viernes, 26 de julio de 2024
Drug Trials Snapshots: SOHONOS (palovarotene)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which there is abnormal growth of bone tissue (heterotopic ossification or HO) within muscles, tendons, and other soft tissues, which restricts mobility and can be disabling. SOHONOS is a retinoid drug that is indicated to reduce the amount (measured as volume) of new HO in patients with FOP who are aged 8 years and older for females and 10 years and older for males.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-sohonos
FDA Approves HPV Tests That Allow for Self-Collection in a Health Care Setting
https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-hpv-test-self-collection-health-care-setting?cid=eb_govdel
On May 14, the Food and Drug Administration (FDA) expanded the approvals of two tests that detect cancer-causing types of human papillomavirus (HPV) in the cervix. Both tests are used as part of screening for cervical cancer.
Call for Papers: Supplemental Issue of Prevention Science Structural Approaches to Youth Violence Prevention: Addressing Racism and Discrimination Released: May 31, 2024 Letters of intent due: September 30, 2024
https://nimhd.nih.gov/about/publications/call-for-papers-supplemental-issue-of-prevention-science.html?utm_medium=email&utm_source=govdelivery
Submit Your Letter of Intent by September 30, 2024
NIMHD is inviting researchers to contribute to an upcoming supplemental issue of the journal Prevention Science. This supplemental issue will focus on youth violence prevention interventions that address structural racism and discrimination, and other structural factors and social determinants.
Topics of Interest:
Empirical research on the impact of interventions on individual, community, social, and structural factors.
Prospective intervention studies and natural policy experiments at local, state, regional, or national levels.
Conceptual papers that describe current challenges and viable solutions to implementing sustainable multilevel, multisectoral interventions that address social and structural factors that place youth at highest risk for violence as well as those that address disparities in youth violence.
Authors interested in contributing should submit a letter of intent by September 30, 2024.
Epigenetic Editor Silences Toxic Proteins in the Mouse Brain, Offering Promising Path to Treat Deadly Prion Diseases Posted on July 25th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/07/25/epigenetic-editor-silences-toxic-proteins-in-the-mouse-brain-offering-promising-path-to-treat-deadly-prion-diseases/
Prion diseases are fatal neurodegenerative disorders caused by a malfunction of the prion protein in the brain. Exposure to a misfolded version of the protein triggers normal proteins of the same type in the brain to misfold, forming clumps that produce infectious disease and fatal brain damage over time. There are currently no treatments, preventive vaccines, or cures for prion diseases, which can be acquired, like mad cow disease, or inherited, like fatal familial insomnia. But an encouraging new study in mice suggests a potentially promising path for developing a treatment for people with these deadly conditions.
https://www.niaid.nih.gov/diseases-conditions/prion-diseases
Findings from an NIH-supported study reported in Science show that the key to this approach is a molecular tool capable of silencing prion protein throughout the brain using epigenetic editing. Unlike gene editing approaches, which change the sequence of genes, epigenetic editing can turn gene expression off with the addition of a chemical tag that prevents genes from being translated into proteins. Such a strategy may be able to deliver modifying tools to the brain or other parts of the body to silence specific toxic or disease-causing genes, including the one encoding the prion protein, without the risks associated with altering DNA sequences.
https://pubmed.ncbi.nlm.nih.gov/38935715/
Suscribirse a:
Entradas (Atom)
