Coffee’s link to Parkinson’s risk may depend on how your body handles caffeine

https://www.news-medical.net/news/20260902/Coffeee28099s-link-to-Parkinsone28099s-risk-may-depend-on-how-your-body-handles-caffeine.aspx Why does coffee appear to have different links with Parkinson’s risk from one person to another? A study of more than 435,000 people points to the interplay between caffeine metabolism, genetics, and sex. In a recent study published in the journal npj Parkinson's disease, researchers investigated whether the cytochrome P450 1A2 (CYP1A2) genotype and sex modify the association between Parkinson's disease (PD) and coffee consumption.

Europe has a new mosquito problem, but it may not be the one you think

https://www.news-medical.net/news/20260902/Europe-has-a-new-mosquito-problem-but-it-may-not-be-the-one-you-think.aspx Europe’s cold-tolerant Korean bush mosquito can thrive where other invasive mosquitoes struggle, raising new questions about how it should be tracked, identified, and assessed for disease risk. In a recent review accepted for publication in the journal Acta Tropica, a group of authors mapped the available evidence on Aedes koreicus in Europe and identified priorities for surveillance, research, and public communication

Researchers discover dozens of genes tied to OCD and tic disorders

https://www.news-medical.net/news/20260902/Researchers-discover-dozens-of-genes-tied-to-OCD-and-tic-disorders.aspx A Rutgers-led international collaboration has identified 36 genes that substantially raise the risk for obsessive-compulsive disorder (OCD) and chronic tic disorders – providing what two researchers said is the most detailed biological understanding of how these conditions develop – and how they might eventually be treated.

Flavorings, colors and sweeteners emerge as UPF markers linked to depression risk

By tracking dozens of ingredients associated with ultra-processed foods, researchers investigated whether some components of the modern diet may matter more for mental health than others. https://www.news-medical.net/news/20260901/Flavorings-colors-and-sweeteners-emerge-as-UPF-markers-linked-to-depression-risk.aspx Higher estimated dietary exposure to certain markers of ultra-processed foods, including flavoring agents, coloring agents, and sweeteners, was dose-dependently associated with a higher risk of incident depression, according to a new study published in the European Journal of Nutrition.

3D retina model reveals cause of vision loss in Batten disease The novel stem-cell derived retinal organoid provided a new understanding of the disease by showing that damage to retinal pigment epithelium cells is enough to cause neurodegeneration of photoreceptors. Written byAllison Whitten, PhD

3D retina model reveals cause of vision loss in Batten disease The novel stem-cell derived retinal organoid provided a new understanding of the disease by showing that damage to retinal pigment epithelium cells is enough to cause neurodegeneration of photoreceptors. Written byAllison Whitten, PhD https://www.drugdiscoverynews.com/3d-retina-model-reveals-cause-of-vision-loss-in-batten-disease-17493 In the most common form of Batten disease, known as CLN3 disease due to mutations in the CLN3 (ceroid-lipofuscinosis, neuronal 3) gene, the first symptom is usually loss of vision in early childhood. “It often precedes neurological decline by years, and it's the one that most immediately changes a child's ability to read, learn, and move through the world independently,” Ruchira Singh, a retinal and neurodegenerative researcher at the University of Rochester, told DDN. A rare, fatal inherited disorder of the nervous system, CLN3 disease typically begins in childhood and causes progressive mental and physical decline.

Cervical cancer elimination: progress made, but not for all The Lancet Obstetrics, Gynaecology, & Women's Health +..+ ++

https://www.thelancet.com/journals/lanogw/issue/vol2no9/PIIS3050-5038(26)X2008-8 Cervical cancer elimination: progress made, but not for all The Lancet Obstetrics, Gynaecology, & Women's Health https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(26)00263-3/fulltext?dgcid=raven_jbs_etoc_email Gut, vaginal, and seminal microbiomes in couples with infertility or recurrent pregnancy loss: a two-cohort prospective study of reproductive outcomes Ida Behrendt-Møller, MDa,* ∙ Maria Christine Krog, PhDa,c,* ∙ Pernille Neve Myers, PhDa,* ∙ Cathrine Voigt Dalgaard, MDd,e ∙ Nathalie Friis Wang, PhDd,e ∙ Anna Mathilde Yde, MDd ∙ et al. https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(26)00213-X/fulltext?dgcid=raven_jbs_etoc_feature_lanogw Effectiveness of a quality improvement collaborative on choice of postpartum contraception (IMPROVE-it): a cluster-randomised controlled trial in Sweden Sofia Berglundh, MDa ∙ Helena Kilander, PhDb,c ∙ Anna Wängborg, RNMb ∙ Karin Emtell Iwarsson, PhDb,d ∙ Gunnar Brandén, PhDa,g ∙ Mattias Elg, PhDh ∙ et al. https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(26)00151-2/abstract?dgcid=raven_jbs_etoc_feature_lanogw

From navigating a system that was not built for people with rare diseases, to working to change that system from both sides

https://rarerevolutionmagazine.com/from-navigating-a-system-that-was-not-built-for-people-with-rare-diseases-to-working-to-change-that-system-from-both-sides/ From overcoming daily physical and societal hurdles in the classroom to facing misconceptions within the medical community, Sarah Mullahy shares her personal journey of advocacy and her path toward becoming a doctor dedicated to patient-centered care. Written by Sarah Mullahy In 2003, after a short stay in the neonatal intensive care unit, I was discharged home, only to be readmitted months later with failure to thrive. An atrial septal defect was found during that admission. When I was still very young my family moved to South Africa for a year. It was a specialist there who looked at the wider picture and insisted we see a geneticist once we returned to Ireland. I was diagnosed clinically with Noonan syndrome in 2005, at the age of two. In 2008, when genetic testing became more available, an alteration in the PTPN11 gene confirmed what the clinicians had already recognised.