60,000 Years of Food Knowledge: Traditional Aboriginal Diets and Nutrition

https://www.news-medical.net/health/60000-Years-of-Food-Knowledge-Traditional-Aboriginal-Diets-and-Nutrition.aspx What can native foods and generations of Aboriginal food knowledge reveal about nutrition, gut health, and the challenges shaping diets today? Across Australia's diverse environments, traditional diets included a wide variety of plant and animal foods, including over 300 native fruit and vegetable species and 150 varieties of roots and tubers, along with seeds, nuts, seafood, and lean game meats. These foods varied across regions and communities, rather than forming a single uniform diet. Revitalizing Indigenous food systems and incorporating native foods into contemporary diets may support healthier, more sustainable food systems while addressing climate change and diet-related chronic disease.

Diet and Sepsis: How Nutrition Influences the Gut Barrier and Immune Function

https://www.news-medical.net/health/Diet-and-Sepsis-How-Nutrition-Influences-the-Gut-Barrier-and-Immune-Function.aspx From intestinal microbes to the liver’s pathogen-clearing cells, researchers are investigating whether nutrition can influence the body’s response to severe infection. This article discusses emerging research on the relationship between sepsis, intestinal hyperpermeability, and dietary patterns. Animal studies suggest that dietary fiber and microbial metabolites can support intestinal and systemic immune defenses; however, clinical evidence that plant-rich diets prevent sepsis or improve survival remains insufficient.

Food Synergy Explained: How Nutrients Work Together to Influence Health

https://www.news-medical.net/health/Food-Synergy-Explained-How-Nutrients-Work-Together-to-Influence-Health.aspx What happens when nutrients share a meal? From plant-based iron to dietary fats, food pairings offer clues to how the body uses what we eat. Nutrition research spent much of the 20th century focusing on single molecules like vitamin C, calcium, and beta-carotene, an approach that helped identify and treat nutrient deficiencies. Later research on chronic disease showed that isolated nutrients do not consistently reproduce the health effects associated with the foods that contain them.

Two healthy diets stood out in a study of more than 7,000 adults

https://www.news-medical.net/news/20261102/Two-healthy-diets-stood-out-in-a-study-of-more-than-7000-adults.aspx Can what you eat influence the subtle rhythms of your heart? Researchers examined four popular dietary patterns and 24-hour heart recordings from more than 7,000 adults, investigating how diet and medication use relate to cardiac autonomic function. In a recent study published in the journal Scientific Reports, researchers investigated the associations between adherence to four healthy dietary patterns and heart rate variability (HRV) among adults participating in the Maastricht Study.

Adenomyosis: common, overlooked, under-researched The Lancet Obstetrics, Gynaecology, & Women's Health (+...)

Adenomyosis: common, overlooked, under-researched The Lancet Obstetrics, Gynaecology, & Women's Health https://www.thelancet.com/journals/lanogw/issue/vol2no11/PIIS3050-5038(26)X2010-6 Although the research spotlight is beginning to shine on endometriosis, other uterine conditions remain critically under-resourced and understudied. One key example is adenomyosis. First described in 1860 by the Austrian pathologist Carl von Rokitansky as a single case of fibrous uterine polyps containing nests of endometrial cells, adenomyosis is now characterised by endometrial glands and stroma within the myometrium, often resulting in heavy menstrual bleeding and pain. For over a century, adenomyosis was only diagnosed via hysterectomy specimens. This diagnostic limitation meant that adenomyosis was thought to primarily affect older women. Since the early 2000s, transvaginal ultrasound (TVUS) and MRI have enabled the identification of adenomyosis in adolescents, women of reproductive age, and after menopause, with preliminary prevalence estimates suggesting that one in ten women have the condition. Often erroneously described as endometriosis of the uterus, a Series co-published by The Lancet Obstetrics, Gynaecology, & Women's Health and eBioMedicine aims to bring adenomyosis to the fore.

Hepatocellular carcinoma: Europe's paradox of preventable mortality The Lancet Regional Health – Europe (+...)

Hepatocellular carcinoma: Europe's paradox of preventable mortality The Lancet Regional Health – Europe https://www.thelancet.com/journals/lanepe/issue/vol70nonull/PIIS2666-7762(26)X2007-5 Europe has made important advances against hepatocellular carcinoma, which accounts for 75–85% a primary liver cancers, yet incidence and mortality continue to rise. Liver cancer incidence and mortality in Europe increased by around 1% annually between 1990 and 2021, compared with 0·1% globally, and more than 50,000 people a year die from liver cancer in Europe. Around 60% of liver cancers are preventable, yet 5-year survival remains below 20%, despite treatment advances. By contrast, Japan, which has a long-standing national surveillance programme, has reported 5-year survival of around 43%, more than double that in Europe.

Can virtual patients predict whether a drug will succeed? Phase Advance is using mechanistic virtual patient models to predict how LEAF4Life's hypoxia-targeting therapy could perform across multiple indications. Written byBree Foster, PhD

Can virtual patients predict whether a drug will succeed? Phase Advance is using mechanistic virtual patient models to predict how LEAF4Life's hypoxia-targeting therapy could perform across multiple indications. Written byBree Foster, PhD https://www.drugdiscoverynews.com/can-virtual-patients-predict-whether-a-drug-will-succeed-17347?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz--9_CXSD2E22WOascOXS8zG9rgcSTONu_bC5-2kPa_hYqw5r1tyael-SHzaY6z5A2XCpyE2rCp9LNq8M_YhJB8DWtZPWg&_hsmi=447069330&utm_content=447069330&utm_source=hs_email Even after years of laboratory research and early clinical testing, most drug candidates fail before reaching patients. Recent advances in AI and computational drug development have yet to change that reality, with the percentage of Phase 2 and 3 trials terminated before completion more than doubling from 11 percent to 23 percent between 2013 and 2023. While many failures arise from a lack of drug efficacy or issues with safety, fundamental flaws in clinical trial design can also significantly hinder success. Inappropriate patient selection, poorly chosen endpoints, and incorrect dose selection can all undermine a study before it begins. Current modeling approaches are largely retrospective tools, helping researchers understand how a drug behaves in the body or why a clinical study succeeded or failed.