Australian researchers identify new subtype of depression linked to body clock disruptions Study identifies ‘circadian depression’ as affecting nearly a quarter of more than 11,000 participants

https://www.theguardian.com/society/2026/oct/21/australian-researchers-identify-new-subtype-of-depression-linked-to-body-clock-disruptions?utm_source=Live+Audience&utm_campaign=989765235e-nature-briefing-daily-20261021&utm_medium=email&utm_term=0_-33f35e09ea-50432164 Body clock linked to 1 in 4 depression cases A study of more than 11,000 people with depression found that a quarter had a new subtype that makes their condition hard to treat. ‘Circadian depression’ appears to be linked to disruptions in the body’s internal clock, which could be targeted with treatments such as melatonin and light therapy. “Circadian depression is not just depression with bad sleep,” said neuroscientist and study co-author Emiliana Tonini. “There is an underlying biology that is quite distinct from other forms of depression.”

An extra year of secondary school lowered dementia diagnoses later in life NIH-funded study showed the effect was profound, especially among those at elevated genetic risk.

https://www.nih.gov/news-events/news-releases/extra-year-secondary-school-lowered-dementia-diagnoses-later-life An extra year of secondary school lowered dementia diagnoses later in life NIH-funded study showed the effect was profound, especially among those at elevated genetic risk. A new National Institutes of Health (NIH)-funded study provides perhaps the strongest evidence yet that education can help mitigate long-term dementia risk. Led by researchers at the University of Wisconsin–Madison and the University of Southern California, Los Angeles, the analysis demonstrates that an education reform in the United Kingdom, which extended the minimum drop-out age by a year, reduced dementia incidence up to 50 years later. Study participants whose genetics placed them at higher risk of developing Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) benefited most from the reform. U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH NIH News National Institutes of Health For Immediate Release: Friday, October 23, 2026 CONTACT: NIH Office of Communications, AN EXTRA YEAR OF SECONDARY SCHOOL LOWERED DEMENTIA DIAGNOSES LATER IN LIFE NIH-funded study showed the effect was profound, especially among those at elevated genetic risk A new National Institutes of Health (NIH)-funded study provides perhaps the strongest evidence yet that education can help mitigate long-term dementia risk. Led by researchers at the University of Wisconsin–Madison and the University of Southern California, Los Angeles, the analysis demonstrates that an education reform in the United Kingdom, which extended the minimum drop-out age by a year, reduced dementia incidence up to 50 years later. Study participants whose genetics placed them at higher risk of developing Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) benefited most from the reform. “These findings reinforce the understanding that dementia risk is determined by factors beyond one’s genetic makeup and that changes such as additional schooling can offset inherited vulnerability,” said Richard Hodes, M.D., director of NIH’s National Institute on Aging (NIA). Higher levels of education being linked to reductions in dementia risk is not a novel idea. In fact, the two have a long-documented correlative relationship. However, scientists have struggled to determine whether this link is causal. Doing so would require comparing an intervention to a control in a large population of students and following them for an extended period. Coincidentally, a law enacted in England, Wales, and Scotland in 1972 afforded researchers this type of opportunity. A compulsory education reform in the UK raised the minimum age at which students could drop out of school from 15 to 16, affecting students who were born after Sept. 1, 1957. The change led to a 14% increase in the number of students enrolled in school until they reached 16. To gauge the impact of this bump on long-term AD/ADRD incidence, the authors analyzed medical data from more than 100,000 participants in a large aging cohort, the UK Biobank . Diagnoses made before December 2022, when the oldest study participants became 65, served as the primary point of comparison between groups who were affected or unaffected by the educational reform. Importantly, the researchers obtained diagnoses from multiple sources, including medical histories, hospital records, and death registries, to limit the impact of survival and other biases that could skew the data toward individuals capable of obtaining diagnoses during life. The researchers found that the additional year of school reduced AD/ADRD incidence over the following 50 years by .88% — a considerably large effect given that overall rates of dementia in the study population were low. This signal was strongest for high-risk participants carrying specific genetic variants known to increase AD/ADRD incidence. They also tied the reform to improvements in socioeconomic factors and other realms of health, hinting at potential avenues by which education can mitigate dementia risk. While the findings support the argument that increases in education mitigate dementia later in life, the authors express caution when interpreting the results because participant age was capped at 65. As the study cohort continues to age and dementia diagnoses become more prevalent, differences between groups may become larger or smaller with time. “The message here is less about the specific numbers and more about the nature of education’s connection to dementia. There are few preventative options out there so even one could make a world of difference,” said lead author Silvia Barcellos, Ph.D., a health economist at UW–Madison. NIH supported this research through NIA grants R01AG078522, K01AG0669991, RF1AG055654, R56AG058726, and R00AG062787. About the National Institute on Aging (NIA): NIA seeks to understand the nature of aging and diseases associated with growing older, with the goal of extending the healthy, active years of life. https://www.nia.nih.gov About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov. NIH...Turning Discovery into Health -- Registered, U.S. Patent and Trademark Office --- REFERENCE: Silvia H. Barcellos, et al. Education Reduces Dementia Incidence and Mitigates Genetic Risk. Proceedings of the National Academy of Sciences. October 23, 2026. DOI: 10.1073/pnas.2529506123 ### This NIH News Release is available online at:

Cracking the Code: Optimizing Outcomes in All Patients With High-Risk HR+/HER2-Negative Early Breast Cancer Authors: Manali Bhave, MD; Shaheenah Dawood, MBBCh, MPH, FACP; Erika Hamilton, MD, FASCO

https://www.medscape.org/viewarticle/cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj?page=1&src=mkmcmr_driv_stan_mscpedu_261023-OUS-HONC-cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj-cta&uac=148436CN

Lessons From the Real World: Treating High Risk HR+/HER2- Breast Cancer According to the Latest Evidence Authors: Nadia Harbeck, MD, PhD; Stephen Johnston, MA, FRCP, PhD; Sara Tolaney, MD, PhD

https://www.medscape.org/viewarticle/lessons-real-world-treating-high-risk-hr-her2-breast-cancer-2026a1000bhd?page=1&src=mkmcmr_driv_stan_mscpedu_261022-OUS-HONC-lessons-real-world-treating-high-risk-hr-her2-breast-cancer-2026a1000bhd-cta&uac=148436CN

The Accelerating Rare disease Cures (ARC) Program has released its 2026 Annual Report: Sustaining Progress, Expanding Possibilities in Rare Disease Drug Development, documenting a year of scientific and regulatory innovation, meaningful engagement, and operational progress in rare disease drug development.

https://www.fda.gov/media/195846/download?attachment

RFK Jr.’s anti-vaccine obsession and fear of MAHA derailed bird flu containment plan Politico | October 22, 2026

https://geneticliteracyproject.org/2026/10/22/rfk-jr-s-anti-vaccine-obsession-and-fear-of-maha-derailed-bird-flu-containment-plan/ Robert F. Kennedy Jr.’s anti-vaccine views helped push the Agriculture Department to shelve its plan for vaccinating poultry against avian flu, just as wild birds begin the winter migration that spreads the virus. That’s according to five people with direct knowledge of the matter, as Politico’s Rachel Shin and Marcia Brown report.

‘Weird food’? Testicle- and brain-eating, supplement-gulping MAHA health food enthusiasts defend their ‘natural’ diets New York Times | October 22, 2026

https://geneticliteracyproject.org/2026/10/22/weird-food-testicle-and-brain-eating-supplement-gulping-maha-health-food-enthusiasts-defend-their-natural-diets/ Raw buffalo brains, bull testicles and roadkill are on the menu for a growing community of diet contrarians who insist the standard American diet is the truly strange one, as Sophie Haigney writes for The New York Times Magazine. Haigney spent months with followers of what a friend dubbed “dark nutrition.” It’s less a single diet than a worldview that doctors, public health officials and food companies can’t be trusted.