jueves, 4 de junio de 2020

Study ties stroke-related brain blood vessel abnormality to gut bacteria | National Institutes of Health (NIH)

Study ties stroke-related brain blood vessel abnormality to gut bacteria | National Institutes of Health (NIH)

National Institutes of Health (NIH) - Turning Discovery into Health



Study ties stroke-related brain blood vessel abnormality to gut bacteria

NIH funded study supports link between high levels of gram-negative bacteria and a stroke- seizure- and headache-inducing vascular malformation


In a nationwide study, NIH funded researchers found that the presence of abnormal bundles of brittle blood vessels in the brain or spinal cord, called cavernous angiomas (CA), are linked to the composition of a person’s gut bacteria. Also known as cerebral cavernous malformations, these lesions which contain slow moving or stagnant blood, can often cause hemorrhagic strokes, seizures, or headaches. Current treatment involves surgical removal of lesions when it is safe to do so. Previous studies in mice and a small number of patients suggested a link between CA and gut bacteria. This study is the first to examine the role the gut microbiome may play in a larger population of CA patients.
Led by scientists at the University of Chicago, the researchers used advanced genomic analysis techniques to compare stool samples from 122 people  who had at least one CA as seen on brain scans, with those from age- and sex-matched, control non-CA participants, including samples collected through the American Gut Project(link is external). Initially, they found that on average the CA patients had more gram-negative bacteria whereas the controls had more gram-positive bacteria, and that the relative abundance of three gut bacterial species distinguished CA patients from controls regardless of a person’s sex, geographic location, or genetic predisposition to the disease. Moreover, gut bacteria from the CA patients appeared to produce more lipopolysaccharide molecules which have  been shown to drive CA formation in mice. According to the authors, these results provided the first demonstration in humans of a “permissive microbiome” associated with the formation of neurovascular lesions in the brain.
Further analysis showed that some gut bacteria compositions could identify aggressive versus non-aggressive forms of the disease as well as those with recent symptomatic hemorrhages. Also, for the first time, they showed how combining gut bacteria data with results from blood plasma tests might help doctors better diagnose the severity of a brain disorder. The results, published in Nature Communications, support a growing body of evidence for the role of gut bacteria in brain health.


Jim Koenig, Ph.D., program director, NIH’s National Institute of Neurological Disorders and Stroke (NINDS)


Polster, S.P.; Sharma, A. et al. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma, May 27, 2020, Nature Communications; DOI: 10.1038/s41467-020-16436-w(link is external).
This study was supported by the NIH (NS092521, NS100949, NS065705, NS100252, HL094326, TR001863), the Department of Defense (W81XWH-18-1-0501), the BeBrave for Life Foundation, The University of Chicago Safadi Clinical and Translational Neuroscience Awards, The American Association of Neurological Surgeons/Congress of Neurological Surgeons Joint Cerebrovascular Section Robert J. Dempsey MD Cerebrovascular Research Grant, the Sigrid Juselius Foundation, and the William and Judith Davis Fund in Neurovascular Surgery Research.
NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIH…Turning Discovery Into Health®

My MedlinePlus Weekly Newsletter: Headache & Migraine | Teen Mental Health | Vitamin E

My MedlinePlus
June 3, 2020
african american woman pressing her temples with her fingers

Is it a Headache or Migraine?

Almost everyone gets headaches, but did you know that 12% of Americans also get migraines? Migraines are a recurring type of headache that can cause throbbing or pulsing pain, often on one side of your head. You may also have other symptoms like nausea, weakness, and light and sound sensitivity. Learn more about the available treatments to relieve and prevent migraines.

Teens and Mental Health

When things get stressful, how does your teenager respond? It's normal to feel angry or sad, but if these emotions continue for a long period of time it may be a sign of a more serious mental health concern. Learn how to recognize the signs and where to find help.

Risks of Inactive Lifestyle

If you spend a lot of time sitting at a desk working or on the couch watching TV or playing video games, you might be putting yourself at risk for certain health issues. A sedentary or inactive lifestyle means that you burn fewer calories, may have poorer blood circulation, and your body might experience more inflammation. This can lead to:
  • Heart disease
  • High blood pressure
  • Type 2 Diabetes
  • Depression and anxiety

Find out how you can get started with exercise and be more active at work and at home.

Kawasaki Disease

Kawasaki disease is a rare illness that mainly affects young children and happens when the immune system attacks the blood vessels by mistake. This can lead to inflammation of blood vessels and can cause them to become narrow or close completely. Most children can recover from Kawasaki disease if treated right away. Learn more about the causes and symptoms.

Vitamin E

Vitamin E helps protect your body from damage caused by free radicals, keeps your immune system strong against viruses and bacteria, and is important in the formation of red blood cells. You can get vitamin E from your diet and from supplements. How much vitamin E do you need?

Southwestern Stuffed Potatoes

Southwestern Stuffed Potatoes make a satisfying main course or side dish.

Disaster Lit® Database Daily Updates | COVID-19

Disaster Lit® Database Daily Updates

Disaster Information and Emergency Response

06/03/2020 12:00 AM EDT

Source: United Nations High Commissioner for Refugees (UNHCR). Published: 6/3/2020. This 10-page paper is an initial compilation of the promising practices on risk communication and community engagement that have developed in Europe during the COVID-19 pandemic, in complementarity to the UNHCR’s Practical Recommendations and Good Practice to Address Protection Concerns in the Context of the COVID-19 Pandemic. It seeks to document and share such practices, but also to inspire new initiatives, foster exchange, and further develop a community of practice within the region. (PDF)
06/02/2020 12:00 AM EDT

Source: U.S. Government Accountability Office (GAO). Published: 6/2/2020. This 31-page Congressional testimony describes how the outbreak of COVID-19 has called greater attention to the United States’ reliance on foreign drug manufacturers. The Food and Drug Administration (FDA) began to postpone almost all inspections of foreign manufacturing establishments in March 2020 due to COVID-19, and the testimony explains that this lack of foreign inspections removes a critical source of information about the quality of drugs manufactured for the U.S. market. (PDF)
06/02/2020 12:00 AM EDT

Source: Office of the Assistant Secretary for Preparedness and Response [U.S. Department of Health and Human Services] (HHS ASPR). Published: 6/2/2020. This one-hour, 35-minute webinar from TRACIE (Technical Resources, Assistance Center, and Information Exchange) features speakers who share recent experiences and lessons learned while adjusting their healthcare systems during the COVID-19 pandemic in order to maintain safety within their organizations. (Video or Multimedia)
06/02/2020 12:00 AM EDT

Source: National Academies of Sciences, Engineering, and Medicine. Published: 6/2/2020. This one-hour, 25-minute webinar explores the challenges to—and appreciates the urgency of—effective cohorting of nursing home residents during the COVID-19 outbreak to prevent virus transmission; discusses the design and implementation of an actionable cohorting strategy based on CDC guidance; and examines approaches to mitigate risk associated with new admissions, readmissions, and residents who must routinely leave the nursing home or long-term care facility for medical appointments. (Video or Multimedia)
06/01/2020 12:00 AM EDT

Source: World Health Organization (WHO). Published: 6/2020. This 32-page technical brief on water, sanitation, and hygiene (WASH) and wastewater management to reduce the spread of antimicrobial resistance (AMR) was published by the World Health Organization (WHO), Food and Agriculture Organization of the United Nations (FAO), and World Organisation for Animal Health (OIE). It provides a summary of evidence and rationale for WASH and wastewater actions within AMR NAPs and sector-specific policy to combat AMR. Evidence and actions are presented in the domains of coordination and leadership, households and communities, health care facilities, animal and plant production, manufacturing of antimicrobials, and surveillance and research. (PDF)
06/01/2020 12:00 AM EDT

Source: Federal Emergency Management Agency [Department of Homeland Security] (FEMA). Published: 6/1/2020. This Preparedness in a Pandemic Exercise Starter Kit helps whole community partners by providing three sample documents that state, local, tribal, and territorial governments can use to conduct their own workshops on preparedness in a pandemic. (Text)
06/01/2020 12:00 AM EDT

Source: United Nations Children's Fund (UNICEF). Published: 6/2020. The response to the COVID-19 pandemic has seen an unprecedented rapid scaling up of technologies to support digital contact tracing and surveillance. This 26-page working paper explores the implications for privacy as the linking of datasets increases the likelihood that children will be identifiable; increases the opportunity for (sensitive) data profiling; and frequently involves making data available to a broader set of users or data managers. (PDF)
06/01/2020 12:00 AM EDT

Source: United Nations Children's Fund (UNICEF). Published: 6/2020. This 54-page rapid review seeks to inform the initial and long-term public policy responses to the COVID-19 pandemic, by assessing evidence on past economic policy and social protection responses to health and economic crises and their effects on children and families. It focuses on virus outbreaks/emergencies, economic crises, and natural disasters, which, like the COVID-19 pandemic, were rapid in onset, had wide-ranging geographical reach, and resulted in disruption of social services and economic sectors, without affecting governance systems. (PDF)
06/01/2020 12:00 AM EDT

Source: RAND Corporation. Published: 6/2020. This 172-page research paper finds minor changes to the Air Force's Expeditionary Medical Support System (EMEDS) that produce significant impacts on patient outcomes in mass casualty events. It confirms that the EMEDS is not well-suited to handle patient surges. Though large-scale changes to the EMEDS structure are impractical, two small changes were found that each produce beneficial and statistically significant impacts on patient outcomes. (PDF)
06/01/2020 12:00 AM EDT

Source: Nextstrain. Published: 6/2020. This resource is an open-source project to harness the scientific and public health potential of pathogen genome data, and visualizes 4,305 coronavirus genomes sampled between December 2019 and May 2020. (Text)
05/29/2020 12:00 AM EDT

Source: World Health Organization (WHO). Published: 5/29/2020. This 23-page report provides information and statistics about how the COVID-19 pandemic has become an amplifier for health systems to better respond to non-communicable diseases (NCDs), and assesses service delivery for NCDs during the pandemic. It found that 120 countries reported that NCD services have been disrupted since the outbreak started. (PDF)
05/26/2020 12:00 AM EDT

Source: Centers for Disease Control and Prevention (CDC). Published: 5/26/2020. This 56-page guidance aims to provide a foundation for state, territorial, local, and tribal development of COVID-19 case investigation and contact tracing plans. It is important to note that COVID-19 case investigation and contact tracing activities will vary based on the level of community transmission, characteristics of the community and their populations, and the local capacity to implement case investigation, contact tracing, and COVID-19 testing. (PDF)
05/26/2020 12:00 AM EDT

Source: United Nations Office for the Coordination of Humanitarian Affairs, Inter-Agency Standing Committee (IASC). Published: 5/26/2020. This 26-page illustrated guide, developed by the IASC Mental Health and Psychosocial Support Reference Group, aims at building basic psychosocial skills among all essential workers responding to COVID-19 in all sectors. (PDF)
05/05/2020 12:00 AM EDT

Source: United Nations (UN). Published: 5/5/2020. This 18-page Policy Brief highlights the impact of COVID-19 on persons with disabilities and in doing so, outlines key actions and recommendations to make the response and recovery inclusive of persons with disabilities. While the brief contains specific recommendations focusing on key sectors, it identifies four overarching areas of action that are applicable for all. (PDF)
05/01/2020 12:00 AM EDT

Source: United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Published: 5/2020. In this introductory session to visualizing data using examples from the COVID-19 pandemic, participants will learn best practices for designing thoughtful data visualizations; how to identify and visually represent different relationships in data; and how to prepare and structure data in order to make a simple line graph. (Video or Multimedia)
04/24/2020 12:00 AM EDT

Source: United Kingdom Department for International Development (DFID). Published: 4/24/2020. The COVID-19 pandemic presents an unprecedented challenge to health systems globally. This four-page brief summarizes key principles for promoting resilient health systems in the face of this challenge. (PDF)
04/23/2020 12:00 AM EDT

Source: ADA [Americans with Disabilities Act] National Network. Published: 4/23/2020. Presenters in this one-hour, 31-minute webinar review general health care provisions in the Americans with Disabilities Act (ADA) and how they apply to new issues such as temporary medical facilities, drive-through testing sites, and other current health care issues related to the COVID-19 pandemic. They discuss effective communication issues to public information notices and warnings; masked care by professionals in all situations, including medical drive-throughs; qualified interpreters; and modifications to service animals, personal assistants, and bringing own assistive technology to a site. (Video or Multimedia)
04/07/2020 12:00 AM EDT

Source: World Health Organization, Regional Office for the Eastern Mediterranean. Published: 4/7/2020. This 17-page document details how communities on the move such as refugees, internally displaced persons, migrants, and returnees remain highly vulnerable to contracting COVID-19, and provides guidance to countries of the Eastern Mediterranean region and partners for the prevention and management of COVID-19 outbreaks in internally displaced person, refugee, migrant, and returnee communities. (PDF)
04/01/2020 12:00 AM EDT

Source: Center for the Study of Traumatic Stress [Uniformed Services University of the Health Sciences] (CSTS). Published: 4/2020. This one-page fact sheet summarizes psychological challenges associated with prolonged work in personal protective equipment (PPE), and recommendations for workers and managers to overcome those challenges during the COVID-19 pandemic. (PDF)
04/01/2020 12:00 AM EDT

Source: Center for the Study of Traumatic Stress [Uniformed Services University of the Health Sciences] (CSTS). Published: 4/2020. Whether due to long work hours or infection control precautions during the COVID-19 pandemic, healthcare workers may be separated from their families, which can add to family distress due to physical separations or infrequent communication. This two-page document provides several strategies to help families. (PDF)
03/01/2020 12:00 AM EST

Source: Center for the Study of Traumatic Stress [Uniformed Services University of the Health Sciences] (CSTS). Published: 3/2020. This one-page document provides recommendations on how hospital workers can take steps during the COVID-19 pandemic to ensure healthy sleep from the moment they wake up, to have a positive impact on the health and well-being of themselves and their patients. (PDF)

Safe Driving | NIH News in Health

Safe Driving | NIH News in Health

NIH News in Health

06/02/2020 12:29 PM EDT

From the National Institutes of Health
Related MedlinePlus Pages: Motor Vehicle Safety

Communication Breakdown | NIH News in Health

Communication Breakdown | NIH News in Health

NIH News in Health

06/02/2020 12:39 PM EDT

Source: National Institutes of Health - From the National Institutes of Health
Related MedlinePlus Pages: Aphasia

Comparing Heart Disease Treatments | NIH News in Health

Comparing Heart Disease Treatments | NIH News in Health

NIH News in Health

06/02/2020 12:42 PM EDT

Source: National Institutes of Health - From the National Institutes of Health
Related MedlinePlus Pages: Heart Diseases

Pelvic Fractures - Injuries and Poisoning - Merck Manuals Consumer Version

Pelvic Fractures - Injuries and Poisoning - Merck Manuals Consumer Version


06/02/2020 12:53 PM EDT

Source: Merck & Co., Inc.
Related MedlinePlus Pages: OsteoporosisPelvic Pain