Cracking the Code: Optimizing Outcomes in All Patients With High-Risk HR+/HER2-Negative Early Breast Cancer Authors: Manali Bhave, MD; Shaheenah Dawood, MBBCh, MPH, FACP; Erika Hamilton, MD, FASCO

https://www.medscape.org/viewarticle/cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260906-OUS-HONC-cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj-cta

Redefining the Patient Journey: The Promise and Practice in NTRK Fusion–Positive Cancers Authors: Theodore W. Laetsch, MD; Nicole A. Cipriani, MD; Herbert H. Loong, MBBS; Jonathan C. Trent, MD, PhD

https://www.medscape.org/viewarticle/redefining-patient-journey-promise-and-practice-ntrk-fusion-2026a1000lot?page=1&src=mkmcmr_driv_stan_mscpedu_260906-OUS-HONC-redefining-patient-journey-promise-and-practice-ntrk-fusion-2026a1000lot-cta&uac=148436CN

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Catheter ablation for symptomatic atrial fibrillation Catheter ablation for symptomatic atrial fibrillation (PVI-SHAM-AF): a randomised, double-blind, sham-controlled, multicentre trial Rolf Wachter, MDa Send email to rolf.wachter@medizin.uni-leipzig.de ∙ Patrick Haag, MDb ∙ Tobias Uhe, MDa ∙ Miroslav Bacak, PhDc ∙ David Petroff, PhDc ∙ Mathias Forkmann, MDd ∙ et al. (PVI-SHAM-AF): a randomised, double-blind, sham-controlled, multicentre trial Open Access https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01558-8/fulltext?dgcid=hubspot_email_conferencealerts_esc26&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_4KbNX9GG0sIBon7IXi5txJPr778uNuxgLTq-Twtu4Czr9JeAnoYcOcXgTsGsD7AzYUgkfSLfToRbMHyl-VKaC6CF_Sw&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Aetiology, management, and outcomes of acute heart failure in 17 African countries (THESUS-HF II): a prospective, multicentre, observational cohort study Free with registration until Sept 8th, 2026 Aetiology, management, and outcomes of acute heart failure in 17 African countries (THESUS-HF II): a prospective, multicentre, observational cohort study Prof Karen Sliwa, MD PhDa,* Send email to karen.sliwa-hahnle@uct.ac.za ∙ Julia Hahnle, MDa,* ∙ Prof Simon Stewart, MDe ∙ Shaazia Allie, MDa ∙ Prof Albertino Damasceno, MD PhDb ∙ Duard Smita,c ∙ et al. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01657-0/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-82o-8ftcrIHVYlBS9gHFTPCjbc2U_3vDgesRNqQ-t9BoPdGPkm3M0cjJqotTVbenGIfxx47hGM_h3SPYBI9y6z-Ysksw&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Discontinuation of β-blockers in stable patients with previous myocardial infarction, preserved left ventricular ejection fraction, and no heart failure: a pooled analysis of individual patient data https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01426-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-9oMOeWl36jVJnzvOWtfuVgZZKC8W6EZbSEo2JbkXddoIo3l1aKrdMzYelwSrzKGMAxvbmn9mc99soJzZfIXYYfiRA8dQ&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration until Sept 8th, 2026 Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01484-4/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-9V8CgA4_A6BWwFT2ZwraWbpk2M7_ikrqwrfOhaMtDBTF6HcYJ6QJsPPkkqXOwVFT2QQBSEREvNlIoIWLBLnL8Wh2RLBw&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration until Sept 8th, 2026 Safety and efficacy of the 0/1 h pathway for myocardial infarction in the emergency department: an international, pragmatic, stepped-wedge, cluster-randomised, controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01654-5/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-_-fdacbtFc1vXK8MQQipRYGCkXpijnZ9LbZF4OxMubXVTC0qh1d6FfZAbPadXHQY8VGOMnZY7nRW4T27wFOWz_bgHeWw&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration until Sept 8th, 2026 Targeted left ventricular lead placement in biventricular pacing for heart failure: a national, multicentre, double-blind, randomised controlled trial in Denmark https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01597-7/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-_nmppg2_wL1OALk-iw_mGm7k5a-O8PdVSaf_nPRhr7JX-qHoiL88oc92dq9NQ43M5o3WJNXzpRY9UOpJKqbjTVH_cG0A&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration until Sept 8th, 2026 Multimodal artificial intelligence-based long-term mortality prediction after transcatheter aortic valve implantation: a multicentre development, validation, and testing study https://www.thelancet.com/journals/landig/article/PIIS2589-7500(26)00072-5/fulltext?dgcid=hubspot_email_conferencealerts_esc26&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_94EOnoD86hYv3UpNC80uHfP2Lr_LjEra5cWZP6s8iENMc8aWcbNSgDKrE6x3NbB7EvNBa6_cdO74c7w2wGFUx368WRg&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Open Access Contributions of diet and lifestyle to sex differences in ischaemic heart disease burden in Central Europe: an analysis of the Global Burden of Disease Study 2023 https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(26)00258-9/fulltext?dgcid=hubspot_email_conferencealerts_esc26&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-8NH95b3jQhZSwKf-D6fpgmuckkH5U0pIO_7aXu-bqjiTkDSkXIA9A0HFwIF3F9nHTQVsqZeATiXH6ItUULAfTdAVthZw&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Open Access SERIES Cardiovascular disease in pregnancy: physiology, global burden, risk stratification, and opportunities in care https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01234-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-84015CiFfyB68ezI5uJ6ml3EWLIQ7MZwFcDXRKSGU-0BJXm5Q53de3m4DdnbaAhEn91Wl7gWAOk-ndI2jILiQVHBWKHg&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration Adverse pregnancy outcomes and long-term cardiovascular disease risk https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01235-3/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-8fgfBf_yAtWIFI5TMPABKW9CT17mkQqmQKBJihV0j8gIBfZLSTTwSp0marJJYU5JjhNGXacP61vIaOzX70L3drAeRk3A&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration Hypertensive disorders of pregnancy: risk stratification and management https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(26)00190-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esc26&_hsenc=p2ANqtz-8USnv_aXLOzwLCkWJacFU1mmxq3qWENnjJ0o0vsx1ojYx3WhI6jayIpe6p3WAYemprVwbzo2EsQfEdqfOzuzTyx-3q7A&_hsmi=437695803&utm_content=437464180&utm_source=hs_email Free with registration

Chronic Eosinophilic Pneumonia in Man With Persistent Cough Wolfgang Paik

https://www.medscape.com/viewarticle/chronic-eosinophilic-pneumonia-man-persistent-cough-2026a1000x2z Chronic eosinophilic pneumonia (CEP) is an uncommon idiopathic respiratory disorder that can mimic common pulmonary conditions, particularly infectious pneumonia. Diagnosis should be considered when respiratory symptoms and pulmonary opacities do not follow the expected course of infection. Careful assessment of clinical history and serial imaging can help identify patterns that warrant further investigation.

BRCA Mutation Carriers Likely to Have Risk-Reducing Surgery Edited by Katie Lennon September 07, 2026

https://www.medscape.com/viewarticle/brca-mutation-carriers-likely-have-risk-reducing-surgery-2026a1000x44?src= Women with pathogenic variants (PVs) in BRCA1/2 genes were more than seven times as likely to undergo risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) as were those carrying genetic variants for which there is “insufficient evidence” for discussion, consideration, or recommendation related to use of either procedure for such patients. Pancreatic screening via endoscopic ultrasound (EUS) or magnetic resonance cholangiopancreatography (MRCP) was used by fewer than 11% of eligible women, regardless of gene type, within 12 months after genetic testing.

NICE Expands Drug Access for Young Children With NF1 Tumours Edited by Zeel Mehta

https://www.medscape.com/viewarticle/nice-expands-drug-access-young-children-nf1-tumours-2026a1000x4h?src= The National Institute for Health and Care Excellence (NICE) has recommended mirdametinib (Ezmekly, Merck Serono) as an option for children and young people aged 2-17 years with symptomatic, inoperable plexiform neurofibromas associated with neurofibromatosis type 1 (NF1). Around 200 patients are expected to benefit.

Bilateral Mastectomy Rises in Young BRCA1/2 Carriers Edited by Victoria Stern September 07, 2026

https://www.medscape.com/viewarticle/bilateral-mastectomy-rises-young-brca1-2-carriers-2026a1000wsl?src= Among young women carrying germline BRCA1/2 pathogenic or likely pathogenic variants diagnosed with early-onset breast cancer, bilateral mastectomy rates increased substantially over two decades, rising from 8% in 2000 to 44.4% in 2020, a recent international study found. Women who underwent genetic testing before or at the time of diagnosis were significantly more likely to undergo bilateral mastectomy compared with those tested after diagnosis.