Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

https://www.news-medical.net/news/20260522/Pim1-identified-as-promising-therapeutic-target-for-inflammatory-arthritis-treatment.aspx The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which Pim1 regulated Th17 cell differentiation through mitochondrial metabolism. Through molecular docking screening, they identified Nilotinib as an effective candidate drug for the treatment of inflammatory arthritis by targeting Pim1. The relevant achievement has been published in Research (DOI: 10.34133/research.1137) with the title "Pim1 Serves as a Therapeutic Target for Inflammatory Arthritis via Mitochondrial Metabolism and Th17 Cell Differentiation."

Specialized care helps child thrive despite chronic swallowing disorder

https://www.news-medical.net/news/20260522/Specialized-care-helps-child-thrive-despite-chronic-swallowing-disorder.aspx Today, 11-year-old Logan Fitzpatrick of Malverne, New York, spends his time playing baseball, practicing tae kwon do, painting, and cheering on the Mets and the Islanders. But behind the scenes, he continues to manage eosinophilic esophagitis (EoE), a chronic allergic disease of the esophagus that can make swallowing and eating painful and difficult.

Mobility as a pillar for healthy ageing The Lancet Healthy Longevity ++... ++

Mobility as a pillar for healthy ageing The Lancet Healthy Longevity https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(26)00042-5/fulltext?dgcid=raven_jbs_etoc_email Apr 2026 Volume 7Number 4 https://www.thelancet.com/journals/lanhl/issue/vol7no4/PIIS2666-7568(26)X2004-9 Physical activity and biological age measured by DNA methylation clocks: a systematic review and meta-analysis Jiatong Shan, BSa,b,c,g,∗ ∙ Jian Hua Tay, BSc,d,∗ ∙ Weilan Wang, PhDc,d,∗ ∙ Riise Tan, Dipe ∙ Rujina Joshi, MSf ∙ Prof Andrea B Maier, MD PhDc,d,g Send email to a.b.maier@vu.nl ∙ et al. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(26)00019-X/fulltext?dgcid=raven_jbs_etoc_feature_lanhl Trends of PM2·5-attributable dementia deaths in the context of population ageing in China, 2000–60: a health impact assessment Ning Kang, MPHa ∙ Jianyu Deng, BAa ∙ Pengfei Li, PhDb,c,d ∙ Meiling Zhong, MPHa ∙ Prof Huali Wang, MDe,f,∗ ∙ Tao Xue, PhDa,c,g,∗ Send email to txue@hsc.pku.edu.cn ∙ et al. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(26)00025-5/fulltext?dgcid=raven_jbs_etoc_feature_lanhl

Charting the Course for Metastatic Breast Cancer Care: Optimizing First-Line Treatment and Beyond Authors: Wolfgang Janni, MD, PhD; Rebecca A. Dent, MD; Peter Schmid, MD, PhD, FRCP; Nicholas Turner, MD, PhD, FRCP, FMedSci

https://www.medscape.org/viewarticle/charting-course-metastatic-breast-cancer-care-optimizing-2025a1000v4s?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260523-OUS-HONC-charting-course-metastatic-breast-cancer-care-optimizing-2025a1000v4s-cta

Stress impairs your brain’s ability to link memories — dampening insight Imaging suggests why the ability to make inferences declines after an episode of acute stress, such as a job interview. By Simon Spichak

https://www.nature.com/articles/d41586-026-01644-z

Ebola outbreak: the data that show why researchers are so alarmed The size of the outbreak in its initial days is worrying researchers. The next few weeks will determine how large it grows, they say. By Ewen Callaway, Mariana Lenharo & Lauren Wolf

https://www.nature.com/articles/d41586-026-01646-x?utm_source=Live+Audience&utm_campaign=b4f9d9a103-nature-briefing-daily-20260522&utm_medium=email&utm_term=0_-33f35e09ea-50432164 Compared with past outbreaks of Ebola, the number of cases this early in the current one are a serious cause for concern, say researchers. However, there’s “no indication that this is likely to lead to tens of thousands of infections”, as happened in the record-setting outbreak that began in 2014, says infectious-disease specialist David Wohl. The trajectory of the current outbreak will hinge on how quickly and effectively control measures can be put into place in the coming weeks, officials say.

Title Inflation: Bigger Title Without Bigger Pay By Ivanhoe Broadcast News on May 29, 2026

Orlando, Fla. (Ivanhoe Newswire) — A new job title can feel like a big step forward. But more workers are discovering that the promotion they celebrated may not be a real promotion at all. Surveys show two-thirds of workers say companies are handing out bigger-sounding titles without better pay or real advancement. https://www.ivanhoe.com/?p=37105&preview=1&_ppp=a0e9bf022c