viernes, 13 de marzo de 2026
Deep remission in early relapse 2L DLBCL with COLUMVI + GemOx 56~ durable CR in early relapse 2L DLBCL at 3 years
https://mcj20l77mmv6zbm64ff24smgz911.pub.sfmc-content.com/m2x3t01tdmu?cid=na5589337334&utm_source=medscape&utm_medium=na&utm_campaign=columvi_branded_phase2&utm_content=tx%3Anc3yosdata%3A2512%3Axx&dclid=CjkKEQjw687NBhCM3eyk7NqR_qgBEiQAhPZfllSj2GnUd4bzsCi887ju7qZJJSl31TosJ7ejhjMojAvw_wcB&gad_source=7&gad_campaignid=23190769370
At 3 years, COLUMVI + GemOx continues to deliver a sustained overall survival benefit with a manageable safety profile. As the first and only off‑the‑shelf therapy with curative potential in 2L DLBCL, COLUMVI + GemOx is now recommended by EHA and ESMO Guidelines with the highest category of evidence (I,A).1-6
COLUMVI in combination with gemcitabine and oxaliplatin is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) who are ineligible for autologous stem cell transplant (ASCT).1
COLUMVI as monotherapy is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), after two or more lines of systemic therapy.1
Dysuria: When It Hurts to Go With the Flow Josh Palka, DO; Christopher Atalla, DO March 05, 2026 ++++
https://reference.medscape.com/p11/dysuria-when-it-hurts-go-flow-2026a100064x?ecd=wnl_critimg_260313_mscpref_etid8180276&uac=148436CN&impID=8180276
Why Genitourinary Syndrome of Menopause Is Often Missed
Zoé Trinh
https://www.medscape.com/viewarticle/why-genitourinary-syndrome-menopause-often-missed-2025a1000ojg?ecd=wnl_critimg_260313_mscpref_etid8180276&uac=148436CN&impID=8180276
September 17, 2025
Should You Trust the Symptoms? Clinical Judgment in After-Hours Primary Care
Charles P. Vega, MD, FAAFP
https://www.medscape.com/viewarticle/should-you-trust-symptoms-clinical-judgment-after-hours-2025a1000hbf?ecd=wnl_critimg_260313_mscpref_etid8180276&uac=148436CN&impID=8180276
July 01, 2025
Myth of the Month: Altered Urine Is Not Altered Mentation
John E. Kearney, MS; Douglas S. Paauw, MD
https://www.medscape.com/viewarticle/myth-month-altered-urine-not-altered-mentation-2025a1000xqn?ecd=wnl_critimg_260313_mscpref_etid8180276&uac=148436CN&impID=8180276
December 17, 2025
A Decade of Innovation in Breast Cancer (2015-2025): A Comprehensive Review of Clinical Trials, Targeted Therapies and Molecular Perspectives.
https://read.qxmd.com/collection/1133?ecd=wnl_readmost_260313
A Decade of Innovation in Breast Cancer (2015-2025): A Comprehensive Review of Clinical Trials, Targeted Therapies and Molecular Perspectives.
Klaudia Dynarowicz, Dorota Bartusik-Aebisher, Sara Czech, Aleksandra Kawczyk-Krupka, David Aebisher
The past decade has witnessed an unprecedented transformation in breast cancer management, driven by parallel advances in targeted therapies, immunomodulation, drug-delivery technologies, and molecular diagnostic tools. This review summarizes the key achievements of 2015-2025, encompassing all major biological subtypes of breast cancer as well as technological innovations with substantial clinical relevance. In hormone receptor-positive (HR+)/HER2- disease, the integration of CDK4/6 inhibitors, modulators of the PI3K/AKT/mTOR pathway, oral Selective Estrogen Receptor Degraders (SERDs), and real-time monitoring of Estrogen Receptor 1 (ESR1) mutations has enabled clinicians to overcome endocrine resistance and dynamically tailor treatment based on evolving molecular alterations detected in circulating biomarkers...
Energy’s long game: thermogenic adipocytes and the metabolic diseases of modern life Silvia Corvera, Michael P. Czech Volume 4, Issue 1
https://www.academia.edu/journals/academia-biology/articles?source=journal-top-nav
Abstract
The ability to generate, store, and mobilize energy is fundamental to life, and disruptions in these processes underlie metabolic disease. This review examines how these mechanisms evolved to rely profoundly on lipids, a large family of molecules that serve an unusually wide range of biological functions. From early evolutionary times, lipids have enabled chemiosmotic energy transduction, organized the endomembrane systems that synthesize and package neutral lipids, served as concentrated reservoirs of metabolic energy, and functioned as signaling molecules that coordinate cellular and systemic physiology. Adipocytes are specialized cells that can accumulate large amounts of lipid within specialized lipid droplet organelles. Over evolutionary time, mammals developed distinct adipocyte subtypes with tailored physiological roles. White adipocytes, characterized by a single large unilocular lipid droplet, coordinate energy storage and release in response to systemic cues. In contrast, the role of brown and beige adipocytes is to protect the organism from cold exposure by generating heat as a primary output of UCP1-mediated mitochondrial uncoupling. Crucially, this thermogenic process requires extensive systemic coordination: sympathetic neural input triggers lipolysis, vascular networks deliver fuel from multiple adipose depots, and hormonal signals integrate metabolic demand across organs. These requirements position thermogenic adipocytes as metabolic integration “nodes” that orchestrate whole-body fuel allocation and energy homeostasis. The presence of functional thermogenic adipocytes is strongly associated with improved cardiometabolic health, protecting against obesity, type 2 diabetes, and cardiovascular disease. Understanding how these specialized cells sense and respond to systemic signals offers a powerful entry point for developing strategies to counteract metabolic disease.
https://www.academia.edu/2837-4010/4/1/10.20935/AcadBiol8131
Designing evidence-based digital mental health check-ins in higher education Madison Westley, Jennifer Laffier, Aalyia Rehman, Gorm Eriksen, Rune Sønderby, Morten Sørdahl Volume 3, Issue 1
https://www.academia.edu/journals/academia-mental-health-and-well-being/articles?source=journal-top-nav
Abstract
Introduction: Due to the urgent need for more sustainable support for post-secondary student mental health, many institutions are exploring alternative ideas for intervention, such as the role of technology, including artificial intelligence (AI) and wellness apps. However, if technological programs or devices are used for student mental health, their design and delivery should align with research on student well-being, best practices in psychological interventions, and learning theories.
Materials and methods: This study used a case study approach to examine how cognitive, industrial, and positive psychology principles can inform the design and delivery of mental health apps and programs. An emerging platform from Denmark, StudentPulse, which has students complete mental health check-ins, was examined using a comparison analysis approach between design features and research on post-secondary wellness and learning.
Results: The analysis revealed how the platform’s features are rooted in three areas of psychological wellness: cognitive, positive, and industrial. This included design features such as AI-trained responses for students that provide immediate feedback, choice, reflection, and flourishing questions. The feedback design is based on cognitive principles of retention, attention, and motivation.
Conclusions: As post-secondary institutions continue to adopt technological tools that support student mental health, these tools must be grounded in psychological principles to ensure they minimize harm and promote student wellness. The study recommends that wellness-based technologies incorporate evidence-based research in mental health, learning, and psychology in their design and implementation.
https://www.academia.edu/2997-9196/3/1/10.20935/MHealthWellB8157
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