Proton Transfer Mechanisms in the MmpL3 Transporter of Mycobacterium tuberculosis Studied by Computer SimulationsClick to copy article link Yong-Sok Lee*Sergio A. HassanDarrell E. Hurt

https://pubs.acs.org/doi/10.1021/acsbiomedchemau.5c00274 NIAID Researchers Uncover How a Key Tuberculosis Protein Works, Opening New Paths to Combat Drug-Resistant TB Tuberculosis (TB) is the world's leading infectious disease killer, and drug-resistant strains are becoming more common. A new study from NIAID's Bioinformatics and Computational Biosciences Branch (BCBB) has uncovered how a critical TB protein works at the atomic level, laying the groundwork for new drug design strategies to address emerging resistance to current MmpL3 inhibitors. The paper, "Proton Transfer Mechanisms in the MmpL3 Transporter of Mycobacterium tuberculosis Studied by Computer Simulations," has been published in ACS Bio & Med Chem Au, selected as the Front Cover, and named an ACS Editors' Choice article for its potential for broad public interest. This research was conducted in connection with the TB Portals program. https://tbportals.niaid.nih.gov/