Global childhood cancer surveillance: too many left in the dark The Lancet Child & Adolescent Health ++... ++

Global childhood cancer surveillance: too many left in the dark The Lancet Child & Adolescent Health https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00136-7/fulltext?dgcid=raven_jbs_etoc_email Jul 2026 Volume 10Number 7p469-540, e17-e22 https://www.thelancet.com/journals/lanchi/issue/vol10no7/PIIS2352-4642(26)X2005-3 Global variation in injury patterns, interventions, and post-operative outcomes for children and adolescents undergoing trauma laparotomy: an international cohort study Riaz Aziz, FFICMa ∙ Dr Michael F Bath, MRCSa Send email to mb2583@cam.ac.uk ∙ Sarah M Abdelmohsen, MDb ∙ Isaac Chukwu, FWACSc ∙ Raoof Saleh, FRCSd ∙ Eder Cáceres, PhDe ∙ et al. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00069-6/fulltext?dgcid=raven_jbs_etoc_feature_lanchi Effectiveness of nirsevimab immunisation after birth versus RSVpreF maternal vaccination in preventing RSV-related hospitalisations in infants: a population-based retrospective cohort study Zaba Valtuille, PhDa,† ∙ Inès Fafi, MDa,b,c,† ∙ Prof Florentia Kaguelidou, MD PhDb,d ∙ Corinne Levy, MDe,f,g ∙ Prof Robert Cohen, MD PhDe,f,g ∙ Prof Laurent Mandelbrot, MD PhDh,i ∙ et al. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00075-1/abstract?dgcid=raven_jbs_etoc_feature_lanchi

Challenging the Confines of Risk of Recurrence in High-Risk HR+/HER2- Early Breast Cancer Authors: Joyce A. O’Shaughnessy, MD; Priya Rastogi, MD; Seth Wander, MD, PhD

https://www.medscape.org/viewarticle/challenging-confines-risk-recurrence-high-risk-hr-her2-early-2026a1000bq3?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260607-OUS-HONC-challenging-confines-risk-recurrence-high-risk-hr-her2-early-2026a1000bq3-cta

Advancing Personalized Care for Prostate Cancer: Patient-Centered Solutions for mHSPC and nmCRPC Authors: Alicia K. Morgans, MD, MPH, FASCO; Christian Gratzke, MD; Fred Saad, MD, FRCS, FCAHS; Tony Collier, BEM

https://www.medscape.org/viewarticle/advancing-personalized-care-prostate-cancer-patient-centered-2025a1000uyb?page=1&src=mkmcmr_driv_stan_mscpedu_260607-OUS-HONC-advancing-personalized-care-prostate-cancer-patient-centered-2025a1000uyb-cta&uac=148436CN

Researchers trigger sleep’s restorative effect in parts of the awake brain

Researchers trigger sleep’s restorative effect in parts of the awake brain NIH-funded study in animals offers new details about how the brain resets during sleep. https://www.nih.gov/news-events/news-releases/researchers-trigger-sleeps-restorative-effect-parts-awake-brain By inducing specific patterns of activity in small portions of the brain in awake mice, researchers supported by the National Institutes of Health (NIH) have triggered a recalibration of neural connections that normally only occurs during sleep. This new approach offset the effects of sleep deprivation in memory tasks and revealed features of sleep that are key to its restorative effect. U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH NIH News National Institutes of Health For Immediate Release: Monday, June 8, 2026 CONTACT: NIH Office of Communications, RESEARCHERS TRIGGER SLEEP’S RESTORATIVE EFFECT IN PARTS OF THE AWAKE BRAIN NIH-funded study in animals offers new details about how the brain resets during sleep By inducing specific patterns of activity in small portions of the brain in awake mice, researchers supported by the National Institutes of Health (NIH) have triggered a recalibration of neural connections that normally only occurs during sleep. This new approach offset the effects of sleep deprivation in memory tasks and revealed features of sleep that are key to its restorative effect. “What we’re essentially doing is forcing sleep in a local region of the brain. While that part is solidifying memories and restoring learning capacity, other parts stay aware/vigilant and connected to environment,” said corresponding author Chiara Cirelli, M.D., Ph.D., a professor of psychiatry at the University of Wisconsin-Madison. “Dolphins do something similar, sleeping with only one brain hemisphere at a time.” Non-rapid eye movement (NREM) sleep, which makes up about 80% of sleep for adults, is when the junctions between neurons that make memories are evaluated. During this phase, the brain protects important connections for long-term storage, prunes those that are less necessary, and makes space for new ones. Cirelli and her colleagues previously showed that, when sleep-deprived, both rats and humans can exhibit local slow-wave brain activity — a hallmark of NREM sleep — while awake. These deprivation-induced dips into sleep-like activity may have been too sporadic and brief to be beneficial, but the findings raised questions about the possible effects of a longer, more systematic version of this activity. In the new research, the authors used a combination of light-pulsing implants and genetic modifications to induce rhythmic on-and-off activity in one side of the brains of sleep deprived mice for 30 minutes at a time, mimicking patterns that occur during NREM sleep. When mice subsequently slept, slow-wave activity was lower in the specific brain regions the authors had stimulated, indicating less need for sleep. Additional experiments suggested that this effect hinged not on the overall reduction in neuronal firing, which some scientists had suggested was critical to recover from wake-induced neuronal fatigue, but rather on the specific alternating on-and-off pattern of activity. The researchers explored potential benefits through a behavioral test of tactile memory, for which sleep is important. Sleep-deprived mice who received stimulation in motor and sensory regions on both sides of the brain performed similarly to those who were well rested. Sleep-deprived mice who did not receive stimulation performed significantly worse. In future studies, Cirelli aims to learn whether similar effects could be replicated in humans using less invasive, transcranial stimulation technology. “This research further decodes why we sleep and how we learn, which brings us a step closer to understanding how to better prevent and treat cognitive decline,” said Amy Bany Adams, Ph.D., acting director of the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which funded the research. About the National Institute of Neurological Disorders and Stroke (NINDS): NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. https://www.ninds.nih.gov. About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov. NIH...Turning Discovery into Health -- Registered, U.S. Patent and Trademark Office --- REFERENCES: Kort Driessen et al. Induction of cortical ON/OFF periods in awake mice fulfills sleep functions. Nature Neuroscience. 2026. DOI: 10.1038/s41593-026-02318-9 ### This NIH News Release is available online at:

Psychological well-being and associated factors among orthopedic surgery residents in the United States Kyla A. Petrie, Paul Gaschen, Trent A. Petrie Volume 3, Issue 2

https://www.academia.edu/journals/academia-mental-health-and-well-being/articles?source=journal-top-nav Introduction: Over the last decade, mental health concerns have increased for medical students and residents. Our goal was to add to the literature by examining U.S. orthopedic surgery residents’ (N = 179; women = 84; White = 126) psychological well-being and the demographic and program-related factors associated with it. https://www.academia.edu/2997-9196/3/2/10.20935/MHealthWellB8314 Materials and methods: Residents anonymously completed a cross-sectional, online survey from September 2024 through January 2025. They provided demographic information as well as program factors. We assessed psychological well-being via life satisfaction, measuring it through the Satisfaction with Life Scale (SWLS). Faculty support was measured through the Johns Hopkins Learning Environment Scale (JHLES). Results: Just over 25% of residents reported neutral or lower levels of life satisfaction. Higher levels of life satisfaction were significantly correlated with sleep satisfaction (r = 0.29, p < 0.001), sleeping 6 to 8 h per night (r = 0.23, p = 0.002), having an ongoing interest in orthopedics (r = 0.56, p < 0.001), and support from residency program faculty (r = 0.52, p < 0.001). Further, the residents’ postgraduate year in their program (F (4, 174) = 3.57, p = 0.009) and their relationship status (F (2, 176) = 5.89, p = 0.003) mattered in terms of their reported levels of life satisfaction. Postgraduate year (PGY)-1 and PGY-5 residents had significantly higher life satisfaction than PGY-2 residents. Married residents were the most satisfied with their lives. Conclusions: Although generally satisfied, residents’ well-being varied significantly based on several key factors. Residency training programs can take active measures to help improve their residents’ well-being and life satisfaction, which may improve their surgical performance.

AI-designed miniproteins unlock control of GPCR signaling Study demonstrates that computationally-designed miniproteins can modulate GPCR activity in native cellular environments, expanding access to a major drug target family. Written byBree Foster, PhD

https://www.drugdiscoverynews.com/ai-designed-miniproteins-unlock-control-of-gpcr-signaling-17208?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8o7WUg7Idl3S1RjjWIyU6fsc1jkRuUpVuhQ043ikSWj46QYVUidvfFc5NTsICqQjyqvnqW11IdDLZUaaPFBpAcoUf0BQ&_hsmi=422305080&utm_content=422305080&utm_source=hs_email G-protein-coupled receptors (GPCRs) are the largest and most versatile of cell surface receptors, with a broad repertoire of ligands and functions. Around one-third of approved medicines act on these membrane proteins, targeting a wide range of diseases from allergic rhinitis to pain, hypertension, and schizophrenia.

Weekly Rundown: Once-weekly HIV pill clears Phase 3 trials ​Microbubble-based genetic medicines, pharma deals, trial misses, and more led the news this week. Written byDDN editorial team

https://www.drugdiscoverynews.com/weekly-rundown-once-weekly-hiv-pill-clears-phase-3-trials-17254 Gilead Sciences and Merck announced this week that their investigational once-weekly single-tablet HIV regimen, islatravir/lenacapavir, met its primary efficacy endpoint at week 48 in both the ISLEND-1 and ISLEND-2 Phase 3 trials. The combination pairs Merck's islatravir, a next-generation nucleoside analog that blocks HIV replication through multiple mechanisms including reverse transcriptase translocation inhibition, with Gilead's lenacapavir, a first-in-class capsid inhibitor that disrupts HIV at multiple stages of its lifecycle. In ISLEND-1, the once-weekly tablet was non-inferior to Biktarvy, Gilead's current daily standard-of-care regimen, in virologically suppressed patients. In ISLEND-2, it was non-inferior to a broad range of daily antiretroviral regimens. Safety was comparable across arms with no new concerns identified. Both companies plan to file the Phase 3 data with regulatory authorities globally. If approved, islatravir/lenacapavir would become the first long-acting oral HIV treatment taken once weekly, a meaningful shift in a field where daily dosing has long been the norm and where adherence remains one of the most persistent barriers to sustained viral suppression. – Andrea Corona