viernes, 26 de julio de 2024
Drug Trials Snapshots: SOHONOS (palovarotene)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which there is abnormal growth of bone tissue (heterotopic ossification or HO) within muscles, tendons, and other soft tissues, which restricts mobility and can be disabling. SOHONOS is a retinoid drug that is indicated to reduce the amount (measured as volume) of new HO in patients with FOP who are aged 8 years and older for females and 10 years and older for males.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-sohonos
FDA Approves HPV Tests That Allow for Self-Collection in a Health Care Setting
https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-hpv-test-self-collection-health-care-setting?cid=eb_govdel
On May 14, the Food and Drug Administration (FDA) expanded the approvals of two tests that detect cancer-causing types of human papillomavirus (HPV) in the cervix. Both tests are used as part of screening for cervical cancer.
Call for Papers: Supplemental Issue of Prevention Science Structural Approaches to Youth Violence Prevention: Addressing Racism and Discrimination Released: May 31, 2024 Letters of intent due: September 30, 2024
https://nimhd.nih.gov/about/publications/call-for-papers-supplemental-issue-of-prevention-science.html?utm_medium=email&utm_source=govdelivery
Submit Your Letter of Intent by September 30, 2024
NIMHD is inviting researchers to contribute to an upcoming supplemental issue of the journal Prevention Science. This supplemental issue will focus on youth violence prevention interventions that address structural racism and discrimination, and other structural factors and social determinants.
Topics of Interest:
Empirical research on the impact of interventions on individual, community, social, and structural factors.
Prospective intervention studies and natural policy experiments at local, state, regional, or national levels.
Conceptual papers that describe current challenges and viable solutions to implementing sustainable multilevel, multisectoral interventions that address social and structural factors that place youth at highest risk for violence as well as those that address disparities in youth violence.
Authors interested in contributing should submit a letter of intent by September 30, 2024.
Epigenetic Editor Silences Toxic Proteins in the Mouse Brain, Offering Promising Path to Treat Deadly Prion Diseases Posted on July 25th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/07/25/epigenetic-editor-silences-toxic-proteins-in-the-mouse-brain-offering-promising-path-to-treat-deadly-prion-diseases/
Prion diseases are fatal neurodegenerative disorders caused by a malfunction of the prion protein in the brain. Exposure to a misfolded version of the protein triggers normal proteins of the same type in the brain to misfold, forming clumps that produce infectious disease and fatal brain damage over time. There are currently no treatments, preventive vaccines, or cures for prion diseases, which can be acquired, like mad cow disease, or inherited, like fatal familial insomnia. But an encouraging new study in mice suggests a potentially promising path for developing a treatment for people with these deadly conditions.
https://www.niaid.nih.gov/diseases-conditions/prion-diseases
Findings from an NIH-supported study reported in Science show that the key to this approach is a molecular tool capable of silencing prion protein throughout the brain using epigenetic editing. Unlike gene editing approaches, which change the sequence of genes, epigenetic editing can turn gene expression off with the addition of a chemical tag that prevents genes from being translated into proteins. Such a strategy may be able to deliver modifying tools to the brain or other parts of the body to silence specific toxic or disease-causing genes, including the one encoding the prion protein, without the risks associated with altering DNA sequences.
https://pubmed.ncbi.nlm.nih.gov/38935715/
Can bacteria in your gut make you want to exercise?
https://magazine.medlineplus.gov/article/can-bacteria-in-your-gut-make-you-want-to-exercise?utm_medium=email&utm_source=govdelivery
Have you ever wondered why some people enjoy exercise while others find it unbearable? New research hints at a surprising connection: the gut microbiome! You read that right—the trillions of tiny organisms, or microbes, that live in our digestive system may play a role in whether we feel like exercising. We know that the bacteria in our guts are important for our digestion and overall health. Recent research suggests that
Multiple Sclerosis and Psychological and Physical Approaches
https://www.nccih.nih.gov/health/multiple-sclerosis?nav=govd
Multiple sclerosis is a disease of the central nervous system. Its symptoms may include muscle weakness, tingling and burning sensations, numbness, chronic pain, fatigue, and coordination problems. People with multiple sclerosis may also feel depressed and have trouble thinking clearly. Research has shown that several psychological and physical complementary health approaches (mind and body practices) may help people with multiple sclerosis manage their symptoms.
Practicing yoga may help with fatigue and mood, but not with mobility or thinking ability.
Reflexology (applying pressure to the soles of the feet) may reduce burning or prickling sensations; however, larger studies are needed to provide a reliable conclusion.
A few studies of acupuncture for multiple sclerosis symptoms have suggested that it may be helpful.
Experts laud injection that reportedly offers 100% protection against HIV/AIDS The shots, made by US drugmaker Gilead, are currently approved as a treatment for HIV in several regions Associated Press Published July 24, 2024 9:23am EDT
Experts laud injection that reportedly offers 100% protection against HIV/AIDS
The shots, made by US drugmaker Gilead, are currently approved as a treatment for HIV in several regions
Associated Press
Published July 24, 2024 9:23am EDT
https://www.foxnews.com/health/experts-laud-injection-reportedly-offers-100-protection-against-hiv-aids
Ask a doctor: ‘I swallowed a bug — now what should I do?' What to know about the potential risks and what to do after it happens Melissa Rudy By Melissa Rudy Fox News Published July 26, 2024 5:38am EDT
Ask a doctor: ‘I swallowed a bug — now what should I do?'
What to know about the potential risks and what to do after it happens
Melissa Rudy By Melissa Rudy Fox News
Published July 26, 2024 5:38am EDT
https://www.foxnews.com/health/ask-doctor-swallowed-bug-what-should-do
Joe Biden's health: Leadership ability questions mount as Oval Office speech gave no reason for exiting race Biden, at 81 years old, still has 178 days in office as Americans face border crisis, crime, inflation Melissa Rudy By Melissa Rudy Fox News Published July 26, 2024 4:00am EDT
Joe Biden's health: Leadership ability questions mount as Oval Office speech gave no reason for exiting race
Biden, at 81 years old, still has 178 days in office as Americans face border crisis, crime, inflation
Melissa Rudy By Melissa Rudy Fox News
Published July 26, 2024 4:00am EDT
https://www.foxnews.com/health/biden-health-leadership-ability-questions-mount-oval-office-speech-no-reason-exiting-race
Why higher UV index numbers are more dangerous during sun exposure Skin cancer risk can increase with extreme UV exposure, experts warn Angelica Stabile By Angelica Stabile Fox News Published July 26, 2024 9:00am EDT
Why higher UV index numbers are more dangerous during sun exposure
Skin cancer risk can increase with extreme UV exposure, experts warn
Angelica Stabile By Angelica Stabile Fox News
Published July 26, 2024 9:00am EDT
https://www.foxnews.com/health/higher-uv-index-numbers-more-dangerous-sun-exposure
Risky Drinking Can Put a Chill on Your Summer Fun
Risky Drinking Can Put a Chill on Your Summer Fun
Summer is typically a wonderful season for outdoor activities and spending additional time with family and friends. For some people, these activities include drinking beverages containing alcohol. This summer, take measures to protect your own health and that of your loved ones.
https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/risky-drinking-can-put-chill-on-your-summer-fun
jueves, 25 de julio de 2024
Dengue surges in UAE after record-breaking rainfall leaves ideal conditions for mosquitoes World Health Organization warns of global spike in dengue Associated Press Published July 24, 2024 1:51pm EDT
Dengue surges in UAE after record-breaking rainfall leaves ideal conditions for mosquitoes
World Health Organization warns of global spike in dengue
Associated Press
Published July 24, 2024 1:51pm EDT
https://www.foxnews.com/health/dengue-surges-uae-after-record-breaking-rainfall-makes-homes-mosquitoes
New study reveals extreme weather's impact on seniors' attendance at doctor appointments Given issues with extreme heat or cold, experts share 4 tips to ensure aging patients get the care they need Melissa Rudy By Melissa Rudy Fox News Published July 24, 2024 6:01pm EDT
New study reveals extreme weather's impact on seniors' attendance at doctor appointments
Given issues with extreme heat or cold, experts share 4 tips to ensure aging patients get the care they need
Melissa Rudy By Melissa Rudy Fox News
Published July 24, 2024 6:01pm EDT
https://www.foxnews.com/health/study-reveals-extreme-weathers-impact-seniors-attendance-doctor-appointments
Doctors say Biden exiting race may be best health move, plus a history of presidential illnesses And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published July 24, 2024 6:34pm EDT | Updated July 24, 2024 6:42pm EDT
Doctors say Biden exiting race may be best health move, plus a history of presidential illnesses
And more of the top Fox News Health stories and videos from the past week
By Fox News Staff Fox News
Published July 24, 2024 6:34pm EDT | Updated July 24, 2024 6:42pm EDT
https://www.foxnews.com/health/docs-say-biden-exiting-race-may-best-health-move-history-presidential-illnesses
11 tips for adults age 65 and over to ‘live well’ over time, according to gerontologists From sleep to socializing to a sense of purpose, here’s how seniors can optimize their health, experts say Melissa Rudy By Melissa Rudy Fox News Published July 25, 2024 5:19am EDT
11 tips for adults age 65 and over to ‘live well’ over time, according to gerontologists
From sleep to socializing to a sense of purpose, here’s how seniors can optimize their health, experts say
Melissa Rudy By Melissa Rudy Fox News
Published July 25, 2024 5:19am EDT
https://www.foxnews.com/health/tips-adults-age-65-live-well-age-gerontologists
Doctors react after Biden’s live address to the nation: A concerning ‘lack of emotion’ It's a 'very emotional time for him and he isn't showing it,' said one doctor, also perceiving a 'lack of conviction' Melissa Rudy By Melissa Rudy Fox News Published July 24, 2024 10:01pm EDT
Doctors react after Biden’s live address to the nation: A concerning ‘lack of emotion’
It's a 'very emotional time for him and he isn't showing it,' said one doctor, also perceiving a 'lack of conviction'
Melissa Rudy By Melissa Rudy Fox News
Published July 24, 2024 10:01pm EDT
https://www.foxnews.com/health/doctors-react-bidens-live-address-nation-lack-emotion
Hepatitis C and Dietary Supplements: What the Science Says
https://www.nccih.nih.gov/health/providers/digest/hepatitis-c-and-dietary-supplements-science?nav=govdcd
Several dietary and herbal supplements have been studied for hepatitis C, and substantial numbers of people with hepatitis C have tried herbal supplements. The most commonly used supplement for hepatitis C is silymarin (an extract from milk thistle). However, no dietary supplement has been shown to be efficacious for hepatitis C.
This issue provides information on what the science says about several dietary supplements studied for hepatitis C.
Symptom Clusters in Cancer (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/side-effects/cancer-symptom-clusters-hp-pdq?cid=eb_govdel#top
A symptom cluster is two or more concurrent symptoms with the following properties:[1,8]
The concurrent symptoms within the cluster are stable (i.e., the same symptoms that comprise clusters are identified at different time points throughout the cancer care trajectory).
The symptoms within a cluster may share underlying mechanisms.
The symptoms within a cluster may share outcomes.
The symptom cluster may have a temporal dimension (i.e., the severity of the symptoms within the cluster may shift together over time).
Training Institute for Dissemination and Implementation Research in Genomics and Precision Public Health (TIDIR-GPPH) Facilitated Course
https://orise.orau.gov/genomics-precision-public-health/tidir-gpph.html
From the website: "The Training Institute for Dissemination and Implementation Research in Genomics and Precision Public Health (TIDIR-GPPH) Facilitated Course is being offered in 2024 and is open to all current ORISE fellows and mentors! The course is intended to provide participants with a thorough grounding in conducting dissemination and implementation (D&I) research with a specific focus on genomics and precision public health. TIDIR-GPPH will be a hybrid course including training through open access modules with assigned reading material and office hours and culminating with a 2-day in-person event (September 5-6, 2024)."
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity
https://www.pnas.org/doi/10.1073/pnas.2400413121?utm_campaign=+61510452&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
NIAID-supported scientists have identified small molecules that trigger trained immunity, a form of innate immune-system memory, without a pathogen or host molecule activating innate immunity first. These newly identified compounds surprisingly include steroids, which are usually immunosuppressive. Also, unlike the few previously identified molecules that trigger trained immunity, the new ones are easy to make and deliver, the scientists say. These findings could help researchers develop new or improved vaccines and treatments.
Where the Sugars and the Proteins Play: Q&A With Mia Huang by Abbey Bigler-Coyne
https://biobeat.nigms.nih.gov/2024/07/where-the-sugars-and-the-proteins-play-qa-with-mia-huang/?utm_medium=email&utm_source=govdelivery
Mia Huang, Ph.D., studies sugar-coated proteins and how they interact with other proteins to help our cells function. She hopes that by better understanding these interactions, researchers can find ways to disrupt those involved in diseases such as cancer. In this Q&A, Dr. Huang shares not only her work, but also her thoughts on the role of creativity in science and why she became a researcher.
Could a Spoonful of Sugar Be a Medicine?
by Abbey Bigler-Coyne
https://biobeat.nigms.nih.gov/2021/09/could-a-spoonful-of-sugar-be-a-medicine/?utm_medium=email&utm_source=govdelivery
Nearly every aspect of biology involves sugars, and researchers have only begun to explore these molecules’ complexities and potential uses. In this post, three NIGMS-supported scientists describe how their work with sugars could help fight bacterial infections, treat cholera, and more.
miércoles, 24 de julio de 2024
Ayurveda in the 21st Century
https://www.news-medical.net/health/Ayurveda-in-the-21st-Century.aspx
Ayurveda, which means "science of life" or "knowledge of life" in Sanskrit, is an ancient holistic healing approach that originated in India. Millions of people have been practicing Ayurveda for over 2,000 years to live a balanced life and maintain optimal health. This ancient Indian medical system relies on a natural and holistic approach to promote a healthy lifestyle and treat diseases with minimal side effects.
AIDS 2024: NIH Research Updates, Inequities, U=U, and Doxy PrEP (VIDEO)
https://www.niaid.nih.gov/news-events/aids-2024-nih-research-updates-inequities-uu?utm_campaign=+61498851&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
The AIDS 2024 conference is taking place in Munich, Germany. Check out the NIAID blog covering NIH research updates, HIV prevention, inequities, and DoxyPrEP.
A human autoimmune organoid model reveals IL-7 function in coeliac disease
https://www.nature.com/articles/s41586-024-07716-2?utm_campaign=+61507613&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
NIAID-supported researchers have created an organoid model of celiac disease that enabled them to identify a potential treatment target: an immune-system protein called interleukin 7 (IL-7). The model is unique because it has the tissue structure and immune features of the human intestine, and it mimics celiac disease when exposed to gluten. Scientists hope the model will advance their understanding of how celiac disease develops, which could lead to new treatments. The findings were published today in the journal Nature.
Urine test identifies high-risk prostate cancers
https://www.nih.gov/news-events/nih-research-matters/urine-test-identifies-high-risk-prostate-cancers
At a Glance
Researchers developed a urine-based test that can distinguish between slow-growing prostate cancers that pose little risk and more aggressive cancers that need treatment.
The test could help some patients avoid unnecessary biopsies and other tests that carry potential risks.
Research in Context: Movement after paralysis
https://www.nih.gov/news-events/nih-research-matters/research-context-movement-after-paralysis
From electrical stimulation to robotics
NIH-funded researchers have been working to restore movement to people living with paralysis. This special Research in Context feature explores the different experimental approaches scientists are developing to allow people without control of their body’s movements to become more independent and improve their quality of life.
How excess niacin may promote cardiovascular disease
https://www.nih.gov/news-events/nih-research-matters/how-excess-niacin-may-promote-cardiovascular-disease
At a Glance
A metabolite of niacin (vitamin B3) was associated with elevated risk of heart attack and stroke, likely due to inflammation in arteries.
The findings suggest new measures that may prevent or treat cardiovascular disease and raise concerns about the health effects of too much niacin.
Developing treatments for prion diseases
https://www.nih.gov/news-events/nih-research-matters/developing-treatments-prion-diseases
At a Glance
Researchers developed a novel method to turn off prion protein production in mice.
The technique could lead to treatments for prion diseases such as mad cow disease.
Gene variant slows form of inherited Alzheimer’s disease
https://www.nih.gov/news-events/nih-research-matters/gene-variant-slows-form-inherited-alzheimer-s-disease
At a Glance
In a family with an inherited form of Alzheimer’s disease, those who carried a gene variant called APOE3Ch had a delay in cognitive impairment and dementia.
More research is needed to see whether APOE3Ch has a protective effect in people beyond this family and to understand how it exerts its protective effect.
Testing transmission and infection of H5N1 from cows
https://www.nih.gov/news-events/nih-research-matters/testing-transmission-infection-h5n1-cows
At a Glance
Researchers found that an H5N1 flu virus from cows could infect mice and ferrets, but airborne transmission wasn’t very efficient.
The findings increase our understanding of whether the H5N1 outbreak in cows could lead to a human pandemic.
In the News: Diamond Shruumz-Brand Chocolate Bars, Cones, and Gummies
https://www.nccih.nih.gov/health/in-the-news-diamond-shruumz-brand-chocolate-bars-cones-and-gummies?nav=govd
The U.S. Food and Drug Administration (FDA) is investigating serious illnesses linked to Diamond Shruumz brand chocolate bars, cones, and gummies marketed as containing a proprietary mushroom blend. Symptoms include seizures, confusion, abnormal heart rates, and nausea. The exact cause of the illnesses is still under investigation.
Edible products containing psychoactive compounds such as cannabis or mushroom are increasing in availability. Reactions to these products can vary among individuals. In addition, the products might contain undisclosed ingredients, including illicit substances, other adulterants, or potentially harmful contaminants that are not approved for use in food.
The Centers for Disease Control and Prevention (CDC), FDA, and America’s Poison Centers are continuing to monitor cases of illness reported to poison centers nationwide. Any suspected adverse effects after consuming any Diamond Shruumz brand products should be reported to the Poison Help Line (1-800-222-1222).
Whole Person Health: What You Need To Know
https://www.nccih.nih.gov/health/whole-person-health-what-you-need-to-know?nav=govd
Much of our work at the National Center for Complementary and Integrative Health centers around the concept of whole person health.
Whole person health involves looking at all aspects of a person—not just separate organs or body systems— considering multiple factors that promote either health or disease. It means helping and empowering individuals, families, communities, and populations to improve their health in multiple areas—biological, behavioral, social, and environmental. And it means not just treating specific diseases but also focusing on restoring health, promoting resilience, and preventing diseases across the lifespan.
martes, 23 de julio de 2024
One size does not fit all when to comes to dieting
https://www.news-medical.net/news/20240723/One-size-does-not-fit-all-when-to-comes-to-dieting.aspx
In a recent study published in the journal Nutrients, researchers in the United States investigated the effects of low-fat and lower-carbohydrate diets on weight loss using the Preventing Overweight by Novel Dietary Strategies (POUNDS) Lost study.
The burden of cirrhosis mortality by county, race, and ethnicity in the USA, 2000-19: a systematic analysis of health disparities
https://pubmed.ncbi.nlm.nih.gov/39004094/
The burden of cirrhosis mortality by county, race, and ethnicity in the USA, 2000-19: a systematic analysis of health disparities
Cirrhosis is responsible for substantial health and economic burden in the USA. Reducing this burden requires better understanding of how rates of cirrhosis mortality vary by race and ethnicity and by geographical location. This study describes rates and trends in cirrhosis mortality for five racial and ethnic populations in 3110 US counties from 2000 to 2019.
Author: Hasan Nassereldine, Kelly Compton, Zhuochen Li, Mathew M. Baumann, Yekaterina O. Kelly, Wichada La Motte-Kerr, Farah Daoud, Erik J. Rodriquez, George A. Mensah, Anna M. Nápoles*, Eliseo J. Pérez-Stable*, Christopher J. L. Murray, Ali H Mokdad, Laura Dwyer-Lindgren
Journal: The Lancet - Public Health, July 11
Multiple chronic diseases and psychological distress among adults in the United States: the intersectionality of chronic diseases, race/ethnicity, immigration, sex, and insurance coverage
https://pubmed.ncbi.nlm.nih.gov/39017703/
Multiple chronic diseases and psychological distress among adults in the United States: the intersectionality of chronic diseases, race/ethnicity, immigration, sex, and insurance coverage
Psychological distress significantly contributes to the burdens of morbidity and mortality in the United States, but the understanding is limited with regards to the risk factors associated with psychological distress. Researchers used nationally representative data to examine (1) the comorbidities of chronic diseases and their risks for psychological distress and (2) the ways in which chronic diseases combine with demographic factors such as sex, race/ethnicity, immigration status, and health insurance coverage to affect the patterning of psychological distress.
Author: David Adzrago*, David R. Williams, Faustine Williams*
Journal: Social Psychiatry and Psychiatric Epidemiology, July 17
Noninvasive early heart-disease detection with AI Israeli startup AccuLine has secured $4.2 million for technology that aims to improve early CAD diagnosis and reduce healthcare costs.
https://www.israel21c.org/noninvasive-early-heart-disease-detection-with-ai/
In the time it takes to read this article, several people in the United States will likely experience a heart attack — according to the CDC, someone in the US suffers from one every 40 seconds.
Step-length sensor monitors neurological disease progression Researchers develop an efficient, convenient wearable solution that will allow for quantifying and collecting data on step length throughout the day.
https://www.israel21c.org/step-length-sensor-monitors-neurological-disease-progression/
Researchers in Israel have developed a wearable step sensor to monitor the wellbeing of the elderly and patients with cognitive decline or neurological diseases.
About Pesticides and Reproductive Health
https://www.cdc.gov/niosh/reproductive-health/prevention/pesticides.html?utm_source=news-releases-email-A&utm_medium=email&utm_campaign=july-22-2024&utm_content=module-1&j=2433249&sfmc_sub=6992026&l=69_HTML&u=57518288&mid=100038678&jb=7
Exposure to pesticides can affect people's hormones and fertility. Pesticide exposure during pregnancy could cause a miscarriage or birth defects. Some pesticides may pass into breast milk. Learn more about these chemicals and how to reduce your exposure.
https://www.hhs.gov/about/news/index.html?utm_source=news-releases-email-A&utm_medium=email&utm_campaign=july-22-2024&utm_content=cta-button-1
Restoring color vision with gene therapy | Drug Discovery News
Restoring color vision with gene therapy | Drug Discovery News: People with achromatopsia have never seen color. Restorative gene therapies have had mixed success, leaving researchers wondering why.
What will it take to make precision health a global reality
https://www.nature.com/articles/s41591-024-03163-8
From the article: "In this special issue, we ask what it means to deliver precision health — that is, tailoring preventive or treatment approaches to groups of people or individual people on the basis of certain characteristics — in different geographical and clinical contexts. Alongside the big questions addressing infrastructure, capacity, policy and access, our ‘Turning points’ articles zoom in on researchers’ personal stories of what precision health means to them, and how they came to dedicate their careers to this cause. "
Advancing Genomic Cancer Medicine in Rural and Underserved States
https://jamanetwork.com/journals/jamaoncology/article-abstract/2821206
From the article: "In the evolving landscape of oncology, the integration of powerful genomic technologies into practice has ushered in a new era of precision cancer medicine. Complex genomic information such as mutational analyses, transcriptional signatures, and polygenic risk scores have become key diagnostics guiding therapeutic decisions and management of inherited cancer risk. However, the expertise to interpret these data for clinical decision-making remains constrained and is a significant challenge for community oncologists, especially those in rural regions and in medically underserved areas. While physical access to these tests is readily available, poor access to interpretive expertise has become the key limiting factor. "
FDA Rare Disease Innovation Hub to Enhance and Advance Outcomes for Patients
https://www.fda.gov/news-events/fda-voices/fda-rare-disease-innovation-hub-enhance-and-advance-outcomes-patients?utm_medium=email&utm_source=govdelivery
From the website: "An estimated 10,000+ rare diseases affect more than 30 million people – approximately one out of every 10 people – in the U.S., and about half of these people are children. Many rare conditions are life threatening, and most do not have approved treatments. Fundamental to the mission of the U.S. Food and Drug Administration is to engage patients and caregivers – to understand their unique perspectives and experiences and keep these front of mind as we review medical products for rare disease patients. "
lunes, 22 de julio de 2024
From wildlife to bedside: Nature’s wisdom meets modern medicine | Drug Discovery News
From wildlife to bedside: Nature’s wisdom meets modern medicine | Drug Discovery News: Inspired by nature, Peel Therapeutics scientists look to evolution to find the next life changing drug.
Circular RNA: a new era in therapeutics | Drug Discovery News
Circular RNA: a new era in therapeutics | Drug Discovery News: The durability and capacity to boost protein expression of circular RNA makes it a promising candidate for next-generation vaccines and gene therapies.
Mini-retinas model human disease in a dish | Drug Discovery News
Mini-retinas model human disease in a dish | Drug Discovery News: Researchers use retinal organoids to screen drugs and hope to transplant them into the eyes of people with blindness in the coming years.
CAR T cells in a SNAP | Drug Discovery News
CAR T cells in a SNAP | Drug Discovery News: A modular CAR T cell could make cancer therapy safer and more effective.
How a mother's immune system can shape her baby's brain | Drug Discovery News
How a mother's immune system can shape her baby's brain | Drug Discovery News: Researchers discovered that a cytokine surge during mid-gestation in mice influenced anxiety behavior in offspring.
The Rising Tide: Trends and Challenges of Lung Cancer in Asia Published: July 8, 2024
Lung cancer is a significant public health issue in Asia, representing one of the leading causes of cancer-related mortality. The incidence of both non-small cell lung cancer and small-cell lung cancer in this region is high, driven by high rates of smoking, air pollution, and specific genetic mutations. Despite ongoing research and health-care efforts, the rising incidence and mortality rates of lung cancer pose an urgent challenge for health-care systems across Asia.
In this Series of three Review articles published in eClinicalMedicine, The Lancet Regional Health – Western Pacific, and The Lancet Regional Health – Southeast Asia, Roselle de Guzman and colleagues explore the impact of climate change on lung cancer rates in the region, including screening, early detection, management, and treatment; Yi-Long Wu and colleagues highlight the development of genetic testing technology in the Western Pacific region; and Kumar Prabhash and colleagues examine the unique factors that are associated with lung cancer in Southeast Asian population.
https://www.thelancet.com/series/lung-cancer-asia?dgcid=hubspot_update_feature_infocusoncology_lungcancerasia24_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-96Coj3hok4mknkNShplGx3lQvPTmVvt6XHdMJbKyQgFUFLUJe7-WVKcmSrQsCwvrGjorQLLvYXXQXRJgOr27aJMSb_4Q&_hsmi=316670270&utm_content=316447178&utm_source=hs_email
IAPAC-Lancet HIV Commission on the future of urban HIV responses
Cities are home to a disproportionate number of many countries’ population of people living with HIV. The future of urban HIV responses is therefore crucial to the future of the global HIV epidemic. The Commission report offers cities and their communities an equity-centred, rights-based framework to guide the future direction of urban HIV responses in line with Sustainable Development Goal (SDG) 3.3 of ending the HIV epidemic by 2030.
https://www.thelancet.com/infographics-do/urban-hiv-responses?dgcid=hubspot_email_conferencealerts_lanhivftc24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz--0Bxqx5CdG9mO7hDYtR89lgcuQz0ZRQCVXk3FbNhs-OqIlnifXmkiFh__xkDmXNoPYHcgWBvHs1qTfDbXPG6P1Y6tvFg&_hsmi=316285152&utm_content=316285152&utm_source=hs_email
The IAPAC–Lancet HIV Commission on the future of urban HIV responses Published: July 20, 2024
With urbanisation trends projecting more than twice as many people in the world will be living in urban versus rural settings by 2050, cities have an increasingly important role to play in achieving the health-related Sustainable Development Goals (SDGs), including ending the HIV epidemic by 2030 (SDG 3.3). The International Association of Providers of AIDS Care (IAPAC)–Lancet HIV Commission on the Future of Urban HIV Responses report centres health equity in urban HIV responses, with cross-cutting recommendations made across intersectional domains. Among these domains are the right to health, health system resilience, syndemic conditions and comorbidities, social determinants of health, and data-driven accountability. The report also proposes opportunities to accelerate progress towards SDG 3.3, and more broadly SDG 10 (making cities inclusive, safe, resilient, and sustainable), with the aim of guiding local, national, and international stakeholders in their efforts to optimise urban HIV responses.
https://www.thelancet.com/commissions/urban-hiv-responses?dgcid=hubspot_email_conferencealerts_lanhivftc24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-83ILwGKcuP14L-PTkoz0ojfFgNC6b3JOlRCn6YLAZdQSJrNEjcMnluuAoVVAywDj8ej6USKfaPGhjWV4Lo6ZSKRwqtrg&_hsmi=316285152&utm_content=316285152&utm_source=hs_email
Three generations of nurses deliver hope at Children's National Hospital NICU
https://wjla.com/news/local/childrens-national-hospital-washington-dc-nursing-nurses-family-sister-mother-daughter-nicu-baby-patients-premature-preemie-kelly-hartge-chrissy-marsh-carmen-blake
Three generations of nurses deliver hope at Children's National Hospital
NICU nursing runs in the family for several team members at Children’s National. Chrissy Marsh and Kelly Hartge are two sisters who currently work in the NICU, inspired by their mom, Carmen Blake, who spent five years working with them in the same unit until her retirement in 2020. (ABC 7)
AI Analysis of Large Registries Identifies New Risk Factors for Perinatal Stroke
https://journals.lww.com/neurotodayonline/fulltext/2024/06060/ai_analysis_of_large_registries_identifies_new.7.aspx
AI analysis of large registries identifies new risk factors for perinatal stroke
Sarah Mulkey, M.D., Ph.D., prenatal-neonatal neurologist, explains how an artificial intelligence (AI) model that identifies new risk factors for perinatal arterial ischemic stroke (PAIS) is helpful. (Neurology Today)
Pandemic stress in pregnant mothers may affect anxiety regions of babies' brains
https://www.msn.com/en-us/health/other/pandemic-stress-in-pregnant-mothers-may-affect-anxiety-regions-of-babies-brains/ar-BB1oDEa5?ocid=BingNewsVerp&apiversion=v2&noservercache=1&domshim=1&renderwebcomponents=1&wcseo=1&batchservertelemetry=1&noservertelemetry=1
Nickie Andescavage, M.D., neonatologist, led a study that discovered children born during the pandemic require ongoing developmental or mental health evaluations. (MSN)
‘Healthy moms equal healthy babies': Children's National offers maternal health care
https://www.nbcwashington.com/news/health/healthy-moms-equal-healthy-babies-childrens-national-offers-maternal-health-care/3604243/?_branch_match_id=1288163324046319662&utm_medium=share&_branch_referrer=H4sIAAAAAAAAA8soKSkottLXz0tKLk8szsjMSy%2FJz9NLLCjQy8nMy9Y3za4M9PW3LEnxSgIAgusMfCoAAAA%3D
Catherine Limperopoulos, Ph.D., director of the Center for Prenatal, Neonatal and Maternal Health Research and director of research for the Zickler Family Prenatal Pediatrics Institute, explains the new DC Mother-Baby Wellness Program at Children’s National and how it provides mothers with medical, social and mental health support in the same place where their babies get checkups.
Pandemic stress in pregnant mothers may affect anxiety regions of babies’ brains
https://innovationdistrict.childrensnational.org/pandemic-stress-in-pregnant-mothers-may-affect-anxiety-regions-of-babies-brains/
A critical part of the brain linked to risks for anxiety later in life – the left amygdala – was significantly smaller by volume in babies of mothers who reported stress during the COVID-19 pandemic, according to a new manuscript published in JAMA Network Open.
Supporting breakthroughs in at-home pediatric monitoring
https://innovationdistrict.childrensnational.org/supporting-breakthroughs-in-at-home-pediatric-monitoring/
Children’s National was part of a clinical trial that helped advance Gabi SmartCare, an innovative monitoring device that recently achieved Food and Drug Administration clearance. The device features a tiny, lightweight, wearable band that enables at-home monitoring of a patient’s vital signs.
First-of-its-kind study on impacts of Lyme disease in pregnancy and infant development
https://innovationdistrict.childrensnational.org/lyme-disease-in-pregnancy-and-infant-development/
First-of-its-kind study on impacts of Lyme disease in pregnancy and infant development
Understanding the effects of Lyme disease on the developing fetal brain is essential to ensure timely prenatal and postnatal treatments to protect the fetus and newborn.
In response to this need, Children’s National Hospital is leading a pilot study to establish the groundwork needed for a larger study to determine the effect of in utero exposure to Lyme disease on pregnancy and early childhood neurodevelopmental outcomes.
domingo, 21 de julio de 2024
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00607-1
The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. One barrier to translation is that cancer phenotypes cannot be segregated into distinct male versus female categories. Instead, within this convenient but contrived dichotomy, male and female cancer phenotypes are highly overlapping and vary between female- and male- skewed extremes. Thus, sex and gender-specific treatments are unrealistic, and our translational goal should be adaptation of treatment to the variable effects of sex and gender on targetable pathways.
Browsing: Positive Parenting
Positive Parenting is a collaboration between the Child Trends Hispanic Institute, a Child Trends initiative, and Ivanhoe Broadcast News, a syndicated news company. Child Trends received a grant from the National Science Foundation to support this work as well as the Institute of Education Sciences (IES).
https://www.ivanhoe.com/channels/positive-parenting/
NUTRITION LIES: SERVING UP FACT FROM FICTION
Nutrition Lies: Serving Up Fact From Fiction
By Ivanhoe Broadcast News on July 20, 2024
https://www.ivanhoe.com/smart-living/nutrition-lies-serving-up-fact-from-fiction/
FINANCIAL FALLOUT: COST OF A GRAY DIVORCE
Financial Fallout: Cost Of Gray Divorce
By Ivanhoe Broadcast News on July 20, 2024
https://www.ivanhoe.com/smart-living/financial-fallout-cost-of-gray-divorce/
SODIUM OVERLOAD: DANGERS OF TOO MUCH SALT
Sodium Overload: Dangers of Too Much Salt
By Ivanhoe Broadcast News on July 21, 2024
https://www.ivanhoe.com/smart-living/sodium-overload-dangers-of-too-much-salt/
KATIE KICKS CANCER WITH A FIRST
Katie Kicks Rare Cancer with A First
By Ivanhoe Broadcast News on July 17, 2024
https://www.ivanhoe.com/medical-breakthroughs/katie-kicks-rare-cancer-with-a-first/
BALTIMORE, MD (Ivanhoe Newswire) – Almost two million people will be told they have cancer this year. More than 200,000 of those will be considered a rare cancer. The rarer it is, the harder it is to find ways to not just treat it, but also get the right diagnosis. That’s why one woman is sharing her journey in hopes of giving patients like her a fighting chance to survive it.
CATCHING GUM DISEASE EARLY SAVES TEETH LATER
Catching Gum Disease Early Saves Teeth Later
By Ivanhoe Broadcast News on July 19, 2024
https://www.ivanhoe.com/medical-breakthroughs/catching-gum-disease-early-saves-teeth-later/
INDIANAPOLIS, IN (Ivanhoe Newswire) – Periodontal disease is a common and a growing issue. About 40% of adults ages 30 and over have some form of it. That number increases to 70% for people over age 65. Here are some of the symptoms to look for and why it’s so important to catch gum disease early.
RARE BRAIN SURGERY STOPS SEIZURES IN BABY REAGAN
Rare Brain Surgery Stops Seizures in Baby Reagan
By Ivanhoe Broadcast News on July 18, 2024
https://www.ivanhoe.com/family-health/children/rare-brain-surgery-stops-seizures-in-baby-reagan/
SAN ANTONIO, TX (Ivanhoe Newswire) – A rare brain surgery performed in San Antonio, stopped up to 200 seizures per day in the brain of a 15-month-old. Those seizures were caused by a malformation in the right side of the brain. And, if the surgery had not been performed, the now 3-year-old child would have never walked or talked.
HEALTH ALERT: STROKES STRIKING UNDER 40
Health Alert: Strokes Striking Under 40
By Ivanhoe Broadcast News on July 28, 2024
https://www.ivanhoe.com/?p=33720&preview=1&_ppp=7f3efd32d0
ORLANDO, Fla. (Ivanhoe Newswire) — Every 40 seconds someone in the United States has a stroke. The most common type of stroke happens when a blood vessel in your brain becomes blocked by a clot or plaque. While strokes mostly affect older adults in their 70s, rates in young people are going up.
HANG UP ON YOUR CELLPHONE ADDICTION
Hang Up on Your Cellphone Addiction
By Ivanhoe Broadcast News on July 27, 2024
https://www.ivanhoe.com/?p=33717&preview=1&_ppp=81aa1561f5
ORLANDO, Fla. (Ivanhoe Newswire) — Almost 50 percent of Americans are addicted to their cellphones. On average, people check their phones every 12 minutes throughout the day. Almost 44 percent of Americans say being away from their phones give them anxiety and two-thirds of children spend four hours or more a day on smartphones. So how can we hang up on this cellphone addiction and dial into our mental health?
RETHINKING RETIREMENT: REASONS TO KEEP WORKING
Keep Working: Rethinking Retirement
By Ivanhoe Broadcast News on July 27, 2024
https://www.ivanhoe.com/?p=33714&preview=1&_ppp=a67e9bcb62
ORLANDO, Fla. (Ivanhoe Newswire) — Some people may be counting down the years until retirement. But studies show an increasing number of older adults are choosing to work longer in life.
EMILY SAYS KETAMINE CHANGED HER LIFE
Ketamine: Emily Says It Changed Her Life!
By Ivanhoe Broadcast News on July 26, 2024
https://www.ivanhoe.com/?p=33761&preview=1&_ppp=e00b4d17eb
CLEVELAND, OH (Ivanhoe Newswire) – Almost 52 million Americans have dealt with chronic pain — a debilitating pain that persists for months or years. Chronic pain can be caused by anything from an illness to an injury, but many people suffer in the absence of any past injury or illness. Cleveland Clinic is taking a different approach at treating chronic pain — with a well-known drug that’s typically used as an anesthetic agent. Ketamine
JIM’S LIFELINE: BREAKTHROUGH IMPLANT FOR HEART FAILURE
Heart Implant for Heart Failure
By Ivanhoe Broadcast News on July 25, 2024
https://www.ivanhoe.com/?p=33753&preview=1&_ppp=af4f72825d
CLEVELAND, OH (Ivanhoe Newswire) – More than six and a half million Americans are living with heart failure. In the next five years, that number will grow to eight and a half million people. It’s the leading cause of death for men and women. It’s a debilitating disease leaving patients breathless, fatigued, confused and in pain. Current therapies, devices and medications can be lifesaving, they do not improve the symptoms of heart failure — but now, for the first time, new technology will help.
DOCTORS OF THE FUTURE: IT’S ALL ABOUT AI
Artificial intelligence and Doctors Of the Future
By Ivanhoe Broadcast News on July 24, 2024
https://www.ivanhoe.com/?p=33746&preview=1&_ppp=9d5aa09d9a
SAN ANTONIO, TX (Ivanhoe Newswire) – Artificial intelligence can already emulate human cognition and is utilized by physicians to customize patient treatment and perform robotic surgery. Now, two Texas institutions are joining medicine and AI with a dual degree offered to medical students.
From A Head Cold to A Rare Heart Condition By Ivanhoe Broadcast News on July 23, 2024
https://www.ivanhoe.com/?p=33737&preview=1&_ppp=57a150125d
SAN ANTONIO, TX (Ivanhoe Newswire) – An eight-year-old boy’s experience could be your own. He went to the doctor for head cold symptoms. He ended up in the OR to fix a rare heart condition.
NEW HOPE FOR BABIES BORN WITH HIV
New Hope for Babies Born With HIV
By Ivanhoe Broadcast News on July 22, 2024
https://www.ivanhoe.com/?p=33730&preview=1&_ppp=dead62b464
WASHINGTON, DC (Ivanhoe Newswire) – 39 million people worldwide are living with HIV, the virus that leads to aids. In the 80’s, contracting HIV was considered a death sentence. In the 90’s HIV was the number one cause of death among Americans ages 25 to 44. Fast forward to 2024 — there are anti-viral drugs that can keep people infected with the virus alive into their 70’s and 80’s. There are even drugs that can lower a person’s risk of catching HIV to almost zero. And now, a new breakthrough — this one impacting the youngest patients. Babies born with HIV
sábado, 20 de julio de 2024
Treating the Whole Person: How Cancer Centers Are Addressing Social Needs
https://www.cancer.gov/news-events/cancer-currents-blog/2024/cancer-disparities-transportation-food-housing?cid=eb_govdel
While treating people’s health-related social needs has always been a part of health care in one form or other, cancer centers and community cancer clinics are increasingly viewing the people they treat through a social lens—and addressing social needs—including transportation, food, and housing—as part of patient care.
Global Burden of Disease
https://www.thelancet.com/gbd?dgcid=hubspot_email_infocusalerts-obgyn_feature&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-9OZuo_eURU-mj8kCbFOCyc0F3DlMHWDVb8wlJQnyL5xlTqUeYLkvuk8AaxED4asWTyqAH_YfnS21shzYEKwW7rbrWdSQ&_hsmi=316510222&utm_content=314995446&utm_source=hs_email
Welcome to the Lancet Global Burden of Disease (GBD) Resource Centre, bringing together the most comprehensive data and analysis of worldwide trends in global health, published across the Lancet family of journals.
The Lancet 2024 Series on menopause
https://www.thelancet.com/infographics-do/menopause-2024?dgcid=hubspot_email_infocusalerts-obgyn_feature_lancetmenopause24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-_ivmH1TtpSCceAWzTj1ym10fzYG1R2QzcBV6ZgdufFlnxQqkwZh2Kul5V2lxPinWpcaFofotCU9eWs1-gaEVtRnuIfjg&_hsmi=316510222&utm_content=314995446&utm_source=hs_email
Menopause is a life stage for half the world’s population, but experiences vary hugely. The Lancet 2024 Series on menopause argues for a new approach supporting and empowering women transitioning this life stage.
Pregnancy and rheumatic diseases Published: June 11, 2024
https://www.thelancet.com/series/pregnancy-rheumatic-diseases?dgcid=hubspot_email_infocusalerts-obgyn_feature_lanrhepregnancyrmd24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-9rZER3yoEQl37Y2w-XNZJzJzhVNR0R5mB3_i-uhgfYmMXX5Dam-uiAr4shV-5e0-jVF3DkKY-d_mIGL49tG_QCRCZvdQ&_hsmi=316510222&utm_content=314995446&utm_source=hs_email
Pregnancy can be a time of concern for any individual, particularly for those with chronic conditions. Rheumatic diseases disproportionally affect individuals of childbearing age and active inflammatory disease in pregnancy is associated with an increased risk of adverse pregnancy outcomes. Maintenance of low disease activity with disease-modifying antirheumatic drugs (DMARDs) is the best way to reduce the risks of adverse pregnancy outcomes. However, therapeutic decisions are complicated by scarce data on the efficacy and safety of DMARDs in pregnant people due to exclusion of these individuals from studies, which has led to inappropriate withdrawal of treatment and consequential harm. This Series in The Lancet Rheumatology calls for a reconsideration of therapeutic decisions for treating rheumatic diseases in and around pregnancy to optimise the safe and effective use of DMARDs, proposes solutions to change the challenging landscape around studies in pregnancy, and provides guidance on discussing these topics with patients.
Health experts raise concern over the disposal of infected poultry birds as avian flu spreads About 95 million poultry birds have been killed and disposed of since February 2022, according to USDA data Reuters Published July 18, 2024 9:03am EDT
Health experts raise concern over the disposal of infected poultry birds as avian flu spreads
About 95 million poultry birds have been killed and disposed of since February 2022, according to USDA data
Reuters
Published July 18, 2024 9:03am EDT
https://www.foxnews.com/health/health-experts-raise-concern-over-disposal-infected-poultry-birds-avian-flu-spreads
Most US adults worry about future of Medicare, Social Security, Gallup poll finds: ‘Magnitude of concern’ Availability of programs likely influences older adults’ voting decisions, respondents say Melissa Rudy By Melissa Rudy Fox News Published July 18, 2024 4:12pm EDT
Most US adults worry about future of Medicare, Social Security, Gallup poll finds: ‘Magnitude of concern’
Availability of programs likely influences older adults’ voting decisions, respondents say
Melissa Rudy By Melissa Rudy Fox News
Published July 18, 2024 4:12pm EDT
https://www.foxnews.com/health/most-us-adults-worry-future-medicare-social-security-gallup-poll-magnitude-concern
Mayo Clinic finds new type of memory loss that’s often mistaken for Alzheimer’s Syndrome is very similar to Alzheimer’s but is slower to progress, say researchers Melissa Rudy By Melissa Rudy Fox News Published July 18, 2024 7:20pm EDT
Mayo Clinic finds new type of memory loss that’s often mistaken for Alzheimer’s
Syndrome is very similar to Alzheimer’s but is slower to progress, say researchers
Melissa Rudy By Melissa Rudy Fox News
Published July 18, 2024 7:20pm EDT
https://www.foxnews.com/health/mayo-clinic-finds-new-type-memory-loss-thats-often-mistaken-alzheimers
Follow these 9 safe hiking tips to prevent tragedy on the trail Experts share the most important things hikers should know before heading out By Amy McGorry Fox News Published July 19, 2024 6:43am EDT
Follow these 9 safe hiking tips to prevent tragedy on the trail
Experts share the most important things hikers should know before heading out
By Amy McGorry Fox News
Published July 19, 2024 6:43am EDT
https://www.foxnews.com/health/follow-9-safe-hiking-tips-prevent-tragedy-trail
This is how we get fentanyl off our streets Our legislation would empower law enforcement to crack down on these criminals and help save American lives By David Kustoff , Rep. Abigail Spanberger Fox News Published July 20, 2024 8:00am EDTThis is how we get fentanyl off our streets Our legislation would empower law enforcement to crack down on these criminals and help save American lives By David Kustoff , Rep. Abigail Spanberger Fox News Published July 20, 2024 8:00am EDT
This is how we get fentanyl off our streets
Our legislation would empower law enforcement to crack down on these criminals and help save American lives
By David Kustoff , Rep. Abigail Spanberger Fox News
Published July 20, 2024 8:00am EDT
https://www.foxnews.com/opinion/how-we-get-fentanyl-off-our-streets
viernes, 19 de julio de 2024
Meet Cari Kitahara & Elisa Pasqual in DCEG Radiation Epidemiology Branch
Cari Kitahara, senior investigator, and Elisa Pasqual, former postdoctoral fellow, both in the Radiation Epidemiology Branch (REB) in the Division of Cancer Epidemiology and Genetics (DCEG) at the National Cancer Institute, discuss their research on thyroid cancer. In this video, Cari and Elisa describe their investigation into the late effects of treatment with radioactive iodine for thyroid cancer. These findings are just one example of the important contributions the REB makes to inform long-term follow-up and care of cancer patients and other exposed populations. The mission of REB is to identify, understand, and quantify the risk of cancer in populations exposed to medical, occupational, or environmental radiation, and to advance understanding of radiation carcinogenesis. REB is the largest radiation epidemiology research group in the world. The REB Dosimetry Unit develops tools to improve the measurement of radiation doses from medical and other exposures. REB also houses the DCEG Cancer Survivorship Research Unit. Learn more about the Radiation Epidemiology Branch at https://dceg.cancer.gov/reb Learn more about the Cancer Survivorship Research Unit at https://dceg.cancer.gov/csru Learn more about Cari Kitahara at https://dceg.cancer.gov/about/staff-directory/kitahara-cari Elisa is now a scientist at International Agency for Research on Cancer. For audio description and interactive transcript visit: https://smartplayer.captionsync.com/play.php?vid=1721073818nciocplopa_b75e1e8a987dbfe8
A New Way to Measure and Predict Human Immune Health
https://www.niaid.nih.gov/news-events/new-way-measure-and-predict-human-immune-health?utm_campaign=+61447959&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
The immune system senses and responds to changes in physiologic health, and a new tool called the immune health metric (IHM) can measure and even predict some of these changes, an NIAID study has found. If doctors could use the IHM to detect health problems long before symptoms appear, they could potentially act early to prevent disease, the researchers suggest. Their findings are published in the journal Nature Medicine.
jueves, 18 de julio de 2024
Study of Protective Gene Variant Provides Insight into Delaying Onset of Alzheimer’s Dementia Posted on July 18th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/07/18/study-of-protective-gene-variant-provides-insight-into-delaying-onset-of-alzheimers-dementia/
Alzheimer’s disease is currently the seventh leading cause of death in the U.S. While your likelihood of developing Alzheimer’s-related cognitive impairment increases with age, risk for this disease and age of its onset depend on many factors, including the genes you carry. An intriguing new study suggests that having just one copy of a protective gene variant may be enough to delay cognitive impairment from this devastating disease in individuals who are otherwise genetically predisposed to developing early-onset Alzheimer’s dementia.
IBS: What you need to know - Irritable bowel syndrome (IBS)
https://magazine.medlineplus.gov/article/ibs-what-you-need-to-know?utm_medium=email&utm_source=govdelivery
Irritable bowel syndrome (IBS) refers to a group of symptoms that occur together and cause pain in the abdomen. They also cause changes in your bowel movements. The type of IBS you have depends on whether you have constipation, diarrhea, or both. Other symptoms may include abdominal cramping, bloating, or whitish mucus in your stool. You also may feel like you haven't finished a bowel movement. The condition can
miércoles, 17 de julio de 2024
7 Things To Know About Complementary Approaches for Fibromyalgia
https://www.nccih.nih.gov/health/tips/things-to-know-about-complementary-approaches-for-fibromyalgia?nav=govd
Fibromyalgia syndrome is a chronic disorder involving widespread pain and tenderness, fatigue, and other symptoms that can interfere with a person’s ability to carry out daily activities. It’s estimated that 4 million U.S. adults have fibromyalgia. A variety of complementary health approaches have been studied to see whether they might be helpful for fibromyalgia symptoms.
Meditative movement therapies, such as tai chi, may provide modest relief of some fibromyalgia symptoms.
Massage therapy or a type of manual therapy called myofascial release, which is directed at connective tissue (fascia), may lead to a small improvement in fibromyalgia symptoms.
Vitamin D supplements may reduce pain in people with fibromyalgia who are deficient in this vitamin. There is insufficient evidence that any other dietary supplements can relieve fibromyalgia pain.
Doctors reluctant to treat addiction most commonly report “lack of institutional support” as barrier NIH study highlights need for greater education, training, and policies to increase adoption of evidence-based care for addiction among physicians.Doctors reluctant to treat addiction most commonly report “lack of institutional support” as barrier NIH study highlights need for greater education, training, and policies to increase adoption of evidence-based care for addiction among physicians.
What Is a Hormone? BY HEATHER HAYES
https://biobeat.nigms.nih.gov/2024/07/what-is-a-hormone/?utm_medium=email&utm_source=govdelivery
Hormones are tiny messengers in our bodies that regulate many important functions throughout our lives, including big changes during development and small changes every day. This post explains what hormones are and how they function.
What Is Metabolism?
BY ABBEY BIGLER-COYNE
https://biobeat.nigms.nih.gov/2024/06/what-is-metabolism/?utm_medium=email&utm_source=govdelivery
Metabolism encompasses all the chemical reactions our bodies use to build up and break down molecules to keep us alive and healthy. Our cells must constantly balance many metabolic pathways. If these pathways are disrupted, serious diseases can occur.
Rhodiola: Science and Safety
https://www.nccih.nih.gov/health/rhodiola?nav=govd
Background
Rhodiola grows in cold regions and at high altitudes in Europe and Asia. People have traditionally used it to try to increase endurance, work performance, and tolerance of high altitudes and to treat fatigue, weakness, and other symptoms.
Today, rhodiola is promoted to increase energy, stamina, strength, and mental capacity; improve athletic performance; resist the effects of stress; and help manage depression, anxiety, and other symptoms.
What Have We Learned?
Some preliminary research has been done on rhodiola, but few rigorous studies of this herb have been done in people.
There isn’t enough evidence from studies in people to allow conclusions to be reached about whether rhodiola is helpful for any health-related purpose.
What Do We Know About Safety?
Rhodiola has been used safely in studies lasting 6 to 12 weeks.
Little is known about whether it’s safe to use rhodiola during pregnancy or while breastfeeding.
martes, 16 de julio de 2024
From Awareness to Action: Tackling the Rising Burden of Common Chronic Diseases
https://www.fda.gov/news-events/fda-voices/awareness-action-tackling-rising-burden-common-chronic-diseases?utm_medium=email&utm_source=govdelivery
Since graduating from medical school in 1978, I’ve seen medicine and healthcare change in unimaginable ways for the better. However, one of the most alarming changes is the recent decline in life expectancy in our country, largely due to the cumulative impact of common chronic diseases (CCDs), combined with excessive rates of suicide, drug overdose and gun violence, and, of course, COVID-19. How can it be that our prowess in technology is not translating into better health and longevity for the American public?
Chronic Disease Day, marked earlier this month, originated in part from the recognition of these trends, now resulting in a serious state of affairs: 7 of the 10 leading causes of death in the U.S. are CCDs. But the recognition of the importance of chronicity of disease is a relatively new issue. The focus of my early career was heart attacks, which at that time killed about 50% of those affected. Today, due to advances in treatments for heart attacks that have transformed the field of cardiology with significant support from U.S. Food and Drug Administration policies supporting innovation and evidence generation, the vast majority of people survive heart attacks. However, many of these survivors go on to develop chronic conditions like heart failure. Chronic diseases of the heart, lung, kidneys, liver, and metabolism (such as obesity and diabetes) account for the vast majority of deaths in this country. Even many patients with cancer now can often expect to be long term survivors, although many cancer survivors continue to have chronic manifestations of the cancer or related diseases.
Treatments for blindness target the retina and the brain | Drug Discovery News
Treatments for blindness target the retina and the brain | Drug Discovery News: Researchers are developing gene and cell therapies and prosthetics to help patients with blindness regain some vision. The first major prosthetic, the Argus II, was just discontinued. Where will the field go from here?
A vision of the future: Stem cells offer hope for retinal degeneration | Drug Discovery News
A vision of the future: Stem cells offer hope for retinal degeneration | Drug Discovery News: Cell therapies derived from stem cells could one day prevent vision loss or even restore sight in retinal degenerative disease.
Mini-retinas model human disease in a dish | Drug Discovery News
Mini-retinas model human disease in a dish | Drug Discovery News: Researchers use retinal organoids to screen drugs and hope to transplant them into the eyes of people with blindness in the coming years.
Half of cancer deaths could have been prevented through lifestyle changes, says American Cancer Society report Experts identify the most important behaviors to reduce cancer risk Melissa Rudy By Melissa Rudy Fox News Published July 13, 2024 9:38am EDT
Half of cancer deaths could have been prevented through lifestyle changes, says American Cancer Society report
Experts identify the most important behaviors to reduce cancer risk
Melissa Rudy By Melissa Rudy Fox News
Published July 13, 2024 9:38am EDT
https://www.foxnews.com/health/half-cancer-deaths-could-have-been-prevented-through-lifestyle-changes-says-american-cancer-society-report
Chemotherapy drug could have a serious and surprising side effect, study finds Cisplatin has been linked to ‘significant difficulties’ among a majority of cancer survivors, say researchers Melissa Rudy By Melissa Rudy Fox News Published July 14, 2024 9:14am EDT
Chemotherapy drug could have a serious and surprising side effect, study finds
Cisplatin has been linked to ‘significant difficulties’ among a majority of cancer survivors, say researchers
Melissa Rudy By Melissa Rudy Fox News
Published July 14, 2024 9:14am EDT
https://www.foxnews.com/health/chemotherapy-drug-serious-surprising-side-effect-study-finds
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