CIENCIASMEDICASNEWS

martes, 4 de agosto de 2026

Researchers suggest a potential therapeutic strategy for muscle loss associated with obesity

https://www.news-medical.net/news/20260804/Researchers-suggest-a-potential-therapeutic-strategy-for-muscle-loss-associated-with-obesity.aspx Obesity has been linked to skeletal muscle loss and deterioration. While M2 macrophages may play a role in regulating muscle function, the underlying mechanisms remain poorly understood. Now, researchers from Japan have found that deleting the signaling protein transforming growth factor-beta 1 from a specific population of M2 macrophages protected mice from obesity-induced muscle dysfunction. This enhanced muscle regeneration and mitochondrial function, suggesting a potential therapeutic strategy for muscle loss associated with obesity.

Study connects late-life psychosis to abnormal tau protein buildup

https://www.news-medical.net/news/20260804/Study-connects-late-life-psychosis-to-abnormal-tau-protein-buildup.aspx Hallucinations and delusions that appear for the first time in midlife or later are often treated as psychiatric symptoms whose biological cause is unclear. The study, published online in Molecular Psychiatry on August 2, 2026, suggests that, for many patients, these symptoms may be linked to brain changes also seen in dementia.

Genetic study explains global spread of invasive longhorned ticks

https://www.news-medical.net/news/20260804/Genetic-study-explains-global-spread-of-invasive-longhorned-ticks.aspx The Asian longhorned tick, Haemaphysalis longicornis, spreads serious pathogens, including severe fever with thrombocytopenia syndrome (SFTS) virus, Rickettsia, and Theileria, and its bite can cause a meat allergy in humans. Once confined to Japan, South Korea, North Korea, China, and Russia, the ticks have expanded across Oceania, and in 2017 they were detected in the United States. Perhaps contributing to this spread is the ability of some female ticks to produce offspring without fertilization by a male: a feat known as parthenogenesis. Only parthenogenetic ticks-the vast majority of which are female-have been found outside their previously known range

Cryo-EM study reveals dynamic structure of human norovirus

https://www.news-medical.net/news/20260804/Cryo-EM-study-reveals-dynamic-structure-of-human-norovirus.aspx Human norovirus is the leading cause of acute gastroenteritis worldwide and is estimated to infect 600–700 million people each year. Despite its enormous public health impact, no effective antiviral drugs are currently available. A detailed understanding of the three-dimensional structure of the virus is essential for elucidating its infection mechanism and developing effective therapeutics. However, research on human norovirus has been hampered by the inability to efficiently propagate the virus in cultured cells, making it difficult to obtain sufficient quantities of infectious particles for structural studies. In contrast, studies of murine norovirus, which can readily be propagated in cell culture, have shown that its capsid undergoes conformational changes in response to environmental conditions. Whether human norovirus exhibits similar structural dynamics has remained unknown.

CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression ++

CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression https://www.azolifesciences.com/news/20260723/CRISPR-Gene-Editing-Reveals-How-Enhancer-Hierarchies-Regulate-Gene-Expression.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene ExpressionEnhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated. Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate Cancer https://www.azolifesciences.com/news/20260727/Deep-Learning-Holography-Detects-Elusive-Circulating-Tumor-Cells-in-Prostate-Cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate CancerResearchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells.

UCLA researchers find strategy to improve prostate cancer therapies +++

UCLA researchers find strategy to improve prostate cancer therapies https://www.news-medical.net/news/20260803/UCLA-researchers-find-strategy-to-improve-prostate-cancer-therapies.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 UCLA researchers have identified a promising strategy to make a new class of targeted cancer therapies more effective against one of the deadliest forms of prostate cancer, potentially overcoming treatment resistance that has limited their success. Common heart risk calculators effectively predict certain types of cancerCommon heart risk calculators effectively predict certain types of cancer https://www.news-medical.net/news/20260721/Common-heart-risk-calculators-effectively-predict-certain-types-of-cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 Risk calculators that doctors use to estimate a person's risk of a heart attack or stroke work about as well for predicting certain cancers, according to a new study by UCL (University College London) researchers. New Research Links CALB2 Gene to Mechanoresistance in Metastatic Prostate Cancer https://www.azolifesciences.com/news/20260724/New-Research-Links-CALB2-Gene-to-Mechanoresistance-in-Metastatic-Prostate-Cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 When a cancer cell leaves the original tumor to spread to a new, far away location, it first has to survive what most cells cannot: periodic high force moments in the vessels and heart of up to 5,000 dynes per centimeter squared as it circulates throughout the body.