lunes, 31 de octubre de 2022

An estimated 15% of U.S. adults have long-COVID

An estimated 15% of U.S. adults have long-COVID

SARS-CoV-2 infection can affect menstruation

SARS-CoV-2 infection can affect menstruation

Investigators study symptom trajectories in nondialysis-dependent CKD patients

Investigators study symptom trajectories in nondialysis-dependent CKD patients

New report on the impact of monkeypox on people with HIV

New report on the impact of monkeypox on people with HIV

How COVID-19 impacted sleep and mental health among university students

How COVID-19 impacted sleep and mental health among university students

An innovative nasal vaccine strategy to combat COVID

An innovative nasal vaccine strategy to combat COVID

Research finds a significant increase in stroke incidence in those younger than 55 years

Research finds a significant increase in stroke incidence in those younger than 55 years

Study calls for stronger awareness and control of vascular risk factors leading to stroke

Study calls for stronger awareness and control of vascular risk factors leading to stroke

The impact of genetic and lifestyle factors on the risk of major cardiovascular and thromboembolic events post-COVID-19 diagnosis

The impact of genetic and lifestyle factors on the risk of major cardiovascular and thromboembolic events post-COVID-19 diagnosis

Lower risk of colorectal cancer associated with dietary flavanone and anthocyanidin intake, according to new research

Lower risk of colorectal cancer associated with dietary flavanone and anthocyanidin intake, according to new research

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

What are the implications of microbial ecosystems for female reproductive health?

What are the implications of microbial ecosystems for female reproductive health?

Intensive BP Lowering Harmful in Acute Ischemic Stroke

Intensive BP Lowering Harmful in Acute Ischemic Stroke

Oct 28 2022 This Week in Cardiology

Oct 28 2022 This Week in Cardiology

How Will Lack of Exercise Affect Global Health in the 2020s?

How Will Lack of Exercise Affect Global Health in the 2020s?

AF Ablation May Spark Takotsubo Syndrome: Case Series

AF Ablation May Spark Takotsubo Syndrome: Case Series

COVID-19 Tied to Increased Risk for CV Events and Death

COVID-19 Tied to Increased Risk for CV Events and Death

Global Tuberculosis Cases, Deaths Rise During COVID Pandemic

Global Tuberculosis Cases, Deaths Rise During COVID Pandemic

New COVID Variant Gaining Traction in US

New COVID Variant Gaining Traction in US

Addiction Drug Shows Promise Lifting Long COVID Brain Fog, Fatigue

Addiction Drug Shows Promise Lifting Long COVID Brain Fog, Fatigue

Challenges to Colonoscopy as Gold Standard for CRC Screening?

Challenges to Colonoscopy as Gold Standard for CRC Screening?

Novel Head-Up CPR Position Raises Odds of Survival

Novel Head-Up CPR Position Raises Odds of Survival

Vitamin D: Recent Findings and Implications

Vitamin D: Recent Findings and Implications

Latest Clinical Research & Medical News | Univadis Global

Latest Clinical Research & Medical News | Univadis Global

NIMH » NIMH Research Domain Criteria Roundtable - Data-Driven Refinement of Psychopathology: Toward Precision Diagnostics

NIMH » NIMH Research Domain Criteria Roundtable - Data-Driven Refinement of Psychopathology: Toward Precision Diagnostics

domingo, 30 de octubre de 2022

Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke. Cho Bernard P H et al. JAMA neurology 2022 10

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Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case — New York, March 9–October 11, 2022 AB Ryerson et al, MMWR, October 29, 2022

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Integrating Internet multisource big data to predict the occurrence and development of COVID-19 cryptic transmission. Gao Chengcheng et al. NPJ digital medicine 2022 10 (1) 161

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Advanced Molecular Detection Clips Database|AMD Clips|PHGKB

Advanced Molecular Detection Clips Database|AMD Clips|PHGKB

Precision Health Database| Genomics Precision Health Weekly Scan|PHGKB

Precision Health Database| Genomics Precision Health Weekly Scan|PHGKB

Increasing Use and Impact of Family Health History in Medically Underserved Populations | CDC

Increasing Use and Impact of Family Health History in Medically Underserved Populations | CDC

Prevalence of psychological symptoms and associated risk factors among nurses in 30 provinces during the COVID-19 pandemic in China - The Lancet Regional Health – Western Pacific

Prevalence of psychological symptoms and associated risk factors among nurses in 30 provinces during the COVID-19 pandemic in China - The Lancet Regional Health – Western Pacific

Lower risk of multi-system inflammatory syndrome in children (MIS-C) with the omicron variant - The Lancet Regional Health – Western Pacific

Lower risk of multi-system inflammatory syndrome in children (MIS-C) with the omicron variant - The Lancet Regional Health – Western Pacific

Association of Molnupiravir and Nirmatrelvir-Ritonavir with preventable mortality, hospital admissions and related avoidable healthcare system cost among high-risk patients with mild to moderate COVID-19 - The Lancet Regional Health – Western Pacific

Association of Molnupiravir and Nirmatrelvir-Ritonavir with preventable mortality, hospital admissions and related avoidable healthcare system cost among high-risk patients with mild to moderate COVID-19 - The Lancet Regional Health – Western Pacific

Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial - eClinicalMedicine

Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial - eClinicalMedicine

Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networks - eClinicalMedicine

Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networks - eClinicalMedicine

Thrombopoietin participates in platelet activation in COVID-19 patients - eBioMedicine

Thrombopoietin participates in platelet activation in COVID-19 patients - eBioMedicine

SARS-CoV-2 vaccine strategies in kidney transplant recipients - The Lancet Infectious Diseases

SARS-CoV-2 vaccine strategies in kidney transplant recipients - The Lancet Infectious Diseases

Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial - The Lancet Infectious Diseases

Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial - The Lancet Infectious Diseases

Durability of AZD1222 and hybrid humoral immunity against omicron BA.1 and BA.4 - The Lancet Infectious Diseases

Durability of AZD1222 and hybrid humoral immunity against omicron BA.1 and BA.4 - The Lancet Infectious Diseases

Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial - The Lancet Infectious Diseases

Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial - The Lancet Infectious Diseases

Learning and confirming in publicly funded antiviral trials - The Lancet Infectious Diseases

Learning and confirming in publicly funded antiviral trials - The Lancet Infectious Diseases

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial - The Lancet Infectious Diseases

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial - The Lancet Infectious Diseases

Risk of reinfection, vaccine protection, and severity of infection with the BA.5 omicron subvariant: a nation-wide population-based study in Denmark - The Lancet Infectious Diseases

Risk of reinfection, vaccine protection, and severity of infection with the BA.5 omicron subvariant: a nation-wide population-based study in Denmark - The Lancet Infectious Diseases

After 2 years of the COVID-19 pandemic, translating One Health into action is urgent - The Lancet

After 2 years of the COVID-19 pandemic, translating One Health into action is urgent - The Lancet

Resistance to COVID-19 controls in an anthropologist's home town - The Lancet

Resistance to COVID-19 controls in an anthropologist's home town - The Lancet

The legacy of the COVID-19 pandemic for childhood vaccination in the USA - The Lancet

The legacy of the COVID-19 pandemic for childhood vaccination in the USA - The Lancet

Prioritisation of COVID-19 boosters in the omicron era - The Lancet

Prioritisation of COVID-19 boosters in the omicron era - The Lancet

Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales - The Lancet

Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales - The Lancet

viernes, 28 de octubre de 2022

Doctors Say Ultrasound Breast Exams May Not Be Needed

Doctors Say Ultrasound Breast Exams May Not Be Needed

Progesterone Recommended for Perimenopause

Progesterone Recommended for Perimenopause

New Guidance on Using High-Efficacy DMTs in Multiple Sclerosis

New Guidance on Using High-Efficacy DMTs in Multiple Sclerosis

Endometriosis Linked With Genital Microbiome Changes

Endometriosis Linked With Genital Microbiome Changes

Anti-drug antibodies lower efficacy of anti-cancer treatment

Anti-drug antibodies lower efficacy of anti-cancer treatment

Ivermectin ineffective for mild or moderate COVID-19

Ivermectin ineffective for mild or moderate COVID-19

Anorectal and penile lesion swabs best for monkeypox diagnosis

Anorectal and penile lesion swabs best for monkeypox diagnosis

Type 2 diabetes: cardiovascular and renal benefits of empagliflozin vs dapagliflozin

Type 2 diabetes: cardiovascular and renal benefits of empagliflozin vs dapagliflozin

Recent Medical News & Clinical Studies | Univadis

Recent Medical News & Clinical Studies | Univadis

NCI Minute: Annual Report to the Nation on the Status of Cancer

Experimental Monoclonal Antibodies Show Promise Against Epstein-Barr Virus | NIH: National Institute of Allergy and Infectious Diseases

Experimental Monoclonal Antibodies Show Promise Against Epstein-Barr Virus | NIH: National Institute of Allergy and Infectious Diseases

Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies | The BMJ

Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies | The BMJ

FDA Continues to Advance Medicines for Children | FDA

FDA Continues to Advance Medicines for Children | FDA

Experimental monoclonal antibodies show promise against Epstein-Barr virus | National Institutes of Health (NIH)

Experimental monoclonal antibodies show promise against Epstein-Barr virus | National Institutes of Health (NIH)

NIH researchers home in on a new cause of Stargardt disease | National Institutes of Health (NIH)

NIH researchers home in on a new cause of Stargardt disease | National Institutes of Health (NIH)

Jaundice | Breast Cancer Research | Diabetes Drugs Compared | Lung Diseases | Dental Hygiene

Jaundice | Breast Cancer Research | Diabetes Drugs Compared | Lung Diseases | Dental Hygiene

jueves, 27 de octubre de 2022

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

First report of natural recombination of monkeypox virus genome

First report of natural recombination of monkeypox virus genome

The effectiveness of BNT162b2 COVID-19 vaccine against infection with SARS-CoV-2 Omicron subvariants BA.4/5

The effectiveness of BNT162b2 COVID-19 vaccine against infection with SARS-CoV-2 Omicron subvariants BA.4/5

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Annual Report to the Nation: Cancer deaths continue downward trend; modest improvements in survival for pancreatic cancer | National Institutes of Health (NIH)

Annual Report to the Nation: Cancer deaths continue downward trend; modest improvements in survival for pancreatic cancer | National Institutes of Health (NIH)

Annual Report to the Nation shows progress against cancer - NCI

Annual Report to the Nation shows progress against cancer - NCI

A farm where animals and people heal from trauma together - ISRAEL21c

A farm where animals and people heal from trauma together - ISRAEL21c

How dyslexia inspired an app using music to teach English - ISRAEL21c

How dyslexia inspired an app using music to teach English - ISRAEL21c

How to improve emotional wellbeing of cancer gene carriers - ISRAEL21c

How to improve emotional wellbeing of cancer gene carriers - ISRAEL21c

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022 | HIV.gov

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022 | HIV.gov

A London Global Cancer Week webinar: Fatty liver disease in Latin America—an emerging public health threat

A London Global Cancer Week webinar: Fatty liver disease in Latin America—an emerging public health threat

The Lancet Gastroenterology and Hepatology: Homepage

The Lancet Gastroenterology and Hepatology: Homepage

NIH scientists discover essential step in recharging the eye’s light-sensing retina | National Institutes of Health (NIH)

NIH scientists discover essential step in recharging the eye’s light-sensing retina | National Institutes of Health (NIH)

NIH-funded studies show damaging effects of vaping, smoking on blood vessels | National Institutes of Health (NIH)

NIH-funded studies show damaging effects of vaping, smoking on blood vessels | National Institutes of Health (NIH)

miércoles, 26 de octubre de 2022

How To Make Sense of a Scientific Journal Article | NCCIH

How To Make Sense of a Scientific Journal Article | NCCIH

Imaging That Helps Us Build a Picture of Whole Person Health | NCCIH

Imaging That Helps Us Build a Picture of Whole Person Health | NCCIH

Cancer drugs are closing in on some of the deadliest mutations

Cancer drugs are closing in on some of the deadliest mutations

COVID research is free to access — but for how long?

COVID research is free to access — but for how long?

Immune system-evading hybrid virus observed for first time | Infectious diseases | The Guardian

Immune system-evading hybrid virus observed for first time | Infectious diseases | The Guardian

A London Global Cancer Week webinar: Groundshot—levelling up cancer outcomes in Europe

A London Global Cancer Week webinar: Groundshot—levelling up cancer outcomes in Europe

A London Global Cancer Week webinar: Fatty liver disease in Latin America—an emerging public health threat

A London Global Cancer Week webinar: Fatty liver disease in Latin America—an emerging public health threat

A London Global Cancer Week webinar: Cancer control in sub-Saharan Africa

A London Global Cancer Week webinar: Cancer control in sub-Saharan Africa

The Lancet Webinars London Global Cancer Week

The Lancet Webinars London Global Cancer Week

FDA approves teclistamab-cqyv for relapsed or refractory multiple myeloma | FDA

FDA approves teclistamab-cqyv for relapsed or refractory multiple myeloma | FDA

Popular diabetes drugs compared in large trial | National Institutes of Health (NIH)

Popular diabetes drugs compared in large trial | National Institutes of Health (NIH)

“Slow” vaccine delivery improves immune response to HIV | National Institutes of Health (NIH)

“Slow” vaccine delivery improves immune response to HIV | National Institutes of Health (NIH)

Potential contributor to sex differences in Alzheimer’s risk | National Institutes of Health (NIH)

Potential contributor to sex differences in Alzheimer’s risk | National Institutes of Health (NIH)

Robotic exoskeleton helps people walk | National Institutes of Health (NIH)

Robotic exoskeleton helps people walk | National Institutes of Health (NIH)

International Domestic Violence Resource Guide (2022)

International Domestic Violence Resource Guide: Coronavirus Update

martes, 25 de octubre de 2022

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Researchers focus on the identification of markers to improve head and neck cancer risk assessment

Researchers focus on the identification of markers to improve head and neck cancer risk assessment

New type of antibiotic effectively kills hard-to-fight bacteria

New type of antibiotic effectively kills hard-to-fight bacteria

Treating Breathing Problems in People with Cancer - NCI

Treating Breathing Problems in People with Cancer - NCI

Alzheimer’s Disease Research Centers: National Research Centers, Local Resources

Alzheimer’s Disease Research Centers: National Research Centers, Local Resources

Rationale for FDA’s Position on the Use of Cefazolin Breakpoints as a Surrogate for Determining Breakpoints for Oral Cephalosporins for the Treatment of Uncomplicated Urinary Tract Infections | FDA

Rationale for FDA’s Position on the Use of Cefazolin Breakpoints as a Surrogate for Determining Breakpoints for Oral Cephalosporins for the Treatment of Uncomplicated Urinary Tract Infections | FDA

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

Study: Moderna COVID vaccine safe, comparably effective in preschoolers | CIDRAP

Study: Moderna COVID vaccine safe, comparably effective in preschoolers | CIDRAP

In pre-clinical trials, drug shows potential to combat exaggerated inflammation associated with COVID-19

In pre-clinical trials, drug shows potential to combat exaggerated inflammation associated with COVID-19

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose | Infectious Diseases | JAMA | JAMA Network

Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose | Infectious Diseases | JAMA | JAMA Network

Loneliness, Anxiety, Depression, and Adoption of the Role of Caregiver of Older Adults with Chronic Diseases during COVID-19

Loneliness, Anxiety, Depression, and Adoption of the Role of Caregiver of Older Adults with Chronic Diseases during COVID-19

SciELO - Brasil - ANALYSIS OF SPORTS BEHAVIOR AND THE CURRENT SITUATION OF YOUNG STUDENTS UNDER THE BACKGROUND OF COVID-19 ANALYSIS OF SPORTS BEHAVIOR AND THE CURRENT SITUATION OF YOUNG STUDENTS UNDER THE BACKGROUND OF COVID-19

SciELO - Brasil - ANALYSIS OF SPORTS BEHAVIOR AND THE CURRENT SITUATION OF YOUNG STUDENTS UNDER THE BACKGROUND OF COVID-19 ANALYSIS OF SPORTS BEHAVIOR AND THE CURRENT SITUATION OF YOUNG STUDENTS UNDER THE BACKGROUND OF COVID-19

Transient ischemic attacks offer a critical window for preventive measures

Transient ischemic attacks offer a critical window for preventive measures

Red meat may not be as bad for health as previously thought

Red meat may not be as bad for health as previously thought

Metformin as a treatment for atrial fibrillation

Metformin as a treatment for atrial fibrillation

Venous thromboembolism: benefits of extended rivaroxaban thromboprophylaxis

Venous thromboembolism: benefits of extended rivaroxaban thromboprophylaxis

Hypertension: medication either in the morning or evening appears safe

Hypertension: medication either in the morning or evening appears safe

Cardiology News, Resources, & Clinical Research | Univadis

Cardiology News, Resources, & Clinical Research | Univadis

Latest Clinical Research & Medical News | Univadis Global

Latest Clinical Research & Medical News | Univadis Global

FDA approves tremelimumab in combination with durvalumab for unresectable hepatocellular carcinoma | FDA

FDA approves tremelimumab in combination with durvalumab for unresectable hepatocellular carcinoma | FDA

Video gaming may be associated with better cognitive performance in children | National Institutes of Health (NIH)

Video gaming may be associated with better cognitive performance in children | National Institutes of Health (NIH)

What to Know About the Risk of Cronobacter in Powdered Infant Formula | FDA

What to Know About the Risk of Cronobacter in Powdered Infant Formula | FDA

Genetic basis of mental illness: Individual genetics and ‘racial’ ancestry impact mental illness, but most studies have focused only on white people - Genetic Literacy Project

Genetic basis of mental illness: Individual genetics and ‘racial’ ancestry impact mental illness, but most studies have focused only on white people - Genetic Literacy Project

Which COVID studies pose a biohazard? Lack of clarity hampers research

Which COVID studies pose a biohazard? Lack of clarity hampers research

What next for Angelman syndrome therapeutics? | Spectrum | Autism Research News

What next for Angelman syndrome therapeutics? | Spectrum | Autism Research News

lunes, 24 de octubre de 2022

Pembrolizumab improves survival in melanoma patients

Pembrolizumab improves survival in melanoma patients

Oncology News, Resources, & Clinical Research | Univadis

Oncology News, Resources, & Clinical Research | Univadis

Tobacco exposure increases breast cancer risk

Tobacco exposure increases breast cancer risk

Trastuzumab deruxtecan in patients with breast cancer

Trastuzumab deruxtecan in patients with breast cancer

Patterns and role of comorbidities in breast cancer

Patterns and role of comorbidities in breast cancer

Dietary guidelines for early breast cancer may need modification

Dietary guidelines for early breast cancer may need modification

HER2-low breast cancer: review of new clinical developments

HER2-low breast cancer: review of new clinical developments

Greater height in women linked to breast cancer risk

Greater height in women linked to breast cancer risk

Latest Clinical Research & Medical News | Univadis Global

Latest Clinical Research & Medical News | Univadis Global

‘Omicron has started to splinter’: Winter COVID wave may come with a ‘dizzying barrage’ of new variants - Genetic Literacy Project

‘Omicron has started to splinter’: Winter COVID wave may come with a ‘dizzying barrage’ of new variants - Genetic Literacy Project

domingo, 23 de octubre de 2022

Proband-mediated interventions to increase disclosure of genetic risk in families with a BRCA or Lynch syndrome condition: a systematic review AL Young et al, EJHG, October 17, 2022

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Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke A Ilinka et al, EJHG, October 17, 2022

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Proband-mediated interventions to increase disclosure of genetic risk in families with a BRCA or Lynch syndrome condition: a systematic review AL Young et al, EJHG, October 17, 2022

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The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer JE Barrett et al, Genome Medicine, October 19, 2022

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Relatives from Hereditary Breast and Ovarian Cancer and Lynch Syndrome Families Forgoing Genetic Testing: Findings from the Swiss CASCADE Cohort M Sarki et al, J Per Med, October 19, 2022

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The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease. Chakaroun Rima Mohsen et al. Nature reviews. Cardiology 2022 10

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Epidemiology and prevention of venous thromboembolism. Lutsey Pamela L et al. Nature reviews. Cardiology 2022 10

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Main|Genetic testing|PHGKB

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CDC-Authored Publications Update|PHGKB

CDC-Authored Publications Update|PHGKB

Precision Health Database| Non-Genomics Precision Health Weekly Scan|PHGKB

Precision Health Database| Non-Genomics Precision Health Weekly Scan|PHGKB

Advanced Molecular Detection Clips Database|AMD Clips|PHGKB

Advanced Molecular Detection Clips Database|AMD Clips|PHGKB

Precision Health Database| Genomics Precision Health Weekly Scan|PHGKB

Precision Health Database| Genomics Precision Health Weekly Scan|PHGKB

Hereditary Breast and Ovarian Cancer | CDC

Hereditary Breast and Ovarian Cancer | CDC

Familial Hypercholesterolemia Screening in Children and Adolescents in the United States: Where Are We Heading? | Blogs | CDC

Familial Hypercholesterolemia Screening in Children and Adolescents in the United States: Where Are We Heading? | Blogs | CDC

The Limits of Risk Prediction: Remembering Cecile Janssens | Blogs | CDC

The Limits of Risk Prediction: Remembering Cecile Janssens | Blogs | CDC

DNA-based Population Screening for Precision Public Health | Frontiers Research Topic

DNA-based Population Screening for Precision Public Health | Frontiers Research Topic

sábado, 22 de octubre de 2022

Early HIV diagnosis and treatment important for better long-term health outcomes | National Institutes of Health (NIH)

Early HIV diagnosis and treatment important for better long-term health outcomes | National Institutes of Health (NIH)

B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B - Full Text View - ClinicalTrials.gov

B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B - Full Text View - ClinicalTrials.gov

Three-dose hepatitis B vaccine regimen protects people with HIV | NIH: National Institute of Allergy and Infectious Diseases

Three-dose hepatitis B vaccine regimen protects people with HIV | NIH: National Institute of Allergy and Infectious Diseases

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection | NEJM

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection | NEJM

Strategic Timing of Antiretroviral Treatment - Full Text View - ClinicalTrials.gov

Strategic Timing of Antiretroviral Treatment - Full Text View - ClinicalTrials.gov

‘Sending a Trojan horse into cancer cells’ Can this genetically-engineered bacteria stop tumors in their tracks? - Genetic Literacy Project

‘Sending a Trojan horse into cancer cells’ Can this genetically-engineered bacteria stop tumors in their tracks? - Genetic Literacy Project

Sickle cell disease gene therapy education project

Sickle cell disease gene therapy education project

Human Gene Therapy | Ahead of Print

Human Gene Therapy | Ahead of Print

Are You Living with Breast Cancer? Palliative Care Can Help

Are You Living with Breast Cancer? Palliative Care Can Help

Call for EMA committees and board members

Call for EMA committees and board members

World Orphan Drug Congress 2022 | 14 - 17 November 2022

World Orphan Drug Congress 2022 | 14 - 17 November 2022

Improving access for rare diseases

Events Archives - eurordis.org

Events Archives - eurordis.org

EURORDIS Open Academy - EURORDIS Open Academy

EURORDIS Open Academy - EURORDIS Open Academy

Another Step Closer: Why Europe should keep striving toward an Action Plan for Rare Diseases - eurordis.org

Another Step Closer: Why Europe should keep striving toward an Action Plan for Rare Diseases - eurordis.org

viernes, 21 de octubre de 2022

EULAR points-to-consider offers support to improve healthy work participation of people with RMDs

EULAR points-to-consider offers support to improve healthy work participation of people with RMDs

Posing a smile can brighten your mood, researchers say

Posing a smile can brighten your mood, researchers say

Overcrowded households, low socioeconomic status influence the impact of pandemic

Overcrowded households, low socioeconomic status influence the impact of pandemic

Top experts to speak about pediatric obesity at ObesityWeek 2022

Top experts to speak about pediatric obesity at ObesityWeek 2022

Study uses pluripotent stem cell models to investigate stress response in PTSD patients

Study uses pluripotent stem cell models to investigate stress response in PTSD patients

Infancy acid suppression and antibiotic use are associated with celiac disease

Infancy acid suppression and antibiotic use are associated with celiac disease

Three-dose regimen of HEPLISAV-B vaccine fully protects people living with HIV, data shows

Three-dose regimen of HEPLISAV-B vaccine fully protects people living with HIV, data shows

Multiple research platforms identify environmental chemical agents that promote intestinal inflammation

Multiple research platforms identify environmental chemical agents that promote intestinal inflammation

Examining how pain could play a direct protective role in the gut

Examining how pain could play a direct protective role in the gut

Three-dose hepatitis B vaccine regimen protects people with HIV | National Institutes of Health (NIH)

Three-dose hepatitis B vaccine regimen protects people with HIV | National Institutes of Health (NIH)

Vitamin D for heart health: where the benefits begin and end | NHLBI, NIH

Vitamin D for heart health: where the benefits begin and end | NHLBI, NIH

The FNIH Announces New Research Initiative to Identify More Precise Treatment Strategies for Patients Suffering from Heart Failure | NHLBI, NIH

The FNIH Announces New Research Initiative to Identify More Precise Treatment Strategies for Patients Suffering from Heart Failure | NHLBI, NIH

Genetic paths to predicting heart disease | NHLBI, NIH

Genetic paths to predicting heart disease | NHLBI, NIH

Spinal Manipulation: What You Need To Know | NCCIH

Spinal Manipulation: What You Need To Know | NCCIH

The brain and memory: Understanding how the brain thinks | NIH MedlinePlus Magazine

The brain and memory: Understanding how the brain thinks | NIH MedlinePlus Magazine

jueves, 20 de octubre de 2022

Energy-Based Treatment Combination Improves Becker's Nevi

Energy-Based Treatment Combination Improves Becker's Nevi

Treating the Person: The Mind-Body-Heart Connection

Treating the Person: The Mind-Body-Heart Connection

Search for Obesity Drugs; Long COVID; and Healthy Gut Microbiomes

Search for Obesity Drugs; Long COVID; and Healthy Gut Microbiomes

Healthy Diet, Less News Key to Preventing Anxiety During COVID

Healthy Diet, Less News Key to Preventing Anxiety During COVID

Recurrent endometrial cancer: letrozole-abemaciclib shows durable response

Recurrent endometrial cancer: letrozole-abemaciclib shows durable response

Screening MRI may not improve cancer detection for high-risk breast lesions

Screening MRI may not improve cancer detection for high-risk breast lesions

Prostate cancer: conventional and stereotactic body radiotherapy show similar 2-year toxicity

Prostate cancer: conventional and stereotactic body radiotherapy show similar 2-year toxicity

Risk of developing brain metastasis for patients with inflammatory breast cancer

Risk of developing brain metastasis for patients with inflammatory breast cancer

Latest Clinical Research & Medical News | Univadis Global

Latest Clinical Research & Medical News | Univadis Global

Langerhans Cell Histiocytosis Treatment (PDQ®)–Health Professional Version - NCI

Langerhans Cell Histiocytosis Treatment (PDQ®)–Health Professional Version - NCI

Esophageal Cancer Treatment (PDQ®)–Health Professional Version - NCI

Esophageal Cancer Treatment (PDQ®)–Health Professional Version - NCI

Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version - NCI

Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version - NCI

Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version - NCI

Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version - NCI

Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version - NCI

Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version - NCI

Breast Cancer Screening (PDQ®)–Health Professional Version - NCI

Breast Cancer Screening (PDQ®)–Health Professional Version - NCI

Breast Cancer Prevention (PDQ®)–Health Professional Version - NCI

Breast Cancer Prevention (PDQ®)–Health Professional Version - NCI

Treatment to Reduce Hearing Loss | Melanoma | Cervical Cancer, Cancer Information Highlights, 10/19/2022

Treatment to Reduce Hearing Loss | Melanoma | Cervical Cancer, Cancer Information Highlights, 10/19/2022

AI recognition of patient race in medical imaging: a modelling study - PubMed

AI recognition of patient race in medical imaging: a modelling study - PubMed

Study finds that artificial intelligence can determine race from medical images

Study finds that artificial intelligence can determine race from medical images

How Do Companies Measure DNA to Discover Your Ancestry? | NIST

How Do Companies Measure DNA to Discover Your Ancestry? | NIST

miércoles, 19 de octubre de 2022

IU researchers suggest the potential for a new approach to determining heart transplant candidacy

IU researchers suggest the potential for a new approach to determining heart transplant candidacy

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

Study suggests relationship between maternal COVID vaccination, SARS-CoV-2 placentitis, and stillbirth

Study suggests relationship between maternal COVID vaccination, SARS-CoV-2 placentitis, and stillbirth

Blood test uses artificial intelligence and biomarkers to prenatally detect fetal congenital heart defects

Blood test uses artificial intelligence and biomarkers to prenatally detect fetal congenital heart defects

Study reveals high level of hybrid immunity in general Swiss population

Study reveals high level of hybrid immunity in general Swiss population

Differential effects of SARS-CoV-2 variants on children and adolescents

Differential effects of SARS-CoV-2 variants on children and adolescents

What is the risk of severe COVID-19 in infants younger than three months?

What is the risk of severe COVID-19 in infants younger than three months?

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Study shows the importance of both obesity and biological sex in COVID-19 outcomes

Study shows the importance of both obesity and biological sex in COVID-19 outcomes

Individuals with inflammatory breast cancer face a higher risk brain metastases

Individuals with inflammatory breast cancer face a higher risk brain metastases

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

Rare case of COVID-19 vaccine-induced hypophysitis in a woman with central diabetes insipidus manifestations

Rare case of COVID-19 vaccine-induced hypophysitis in a woman with central diabetes insipidus manifestations

Patients with clinical depression 'stopped seeking treatment' during the COVID waves

Patients with clinical depression 'stopped seeking treatment' during the COVID waves

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

COLANGIPATÍA POST COVID: REVISIÓN NARRATIVA - ScienceDirect - POST COVID CHOLANGIOPATHY: A NARRATIVE REVIEW.

COLANGIPATÍA POST COVID: REVISIÓN NARRATIVA - ScienceDirect

Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States | Annals of Internal Medicine

Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States | Annals of Internal Medicine

Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 Treatment - PubMed

Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 Treatment - PubMed

Study Shows Benefits of COVID-19 Vaccines and Boosters – NIH Director's Blog

Study Shows Benefits of COVID-19 Vaccines and Boosters – NIH Director's Blog

How Can Health Care Professionals Help Prevent and Treat Diabetic Neuropathy? | NIDDK

How Can Health Care Professionals Help Prevent and Treat Diabetic Neuropathy? | NIDDK

Diversity, inclusion and the Human Pangenome Project: Why capturing human genome diversity in our 4-letter language is such a big deal - Genetic Literacy Project

Diversity, inclusion and the Human Pangenome Project: Why capturing human genome diversity in our 4-letter language is such a big deal - Genetic Literacy Project

How diet may disrupt gut microbes to promote weight gain | National Institutes of Health (NIH)

How diet may disrupt gut microbes to promote weight gain | National Institutes of Health (NIH)

Popular diabetes drugs compared in large trial | National Institutes of Health (NIH)

Popular diabetes drugs compared in large trial | National Institutes of Health (NIH)

No association of Viagra and Cialis with reduced Alzheimer’s disease risk | National Institutes of Health (NIH)

No association of Viagra and Cialis with reduced Alzheimer’s disease risk | National Institutes of Health (NIH)

Bionic pancreas simplifies management of type 1 diabetes | National Institutes of Health (NIH)

Bionic pancreas simplifies management of type 1 diabetes | National Institutes of Health (NIH)

Compounds block pain without sedation in mice | National Institutes of Health (NIH)

Compounds block pain without sedation in mice | National Institutes of Health (NIH)

martes, 18 de octubre de 2022

Heart disease and women | Office on Women's Health

Heart disease and women | Office on Women's Health

WISEWOMAN Home | cdc.gov

WISEWOMAN Home | cdc.gov

Live to the Beat | Million Hearts

Live to the Beat | Million Hearts

Self-Measured Blood Pressure Partnership Program | Office on Women's Health

Self-Measured Blood Pressure Partnership Program | Office on Women's Health

Women And Families: Maternal Health and Hypertension

Women And Families

High Blood Pressure and Older Adults | National Institute on Aging

High Blood Pressure and Older Adults | National Institute on Aging

How to accurately measure blood pressure at home | American Heart Association

How to accurately measure blood pressure at home | American Heart Association

Hypertension Innovation for Healthier Communities Summit | Office on Women's Health

Hypertension Innovation for Healthier Communities Summit | Office on Women's Health

National Women's Blood Pressure Awareness Week | Office on Women's Health

National Women's Blood Pressure Awareness Week | Office on Women's Health

HIV-1 and SARS-CoV-2 Effects on Brain and Mind Health: A Tale of Two Viruses Date/Time: November 9, 2022, 2:00–3:00 p.m. ET Location: Virtual

Inscripción al seminario web - Zoom

lunes, 17 de octubre de 2022

Orphanet Journal of Rare Diseases | Home page

Orphanet Journal of Rare Diseases | Home page

Flu Season Is Starting Early and May Be Severe, Experts Warn

Flu Season Is Starting Early and May Be Severe, Experts Warn

Obesity: epilepsy risk is elevated after bariatric surgery

Obesity: epilepsy risk is elevated after bariatric surgery

Incidence of Guillain-Barré syndrome after COVID-19 vaccine

Incidence of Guillain-Barré syndrome after COVID-19 vaccine

World’s first stem cell treatment for spina bifida

World’s first stem cell treatment for spina bifida

Model predicts all-cause mortality in community-dwelling older adults with dementia

Model predicts all-cause mortality in community-dwelling older adults with dementia

High suicide risk in patients with early-onset dementia

High suicide risk in patients with early-onset dementia

Latest Clinical Research & Medical News | Univadis Global

Latest Clinical Research & Medical News | Univadis Global

How the ‘love hormone’ oxytocin may have heart-healing properties

How the ‘love hormone’ oxytocin may have heart-healing properties

NIH MedlinePlus Magazine

NIH MedlinePlus Magazine

Complementary Health Approaches for Chronic Pain | NCCIH

Complementary Health Approaches for Chronic Pain | NCCIH

Hair straightening chemicals associated with higher uterine cancer risk | National Institutes of Health (NIH)

Hair straightening chemicals associated with higher uterine cancer risk | National Institutes of Health (NIH)

Does it matter when you eat dinner? Earlier in the day — and within a 10 hour window — may help boost metabolism and fight obesity - Genetic Literacy Project

Does it matter when you eat dinner? Earlier in the day — and within a 10 hour window — may help boost metabolism and fight obesity - Genetic Literacy Project

A CRISPR cure for HIV? Gene-editing technology may be able stop viral replication in its tracks and wipe out infections - Genetic Literacy Project

A CRISPR cure for HIV? Gene-editing technology may be able stop viral replication in its tracks and wipe out infections - Genetic Literacy Project

Aspirin versus enoxaparin after total joint arthroplasty

Aspirin versus enoxaparin after total joint arthroplasty

Peptic Ulcer Risk in New Users of Low-Dose Aspirin

Peptic Ulcer Risk in New Users of Low-Dose Aspirin

Can aspirin play a role in ovarian cancer prevention?

Can aspirin play a role in ovarian cancer prevention?

PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD?

PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD?

ESC 2022 —Will aspirin stick around in the fight against cardiovascular disease?

ESC 2022 —Will aspirin stick around in the fight against cardiovascular disease?

sábado, 15 de octubre de 2022

Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial - eClinicalMedicine

Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial - eClinicalMedicine

First steps towards diagnosing long COVID - eBioMedicine

First steps towards diagnosing long COVID - eBioMedicine

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection - eBioMedicine

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection - eBioMedicine

A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core - eBioMedicine

A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core - eBioMedicine

Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia - eBioMedicine

Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia - eBioMedicine

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling - eBioMedicine

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling - eBioMedicine

Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2 - eBioMedicine

Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2 - eBioMedicine

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications - eBioMedicine

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications - eBioMedicine

Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial - eBioMedicine

Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial - eBioMedicine

Long COVID: defining the role of rheumatology in care and research - The Lancet Rheumatology

Long COVID: defining the role of rheumatology in care and research - The Lancet Rheumatology

Respiratory support before venovenous ECMO for COVID-19: what is the price? - The Lancet Respiratory Medicine

Respiratory support before venovenous ECMO for COVID-19: what is the price? - The Lancet Respiratory Medicine

Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis - The Lancet Respiratory Medicine

Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis - The Lancet Respiratory Medicine

COVID-19: ACT trials for colchicine and antithrombotic therapies - The Lancet Respiratory Medicine

COVID-19: ACT trials for colchicine and antithrombotic therapies - The Lancet Respiratory Medicine

Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial - The Lancet Respiratory Medicine

Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial - The Lancet Respiratory Medicine

SARS-CoV-2: can isolation be limited to those who are truly infectious? - The Lancet Respiratory Medicine

SARS-CoV-2: can isolation be limited to those who are truly infectious? - The Lancet Respiratory Medicine

Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial - The Lancet Respiratory Medicine

Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial - The Lancet Respiratory Medicine

Daily use of lateral flow devices by contacts of confirmed COVID-19 cases to enable exemption from isolation compared with standard self-isolation to reduce onward transmission of SARS-CoV-2 in England: a randomised, controlled, non-inferiority trial - The Lancet Respiratory Medicine

Daily use of lateral flow devices by contacts of confirmed COVID-19 cases to enable exemption from isolation compared with standard self-isolation to reduce onward transmission of SARS-CoV-2 in England: a randomised, controlled, non-inferiority trial - The Lancet Respiratory Medicine

Omicron in pregnancy: time to breathe easier? - The Lancet Respiratory Medicine

Omicron in pregnancy: time to breathe easier? - The Lancet Respiratory Medicine

Pregnancy outcomes after SARS-CoV-2 infection in periods dominated by delta and omicron variants in Scotland: a population-based cohort study - The Lancet Respiratory Medicine

Pregnancy outcomes after SARS-CoV-2 infection in periods dominated by delta and omicron variants in Scotland: a population-based cohort study - The Lancet Respiratory Medicine

The elusive goal of COVID-19 vaccine immunity - The Lancet Respiratory Medicine

The elusive goal of COVID-19 vaccine immunity - The Lancet Respiratory Medicine

Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study - The Lancet Respiratory Medicine

Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study - The Lancet Respiratory Medicine

Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies - The Lancet Psychiatry

Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies - The Lancet Psychiatry

Interactions between climate and COVID-19 - The Lancet Planetary Health

Interactions between climate and COVID-19 - The Lancet Planetary Health

The bullwhip effect, T-cell telomeres, and SARS-CoV-2 - The Lancet Healthy Longevity

The bullwhip effect, T-cell telomeres, and SARS-CoV-2 - The Lancet Healthy Longevity

The upcoming flu seasons: how worried should we be? - The Lancet Global Health

The upcoming flu seasons: how worried should we be? - The Lancet Global Health

Rise in diabetic ketoacidosis during the COVID-19 pandemic: several questions remain - The Lancet Diabetes & Endocrinology

Rise in diabetic ketoacidosis during the COVID-19 pandemic: several questions remain - The Lancet Diabetes & Endocrinology

Real-world effectiveness of oral antivirals for COVID-19 - The Lancet

Real-world effectiveness of oral antivirals for COVID-19 - The Lancet

Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study - The Lancet

Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study - The Lancet

The Lancet Voice

The Lancet Voice

Impact of the COVID-19 pandemic on long-term trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes: an international multicentre study based on data from 13 national diabetes registries - The Lancet Diabetes & Endocrinology

Impact of the COVID-19 pandemic on long-term trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes: an international multicentre study based on data from 13 national diabetes registries - The Lancet Diabetes & Endocrinology

viernes, 14 de octubre de 2022

Weight loss gadgets: They provide data to help consumers achieve diet goals, but it still won’t be easy

Weight loss gadgets: They provide data to help consumers achieve diet goals, but it still won’t be easy

Study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil

Study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil

Rapidly fading antibody levels in recovered COVID-19 patients associated with plasma metabolites

Rapidly fading antibody levels in recovered COVID-19 patients associated with plasma metabolites

Heart Foundation's new report takes aim at Australia’s concerning prevalence of high-cholesterol

Heart Foundation's new report takes aim at Australia’s concerning prevalence of high-cholesterol

CCA's research initiative aims to identify progress, challenges in the lives of people with celiac disease

CCA's research initiative aims to identify progress, challenges in the lives of people with celiac disease

COVID-19 vaccination reduced the severity of the Omicron-driven pandemic wave in Saudi Arabia

COVID-19 vaccination reduced the severity of the Omicron-driven pandemic wave in Saudi Arabia

Study presents rare cases of COVID-19-associated pulmonary aspergillosis

Study presents rare cases of COVID-19-associated pulmonary aspergillosis

Scan, Magnetic Resonance Imaging, Breast: Image Details - NCI Visuals Online

Scan, Magnetic Resonance Imaging, Breast: Image Details - NCI Visuals Online

It’s a Good Time to Get Your Flu Vaccine | FDA

It’s a Good Time to Get Your Flu Vaccine | FDA

Music and Health: What You Need To Know | NCCIH

Music and Health: What You Need To Know | NCCIH

Can a Genomic Test Better Detect Aggressive Prostate Cancer? - NCI

Can a Genomic Test Better Detect Aggressive Prostate Cancer? - NCI

FDA Releases New, Prevention Strategies to Enhance Food Safety | FDA

FDA Releases New, Prevention Strategies to Enhance Food Safety | FDA

St. John’s Wort | NCCIH

St. John’s Wort | NCCIH

NIMH » Researchers Develop Method to Study Brain Connectivity, Functionality

NIMH » Researchers Develop Method to Study Brain Connectivity, Functionality

Problem Drinking | ADHD Awareness | Telehealth & Drug Use | Protect Your Hearing | Health Literacy Month

Problem Drinking | ADHD Awareness | Telehealth & Drug Use | Protect Your Hearing | Health Literacy Month

jueves, 13 de octubre de 2022

Sustained blood pressure control necessary to reduce the burden of fatal cardiovascular events

Sustained blood pressure control necessary to reduce the burden of fatal cardiovascular events

Diets not linked to reduced risk of dementia, study finds

Diets not linked to reduced risk of dementia, study finds

Cardiovascular risk factors – not preexisting heart disease – are the main contributors to COVID-19 death

Cardiovascular risk factors – not preexisting heart disease – are the main contributors to COVID-19 death

Bionic pancreas effective at maintaining blood glucose levels in people with type 1 diabetes

Bionic pancreas effective at maintaining blood glucose levels in people with type 1 diabetes

Study finds link between different styles of humor and body perception in women

Study finds link between different styles of humor and body perception in women

The impact of humidity levels on viral transmission and viability

The impact of humidity levels on viral transmission and viability

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

New blood test may detect fetal abnormalities at week 10 - ISRAEL21c

New blood test may detect fetal abnormalities at week 10 - ISRAEL21c

Researchers develop method to study brain connectivity, functionality | National Institutes of Health (NIH)

Researchers develop method to study brain connectivity, functionality | National Institutes of Health (NIH)

Immunotherapy before Surgery Effective against Melanoma - NCI

Immunotherapy before Surgery Effective against Melanoma - NCI

Monkeypox treatment trial begins in the Democratic Republic of the Congo | National Institutes of Health (NIH)

Monkeypox treatment trial begins in the Democratic Republic of the Congo | National Institutes of Health (NIH)

‘Human Genome Project for our diets’: Here’s how bioactive compounds could overcome a dearth of vegetables in Americans’ health - Genetic Literacy Project

‘Human Genome Project for our diets’: Here’s how bioactive compounds could overcome a dearth of vegetables in Americans’ health - Genetic Literacy Project

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

COVID-19 Noticias / Opiniones CHEQUEADAS EN INGLÉS y otros idiomas

Distinct immune response landscapes of COVID-19

Distinct immune response landscapes of COVID-19

US teen athletes suffered during pandemic, study shows | CIDRAP

US teen athletes suffered during pandemic, study shows | CIDRAP

How the splintering of Omicron could shape Covid's next phase - STAT

How the splintering of Omicron could shape Covid's next phase - STAT

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

COVID-19 Informes Científicos CHEQUEADOS COMPLETOS REVISADOS (full texts)

Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study - PubMed

Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study - PubMed

Oculomotor, vestibular, reaction time, and cognitive tests as objective measures of neural deficits in patients post COVID-19 infection - PubMed

Oculomotor, vestibular, reaction time, and cognitive tests as objective measures of neural deficits in patients post COVID-19 infection - PubMed

Can exercise attenuate the negative effects of long COVID syndrome on brain health? - PubMed

Can exercise attenuate the negative effects of long COVID syndrome on brain health? - PubMed

Larger gray matter volumes in neuropsychiatric long-COVID syndrome - ScienceDirect

Larger gray matter volumes in neuropsychiatric long-COVID syndrome - ScienceDirect

Effect of montelukast therapy on clinical course, pulmonary function, and mortality in patients with COVID-19 - PubMed

Effect of montelukast therapy on clinical course, pulmonary function, and mortality in patients with COVID-19 - PubMed

Indice General de Autoevaluaciones

Indice General de Autoevaluaciones

Novedades COVID-19

Novedades COVID-19

COVID-19 ESPECIALISTAS opinan Expertos Invitados (Castellano)

COVID-19 ESPECIALISTAS opinan Expertos Invitados (Castellano)

COVID-19 Noticias / Opiniones CHEQUEADAS

COVID-19 Noticias / Opiniones CHEQUEADAS

miércoles, 12 de octubre de 2022

Immune-mediated inflammatory diseases following COVID-19

Immune-mediated inflammatory diseases following COVID-19

What is the effect of COVID-19 vaccination in pregnant and postpartum women infected with different SARS-CoV-2 variants?

What is the effect of COVID-19 vaccination in pregnant and postpartum women infected with different SARS-CoV-2 variants?

BMI: The mismeasure of weight and the mistreatment of obesity

BMI: The mismeasure of weight and the mistreatment of obesity

Molnupiravir and nirmatrelvir-ritonavir treatments are effective in reducing mortality among high-risk COVID-19 patients

Molnupiravir and nirmatrelvir-ritonavir treatments are effective in reducing mortality among high-risk COVID-19 patients

Study finds an association between early diagnosis of diabetes and earlier menopause

Study finds an association between early diagnosis of diabetes and earlier menopause

What is the association of pneumococcal carriage with SARS-CoV-2 infection?

What is the association of pneumococcal carriage with SARS-CoV-2 infection?

How melanomas reach the brain – and how to stop them - ISRAEL21c

How melanomas reach the brain – and how to stop them - ISRAEL21c

FDA Approves LYTGOBI (Futibatinib) for Adult Patients with Intrahepatic Cholangiocarcinoma Harboring FGFR2 Gene Fusions or Other Rearrangements

label On September 30, 2022, the U.S. Food and Drug Administration (FDA) granted accelerated approval to LYTGOBI (futibatinib) for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). The approved recommended dosage of LYTGOBI is 20 mg orally (five 4 mg tablets) once daily until disease progression or unacceptable toxicity occurs. Presence of an FGFR2 gene fusion or other rearrangement should be confirmed prior to initiation of treatment with LYTGOBI. The tablets can be taken with or without food and swallowed whole, at approximately the same time each day. Additional information regarding dosage and administration as well as warnings and precautions about ocular toxicity, hyperphosphatemia and soft tissue mineralization, and embryo-fetal toxicity can be found in the full prescribing information linked below. Mechanism of Action (MOA), Pharmacokinetics (PK), and Pharmacodynamics (PD) MOA: Futibatinib is a small molecule kinase inhibitor of FGFR 1, 2, 3, and 4. General PK: The futibatinib PK parameters were evaluated in patients with advanced solid tumors and presented as geometric mean (coefficient of variation [CV] %) unless otherwise specified. Futibatinib exposure (AUC) increased proportionally over the dose range from 4 to 24 mg orally once daily (0.2 to 1.2 times the maximum approved recommended dosage). Absorption: Median time to reach maximum futibatinib plasma concentration was 2 (range: 1.2 to 22.8) hours. Effect of Food: Administration of futibatinib with a high-fat and high-calorie meal (900 to 1000 calories, 50% fat) decreased futibatinib AUC by 11% and Cmax by 42% in healthy subjects. Distribution: The apparent volume of distribution of futibatinib is 66 L (18%). Futibatinib is 95% bound to human plasma protein in vitro, primarily to albumin and α1-acid glycoprotein. Elimination: The elimination half-life of futibatinib is 2.9 hours (27%) and the apparent clearance is 20 L/h (23%). Metabolism: Futibatinib is primarily metabolized by CYP3A and to a lesser extent by CYP2C9 and CYP2D6 in vitro. Unchanged futibatinib is the major drug-related moiety in plasma in healthy subjects. Excretion: Following a single oral dose of 20 mg radiolabeled futibatinib, approximately 91% of the total recovered radioactivity was observed in feces and 9% in urine, with negligible unchanged futibatinib in urine or feces. PD: Futibatinib increased serum phosphate levels due to FGFR inhibition. Serum phosphate increased with increasing futibatinib exposure across the dose range of 4 to 24 mg orally once daily, with increased risk of hyperphosphatemia at higher futibatinib exposure. Drug Interactions Dual P-gp and Strong CYP3A Inhibitors: Avoid concomitant use of drugs that are dual P-gp and strong CYP3A inhibitors with LYTGOBI. Concomitant use of drugs that are dual P-gp and strong CYP3A inhibitors with LYTGOBI may increase futibatinib exposure, which may increase the incidence and severity of adverse reactions. Dual P-gp and Strong CYP3A Inducers: Avoid concomitant use of dual P-gp and strong CYP3A inducers with LYTGOBI. Concomitant use of drugs that are dual P-gp and strong CYP3A inducers may decrease futibatinib exposure, which may reduce the efficacy of LYTGOBI. The effect of a P-gp modulator (without CYP3A modulation), or a strong CYP3A modulator (without P-gp modulation) on the exposure of futibatinib has not been investigated. P-gp or BCRP Substrates: Consider more frequent monitoring for adverse reactions associated with concomitantly administered drugs that are sensitive substrates of P-gp or BCRP and reduce the dose of these drugs per their Prescribing Information. Futibatinib may increase exposure of drugs that are substrates of P-gp or BCRP. Use in Specific Populations No clinically meaningful differences in the systemic exposure of futibatinib were observed based on age (18 - 82 years), sex, race (White, Asian, and African American), body weight (36 - 152 kg), mild to moderate renal impairment (creatinine clearance [CLcr] 30 - 89 mL/min estimated by Cockcroft-Gault), or mild hepatic impairment (total bilirubin ≤ upper limit of normal (ULN) and aspartate transaminase (AST) > ULN, or total bilirubin > 1 to 1.5x ULN and any AST). The PK of futibatinib has not been studied in patients with severe renal impairment (CLcr 15 - 29 mL/min), renal dialysis in end-stage renal disease (CLcr < 15 mL/min), or moderate to severe hepatic impairment (total bilirubin > 1.5x ULN and any AST). Efficacy and Safety Efficacy of LYTGOBI was demonstrated in a multicenter, open-label, single-arm trial that enrolled patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma. FGFR2 fusions or other rearrangements were confirmed in 99% of the enrolled patients using next generation sequencing (NGS) testing. The major efficacy outcome measures were overall response rate and duration of response as determined by an independent review committee (IRC) according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Additional information regarding the efficacy trial can be found in the full prescribing information linked below. Most common (≥ 20%) adverse reactions observed with LYTGOBI treatment were nail toxicity, musculoskeletal pain, constipation, diarrhea, fatigue, dry mouth, alopecia, stomatitis, abdominal pain, dry skin, arthralgia, dysgeusia, dry eye, nausea, decreased appetite, urinary tract infection, palmar-plantar erythrodysesthesia syndrome, and vomiting. Most common laboratory abnormalities (≥ 20%) observed with LYTGOBI treatment were increased phosphate, increased creatinine, decreased hemoglobin, increased glucose, increased calcium, decreased sodium, decreased phosphate, increased alanine aminotransferase, increased alkaline phosphatase, decreased lymphocytes, increased aspartate aminotransferase, decreased platelets, increased activated partial thromboplastin time, decreased leukocytes, decreased albumin, decreased neutrophils, increased creatine kinase, increased bilirubin, decreased glucose, increased prothrombin international normalized ratio, and decreased potassium.