Hair
Miriam Kinai, MBBCh
https://reference.medscape.com/viewarticle/27-year-old-model-white-facial-macules-and-graying-hair-2026a1000d47?ecd=WNL_casechlg_260628_MSCPREF_etid8458350&uac=148436CN&impID=8458350
A Violaceous Retiform Rash With Progressive Lower Extremity Ischemia in a 66-Year-Old Man
Margaret Mercante; Rishab Revankar, MD; Shira Lanyi, MD; Gabrielle Schwartzman, MD; Danielle Nelson, MD; Scott Berg, MD; Barrett Zlotoff, MD
https://reference.medscape.com/viewarticle/violaceous-retiform-rash-progressive-lower-extremity-2026a1000d6p?ecd=WNL_casechlg_260628_MSCPREF_etid8458350&uac=148436CN&impID=8458350
Background, Initial Presentation, and Physical Examination
A 66-year-old man with a history of JAK2-positive essential thrombocytosis, polysubstance use disorder, and prior right lower extremity osteomyelitis status post-toe amputation presents with worsening right foot pain, ulceration, and a violaceous rash extending proximally up the lower extremity. The patient reports having progressive pain and discoloration over several weeks. There is no recent history of trauma, new medications, or systemic infectious symptoms.
Human Papillomavirus Vaccination Linked to Substantial Reduction in Cervical Cancer Deaths, Data Reveal Edited by Vineeta Teotia
https://www.medscape.com/viewarticle/human-papillomavirus-vaccination-linked-substantial-2026a1000lo9?src=
In a population-based study, human papillomavirus (HPV) vaccination in England was associated with a 100% reduction in mortality due to cervical cancer between 2020 and 2024 among women aged 20-24 years who were mostly vaccinated at the age of 12-13 years.
Induction Immunotherapy Has Durable Survival Benefit in Locally Advanced Cervical Cancer Christos Evangelou, MSc, PhD June 29, 2026
https://www.medscape.com/viewarticle/induction-immunotherapy-has-durable-survival-benefit-locally-2026a1000lzq?src=
Giving dual checkpoint blockade ahead of chemoradiation yields a high 3-year survival rate for patients with locally advanced cervical cancer, particularly for those with “hot” tumors, according to updated data from the phase 2 COLIBRI-1 trial.
Mezigdomide Triplet Improves PFS in R/R Multiple Myeloma Edited by Gargi Mukherjee Blood. 2026; doi:10.1182/blood.2025032270
https://www.medscape.com/viewarticle/mezigdomide-triplet-improves-pfs-r-r-multiple-myeloma-2026a1000lzr?src=
Mezigdomide in combination with carfilzomib and dexamethasone more than doubled the median progression-free survival (PFS) compared with carfilzomib-dexamethasone in patients with relapsed or refractory (R/R) multiple myeloma, though rates of grade 3 or 4 adverse events, including infections, were higher with the mezigdomide triplet regimen.
EMA Turns Down 3 Therapies Across Oncology, Transplantation Edited by Joyani Das
https://www.medscape.com/viewarticle/ema-turns-down-3-therapies-across-oncology-transplantation-2026a1000lzz?src=
The European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) has recommended refusing marketing authorization for three investigational therapies for cancer and transplant-related conditions: Tacquell (autologous melanoma-derived tumor infiltrating lymphocytes, ex vivo-expanded; Netherlands Cancer Institute), Yartemlea (narsoplimab; Omeros Ireland Limited), and Xervyteg (allogeneic fecal microbiota, pooled; MaaT Pharma).
What Medicine Misses When You Feel Ill Arya Anthony Kamyab, MBBS
https://www.medscape.com/viewarticle/what-medicine-misses-when-you-feel-ill-2026a1000l1r?ecd=WNL_trdalrt_pos1_ous_260629_etid8462876&uac=148436CN&impID=8462876
Medicine is often presented as the science of identifying what has gone wrong within the body. We can generally describe this act as the identification of disease, and it is the primary remit of doctors. Diseases are usually described as conditions that impair normal functioning, yet we also find definitions of disease that tempt us to use disease and illness interchangeably. This is where we ask what it truly means to be ill and whether doctors would do better shifting some of their attention away from disease to understand illness.
Not all clicks are equal: digital dose, content, and user disposition in mental health Lalit Gupta* [1] , Devang Bharti [1] , Shubhi Singhal [2] + +... +
https://www.academia.edu/2997-9196/3/1/10.20935/MHealthWellB8208
Digital environments have become an integral part of our lives, with the global average screen time fast approaching 7 h per day. This rapid shift has sparked ongoing debates regarding its consequences on mental well-being. Existing research on this topic has produced inconsistent findings, partly because it attempts to answer an oversimplified question of whether digital environments are “good” or “bad” for mental health. This mini review aims to examine why such a simplistic binary perspective is inadequate. We conducted a narrative literature search of major scientific databases covering studies published between 1990 and 2025 and analysed the evidence using a tripartite Dose–Content–Disposition (DCD) framework. Dose refers to the quantity and pattern of digital exposure, content to the qualitative nature of digital environments, and disposition to the users’ personality traits and characteristics. Our analysis reveals that high dose is not inherently harmful; rather, its impact is moderated by content (e.g., active versus passive engagement, socially connective versus comparative material) and disposition (e.g., vulnerability factors such as low self-esteem or pre-existing mental health conditions). The reviewed literature suggests that the mental health impact of digital environments is neither linear nor uniform but is shaped by a complex interplay between these DCD variables. This framework provides a tool to analyze the mixed results in the field and also highlights the need for more nuanced research methods, individualized analytical approaches, and ethical, well-being-oriented design principles. Future research should prioritize longitudinal and experience-sampling methodologies, identification of user profiles, and interdisciplinary collaborations to incorporate mental health considerations into platform architecture. As a mini review, this article is limited by its non-systematic approach, which may introduce selection bias, and the inherent challenges of drawing definitive conclusions from methodologically diverse studies.
https://www.academia.edu/journals/academia-mental-health-and-well-being/articles?source=journal-top-nav
Electronic media use, sleep behavior, and internalizing problems in adolescents with ADHD
Jessica Wiepking* [1], Denise Horton [1], Michael Langlais [1,2]
https://www.academia.edu/2997-9196/3/2/10.20935/MHealthWellB8379
domingo, 28 de junio de 2026
Industry focus eBook - Cell and gene therapy (2nd edition)
https://www.news-medical.net/industry-focus/Industry-focus-eBook--Cell-and-gene-therapy-(2nd-edition)
The cell and gene therapy field is moving fast, and this eBook has been hand-picked to help you keep up with the latest developments.
Event guide: The 4th Precision Medicine in Inflammatory Bowel Disease Summit
https://www.news-medical.net/industry-focus/Event-guide-The-4th-Precision-Medicine-in-Inflammatory-Bowel-Disease-Summit
Precision medicine could transform the way Crohn’s disease and ulcerative colitis are treated - shifting the focus from symptom control to targeted, data-driven therapies designed for durable remission.
eBook: Integrated solutions for metabolic disease drug development
https://www.news-medical.net/industry-focus/eBook-Integrated-solutions-for-metabolic-disease-drug-development
This eBook from ACROBiosystems looks at the connected landscape of metabolic diseases - including type 1 and type 2 diabetes, obesity, and metabolic associated steatotic liver disease (MASLD) - and how therapeutic strategies are evolving to address them.
Event guide: 3rd Measuring Patient Engagement Summit
https://www.news-medical.net/industry-focus/Event-guide-3rd-Measuring-Patient-Engagement-Summit
Moving beyond anecdotal engagement, the 3rd Measuring Patient Engagement Summit centres on measurable, data-driven patient involvement across clinical development.
Event guide: 8th Neuroimmunology Drug Development Summit 2026
https://www.news-medical.net/industry-focus/Event-guide-8th-Neuroimmunology-Drug-Development-Summit-2026
The 8th Neuroimmunology Drug Development Summit 2026 is a flagship event for companies advancing therapies at the intersection of neuroscience and immunology.
This guide covers emerging targets, translational models, and clinical trial learnings across MS, neuroinflammation, and neurodegenerative disease pipelines.
Industry Focus eBook - Immunology (3rd edition)
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-Immunology-(3rd-edition)
This Immunology eBook looks at the growing importance of immune research, providing insights into how it can deepen our understanding of disease, improve diagnostics, and support therapeutic development.
Designed for researchers, clinicians, and life science professionals, this edition explores how immune responses are measured, interpreted, and modulated using a combination of biomarker analysis, molecular biology, and emerging therapeutic strategies.
From identifying reliable indicators of immune activation to examining how the gut microbiome influences cancer development and how disrupted iron levels may contribute to long COVID, the eBook highlights the role of immune dysregulation across both acute and chronic conditions.
It also explores the growing importance of biomarkers in clinical and research settings, including periostin in allergic diseases and the clinical measurement of soluble immune receptors such as sIL-2R in diagnostic laboratories, alongside investigations into rare but significant immune-mediated events such as vaccine-induced thrombosis.
Overall, this eBook demonstrates how advances in biomarker discovery, mechanistic insight, and therapeutic innovation are strengthening the field of immunology and supporting improved outcomes across a wide range of diseases.
Industry Focus eBook - Clinical & Point of Care Diagnostics (1st edition)
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-Clinical-Point-of-Care-Diagnostics-(1st-edition)
Advances in clinical and point-of-care diagnostics are helping improve disease detection, patient monitoring, and clinical decision-making across healthcare settings. In our latest Clinical & Point-of-Care Diagnostics Editorial eBook, we’ve brought together expert insights, emerging research, and application-focused articles that explore the technologies shaping modern diagnostic workflows.
What’s inside the Clinical & Point-of-Care Diagnostics eBook?
This eBook explores the growing role of microscopy, biosensing, biomarker research, and AI-driven analysis in clinical diagnostics and healthcare research. From pathology imaging and preventive testing to infectious disease detection and neurological research, the collection highlights how diagnostic technologies are supporting faster, more accurate analysis across laboratories and healthcare environments.
The eBook also examines advances in rapid microfluidic biosensing, the importance of staining and imaging in pathology microscopy, and emerging AI systems capable of mapping gene expression across the whole body. Alongside these developments, it explores new guidance for the care of acute pulmonary embolism and the evolving understanding of antibiotic resistance and tolerance.
Whether you work in clinical laboratories, pathology, diagnostics development, or biomedical research, this eBook provides valuable insight into the technologies and trends shaping the future of clinical and point-of-care diagnostics.
Industry focus eBook: Genomics (4th edition)
https://www.news-medical.net/industry-focus/Industry-focus-eBook-Genomics-(4th-edition)
Advances in genomics and molecular biology are transforming how researchers study disease, gene regulation, and cellular function across healthcare and life science applications. In our latest Genomics Editorial eBook, we’ve compiled expert insights, emerging research, and application-focused articles that explore the technologies and discoveries shaping modern genomics workflows.
What’s inside the Genomics eBook?
This eBook explores the growing role of sequencing technologies, gene editing tools, epigenetics, and molecular analysis in advancing biological research and precision medicine. From single-cell RNA sequencing and PCR purification to CRISPR research and oligonucleotide delivery, the collection highlights how genomics technologies are supporting a stronger understanding of gene expression, cellular behavior, and disease mechanisms.
The eBook also examines emerging research on brain development, epigenetic regulation, and antibiotic persistence, as well as practical workflow considerations, such as liquid-handling solutions for next-generation sequencing laboratories. Advances in genome engineering are also featured, including research into CRISPR enzymes that respond to human DNA methylation.
Whether you work in genomics research, molecular biology, biotechnology, or clinical science, this eBook provides valuable insight into the technologies and discoveries shaping the future of genomics.
Industry Focus eBook - Neurology/Neuroscience - 2nd edition
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-NeurologyNeuroscience-2nd-edition
Neuroscience is advancing at an extraordinary pace, transforming how researchers study the brain, diagnose disease, and develop new therapeutic approaches. From advances in whole-brain mapping to innovative treatment strategies, the field is creating new opportunities for earlier diagnosis, deeper biological understanding, and more targeted interventions.
To highlight some of the latest developments, we've pulled together a collection of research breakthroughs, analytical innovations, and disease-focused discoveries in our latest Neuroscience Industry Focus eBook. The eBook explores how neuroscience research is evolving across biomarker discovery, neurodegenerative disease research, and emerging therapeutic technologies.
Inside the eBook:
How whole-brain mapping and connectomics are helping researchers unravel the brain's complex networks
Why next-generation immunoassay technologies are advancing biological testing capabilities
What insulin resistance may reveal about the connection between metabolism and bipolar disorder
How Alzheimer's disease biomarkers could support earlier detection and improved risk prediction
Emerging research into CAR-T cell therapies for targeting Alzheimer's-related plaques
New insights into Parkinson's disease, including protein aggregation and alpha-synuclein biomarkers
Viva Saliva Book: The ultimate guide to saliva Book preview Download
https://www.news-medical.net/industry-focus/Viva-Saliva-Book-The-ultimate-guide-to-saliva-Book-preview-Download
“Viva Saliva” is a thorough guide for experts interested in improving their laboratory methods. It provides an in-depth look at salivary sample preparation and saliva hormone testing, integrating peer-reviewed research with Tecan's results.
The Book is intended to improve laboratory accuracy and efficiency by providing critical insights into adopting advanced saliva-based hormone testing in research and diagnosis settings.
Introduction to saliva diagnostics
The first chapter establishes saliva as the gold standard diagnostic tool, highlighting its simplicity of collection and non-invasive nature.
Saliva is known for its reliability and consistency across many patient populations, including children and the elderly. The chapter discusses the significance of improving pre-analytics for saliva testing, including best practices for saliva collection, sample equipment, storage, and processing.
eBook: Advancing neurodegenerative research with iPSC-derived microglia models
https://www.news-medical.net/industry-focus/eBook-Advancing-neurodegenerative-research-with-iPSC-derived-microglia-models
Neurodegenerative diseases affect about 15 % of the global population and are on the rise due to aging demographics. Neuroinflammation, driven by the brain’s immune cells known as microglia, is a key factor in these diseases.
Due to microglia’s close link to neurodegenerative diseases like Alzheimer's, ALS, and Parkinson’s, they play an increasingly vital role in in vitro neurodegenerative and neurological disease modeling.
Human iPSC-derived microglia retain the donor's phenotypic characteristics, making them ideal for creating human-relevant model systems. These microglia offer exciting opportunities to test potential therapies in disease-specific models, advancing research and drug discovery.
Industry Focus eBook - Pharmaceutical Manufacturing (1st edition)
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-Pharmaceutical-Manufacturing-(1st-edition)
Pharmaceutical manufacturing sits at the intersection of science, technology, and global health - driving critical advances in how medicines are developed, produced, and delivered.
News Medical has compiled a collection of the top articles, interviews, and industry insights from the past 12 months in this latest edition of the Pharmaceutical Manufacturing eBook.
eBook Contents
Top interviews with industry experts driving change in pharmaceutical production.
Standout news pieces covering recent breakthroughs, challenges, and market shifts.
Key pieces written by our scientific collaborators.
Featured articles exploring new manufacturing methods, regulatory trends, and advanced testing tools.
Sources, further reads, and related stories you can find on News Medical.
Industry Focus eBook - Cell & Gene Therapy (1st Edition)
https://www.news-medical.net/industry-focus/Industry-Focus-Cell-Gene-Therapy
This exclusive eBook brings together the latest in research, expert commentary, and personal stories that show how cell and gene therapy is making a real difference. You’ll find everything from firsthand accounts of CAR T-cell breakthroughs to exciting developments in single-cell analysis and CRISPR-based diagnostics - all in one place.
Ultimate guide to the essential tools for the characterization of proteins, polymers and nanoparticles
https://www.news-medical.net/industry-focus/Ultimate-Guide-to-the-essential-tools-for-the-characterization-of-proteins-polymers-and-nanoparticles
This guide offers a clear, in-depth look at the capabilities, applications, and innovations behind Wyatt Technology’s light scattering solutions, equipping you with the information needed to make confident choices in high-resolution macromolecular analysis.
Wyatt instruments measure a wide range of key parameters, including molar mass, particle size, structural conformation, charge, and binding affinity. These tools are essential for characterizing:
Proteins, polymers, nanoparticles, viral vectors, exosomes, and more
Gene therapy and drug delivery systems
Complex conjugates and biotherapeutics
With advanced systems like the DAWN®, miniDAWN®, and DynaPro® instrument families, along with user-friendly software such as ASTRA® and DYNAMICS®, Wyatt gives researchers the power to explore molecular detail with clarity and precision. Whether you're working in life sciences, pharmaceuticals, materials science, or nanotechnology, this guide will help you understand what these technologies can do - and how to choose the right solution for your needs.
Industry Focus eBook - Neurology & Neuroscience (1st edition)
This Industry Focus eBook on Neurology and Neuroscience brings together expert perspectives on Alzheimer’s disease and the broader field of brain health.
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-Neurology-Neuroscience-(1st-edition)
As progress in diagnostics, therapeutics, biomarker development, and digital health continues, our understanding of Alzheimer’s disease and related neurological conditions is becoming more refined. Work taking place across research laboratories and clinical settings is informing earlier detection strategies, more precise measurement tools, and evolving approaches to patient care.
Inside this eBook, you’ll find coverage of key developments across the field, from advances in blood-based biomarkers and metabolic research to the use of artificial intelligence in neurological imaging and luminescence immunoassays designed to improve the detection of tau pathology. It also examines how factors such as the gut microbiome and sex-specific risk profiles are influencing prevention strategies and long-term care planning.
Technology remains central throughout, with insights into how machine learning and sensor-based systems are supporting earlier intervention and more responsive care environments for individuals living with Alzheimer’s and related disorders.
Download the eBook to explore the research, perspectives, and practical insights shaping the future of neurology and neuroscience.
Industry Focus eBook - Medical device (2nd edition)
https://www.news-medical.net/industry-focus/Industry-Focus-eBook--Medical-device-(2nd-edition)
Welcome to this Industry Focus eBook on Medical Devices, a collection of expert perspectives and essential insights into the technologies shaping modern healthcare.
As the landscape of healthcare continues to evolve, the role of medical devices is becoming both broader and more sophisticated. Innovation at the intersection of engineering, data science, and materials is driving real progress in diagnostics, therapy delivery, and patient care.
In the pages that follow, you’ll find thoughtful reflections on emerging tools, from intelligent wearables and advanced implantables to compact electronics built for continuous, real-world use. These systems are increasingly adaptive, data-driven, and integrated into broader care strategies, bringing new possibilities for both clinicians and patients.
We also explore advances in materials science that are improving biocompatibility, durability, and device performance, the quiet achievements that often underpin the success of more visible breakthroughs.
Our hope is that this collection offers a clear, engaging view of where medical device innovation is headed and why it matters.
Untargeted metabolomics approach identifies potential biomarkers for latent tuberculosis diagnosis
https://www.news-medical.net/news/20260605/Untargeted-metabolomics-approach-identifies-potential-biomarkers-for-latent-tuberculosis-diagnosis.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=metabolomics_newsletter_25_june_2026
Announcing a new article publication in BIO Integration. Latent tuberculosis infection (LTBI) is difficult to diagnose due to the lack of a definitive gold standard. This study aimed to explore plasma metabolic alterations associated with LTBIs using an untargeted metabolomics approach.
Scientists map blood chemistry links to hundreds of diseases
https://www.news-medical.net/news/20260624/Scientists-map-blood-chemistry-links-to-hundreds-of-diseases.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=metabolomics_newsletter_25_june_2026
A sweeping plasma metabolite map from nearly 390,000 participants links blood chemistry to disease risk, comorbidity patterns, and future diagnostic possibilities.
Gut changes linger years after polyp removal and may signal colorectal cancer risk
https://www.news-medical.net/news/20260528/Gut-changes-linger-years-after-polyp-removal-and-may-signal-colorectal-cancer-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=metabolomics_newsletter_25_june_2026
More than a decade after adenoma removal, women still carried gut microbial and metabolic signatures that partly mirrored colorectal cancer, pointing to a possible hidden biological link between past polyps and future cancer risk.
Industry Focus eBook - Metabolomics
Metabolomics is rapidly reshaping how researchers decode the molecular foundations of health, disease, and environmental interactions. In this latest Industry Focus eBook, we explore how advances in analytical technologies and multi-omics integration are enabling deeper, more precise investigation of complex biological systems. From improving data quality in LC-MS workflows to extending sensitivity for low-abundance compounds, the field is entering a new phase defined by greater accuracy, reproducibility, and scale.
https://www.news-medical.net/industry-focus/Industry-Focus-eBook-Metabolomics?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=metabolomics_newsletter_25_june_2026
Metabolomics is transforming how researchers understand the complex relationships between health, disease, and the environment.
This eBook explores the latest advances in analytical technologies, multi-omics integration, AI-driven data analysis, and biomarker discovery, highlighting how metabolomics is enabling deeper insights into biological systems, drug development, and precision medicine. Download your copy to discover the innovations shaping the future of life science research.
sábado, 27 de junio de 2026
What Are Brain-Computer Interfaces and How Do They Treat Neurological Disorders?
https://www.news-medical.net/life-sciences/What-Are-Brain-Computer-Interfaces-and-How-Do-They-Treat-Neurological-Disorders.aspx
Precision brain interfaces are transforming neurostimulation by combining brain-computer interfaces, neural biomarkers, artificial intelligence, and closed-loop feedback systems to deliver personalized treatment for treatment-resistant neurological and psychiatric disorders.
Treatment-resistant neurological and psychiatric disorders, including Parkinson’s disease, epilepsy, and major depressive disorder, continue to impose a substantial global health burden despite advances in medication and rehabilitation therapies. Traditional neurostimulation technologies typically rely on fixed stimulation parameters that do not adjust to constantly changing brain activity. However, advances in brain-computer interface systems, neural recording technology, and computational analytic methods are producing a new generation of precision brain interface systems referred to as "Neurostimulation 2.0."
AI designs personalized burgers balancing taste, nutrition and sustainability
https://www.news-medical.net/news/20260626/AI-designs-personalized-burgers-balancing-taste-nutrition-and-sustainability.aspx
Stanford researcher Ellen Kuhl estimates that there are some 1043 potential burger recipes in the world. And with BurgerAI, a new tool developed in her lab, artificial intelligence can now design the best one for you based on your age, taste, nutritional need, and even your sustainability goal.
Gut microbes emerge as potential players in estrogen-driven cancers
https://www.news-medical.net/news/20260625/Gut-microbes-emerge-as-potential-players-in-estrogen-driven-cancers.aspx
Scientists say gut microbes may do more than recycle estrogen, but turning the endocrine-microbiome axis into a cancer therapy target will require stronger causal and clinical evidence.
In a recent review published in the journal npj Biofilms and Microbiomes, researchers reviewed current evidence on how interactions between the microbiome and the endocrine system influence hormone-driven cancers and explored their potential as future therapeutic targets.
One common type of fat may increase diabetes risk, while another helps fight it Palmitic acid promotes inflammation and cellular stress, impairing insulin action, researchers say Melissa Rudy By Melissa Rudy Fox News Published June 24, 2026 7:00am EDT
One common type of fat may increase diabetes risk, while another helps fight it
Palmitic acid promotes inflammation and cellular stress, impairing insulin action, researchers say
Melissa Rudy By Melissa Rudy Fox News
Published June 24, 2026 7:00am EDT
https://www.foxnews.com/health/one-common-type-fat-may-increase-diabetes-risk-another-helps-fight
New blood test detects 90% of aggressive prostate cancer cases, beating current screenings Researchers say the test could enable earlier detection without unnecessary follow-up procedures Angelica Stabile By Angelica Stabile Fox News Published June 27, 2026 9:00am EDT
New blood test detects 90% of aggressive prostate cancer cases, beating current screenings
Researchers say the test could enable earlier detection without unnecessary follow-up procedures
Angelica Stabile By Angelica Stabile Fox News
Published June 27, 2026 9:00am EDT
https://www.foxnews.com/health/new-blood-test-detects-90-aggressive-prostate-cancer-cases-beating-current-screenings
Former reality star opens up about new diagnosis after years-long health ordeal Brandi Glanville claims the tumor is connected to a facial parasite she contracted in Morocco Melissa Rudy By Melissa Rudy Fox News Published June 24, 2026 7:28pm EDT
Former reality star opens up about new diagnosis after years-long health ordeal
Brandi Glanville claims the tumor is connected to a facial parasite she contracted in Morocco
Melissa Rudy By Melissa Rudy Fox News
Published June 24, 2026 7:28pm EDT
https://www.foxnews.com/health/former-reality-star-opens-up-about-new-diagnosis-after-years-long-health-ordeal?lid=unhr21sy36wm
Switching from cigarettes to vapes linked to higher risk of major eye diseases, large study finds Those who switched faced a 24% higher risk of diabetic retinopathy compared to those who quit nicotine entirely By Khloe Quill Fox News Published June 26, 2026 7:00am EDT
Switching from cigarettes to vapes linked to higher risk of major eye diseases, large study finds
Those who switched faced a 24% higher risk of diabetic retinopathy compared to those who quit nicotine entirely
By Khloe Quill Fox News
Published June 26, 2026 7:00am EDT
https://www.foxnews.com/health/switching-cigarettes-vapes-linked-higher-risk-major-eye-diseases-large-study-finds?lid=l7s5m9myk1ic
Latest COVID vaccine may have unexpected health benefit, study suggests Research showed link between vaccine and small reduction in COVID-related cardiovascular events Angelica Stabile By Angelica Stabile Fox News Published June 25, 2026 7:00am EDT
Latest COVID vaccine may have unexpected health benefit, study suggests
Research showed link between vaccine and small reduction in COVID-related cardiovascular events
Angelica Stabile By Angelica Stabile Fox News
Published June 25, 2026 7:00am EDT
https://www.foxnews.com/health/latest-covid-vaccine-may-unexpected-health-benefit-new-study-suggests?lid=4yp5qi3321bh
8 common food preservatives linked to higher risk of high blood pressure and heart disease Researchers tracked dietary intake over eight years and identified potentially dangerous additives Melissa Rudy By Melissa Rudy Fox News Published June 22, 2026 7:00am EDT
8 common food preservatives linked to higher risk of high blood pressure and heart disease
Researchers tracked dietary intake over eight years and identified potentially dangerous additives
Melissa Rudy By Melissa Rudy Fox News
Published June 22, 2026 7:00am EDT
https://www.foxnews.com/health/8-common-food-preservatives-linked-higher-risk-high-blood-pressure-heart-disease?lid=56ssrmspjccr
Childhood cancer control in Asia +...
https://www.thelancet.com/series-do/childhood-cancer-asia?dgcid=hubspot_email_conferencealerts_childhoodcancerasia25&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-9M8d2ua6rw8t-rLsbzbLiNmNo6EjYntZApLNp3slKDrd7tC5gNLdU3TgiiW3VM5iELYl4QB6hdl8qeyyUTVj2-wWkzhw&_hsmi=425534453&utm_content=425534453&utm_source=hs_email
This Series published in The Lancet Child & Adolescent Health and eClinicalMedicine focuses on the challenges and opportunities for childhood cancer care in Asia, which has half the global paediatric cancer burden.
In Paper 1, Nakata and colleagues highlight the wide spectrum of incidence, mortality, and survival estimates, and the need for quality population-based cancer data. In Paper 2, Khan and colleagues summarise the history and status of paediatric cancer trials and review challenges such as gaps in research infrastructure, insufficient funding support, and barriers to patient participation. In Paper 3, Tso and colleagues discuss the hurdles in providing long-term care for childhood cancer survivors and priorities for action to promote equitable and quality survivorship care in the Asian continent.
Dignity and mental health in Latin America: Peruvian observations and perspectives Renato D. Alarcón* [1,2] , Luis Matos-Retamozo [2,3] + +...
https://www.academia.edu/2997-9196/3/1/10.20935/MHealthWellB8170
This is a concise literature-based delineation of dignity and its connections with important mental health issues in the Latin American continent. This review examines the relationship between dignity and mental health in Latin America, focusing mostly on Peruvian socio-cultural studies and clinical perspectives. Drawing on published literature, an introductory geographic description and a historical narrative supported by socio-demographic data and cultural realities of the region, the review explores how dignity is shaped by cultural identity and by the mestizaje process as a decisive ontological feature. A series of seven cases covering different aspects of the impact of clinical events on the dignity of the protagonists is presented. Dignity is explored from the perspective of native healers, mothers and human rights principles, as well as its fragility in the face of socio-political, racism-induced conflicts, and sectarian/religious deformations. The difficulties faced in overcoming reductionistic and alienating influences, as well as social inequalities affecting dignity, are discussed. The review emphasizes, in turn, its consideration as one of the central issues of psychotherapeutic approaches and much-needed investigation projects.
https://www.academia.edu/journals/academia-mental-health-and-well-being/articles?source=journal-top-nav
Electronic media use, sleep behavior, and internalizing problems in adolescent with ADHD
Jessica Wiepking, Denise Horton, Michael Langlais
Volume 3, Issue 2
The Lancet Commission on rethinking misinformation, health, and human security ++...
The Lancet Commission on rethinking misinformation, health, and human security
Heidi J Larsona,b Send email to heidi.larson@lshtm.ac.uk ∙ Alexander Dodooc ∙ Niall Boyced ∙ Yik-Ying Teo
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01128-1/abstract?dgcid=raven_jbs_etoc_feature_lancet
Editorial
p2577
Cancer in young adults: out of the shadows?
The Lancet
https://www.thelancet.com/journals/lancet/issue/vol407no10548/PIIS0140-6736(26)X2023-2
viernes, 26 de junio de 2026
Results From the CEPHEUS Clinical Trial of Daratumumab Combination Therapy in Newly Diagnosed Multiple Myeloma by Madaline Spencer| Published on: Jun 25, 2026
Results From the CEPHEUS Clinical Trial of Daratumumab Combination Therapy in Newly Diagnosed Multiple Myeloma
by Madaline Spencer| Published on: Jun 25, 2026
Saad Usmani, MD, Hematologist-Oncologist at Memorial Sloan Kettering Cancer Center, discusses results from the CEPHEUS clinical trial of daratumumab combination therapy in patients with newly diagnosed multiple myeloma (MM).
https://checkrare.com/results-from-the-cepheus-clinical-trial-of-daratumumab-combination-therapy-in-newly-diagnosed-multiple-myeloma/
Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks by Madaline Spencer| Published on: Jun 25, 2026
Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks
by Madaline Spencer| Published on: Jun 25, 2026
A study published in The Lancet Hematology evaluated the efficacy and safety of deucrictibant for the on-demand treatment of hereditary angioedema (HAE) attacks.
https://checkrare.com/oral-deucrictibant-for-on-demand-treatment-of-hereditary-angioedema-attacks/
Long-Term Results of Ziftomenib Combination Therapy in Patients With Acute Myeloid Leukemia by Madaline Spencer| Published on: Jun 26, 2026
Long-Term Results of Ziftomenib Combination Therapy in Patients With Acute Myeloid Leukemia
by Madaline Spencer| Published on: Jun 26, 2026
Eunice S. Wang, MD, Chief of Leukemia at Roswell Park Comprehensive Cancer Center, discusses long-term results of ziftomenib in combination with venetoclax and azacitidine in patients with acute myeloid leukemia (AML).
https://checkrare.com/long-term-results-of-ziftomenib-combination-therapy-in-patients-with-acute-myeloid-leukemia/
Newborn Resuscitation and Support of Transition of Infants at Birth Source: Resuscitation Council UK
https://reference.medscape.com/cc2/p10/rcuk-guideline-newborn-resuscitation-and-support-2026a1000gt0?ecd=WNL_drugguide_260626_MSCPREF_idhiv_etid8450288&uac=148436CN&impID=8450288
This Medscape guideline summary covers recommendations by the Resuscitation Council UK on how to support newborn transition and perform resuscitation at birth, including preparation, assessment, interventions, and post-resuscitation care. It applies to both hospital and out-of-hospital settings (especially when there is an unexpected and/or preterm birth).
For information on background, rationale and objectives, target audience, scope of the recommendations, and persons affected by them, refer to the full RCUK guideline.
A list of abbreviations can be found at the end of this summary.
Blood Transfusion Source: National Institute for Health and Care Excellence
https://reference.medscape.com/cc2/p10/nice-blood-transfusion-guideline-2026a1000gal?ecd=WNL_drugguide_260626_MSCPREF_idhiv_etid8450288&uac=148436CN&impID=8450288
Latest Guidance Updates
February 2026: The evidence was reviewed, and new recommendations were made on using tranexamic acid during surgery.
Meningitis (Bacterial) and Meningococcal Disease: Recognition, Diagnosis and Management Source: National Institute for Health and Care Excellence
https://reference.medscape.com/cc2/p10/meningitis-bacterial-and-meningococcal-disease-recognition-2024a10004ka?ecd=WNL_drugguide_260626_MSCPREF_idhiv_etid8450288&uac=148436CN&impID=8450288
Latest Guidance Updates
March 2026: The Medscape Team added in-hospital recommendations, including antibiotics, corticosteroids, monitoring, and discharge.
March 2024: This guideline updates and replaces NICE Clinical Guideline 102 (published June 2010).
Acute Kidney Injury: Prevention, Detection, and Management Source: National Institute for Health and Care Excellence
https://reference.medscape.com/cc2/p10/acute-kidney-injury-aki-guidelines-2026a10006od?ecd=WNL_drugguide_260626_MSCPREF_idhiv_etid8450288&uac=148436CN&impID=8450288
October 2024: NICE reviewed the evidence and made new and updated recommendations, and a recommendation for research, on risk factors for acute kidney injury in adults having iodine-based contrast media. Other minor changes were made.
Post-cardiac Arrest and Refractory Cardiac Arrest Source: Canadian Cardiovascular Society, Canadian Cardiovascular Critical Care Society, Canadian Association of Interventional Cardiology; Medically Reviewed by Dr Shouvik Haldar
https://reference.medscape.com/s/cc2/p10/ccs-cancare-caic-post-cardiac-arrest-refractory-guideline-2025a1000mqm?ecd=WNL_drugguide_260626_MSCPREF_idhiv_etid8450288&uac=148436CN&impID=8450288
In 2024, the CCS, CANCARE, and the CAIC published an update to its expert advice on best practice in post-OHCA/IHCA care. This Medscape overview outlines recommendations from the guideline, including timing of catheterization, BP targets, and management of refractory cardiac arrest.
Please refer to the full guideline for all recommendations, rationale, and background information. A list of abbreviations can be found at the end of this summary.
A new era for psychedelic therapeutics Written byBree Foster, PhD
A new era for psychedelic therapeutics
With multiple trials underway and billions in investment, psychedelic therapies are moving from experimental research toward mainstream mental health care.
Written byBree Foster, PhD
https://www.drugdiscoverynews.com/a-new-era-for-psychedelic-therapeutics-16986?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_E9qq93IC4hegH1Rs489_OXz6ekqgZgBScln19dpQ1xDk_a7XXOM9YhcXvU0p3BoddL_AXQytnoY5goPj43kJkQxUCgQ&_hsmi=425730155&utm_content=425730155&utm_source=hs_email
The next wave of psychedelics focuses on brain rewiring without the trip
By separating therapeutic neuroplasticity from hallucinations, new psychedelic-inspired molecules could make treatment safer and more accessible.
Written byBree Foster, PhD
https://www.drugdiscoverynews.com/the-next-wave-of-psychedelics-focuses-on-brain-rewiring-without-the-trip-17014?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9U6D_yH0U8Y_uQGidImavEO_T8XI57EjfQSpmQHg9k3P0pjvly7z23Q6UtgOqc0ZRAksMvXCCEJ6t-o6WUxacB5pTNIQ&_hsmi=425730155&utm_content=425730155&utm_source=hs_email
Weekly Rundown: Definium's psychedelic drug delivers rapid relief in major depression in late-stage study
Weekly Rundown: Definium's psychedelic drug delivers rapid relief in major depression in late-stage study
Phase 3 trial results for neurological drugs, an AI platform for central nervous system drug discovery, a novel long-acting flu antiviral, and more led the news this week.
Written byDDN editorial team
https://www.drugdiscoverynews.com/weekly-rundown-definium-s-psychedelic-drug-delivers-rapid-relief-in-major-depression-in-late-stage-study-17283?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_XNw8RZ8ntT4qwJaLP1hEOpCvpN-teI5KXP8DoI1rwOXCiDmM3PozDYv6wDrkRux3k6W3Ayf-Qpq_CfKtoHBQA0UGlxA&_hsmi=425730155&utm_content=425730155&utm_source=hs_email
Proton Transfer Mechanisms in the MmpL3 Transporter of Mycobacterium tuberculosis Studied by Computer SimulationsClick to copy article link Yong-Sok Lee*Sergio A. HassanDarrell E. Hurt
https://pubs.acs.org/doi/10.1021/acsbiomedchemau.5c00274
NIAID Researchers Uncover How a Key Tuberculosis Protein Works, Opening New Paths to Combat Drug-Resistant TB
Tuberculosis (TB) is the world's leading infectious disease killer, and drug-resistant strains are becoming more common. A new study from NIAID's Bioinformatics and Computational Biosciences Branch (BCBB) has uncovered how a critical TB protein works at the atomic level, laying the groundwork for new drug design strategies to address emerging resistance to current MmpL3 inhibitors.
The paper, "Proton Transfer Mechanisms in the MmpL3 Transporter of Mycobacterium tuberculosis Studied by Computer Simulations," has been published in ACS Bio & Med Chem Au, selected as the Front Cover, and named an ACS Editors' Choice article for its potential for broad public interest. This research was conducted in connection with the TB Portals program.
https://tbportals.niaid.nih.gov/
Lyme Disease Russell W Steele, MD
https://reference.medscape.com/p11/lyme-disease-2026a1000im7?ecd=wnl_critimg_260626_mscpref_etid8450052&uac=148436CN&impID=8450052
Lyme disease (Lyme borreliosis) remains the most common vector-borne infection in the northern hemisphere. Approximately 30,000 cases are reported in the United States each year; however, a 2021 study estimated the prevalence to be closer to 476,000 cases annually based on insurance claims data from 2010-2018.[1,2,3] It is usually caused by the spirochetal organism Borrelia burgdorferi sensu lato, which is transmitted to humans and animals by Ixodes ticks. The nymphs of these vectors are relatively small (1-2 mm, approximately the size of a poppy seed) and can be difficult to spot, often easily mistaken for dirt or environmental particles. Adult ticks are larger and more visible, and thus, more likely to be identified and removed rapidly. Pathogen transmission typically requires prolonged tick attachment (> 24-36 hours), a very important factor for prevention.
jueves, 25 de junio de 2026
Strategic healthcare interventions bring Japan close to eliminating hepatitis
https://www.news-medical.net/news/20260625/Strategic-healthcare-interventions-bring-Japan-close-to-eliminating-hepatitis.aspx
Hepatitis B (HBV) and hepatitis C (HCV) are viral infections that can lead to health conditions such as cirrhosis, cancer, and potentially death if unmanaged. HBV can be transmitted through sexual contact, blood exposure, and mother-to-child transmission, while HCV is primarily transmitted through blood-to-blood contact. Researchers at Hiroshima University aimed to quantify their current burden of HBV and HCV in Japan and project future trends through 2050 to determine the difference sustained efforts across the country, over the course of decades, can make in the prominence of these two viruses.
Scientists map blood chemistry links to hundreds of diseases
A sweeping plasma metabolite map from nearly 390,000 participants links blood chemistry to disease risk, comorbidity patterns, and future diagnostic possibilities.
https://www.news-medical.net/news/20260624/Scientists-map-blood-chemistry-links-to-hundreds-of-diseases.aspx
Sharing the Decision of Treatment Planning in High-Risk HR+/HER2- Early Breast Cancer Authors: Shaheenah Dawood, MBBCh, MPH, FACP
https://www.medscape.org/viewarticle/sharing-decision-treatment-planning-high-risk-hr-her2-early-2026a1000f67?page=3&uac=148436CN&src=mkmcmr_driv_il_mscpedu_260624_&subtitle-lang-code=es
Sharing the Decision of Treatment Planning in High-Risk HR+/HER2- Early Breast Cancer
Authors: Shaheenah Dawood, MBBCh, MPH, FACP
https://www.medscape.org/viewarticle/sharing-decision-treatment-planning-high-risk-hr-her2-early-2026a1000f67?page=1&uac=148436CN&src=mkmcmr_driv_il_mscpedu_260624_12247769_#transcript-download-es
What Lies Beneath Generalized Myasthenia Gravis: Exploring Novel Mechanisms of Action of Emerging Therapies Authors: Heinz Wiendl, MD
https://www.medscape.org/viewarticle/what-lies-beneath-generalized-myasthenia-gravis-exploring-2026a1000fuh?page=2&uac=148436CN&src=mkmcmr_driv_il_mscpedu_260624_&subtitle-lang-code=es
What Lies Beneath Generalized Myasthenia Gravis: Exploring Novel Mechanisms of Action of Emerging Therapies
Authors: Heinz Wiendl, MD
https://www.medscape.org/viewarticle/what-lies-beneath-generalized-myasthenia-gravis-exploring-2026a1000fuh?page=1&uac=148436CN&src=mkmcmr_driv_il_mscpedu_260624_12252637_#transcript-download-es
At ASMS 2026, mass spectrometry stakes its claim Sessions spanning chemoproteomics, AI-driven proteomics, biotherapeutic characterization, single-cell omics, and spatial multiomics all pointed toward mass spectrometry’s growing role in drug discovery and development. Written byAndrea Corona
https://www.drugdiscoverynews.com/at-asms-2026-mass-spectrometry-stakes-its-claim-17280
The 74th annual conference on Mass Spectrometry and Allied Topics ran June 1–5 at the San Diego Convention Center, bringing together researchers across academia, industry, and government for four days of oral sessions, poster presentations, workshops, and exhibits. The program — spanning more than 40 concurrent oral sessions per day across topics from ion mobility instrumentation to clinical analysis, environmental contaminants, and cancer immunology — offered a cross-section of where mass spectrometry currently sits and where it is heading.
Patient-derived mini brains reveal mechanism and treatment for rare genetic disease Dehydrodolichyl diphosphate synthase (DHDSS)-related disease has no available treatments. The new work could finally change that with nicotinamide mononucleotide (NMN). Written byAllison Whitten, PhD
https://www.drugdiscoverynews.com/patient-derived-mini-brains-reveal-mechanism-and-treatment-for-rare-genetic-disease-17282
Last week at the annual conference of the European Society of Human Genetics in Gothenburg, Sweden, researchers presented work on the first cortical brain organoid models of dehydrodolichyl diphosphate synthase (DHDSS)-related disease — a condition with no current treatments. The pioneering work, led by Eva Morava and Tamas Kozicz's team at the Icahn School of Medicine at Mount Sinai, allowed the scientists to not only elucidate the mechanism of the disease, but also test out a widely available therapeutic — nicotinamide mononucleotide (NMN), better known as vitamin B3.
Palbociclib Gains HER2+ Breast Cancer Maintenance Indication M. Alexander Otto, PA, MMSc June 25, 2026
https://www.medscape.com/viewarticle/palbociclib-gains-her2-breast-cancer-maintenance-indication-2026a1000ljr?src=
The FDA has approved palbociclib (Ibrance, Pfizer) in combination with trastuzumab, with or without pertuzumab, and endocrine therapy for the maintenance treatment of hormone receptor-positive (HR+), HER2+ locally advanced or metastatic breast cancer following induction treatment.
In the phase 3 approval trial, PATINA, adding palbociclib to standard anti-HER2 and endocrine therapies for maintenance resulted in a 24% reduction in the risk for disease progression.
Ontario Docs to Screen Younger Patients for Colon Cancer Liz Scherer
https://www.medscape.com/viewarticle/ontario-docs-screen-younger-patients-colon-cancer-2026a1000lix?src=
As of July 1, Ontario will offer publicly funded colorectal cancer (CRC) screening to patients as young as 45 years. Patients at increased risk will be eligible for publicly funded screening starting at age 40 years. Lowering the CRC screening age from 50 years is expected to provide as many as 1 million Ontarians the opportunity for early detection and treatment.
Mirvetuximab Fails to Boost Survival in Platinum-Eligible Ovarian Cancer Christos Evangelou, MSc, PhD June 25, 2026
https://www.medscape.com/viewarticle/mirvetuximab-fails-boost-survival-platinum-eligible-ovarian-2026a1000lka?src=
The antibody-drug conjugate (ADC) mirvetuximab soravtansine boosts tumor response when added to standard chemotherapy for patients with platinum-sensitive ovarian cancer, but it does not improve their survival outcomes, according to a phase 2 trial.
Two Studies Link GLP-1 Use to Lower Breast Cancer Risk Will Pass June 25, 2026
https://www.medscape.com/viewarticle/two-studies-link-glp-1-use-lower-breast-cancer-risk-2026a1000ln4?src=
GLP-1 receptor agonists (GLP-1 RAs) are associated with reduced incidence of breast cancer among women with overweight or obesity, according to two observational studies.
One found that GLP-1 RA users had a roughly 30% lower incidence of breast cancer than was seen in matched nonusers. The smaller of the two, which followed more than 80,000 women at high risk for breast cancer, found a more modest 16% reduction.
miércoles, 24 de junio de 2026
Researchers uncover key mechanism driving chronic Sjögren disease
https://www.news-medical.net/news/20260624/Researchers-uncover-key-mechanism-driving-chronic-Sjogren-disease.aspx
Sjögren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients’ quality of life. While CD4+ T cells are key drivers of immune-mediated tissue damage and chronic inflammation, the role of pathogenic CD4+ T cell subsets and their non-immune cell partners remains unexplored. Researchers have now identified the preferential CD4+ T cell-fibroblast cellular interaction that amplifies inflammatory proteins and tissue damage, representing a potential target for therapeutic intervention in Sjögren disease.
Collagen membranes: Structure and material analysis
https://www.news-medical.net/whitepaper/20260624/Collagen-membranes-Structure-and-material-analysis.aspx
Collagen is a protein found in the body's various connective tissues. It is mainly found in cartilage, bones, tendons, ligaments, and skin.
Collagen tissues may be rigid (bone), compliant (tendon), or somewhere between rigid and compliant (cartilage).
It is also abundant in corneas, blood vessels, the gut, intervertebral discs, tooth dentin, and muscle tissue. It is a long, fibrous structural protein with exceptional tensile strength. Tough bundles of collagen form a key component of the matrix that supports most tissues and provides cells with structure from the outside.
Microbiome Transplants for Skin, Lung, and Metabolic Diseases
https://www.news-medical.net/health/Microbiome-Transplants-for-Skin-Lung-and-Metabolic-Diseases.aspx
From skin inflammation and chronic lung disease to obesity and diabetes, researchers are uncovering how targeted microbiome interventions could reshape disease treatment by harnessing the therapeutic power of the body's microbial ecosystems.
Plant-based Mediterranean-style diet cuts heart disease risk by 26%
https://www.news-medical.net/news/20260624/Plant-based-Mediterranean-style-diet-cuts-heart-disease-risk-by-2625.aspx
A 20-year study of more than 3,000 Greek adults found that people whose diets most closely resembled a plant-based Mediterranean eating pattern had substantially lower cardiovascular disease risk, while calorie-dense diets low in white meat were linked to worse long-term heart health outcomes.
How I used public radio to recruit 20,000 participants for a peer-reviewed study on walking breaks Given the invitation, Americans want to be part of the scientific process
https://www.statnews.com/2026/06/24/short-walking-breaks-sitting-health-research/
By Manoush ZomorodiJune 24, 2026
Zomorodi is the author of “Body Electric: The Hidden Health Costs of the Digital Age and New Science to Reclaim Your Well-Being” and host of NPR’s “TED Radio Hour.”
Wagering on FDA changes, Regenxbio will submit Duchenne gene therapy for approval The agency has recently signaled it’s more open to considering rare disease treatments after a staff shakeup
https://www.statnews.com/2026/06/24/regenxbio-duchenne-gene-therapy-fda-submission/
By Jason MastJune 24, 2026
General Assignment Reporter
AI wades into a vexing medical mystery: What causes sudden cardiac death? Research from University of California, Berkeley adds to evidence linking fibrosis to fatality
https://www.statnews.com/2026/06/24/artificial-intelligence-model-cause-of-sudden-cardiac-death/
By Casey RossJune 24, 2026
Chief Investigative Reporter, Data & Technology
Aortic Hope: connecting hearts one beat at a time Written by Carin Anderson, founder and chair of the Board, Aortic Hope
https://rarerevolutionmagazine.com/aortic-hope-connecting-hearts-one-beat-at-a-time/
Having survived an aortic dissection, Carin Anderson turned a frightening experience into one of hope, founding the charity Aortic Hope to provide support and awareness for others with aortic disease
Generic Drugs
https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs?utm_medium=email&utm_source=govdelivery
FDA Approves First Generic of Priftin (rifapentine) tablets
The U.S. Food and Drug Administration approved the first generic of Priftin (rifapentine) tablets, a medication for the treatment of active pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis in combination with one or more antituberculosis drugs to which the isolate is susceptible in patients 12 years of age and older; and the treatment of latent tuberculosis infection caused by M. tuberculosis in combination with isoniazid in patients 2 years of age and older at high risk of progression to TB disease.
The prescribing information for the generic rifapentine tablets includes the same contraindications, warnings, and precautions as Priftin. Rifapentine tablets are contraindicated in patients with a known history of hypersensitivity to any rifamycin. Rifapentine carries warnings such as the risk of hepatotoxicity, hypersensitivity and related reactions, severe cutaneous adverse reactions, relapse in treatment of active pulmonary tuberculosis, and drug interactions. Rifapentine tablets may produce a red-orange discoloration of body tissues and fluids.
The most common adverse reactions with the active pulmonary tuberculosis treatment regimen (≥3%) include anemia, lymphopenia, hemoptysis, neutropenia, cough, thrombocytosis, increased sweating, elevated ALT/AST, back pain, rash, anorexia, arthralgia, increased blood urea, and headache. The most common adverse reaction (≥3%) with the latent tuberculosis infection regimen is hypersensitivity reaction.
Healthcare providers should review the full prescribing information for complete safety and dosing information.
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