Drug combination shows long-term survival in advanced thymic cancer

https://www.news-medical.net/news/20261113/Drug-combination-shows-long-term-survival-in-advanced-thymic-cancer.aspx Final results from the phase 2 PECATI clinical trial demonstrate encouraging long-term survival outcomes with the combination of lenvatinib and pembrolizumab in patients with previously treated advanced B3-thymoma and thymic carcinoma. The findings, published in the Journal of Thoracic Oncology (JTO), the official journal of the International Association for the Study of Lung Cancer (IASLC), showed after a median follow-up of 24.6 months a median progression-free survival of 22.1 months and median overall survival of 40.2 months.

Study identifies two proteins involved in toxin-related pulmonary hypertension

https://www.news-medical.net/news/20261113/Study-identifies-two-proteins-involved-in-toxin-related-pulmonary-hypertension.aspx A research team has identified two proteins that may help explain how a plant toxin damages the arteries that carry blood to the lungs. In rats exposed to monocrotaline, a reactive breakdown product of the toxin formed lasting chemical bonds with the prostacyclin receptor on platelets and with a protein called PTEN in lung tissue. These changes were associated with sustained platelet activation and increased activity in a pathway that drives blood vessel cells to multiply. The findings give researchers two molecular targets to investigate in studies of toxin-associated pulmonary arterial hypertension.

Early-life environmental exposures linked to multiple health outcomes into adolescence

https://www.news-medical.net/news/20261113/Early-life-environmental-exposures-linked-to-multiple-health-outcomes-into-adolescence.aspx Environmental exposures during pregnancy and childhood can be associated with multiple aspects of health at the same time, with many of these associations persisting into adolescence health, according to a new study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, and in collaboration with the French National Institute for Health and Medical Research (Inserm). Published in Science Advances as part of the Human Early Life Exposome (HELIX) project, the study provides an atlas of associations between early-life environmental exposures and health, highlighting factors such as tobacco smoke, indoor air pollution, dietary quality and features of the built environment that may be relevant for prevention and policy action.

Study maps enzyme target for potential treatment of rare genetic disorder

https://www.news-medical.net/news/20261113/Study-maps-enzyme-target-for-potential-treatment-of-rare-genetic-disorder.aspx Researchers at the Icahn School of Medicine at Mount Sinai have mapped an enzyme that could be targeted to develop new treatments for glutaric aciduria type 1 (GA1), a rare genetic disorder that can lead to brain damage, revealing new details about how the enzyme works and how its activity is controlled. The findings were published in the November 13 online issue of Science Advances

Certain ketogenic diets may increase inflammation through saturated fats

https://www.news-medical.net/news/20261113/Certain-ketogenic-diets-may-increase-inflammation-through-saturated-fats.aspx New University of Cincinnati Cancer Center research found a ketogenic diet high in long-chain saturated fatty acids can increase inflammation. Led by Cancer Center Director David Gius, MD, PhD, the study was published Nov. 13 in the journal Science Advances.

Common classroom accommodations fail to improve outcomes for children with ADHD

https://www.news-medical.net/news/20261113/Common-classroom-accommodations-fail-to-improve-outcomes-for-children-with-ADHD.aspx Extra time on assignments, frequent breaks and quiet workspaces are among the most common ways schools support children with attention deficit hyperactivity disorder (ADHD). But a new Florida International University study finds these accommodations do not significantly improve students' classroom behavior or academic performance. The study, published in JAMA Pediatrics, evaluated four widely used accommodations: extended time, frequent breaks, standing at a desk and working in a low-distraction environment. None produced significant improvements, even when combined with behavioral interventions or stimulant medication.

Yellow Nutsedge Leaves and Stems: Bioactive Compounds and Potential Uses

https://www.news-medical.net/health/Yellow-Nutsedge-Leaves-and-Stems-Bioactive-Compounds-and-Potential-Uses.aspx Best known for its edible tubers, yellow nutsedge has a less-studied above-ground chemical profile. What could its leaves and stems offer researchers investigating plant-derived compounds? Cyperus esculentus occupies an unusual place in agricultural science. In row crops across North America and parts of Europe, it behaves as an aggressive, rhizome-propagating weed. In Spain, particularly Valencia, it is cultivated for its tuber, which is harvested to make the drink horchata.1,2 Botanically, this plant belongs to the sedge family and propagates through underground tubers and rhizomes. This trait supports its persistence as a weed and complicates agricultural management.3 The plant goes by many names, including yellow nutsedge, chufa, earth almond, and tiger nut. The latter names commonly refer to its edible tubers, though their nutritional properties should not be assumed to apply to its aerial tissues or above-ground plant parts.1–3