lunes, 16 de febrero de 2026
GLP-1 drugs in haematology: beyond weight loss The Lancet Haematology + +...
GLP-1 drugs in haematology: beyond weight loss
The Lancet Haematology
https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(26)00002-5/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhae&utm_campaign=update-lanhae&utm_medium=email&_hsenc=p2ANqtz--JBgPfmSamPIENTFgWS6pqIxvOW_SnhPv5bxv_TV-eYyU3NeY8ierOsQhFbPIxh7DNdx9FMwnjIyMbrlm4-6vM5wwPaQ&_hsmi=403816799&utm_content=403596743&utm_source=hs_email
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) began as therapies for type 2 diabetes but have become a breakthrough therapy for obesity, redefining its treatment and broader metabolic landscape. They have lit up medicine, popular culture, and global markets as new benefits and controversies unfold, with no field of medicine immune. By mimicking GLP-1 physiology, these drugs have come a long way, from the US Food and Drug Administration approval to treat type 2 diabetes in 2005 to approval to treat obesity in 2014, peaking with the 2021 subcutaneous weekly semaglutide regimen that delivered unprecedented weight loss. The excitement has only grown as trials reveal benefits in people with cardiovascular disease and sleep apnoea, and as emerging data hint at benefits in metabolic-dysfunction-associated liver disease, chronic kidney disease, peripheral artery disease, and osteoarthritis. In light of this growing evidence, it is reasonable to ask whether these agents could have an effect on haematological conditions.
Feb 2026
Volume 13Number 2e55-e118
https://www.thelancet.com/journals/lanhae/issue/vol13no2/PIIS2352-3026(26)X2001-4
RARE Revolution RARE Bite
https://editions.rarerevolutionmagazine.com/html5/reader/production/default.aspx?pubname=&edid=5fddfc62-9dc6-47bf-aa6a-922d41bce312&pnum=76
Nadine Lipworth shares an all-too-familiar tale. She illustrates in real colour the true cost of inaction and the often untold trauma families face when confronted by that lack of action and an absence of a diagnosis. This is Nadine and her husband, Dave’s, journey so far while saving Sasha.
Machine learning model demonstrates insulin resistance as a risk factor for 12 types of cancer
https://www.news-medical.net/news/20260216/Machine-learning-model-demonstrates-insulin-resistance-as-a-risk-factor-for-12-types-of-cancer.aspx
Insulin resistance - when the body doesn't properly respond to insulin, a hormone that helps control blood glucose levels - is one of the fundamental causes of diabetes. In addition to diabetes, it is widely known that insulin resistance can lead to cardiovascular, kidney and liver diseases. While insulin resistance is tightly associated with obesity, it has been difficult to evaluate insulin resistance itself in the clinic. For the first time, researchers including those from the University of Tokyo applied a machine learning-based prediction model of insulin resistance to half a million participants from the UK Biobank and demonstrated that insulin resistance is a risk factor for 12 types of cancer.
Optimization of CAR T cells to destroy solid tumors
https://www.news-medical.net/news/20260216/Optimization-of-CAR-T-cells-to-destroy-solid-tumors.aspx
A team led by LMU physician Sebastian Kobold has found a way to allow the body's immune system to destroy solid tumors.
Unlocking the potential of phytochemicals in rheumatoid arthritis treatment
https://www.news-medical.net/news/20260216/Unlocking-the-potential-of-phytochemicals-in-rheumatoid-arthritis-treatment.aspx
Announcing a new article publication for BIO Integration journal. In recent years, phytochemicals and medicinal plants have increasingly been used to treat autoimmune diseases, such as rheumatoid arthritis (RA). RA, a systemic inflammatory disease, is a chronic condition that affects primarily the joints, which are lined by synovial membranes, and leads to pain, diminished mobility, and joint deterioration.
Diet and the Reprogramming of Innate Immune Memory
https://www.news-medical.net/health/Diet-and-the-Reprogramming-of-Innate-Immune-Memory.aspx
Emerging research reveals how specific dietary components may reshape innate immune memory at the level of metabolism and chromatin, offering new insight into the biological interface between nutrition and immune resilience.
Eating more plant-based foods may lower breast cancer risk, major international study indicates
https://www.news-medical.net/news/20260215/Eating-more-plant-based-foods-may-lower-breast-cancer-risk-major-international-study-indicates.aspx
Large international cohort data suggest plant-forward eating patterns and certain micronutrients may be linked to lower breast cancer risk and improved survival, highlighting diet as a potentially modifiable factor worth further investigation.
Experimental stem cell therapy aims to repair brain circuits in Parkinson’s A Phase 1 trial at Keck Medicine of USC is testing whether implanted iPSC-derived neurons can restore dopamine signaling and improve motor function.
https://www.drugdiscoverynews.com/experimental-stem-cell-therapy-aims-to-repair-brain-circuits-in-parkinson-s-17009
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder worldwide, affecting an estimated one percent of individuals over the age of 60. In the US, more than one million people live with the disease, and roughly 90,000 new cases are diagnosed each year.
Expert-Driven, Patient-Focused: Mastering Personalized Care for HER2-Low Metastatic Breast Cancer Authors: Kevin Kalinsky, MD, MS, FASCO +++
https://www.medscape.org/viewarticle/1002880?sso=true&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260215-OUS-HONC-1002880-cta
Keyboard typing test could help diagnose Parkinson’s disease early
New software and hardware tools that collect data while a person types can detect fine motor impairment — a possible sign of neurodegeneration.
https://www.drugdiscoverynews.com/keyboard-typing-test-could-help-diagnose-parkinson-s-disease-early-16713?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9jRV2zkFBGFtv7ZuNtKvBMnqlRdAAhsAITRI_X8Yff65KpDf0dcuQ1BKQ5-lQAtlnGZW2srRGlVE7phxe4aeDKL39jTQ&_hsmi=403918635&utm_content=403918635&utm_source=hs_email
A new Parkinson’s disease treatment that adapts to the brain
The FDA approved Medtronic’s adaptive deep brain stimulation system, which delivers electrical stimulation in real time based on the brain’s state.
https://www.drugdiscoverynews.com/a-new-parkinson-s-disease-treatment-that-adapts-to-the-brain-16384?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9B9nWvgDzw34gRM8fwTPDFYg3So-fLxbbpLX6ULAGIg0J6tdoxERYuNXf11BaXtUdjkt0_w0WCdacBLORogALeSvd2aQ&_hsmi=403918635&utm_content=403918635&utm_source=hs_email
domingo, 15 de febrero de 2026
Functional Food
Functional Food
This hub provides a comprehensive overview and the latest news on functional foods, superfoods, and dietary components that contribute to health and disease prevention. The collection highlights bioactive compounds in foods such as lychee, chia seeds, dates, baobab fruit, and black sesame, alongside evidence-based discussions on fermented foods, postbiotics, and algae-based supplements. Readers will also find insights into the health benefits of traditional and modern diets, including the Atlantic and Washoku patterns, as well as functional beverages and plant-derived oils. By combining nutritional science, clinical research, and updates on emerging food innovations, this hub equips healthcare professionals, researchers, and health-conscious individuals with reliable knowledge to evaluate functional foods and their role in supporting long-term wellness.
https://www.news-medical.net/condition/Functional-Food
Cardiologists highlight overlooked heart risks across women’s lives +++
Daily coffee intake linked to fewer atrial fibrillation relapses
https://www.news-medical.net/news/20260130/Daily-coffee-intake-linked-to-fewer-atrial-fibrillation-relapses.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_8_february_2026
The study reveals that moderate coffee consumption may lower atrial fibrillation recurrence risk post-cardioversion, highlighting coffee's potential benefits.
New model predicts redo surgery risk in adult congenital heart disease
https://www.news-medical.net/news/20260131/New-model-predicts-redo-surgery-risk-in-adult-congenital-heart-disease.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_8_february_2026
Heart specialists at Mayo Clinic today presented new research at the 2026 Society of Thoracic Surgeons Annual Meeting that redo surgery for adults with congenital heart disease (CHD) remains high-risk, and a clinically applicable national risk assessment model is needed to help patients and care teams make decisions about procedures.
Cardiologists highlight overlooked heart risks across women’s lives
https://www.news-medical.net/news/20260203/Cardiologists-highlight-overlooked-heart-risks-across-womene28099s-lives.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_8_february_2026
Heart disease remains the leading cause of death for women in the United States, yet awareness of cardiovascular risk—particularly among younger women and women of color—has stalled, even as rates of high blood pressure, diabetes, obesity, and high cholesterol continue to rise.
Men develop premature heart disease earlier than women
https://www.news-medical.net/news/20260202/Men-develop-premature-heart-disease-earlier-than-women.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_8_february_2026
Researchers track heart disease from young adulthood to uncover when sex-based risk differences first emerge.
In a recent study published in the Journal of the American Heart Association, a group of researchers examined sex-based differences in the age of onset of premature cardiovascular disease (CVD) and its major subtypes across adulthood.
Why cardiologist evaluation matters after non-cardiac surgery
https://www.news-medical.net/news/20260203/Why-cardiologist-evaluation-matters-after-non-cardiac-surgery.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_8_february_2026
Many post-surgical heart injuries go unnoticed, but cardiologist input can change outcomes.
In a recent study published in the European Heart Journal, researchers analyzed data from more than 1,000 patients who developed perioperative myocardial injury to explain the potential mortality benefits of including a cardiologist in non-cardiac procedures, particularly for high-risk patients.
Engineered Listeria boosts innate immunity against cancer
https://www.news-medical.net/news/20260213/Engineered-Listeria-boosts-innate-immunity-against-cancer.aspx
After nearly 40 years of research on how Listeria bacteria manipulate our cells and battle our immune system to cause listeriosis, Daniel Portnoy and his colleagues have discovered a way to turn the bacteria into a potent booster of the immune system - and a potential weapon against cancer.
US drinking water kiosks sometimes contain elevated lead levels
https://www.news-medical.net/news/20260213/US-drinking-water-kiosks-sometimes-contain-elevated-lead-levels.aspx
After high-profile water crises like the one in Flint, Michigan, some Americans distrust the safety of tap water, choosing to purchase drinking water from freestanding water vending machines or kiosks. Yet this more expensive water may contain different pollutants than local tap water, according to a study in ACS' Environmental Science & Technology. Researchers report that water sampled from 20 kiosks in six states sometimes contained lead at levels above public health recommendations.
Vitamin A and thyroid hormones in the retina shape fetal vision
https://www.news-medical.net/news/20260213/Vitamin-A-and-thyroid-hormones-in-the-retina-shape-fetal-vision.aspx
Humans develop sharp vision during early fetal development thanks to an interplay between a vitamin A derivative and thyroid hormones in the retina, Johns Hopkins University scientists have found.
Ozempic users continue treatment when weight loss works despite side effects
https://www.news-medical.net/news/20260213/Ozempic-users-continue-treatment-when-weight-loss-works-despite-side-effects.aspx
An examination of user reviews finds that people continue off-label Ozempic when it delivers results, even if side effects persist.
A recent study in the Journal of Medical Internet Research examined patients’ experiences with off-label Ozempic use for weight loss and identified factors that influence user satisfaction and treatment discontinuation.
Stopping vertical transmission requires global resolve The Lancet Microbe ++... ++
Stopping vertical transmission requires global resolve
The Lancet Microbe
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00273-3/fulltext?dgcid=raven_jbs_etoc_email
Feb 2026
Volume 7Number 2
https://www.thelancet.com/journals/lanmic/issue/vol7no2/PIIS2666-5247(26)X2001-8
Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis
Marjorie J Gibbon, PhDa,∗ ∙ Natacha Couto, PhDa,b,∗ ∙ Keira Cozens, MSca ∙ Samia Habib, PhDa ∙ Lauren Cowley, PhDa ∙ Prof David M Aanensen, PhDb ∙ et al.
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00164-8/fulltext?dgcid=raven_jbs_etoc_feature_lanmic
Impact of a multicomponent training intervention (Clean FrontLine) on microbiological cleanliness in Cambodian referral hospitals: a multicentre, stepped-wedge, cluster-randomised trial
Giorgia Gon, PhDa giorgia.gon@lshtm.ac.uk ∙ Sokvy Ma, MScb ∙ Alexander M Aiken, PhDa ∙ Prof Stephanie J Dancer, PhDc ∙ Prof Wendy J Graham, PhDa ∙ Stephen Nash, MScd ∙ et al.
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00190-9/fulltext?dgcid=raven_jbs_etoc_feature_lanmic
Nonmetastatic nasopharyngeal carcinoma: in search of safer therapies The Lancet Regional Health – Americas +++ +...
E-cigarettes versus combination nicotine replacement therapy following a recent failed quit attempt: a pragmatic randomized trial through state tobacco quitlines
Theodore L. Wagenera katrina.vickerman@gmail.com ∙ Alice Hintona ∙ Theodore M. Braskya ∙ Yoo Jin Choa ∙ Laura A. Beebeb ∙ Michael S. Businelleb ∙ et al.
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(25)00362-X/fulltext?dgcid=raven_jbs_etoc_feature_lanam
Incidence rates of twelve chronic diseases/conditions in US adults: findings from a population-based study
Richard L. Nahina Nahinr@mail.nih.gov ∙ Termeh Feinbergb ∙ Hanna Grol-Prokopczykc ∙ Flavia P. Kaposd ∙ Kerri Murraye ∙ Remle Scottf ∙ et al.
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(25)00353-9/fulltext?dgcid=raven_jbs_etoc_feature_lanam
Nonmetastatic nasopharyngeal carcinoma: in search of safer therapies
The Lancet Regional Health – Americas
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(26)00050-5/fulltext?dgcid=raven_jbs_etoc_email
Feb 2026
Volume 54
https://www.thelancet.com/journals/lanam/issue/vol54nonull/PIIS2667-193X(25)X0013-2
Beyond Cure: Long-Term Risks After Childhood Cancer ++++ +++ International Childhood Cancer Day
Late Effects
Beyond Cure: Long-Term Risks After Childhood Cancer
Cured as Children, At Risk as Adults? Long-Term Outcomes After Childhood Cancer
Maurie Markman, MD
https://www.medscape.com/viewarticle/cured-children-risk-adults-long-term-outcomes-after-2026a10000dr?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
January 30, 2026
Certain Childhood Cancer Therapies Tied to Valvulopathy
Certain Childhood Cancer Therapies Tied to Valvulopathy
Edited by Gargi Mukherjee
https://www.medscape.com/viewarticle/certain-childhood-cancer-therapies-tied-valvulopathy-2025a1000rh6?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
October 13, 2025
1 in 3 Childhood Cancer Survivors Face Endocrine Issues
1 in 3 Childhood Cancer Survivors Face Endocrine Issues
Edited by Vinod Rane, BS Pharm
https://www.medscape.com/viewarticle/1-3-childhood-cancer-survivors-face-endocrine-issues-2026a10002bc?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
Medscape UK
January 27, 2026
Childhood Cancer Survivors Face Long-Term Meningioma Risk
Childhood Cancer Survivors Face Long-Term Meningioma Risk
Edited by Gargi Mukherjee
https://www.medscape.com/viewarticle/childhood-cancer-survivors-face-long-term-meningioma-risk-2025a1001026?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
December 22, 2025
Support & Prevention
Teen Exercise May Reshape Breast Cancer Risk
Teen Exercise May Reshape Breast Cancer Risk
Edited by Katie Lennon
https://www.medscape.com/viewarticle/teen-exercise-may-reshape-breast-cancer-risk-2026a10002ji?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
January 27, 2026
The Lingering Fear After Beating Childhood Cancer
The Lingering Fear After Beating Childhood Cancer
Maurie Markman, MD
https://www.medscape.com/viewarticle/lingering-fear-after-beating-childhood-cancer-2025a10006qo?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
April 01, 2025
Travel Help Announced for Families of Children With Cancer
Travel Help Announced for Families of Children With Cancer
Dr Sheena Meredith
https://www.medscape.com/viewarticle/travel-help-announced-families-children-cancer-2026a10003e1?ecd=mkm_ret_260215_mscpmrk-OUS_InFocus_etid8099638&uac=148436CN&impID=8099638
Medscape UK
February 03, 2026
sábado, 14 de febrero de 2026
Editorial e1 Management of diabetes during pregnancy The Lancet Obstetrics, Gynaecology, & Women's Health +++...
Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without AI in the MASAI study: a randomised, controlled, non-inferiority, single-blinded, population-based, screening-accuracy trial
Jessie Gommers, MSca,b ∙ Veronica Hernström, MDb,c ∙ Viktoria Josefsson, MDb,c ∙ Hanna Sartor, PhDb,d ∙ David Schmidt, MDb,d ∙ Annie Hjelmgren, MDd ∙ et al.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02464-X/abstract?utm_campaign=infocusalerts-obgyn&utm_medium=email&dgcid=hubspot_email_infocusalerts-obgyn_feature&_hsenc=p2ANqtz-_7M80FSuvslzvwWswPk3Na_r7ibyL7ZWu-Yyskp5PkSgptvk--XgD6AVn4ZqB_lVgX0b_yfgEwflgJOIOShdkZbORCyA&_hsmi=403618992&utm_content=403597469&utm_source=hs_email
Epidemiological and genetic evidence for shared mechanisms between migraine and pre-eclampsia: a nationwide cohort and genetic risk study in Denmark
Olafur B Davidsson, PhDa,b,c,d oda@cancer.dk ∙ Klaus Rostgaard, MSca,b ∙ Ragnar P Kristjánsson, PhDb,c,d,e ∙ Jojo Biel-Nielsen Dietz, MD PhDb ∙ Noomi Vainer, MDb ∙ Lisette J A Kogelman, PhDc,d ∙ et al.
https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(25)00114-1/abstract?utm_campaign=infocusalerts-obgyn&utm_medium=email&dgcid=hubspot_email_infocusalerts-obgyn_feature&_hsenc=p2ANqtz-9wnhB4dqgJZHH1LzfzNxDpAIEL_AFDcwlALnxma_7O-4sP49NMGtP6s5DSOh5NvtvVh_j8rOuLhX7hTpc-K5r9IPSgMQ&_hsmi=403618992&utm_content=403597469&utm_source=hs_email
Editorial
e1
Management of diabetes during pregnancy
The Lancet Obstetrics, Gynaecology, & Women's Health
https://www.thelancet.com/journals/lanogw/issue/vol2no1/PIIS3050-5038(25)X0006-6
From Cookies To Caregivers: 7 Types Of Grandparents By Ivanhoe Broadcast News on February 20, 2026
https://www.ivanhoe.com/?p=36685&preview=1&_ppp=2dbe0e6937
Orlando, Fla. (Ivanhoe Newswire) — By age 65, AARP reports 96 percent of Americans are grandparents. Grandparents play an important role in children’s lives. Studies show kids who have close relationships with grandparents have fewer emotional and behavioral problems and better social skills. Now, researchers have identified seven distinct grandparenting styles and chances are, you might recognize yourself in more than one of them.
Are You Scam Proof? Who Is Really At Risk? By Ivanhoe Broadcast News on February 19, 2026
https://www.ivanhoe.com/?p=36682&preview=1&_ppp=ca5851d049
Orlando, Fla. (Ivanhoe Newswire) — The New York Times reports Americans over 70 control $53 trillion in wealth and cybercrime against elders is skyrocketing! The Federal Trade Commission reports older adults lost 2.4 billion dollars to scams last year, a sharp increase from just a few years ago. Now, a new study is taking a closer look at what really makes someone vulnerable and why even people who think they’re scam-proof may not be.
Modern Love: Dating Trends Redefining Valentine’s Day By Ivanhoe Broadcast News on February 18, 2026
https://www.ivanhoe.com/?p=36679&preview=1&_ppp=b8b66a7765
Orlando, Fla. (Ivanhoe Newswire) — About 60 percent of people worldwide celebrate Valentine’s Day but for many, the holiday is no longer just about romantic love. From friendship-first celebrations to new dating rules and tech-driven matchmaking, the way people connect is evolving.
Love, Lies, And Money: Inside Today’s Romance Scams By Ivanhoe Broadcast News on February 17, 2026
https://www.ivanhoe.com/?p=36676&preview=1&_ppp=56641a44c9
Orlando, Fla. (Ivanhoe Newswire) — Worldwide, nearly one in four people say they’ve been scammed online. One of the fastest growing, and most devastating type is the romance scam, where fraudsters pretend to fall in love, then ask for money. It’s now the third most common scam targeting adults 60 and older.
Fuel Like A Champion By Ivanhoe Broadcast News on February 16, 2026
https://www.ivanhoe.com/?p=36673&preview=1&_ppp=23b3277d32
Orlando, Fla. (Ivanhoe Newswire) — While the world is watching the Winter Olympics, there’s a lot more going on behind the scenes than gold medals and record-breaking runs. Olympians are training and fueling their bodies for peak performance. But experts say you don’t have to be an elite athlete to apply some of those same principles to your own workouts.
Popular weight-loss drugs linked to rare 'pirate disease,' researchers warn By Angelica Stabile Fox News Published February 13, 2026 7:00am EST
Popular weight-loss drugs linked to rare 'pirate disease,' researchers warn
GLP-1 medications may contribute to malnutrition as clinical trials fail to monitor food intake
Angelica Stabile By Angelica Stabile Fox News
Published February 13, 2026 7:00am EST
https://www.foxnews.com/health/popular-weight-loss-drugs-linked-rare-pirate-disease-scurvy-researchers-warn?lid=zoopmps49qu6
James Van Der Beek’s death highlights alarming colon cancer rise in younger adults By Angelica Stabile , Melissa Rudy Fox News Published February 12, 2026 2:41pm EST
James Van Der Beek’s death highlights alarming colon cancer rise in younger adults
Doctors reveal why colon cancer is now the top deadliest cancer among those 50 and under
Angelica Stabile By Angelica Stabile , Melissa Rudy Fox News
Published February 12, 2026 2:41pm EST
https://www.foxnews.com/health/james-van-der-beeks-death-highlights-alarming-colon-cancer-rise-younger-adults?lid=hz6ixf6p5dwy
Revisiting concepts of mitochondrial transport and energy metabolism in health and cancer Salvatore Passarella* [1]
https://www.academia.edu/2837-4010/3/4/10.20935/AcadBiol8065
Although our understanding of mitochondrial processes has expanded substantially, the contributions of metabolite transport and energy metabolism to mitochondrial function in health and disease remain incompletely characterized. The transport and metabolism of key metabolites, including oxaloacetate, L-lactate and D-lactate, are mediated by distinct transporters and mitochondrial enzymes that together influence cellular bioenergetics in normal and neoplastic tissues. This review reassesses mechanistic aspects of mitochondrial shuttles, gluconeogenesis and the Cori cycle, the mitochondrial transport and oxidation of L-lactate, the Warburg effect, and the methylglyoxal pathway. Emphasis is placed on evidence supporting mitochondrial uptake and metabolism of oxaloacetate and lactate isomers and on the implications of these processes for redox balance, anaplerosis, and biosynthesis in cancer. I propose that a fuller integration of metabolite transport phenomena into models of cellular metabolism is necessary to refine current concepts of mitochondrial physiology and pathophysiology.
The need for echocardiographic reference values in adults over 80 years of age
Miguel Quintana, Mira Carling, Anders Olofsson, Dag Isaksson, Jenny Fahlen, Elin Kärrman, Fredrik Pihl, Roland Forsberg, Björn Persson, Alen Lovric, Thomas Gustafsson, Karin Bouma
Volume 4, Issue 1
https://www.academia.edu/journals/academia-biology/articles?source=journal-top-nav
Hormone Replacement Therapies Can Help Women with Bothersome Menopausal Symptoms
https://www.fda.gov/consumers/consumer-updates/hormone-replacement-therapies-can-help-women-bothersome-menopausal-symptoms?utm_medium=email&utm_source=govdelivery
The effects of menopause can make a woman’s daily life much harder, and therapies approved by the U.S. Food and Drug Administration can help. But too many women might not use these treatments to lessen their menopause symptoms because of the risks associated with these drugs described in the drug labels’ boxed warnings (the FDA’s most prominent warnings).
viernes, 13 de febrero de 2026
FDA Approves Labeling Changes to Menopausal Hormone Therapy Products
https://www.fda.gov/news-events/press-announcements/fda-approves-labeling-changes-menopausal-hormone-therapy-products?utm_medium=email&utm_source=govdelivery
The U.S. Food and Drug Administration has approved drug labeling changes to six menopausal hormone therapy products, also known as hormone replacement therapy (HRT), to clarify risk considerations for these drugs. Specifically, risk statements related to cardiovascular disease, breast cancer and probable dementia were removed from the “boxed warning,” the agency’s most prominent safety-related warning.
“This decision reflects our commitment to follow the science wherever it leads and to correct course when the evidence demands it,” Health and Human Services Secretary Robert F. Kennedy, Jr. said. “By removing these boxed warnings, we ensure that women receive accurate information about hormone therapy—free from exaggeration or fear. A healthcare system worthy of public trust tells the truth, updates its guidance as science evolves, and respects women’s ability to make informed choices about their own health.”
The FDA initiated the removal of these warnings in November 2025, following a comprehensive review of the scientific literature. At the FDA’s request, 29 drug companies have submitted proposed labeling changes. This first batch of six products with approved labeling changes includes products from each of the four categories of HRT for menopausal women:
Systemic combination therapy (estrogen and progestogen)
Systemic estrogen-alone therapy
Systemic progestogen-alone therapy for women with a uterus using systemic estrogen
Topical vaginal estrogen therapy
“With today’s action, we are delivering on our promise to make sure women have accurate, scientifically grounded information about the potentially life-changing benefits of HRT,” said FDA Commissioner Marty Makary, M.D., M.P.H. “Women face symptoms of menopause that can last for years, and our efforts will help these women make well-informed medical decisions.”
Menopause is a normal life stage, but its symptoms can significantly reduce quality of life. Common symptoms include hot flashes and night sweats (called vasomotor symptoms or VMS); vaginal, vulvar, and urinary tract changes caused by lower estrogen levels; and osteoporosis (thinning bones), which increases fracture risk.
The FDA has approved multiple hormone therapies for moderate-to-severe hot flashes, vaginal dryness and discomfort, and preventing bone loss. In addition, randomized studies show that women who initiate HRT within 10 years of the onset of menopause (generally before age 60) have a reduction in all-cause mortality and fractures. Just a small fraction of women who could benefit from these treatments, however, are using them. In 2020, about 41 million U.S. women were ages 45–64 — yet only about 2 million women ages 46–65 received a hormone-therapy prescription.
Today’s action will allow women, working with their health care professionals, to make better-informed decisions about their treatment plan for menopause symptoms. Women are encouraged to consult the drug label, available here, for more detailed information about the benefits and risks of these products.
Menopausal Hormone Therapies with Updated Prescribing Information
https://www.fda.gov/drugs/drug-safety-and-availability/menopausal-hormone-therapies-updated-prescribing-information?utm_medium=email&utm_source=govdelivery
Statin safety: when warnings outlive the evidence The Lancet ++... ´+
Statin safety: when warnings outlive the evidence
The Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00303-X/fulltext?dgcid=raven_jbs_etoc_email
Feb 14, 2026
Volume 407Number 10529p649-732
https://www.thelancet.com/journals/lancet/issue/vol407no10529/PIIS0140-6736(26)X2004-9
Tetanus
Prof Önder Ergönül, MD MPHa,b oergonul@ku.edu.tr ∙ Selin Kolsuz, MDa ∙ Prof J Peter Figueroa, MBBS PhD
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01579-X/abstract?dgcid=raven_jbs_etoc_feature_lancet
Thawing a Frozen Shoulder Arif Musa, MD; Ali Harb, MD | February 4, 2026 |
https://reference.medscape.com/slideshow/Frozen-Shoulder-6019131?ecd=wnl_critimg_260213_mscpref_etid8099014&uac=148436CN&impID=8099014
Frozen shoulder is a condition marked by progressive stiffness and pain that eventually resolves through a "thawing" phase. While traditional treatments range from physical therapy to surgery, new techniques like Adhesive Capsulitis Embolization (ACE) offer additional relief. This presentation reviews current treatment efficacy and new clinical developments.
Alcohol guidance in US dietary guidelines: a step backwards The Lancet Gastroenterology & Hepatology ++... ++
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(26)00016-6/fulltext?dgcid=raven_jbs_etoc_email
Mar 2026
Volume 11Number 3p175-266, e2-e5
https://www.thelancet.com/journals/langas/issue/vol11no3/PIIS2468-1253(26)X2001-5
Definitions, diagnosis, management, and outcomes of upper gastrointestinal Crohn's disease: an international, expert RAND/UCLA appropriateness study
Nathaniel A Cohen, MDa nathanielac@tlvmc.gov.il ∙ Prof Dominik Bettenworth, MDb,c ∙ Neta Sror, MDd ∙ Raneem Khedraki, PhDe ∙ Qijun Yang, MSe ∙ Prof Maria T Abreu, MDf ∙ et al.
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00347-4/abstract?dgcid=raven_jbs_etoc_feature_langas
Appendicectomy versus switching to a JAK inhibitor in inducing remission in patients with active ulcerative colitis after biologic therapy failure (COSTA): 1-year results of a multicentre, prospective, cohort study
Eva Visser, MD PhDa ∙ Maud A Reijntjes, MD PhDa ∙ Lianne Heuthorst, MD PhDa ∙ Merle E Stellingwerf, MD PhDa ∙ Rachel West, MD PhDb ∙ Koen van Dongen, MD PhDc ∙ et al.
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00291-2/abstract?dgcid=raven_jbs_etoc_feature_langas
Editorial e75 GLP-1 receptor agonists in rheumatic disease The Lancet Rheumatology ++... +
Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial
Prof David J Beard, DPhila,d david.beard@ndorms.ox.ac.uk ∙ Loretta J Davies, DPhila ∙ Prof Jonathan A Cook, PhDa ∙ Prof Graeme MacLennan, MScc ∙ Jemma Hudson, PhDc ∙ Prof Andrew J Price, FRCSa ∙ et al.
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00250-4/fulltext?dgcid=hubspot_update_feature_updatealerts_lanrhe&utm_campaign=update-lanrhe&utm_medium=email&_hsenc=p2ANqtz-8EvPIK-fX0yJMuYr9c9Nwpm9DIZRxFz0gOGNEBqrxbEH7fNoROnm7ue3Totl3pYHkiyW_KNOoBIDS2jgAY5gRQeicV4w&_hsmi=403170350&utm_content=402699227&utm_source=hs_email
Editorial
e75
GLP-1 receptor agonists in rheumatic disease
The Lancet Rheumatology
https://www.thelancet.com/journals/lanrhe/issue/vol8no2/PIIS2665-9913(26)X2001-X
Trends in mortality due to haemophagocytic lymphohistiocytosis across 29 European countries from 2011 to 2021: a retrospective, international, population-based study
Leher Gumber, MSca,b ∙ Reza Omidvar, MScc ∙ Francesca Gonnelli, PhDd,e ∙ Adam Taylor, MEngc ∙ Thomas Trimble, BScc ∙ Mark Bishton, PhDe,f ∙ et al.
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00292-9/fulltext?dgcid=hubspot_update_feature_updatealerts_lanrhe&utm_campaign=update-lanrhe&utm_medium=email&_hsenc=p2ANqtz-9aoZkd0o9FGb_nWrlnoJRWFpic0JTPGPQ8_H80f5KTTSL4xH3EWoRoQCgcTqDH1rl4l3LjAYNXar7gys7ODjs8TLebRw&_hsmi=403170350&utm_content=402699227&utm_source=hs_email
Gene therapy startups push past old limits to reach more patients With gene therapy now a clinical reality, innovators are designing delivery systems that can sustain lifelong correction, handle complex genes, and make treatments accessible to more patients. +++++
https://www.drugdiscoverynews.com/gene-therapy-startups-push-past-old-limits-to-reach-more-patients-17003
In 2026, drug discovery faces a higher bar
Biopharma’s recovery is real, but the data show a sector that now rewards validated biology, late-stage execution, and commercial relevance.
https://www.drugdiscoverynews.com/in-2026-drug-discovery-faces-a-higher-bar-16997
A faster route to active GPCRs
GPCRs drive a huge portion of today’s drug market, but producing them in a functional form remains a major bottleneck for discovery and structural studies.
https://www.drugdiscoverynews.com/a-faster-route-to-active-gpcrs-16977
Exploring the tiny robots improving drug delivery from inside the body
Moved by magnets or ultrasound waves, these tiny robots make delivering drugs more accurate and effective.
https://www.drugdiscoverynews.com/exploring-the-tiny-robots-improving-drug-delivery-from-inside-the-body-16998
Sustained-release drug delivery targets pediatric inherited retinal disease
PolyActiva and RareSight are pairing pro-drug chemistry with targeted ocular delivery to address early-stage barriers in rare pediatric retinal disorders.
https://www.drugdiscoverynews.com/sustained-release-drug-delivery-targets-pediatric-inherited-retinal-disease-16945
The Heart Truth® Heart disease is the leading cause of death in the United States. But you can do a lot to protect your heart.
The Heart Truth®
Heart disease is the leading cause of death in the United States. But you can do a lot to protect your heart.
https://www.nhlbi.nih.gov/health-topics/education-and-awareness/heart-truth
People with dementia prescribed risky drugs
https://www.nih.gov/news-events/nih-research-matters/people-dementia-prescribed-risky-drugs
At a Glance
Researchers found that many older adults with dementia were prescribed medications that can increase the risk of confusion, falls, and hospitalization.
Reducing such unnecessary prescriptions could improve the quality of care for older adults.
NIH Research Matters
February 10, 2026 Edition
https://www.nih.gov/news-events/nih-research-matters
Cancer Causes and Prevention
https://www.cancer.gov/about-cancer/causes-prevention
Cancer prevention is action taken to lower the risk of getting cancer. This can include maintaining a healthy lifestyle, avoiding exposure to known cancer-causing substances, and taking medicines or vaccines that can prevent cancer from developing.
Atopic Dermatitis (EnglishEspañol繁體中文한국어tiếng Việt)
https://www.niams.nih.gov/health-topics/atopic-dermatitis
Atopic dermatitis, often referred to as eczema, is a chronic (long-lasting) disease that causes inflammation, redness, and irritation of the skin. It is a common condition that usually begins in childhood; however, anyone can get the disease at any age. Atopic dermatitis is not contagious, so it cannot be spread from person to person.
Recommended CME For You: +++ +++ +++ +
The Rise of Protein Degraders for Hematologic Malignancies: Exploring the Latest Data From ASH 2024 CME
The Rise of Protein Degraders for Hematologic Malignancies: Exploring the Latest Data From ASH 2024
Authors:
Sagar Lonial, MD, FACP; Constatine Tam, MBBS, MD, FRACP, FRCPath; Julio Chavez, MD, MS
https://www.medscape.org/viewarticle/1002295?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Sharing Expert Minds in Lung Cancer and Lung Neuroendocrine Tumors Delivering Optimal Patient Care CME
Sharing Expert Minds in Lung Cancer and Lung Neuroendocrine Tumors Delivering Optimal Patient Care
Authors:
Martin Reck, MD, PhD; Catherine Bouvier; Melanie Lucas; Abdul Masoor, MBChB, PhD, MRCP; Marianne Pavel, MD
https://www.medscape.org/viewarticle/1002284?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
AL Amyloidosis in Focus: Ongoing Innovations and Applicability to Practice CME
AL Amyloidosis in Focus: Ongoing Innovations and Applicability to Practice
Authors: Kevin M. Alexander, MD; Vaishali Sanchorawala, MD; Pedro Vianna, MD; Shahzad Raza, MD, FACP
https://www.medscape.org/viewarticle/al-amyloidosis-focus-ongoing-innovations-and-applicability-2025a100078z?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Myelofibrosis-Associated Anemia: Burden, Management, and Future Directions CME
Myelofibrosis-Associated Anemia: Burden, Management, and Future Directions
Authors:
Francesca Palandri, MD; Jean-Jacques Kiladjian, MD, PhD; Jon Mathias
https://www.medscape.org/viewarticle/1002370?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Shaping the Future of Muscle-Invasive Bladder Cancer Care: Immunotherapy in Focus CME
Shaping the Future of Muscle-Invasive Bladder Cancer Care: Immunotherapy in Focus
Authors:
Andrea Necchi, MD; James W. F. Catto, MB, ChB, PhD, FRCS; Enrique Grande, MD, PhD
https://www.medscape.org/viewarticle/1002445?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Virtual Simulations: Managing the Patient With HR+/HER2- Early Breast Cancer Through a Multidisciplinary Approach CME
Virtual Simulations: Managing the Patient With HR+/HER2- Early Breast Cancer Through a Multidisciplinary Approach
Authors:
Manali Bhave, MD; Jane Meisel, MD
https://www.medscape.org/viewarticle/1002474?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Bridging Gaps in Myelofibrosis Care: Collaborative Strategies for Anemia Management CME
Bridging Gaps in Myelofibrosis Care: Collaborative Strategies for Anemia Management
Authors:
Claire N. Harrison, DM, FRCP, FRCPath; Haifa Kathrin Al-Ali, MD; Claire Woodley
https://www.medscape.org/viewarticle/1002428?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Think You Know IDH-Mutant Glioma? Test Your Clinical Expertise on the Latest Advances CME
Think You Know IDH-Mutant Glioma? Test Your Clinical Expertise on the Latest Advances
Authors: Patrick Y. Wen, MD
https://www.medscape.org/viewarticle/think-you-know-idh-mutant-glioma-test-your-clinical-2025a1000bve?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
New Standards in Diffuse Lower-Grade Gliomas: Integrative Management From Surgery to Survivorship CME
Highlights from the Annual Neurosurgical Conference: New Standards in Diffuse Lower-Grade Glioma
Authors:
Mitchel S. Berger, MD; Macarena de la Fuente, MD; Michael Lim, MD
https://www.medscape.org/viewarticle/1002598?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
H3 K27M-Mutant Glioma: A 360° View of Science, Physician Insights, and Patient Perspectives CME
H3 K27M-Mutant Glioma: A 360° View of Science, Physician Insights, and Patient Perspectives
Authors: Stephen J. Bagley, MD, MSCE; Charles Eberhart, MD, PhD; Carl Koschmann, MD; Ashley L. Sumrall, MD, FACP, FASCO; Michelle Sherman
https://www.medscape.org/viewarticle/h3-k27m-mutant-glioma-360-view-science-physician-insights-2025a1000gki?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Nearly 38% of Cancers Potentially Avoidable, Global Study Finds Frederik Joelving February 12, 2026 ++++
Nearly 38% of Cancers Potentially Avoidable, Global Study Finds
Frederik Joelving
https://www.medscape.com/viewarticle/nearly-38-cancers-potentially-avoidable-global-study-finds-2026a10004k6
February 12, 2026
How to Outsmart Ovarian Cancer With One Surgery
Megan Brooks
https://www.medscape.com/viewarticle/how-outsmart-ovarian-cancer-one-surgery-2026a10004hn
February 12, 2026
Robot-Assisted CT-Guided Cryoablation Shows High Precision in Treating Pulmonary Metastases
Edited by Vineeta Teotia
https://www.medscape.com/viewarticle/robot-assisted-ct-guided-cryoablation-shows-high-precision-2026a10004bm
Medscape UK
February 13, 2026
Study: Cutaneous T-Cell Lymphoma Increasing Among US Children, Young Adults
Edited by Deepa Varma
https://www.medscape.com/viewarticle/study-cutaneous-t-cell-lymphoma-increasing-among-us-children-2026a10004ly
February 13, 2026
New Fat Math: What to Tell Patients About Dairy | GLP-1 Drugs: New Questions on Mental Health & Sarcopenia +++++ +++
The New Fat Math: What to Tell Patients About Dairy
The New Fat Math: What to Tell Patients About Dairy
Lisa O’Mary
https://www.medscape.com/viewarticle/new-fat-math-what-tell-patients-about-dairy-2026a10003hk?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 04, 2026
GLP-1 Drugs: New Questions on Mental Health & Sarcopenia
GLP-1 Drugs: New Questions on Mental Health and Sarcopenia
Jean-Bernard Gervais
https://www.medscape.com/viewarticle/glp-1-drugs-new-questions-mental-health-and-sarcopenia-2026a10003ib?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
Medscape Europe
February 04, 2026
Do Certain Diabetes Medications Increase Depression Risk?
Do Certain Diabetes Medications Increase Depression Risk?
Edited by Devyani Gholap
https://www.medscape.com/viewarticle/do-certain-diabetes-medications-increase-depression-risk-2026a10003ay?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 03, 2026
Is Assisted Death Always Peaceful? We Simply Don’t Know
Is Assisted Death Always Peaceful? Lack of Data Means We Simply Don’t Know
Manuela Callari
https://www.medscape.com/viewarticle/assisted-death-always-peaceful-lack-data-means-we-simply-2026a10003d7?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
Medscape Europe
Published February 03, 2026
Updated February 09, 2026
Weight Loss in Older Adults: Can More Protein Protect Bones?
Weight Loss in Older Adults: Can More Protein Protect Bones?
Edited by Archita Rai
https://www.medscape.com/viewarticle/weight-loss-older-adults-can-more-protein-protect-bones-2026a10003ne?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 05, 2026
COMMENTARY
High Ultra-Processed Food Intake Linked to Lung Cancer Risk
High Ultra-Processed Food Intake Linked to Lung Cancer Risk
Maurie Markman, MD
https://www.medscape.com/viewarticle/high-ultra-processed-food-intake-linked-lung-cancer-risk-2026a10000tn?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 05, 2026
Does Caffeinated Coffee Trigger Atrial Fibrillation?
Does Caffeinated Coffee Trigger Atrial Fibrillation?
Ahmed El Shaer, MBBS; Douglas S. Paauw, MD
https://www.medscape.com/viewarticle/does-caffeinated-coffee-trigger-atrial-fibrillation-2026a100022c?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 04, 2026
GERD vs NERD: Update Your Approach to Reflux Disease
GERD vs NERD: Update Your Approach to Reflux Disease
Matthew F. Watto, MD; Paul N. Williams, MD
https://www.medscape.com/viewarticle/gerd-vs-nerd-update-your-approach-reflux-disease-2026a100033l?ecd=mkm_ret_260213_mscpmrk-OUS_ICYMI_etid8093905&uac=148436CN&impID=8093905
February 05, 2026
jueves, 12 de febrero de 2026
Merck is urged by patient groups to ensure widespread access to an HIV prevention pill being tested A late-stage study is not expected to be over until next year, but advocates want a commitment now
https://www.statnews.com/pharmalot/2026/02/11/merck-aids-hiv-access-gilead-pricing/
By Ed SilvermanFeb. 11, 2026
Pharmalot Columnist, Senior Writer
Drug injection fades as smoking grows more common, marking sea change in U.S. fentanyl epidemic Harm reduction experts applaud shift as safer, even as some officials reject pipe use
https://www.statnews.com/2026/02/12/fentanyl-harm-reduction-smoking-not-injecting/
By Lev FacherFeb. 12, 2026
Addiction Reporter
Maui Derm Hawaii 2026 - Maui Derm Hawaii 2026 January 25 - 29 | Maui, Hawaii - 90% Satisfied with Combo Therapy in Psoriatic Disease ++++
https://www.medscape.com/c25/p14/maui-derm-hawaii-2026-2026a100012f?ecd=WNL_conf_derm_maui-derm-spon_260212_MSCPEDIT_etid8096210&uac=148436CN&impID=8096210
Biologic Plus GLP-1 Agonist Improves Quality of Life in Psoriatic Disease
Ted Bosworth
https://www.medscape.com/viewarticle/biologic-plus-glp-1-agonist-improves-quality-life-psoriatic-2026a10002s0?ecd=WNL_conf_derm_maui-derm-spon_260212_MSCPEDIT_etid8096210&uac=148436CN&impID=8096210
January 28, 2026
Targeted Therapies Create Urgency for Early Diagnosis of Pemphigus and Pemphigoid
Ted Bosworth
https://www.medscape.com/viewarticle/targeted-therapies-create-urgency-early-diagnosis-pemphigus-2026a100037a?ecd=WNL_conf_derm_maui-derm-spon_260212_MSCPEDIT_etid8096210&uac=148436CN&impID=8096210
February 02, 2026
Expert Algorithm Offered to Optimize Treatment Success in Lichen Planopilaris
Ted Bosworth
https://www.medscape.com/viewarticle/expert-algorithm-offered-optimize-treatment-success-lichen-2026a10002z1?ecd=WNL_conf_derm_maui-derm-spon_260212_MSCPEDIT_etid8096210&uac=148436CN&impID=8096210
January 30, 2026
Phase 3 Trials Promise Better Options to Shut Down Connective Tissue Diseases
Ted Bosworth
https://www.medscape.com/viewarticle/phase-3-trials-promise-better-options-shut-down-connective-2026a10002mg?ecd=WNL_conf_derm_maui-derm-spon_260212_MSCPEDIT_etid8096210&uac=148436CN&impID=8096210
January 27, 2026
Rare Disease Week: Genotypes and phenotypes in cholestasis
https://events.teams.microsoft.com/event/702ecd4d-b678-49b3-9fa1-da22861ca71d@37c354b2-85b0-47f5-b222-07b48d774ee3
Rare Disease Day Educational Sessions
The NHS South East Genomic Medicine Service will be hosting four sessions to help colleagues learn and explore a range of rare genetic conditions. In the first session, Professor Richard Thompson (King's College London) will share his perspectives on the power of genomic medicine. The next few sessions will each explore patient and parent experiences of a rare disease diagnosis - sign up to hear Charlotte's, Maisie's and Diana's stories, from uncertainty of diagnosis during pregnancy, to the impacts of gene therapy. Join the sessions daily from 23 February at 12pm (UTC time).
No One Rides Alone - World Premiere - Gent, Belgium Share Sat, 28 Feb, 7pm - 10pm CEST
https://events.humanitix.com/no-one-rides-alone-premiere
Watch "No One Rides Alone" at its Global Premiere
Can someone with Multifocal Motor Neuropathy (MMN) ride the route of the Tour de France? That's what Clive Phillips and a team of fellow veterans set out to discover during the Tour de MMN 2025. "No One Rides Alone" follows the team as they ride along the 1955 Tour de France route, in the wheel tracks of the first British Tour de France team. It follows them as they push their limits, connect with others in the rare disease community, learn more about MMN and come face to face with the impacts of it and conditions like it. Join members of the team and double Paralympic champion Ben Watson on 28 February for the global premiere of the film, taking place in Gent, Belgium, and featuring a Q&A session after the screening. The film will also touring UK cinemas in March.
No One Rides Alone
https://makingthemostofnow.co.nz/no-one-rides-alone/
International advocacy for rare diseases
https://openacademy.eurordis.org/courses/international-advocacy-for-rare-diseases/
Learn with the Open Academy
The EURORDIS Open Academy accompanies patient advocates by offering rare disease-specific comprehensive training programmes that empower advocates with the knowledge, skills and confidence they need to engage with different stakeholders as equal partners. Our Schools, supported by ERDERA, offer a blended learning approach that includes e-learning courses, webinars, in-person training, as well as research visits and networking opportunities.
Increase your knowledge and skills in the rare disease space
https://openacademy.eurordis.org/
The Remarkable Life of Ibelin to Receive EURORDIS Black Pearl Media and Awareness Raising Award 22 January 2026 +++
https://rarerevolutionmagazine.com/the-remarkable-life-of-ibelin-to-receive-eurordis-black-pearl-media-and-awareness-raising-award/
RARE Revolution Magazine recently covered our announcement that the 2026 EURORDIS Media & Awareness Raising Award will be presented to the Norwegian documentary The Remarkable Life of Ibelin at the EURORDIS Black Pearl Awards on 24 February. The film tells the story of Mats Steen, a young man living with Duchenne muscular dystrophy who found friendship, purpose and community through his World of Warcraft avatar. Our Acting CEO, Virginie Hivert, is quoted in the article reflecting on the documentary’s impact.
EURORDIS Black Pearl Awards
https://www.eurordis.org/black-pearl-awards/
The Remarkable Life of Ibelin | Official Trailer | Netflix
https://www.youtube.com/watch?v=lM_hkJ0Rl-c
Podcast: Rare on Air
https://www.eurordis.org/rare-on-air/
Rare Disease Day bonus series
Get ready for Rare Disease Day by tuning into our Rare on Air Stories bonus series, in which we read the stories of people impacted by rare diseases from across the globe. In the latest episode, we hear the story of Léon, who lives with LAMA2-related congenital muscular dystrophy. His mother Hong-Ahh shares her early search for answers and the ongoing efforts to support Léon through physiotherapy and respiratory care. You can also hear Jessa's story, which offers a look into how she has achieved remarkable milestones despite the challenges of chronic illness.
28 February
is Rare Disease Day
Raising awareness and generating change for the 300 million people worldwide living with a rare disease, their families and carers.
https://www.rarediseaseday.org/
“Rare Diseases in a Changing & Competitive Europe: Shaping policies to address the unmet needs of people living with rare diseases”.
https://www.rare-diseases.eu/
ECRD 2026 posters
Our European Conference on Rare Diseases and Orphan Products 2026 is inviting poster abstract submissions. Researchers, clinicians, advocates and experts are encouraged to share work on therapies development and access, diagnosis and prevention, highly specialised care, mental wellbeing, health technology assessment, the social sciences and humanities, and open-topic proposals. Submit your poster abstract by 6 March.
Fostering European political unity for cancer and rare diseases ++
https://www.intergrouponcancerandrarediseases.eu/
EU Budget
Last week, members of the European Parliament's Intergroup on Cancer and Rare Diseases came together to reaffirm the need for a stronger and more explicit commitment to cancer and rare diseases in the 2028-34 Multiannual Financial Framework (MFF). Rosa Castro highlighted that "we, as a health community should come together to advocate for all decision makers to ensure that health remains as a key priority in the next EU budget cycle". Read our full
The EU’s 2028-34 budget: Improving the multiannual financial framework for people living with a rare disease
November 2025
In July 2025, the European Commission presented its proposal for the EU Multiannual Financial Framework (MFF) 2028–2034, setting out a budget of nearly €2 trillion to guide the Union’s spending priorities over the next seven years.
https://www.eurordis.org/improving-multiannual-financial-framework/
Meet our 2026 Regional Representatives! Raising Youth Voices +++
https://www.rarediseaseday.org/raising-youth-voices/
Raising Youth Voices
Last week’s Raising Youth Voices event, held in Barcelona as part of the Rare Disease Day 2026 campaign, brought together young rare disease advocates from every continent. They shared their personal experiences and highlighted the initiatives they are leading to drive change for people living with rare diseases. You can watch the full panel discussion online. A short film from the day, produced by Fondation Ipsen, will be released soon – stay tuned!
Raising Youth Voices 2026
https://www.youtube.com/live/G9HKPZLKkKk
We shed light on rare diseases to accelerate diagnosis
https://www.fondation-ipsen.org/
THE GLOBAL ALLIANCE OF PERSONS LIVING WITH A RARE DISEASE +++
https://www.rarediseasesinternational.org/
European Blueprint
EURORDIS and Rare Diseases International (RDI) are inviting patient organisations, advocates, and other stakeholders from across the WHO European Region to join our European Regional Task Force on Rare Diseases. This group will gather evidence, experience, and expertise to help shape our development of a European Blueprint for Rare Diseases, to be launched at our European Conference on Rare Diseases and Orphan Products (ECRD 2026). Apply now!
Developing a European Blueprint for Rare Diseases: How this work will unfold
February 2026
EURORDIS-Rare Diseases Europe is leading a multi-stakeholder initiative to develop a European Blueprint for Rare Diseases – a detailed design for how rare disease policy can be structured, coordinated, and delivered in practice.
https://www.eurordis.org/blueprint-for-rare-diseases-coordinating-action-across-europe/
European Regional Task Force on Rare Diseases – Expression of Interest
Rare Diseases Europe (EURORDIS), in collaboration with Rare Diseases International (RDI), is establishing the European Regional Task Force on Rare Diseases to bring together stakeholders from across the WHO European Region.
https://forms.office.com/pages/responsepage.aspx?id=uv_BBwRMtkK5WUPa44YsSg_8cYkfEgFJkfThrO_639NUQTQ4SkUyNDFSQ1FCM0g2OE5FU0pZT05IOC4u&route=shorturl
Rare Disease Day 2026: More Than You Can Imagine February 2026
https://www.eurordis.org/rare-disease-day-2026-more-than-you-can-imagine/
On 28 February 2026, people across the globe will once again come together to mark Rare Disease Day. Coordinated by EURORDIS–Rare Diseases Europe and powered by a growing network of National Alliance partners, patient organisations, families and advocates it is a day built from local action and global solidarity, and it continues to expand year after year.
Rapid Review Quiz: Substance Use Disorders Reviewed by Heidi Moawad, MD January 29, 2026 ++++
https://reference.medscape.com/viewarticle/rapid-review-quiz-drug-abuse-2026a10001w6?ecd=WNL_rrq_260212_MSCPEDIT_etid8096465&uac=148436CN&impID=8096465
Rapid Review Quiz: Marijuana Use Health Risks
Heidi Moawad, MD
https://reference.medscape.com/viewarticle/rapid-review-quiz-marijuana-use-health-risks-2025a1000lt3?ecd=WNL_rrq_260212_MSCPEDIT_etid8096465&uac=148436CN&impID=8096465
August 20, 2025
Rapid Rx Quiz: Opioid Overdose
Mary L. Windle, PharmD
https://reference.medscape.com/viewarticle/rapid-rx-quiz-opioid-overdose-2025a1000d2q?ecd=WNL_rrq_260212_MSCPEDIT_etid8096465&uac=148436CN&impID=8096465
July 17, 2025
Rapid Rx Quiz: Benzodiazepines
Reviewed by Mary L. Windle, PharmD
https://reference.medscape.com/viewarticle/rapid-rx-quiz-benzodiazepines-2025a1000wen?ecd=WNL_rrq_260212_MSCPEDIT_etid8096465&uac=148436CN&impID=8096465
December 08, 2025
miércoles, 11 de febrero de 2026
Lessons in living with a rare disease: what living rare has taught me Written by Bailey Hunter
https://rarerevolutionmagazine.com/lessons-in-living-with-a-rare-disease-what-living-rare-has-taught-me/
Bailey Hunter shares her personal insights of living a rare life, teaching her resilience, solidarity, advocacy and to live life fully
Living with a rare disease teaches you lessons you never asked to learn. It changes how you move through the world. It teaches patience in waiting rooms, courage in conversations you never expected to have and resilience in moments when your body does not cooperate. Over time, rare becomes less of a label and more of a lens that shapes how you see yourself, relationships and what truly matters. What I have learned is that rare not only describes a medical condition. It describes a way of living with more intention, more awareness and more strength than you knew you had. Rare teaches you to listen to your body, to advocate for what you need and to find community in places you never imagined. These lessons are shaped by setbacks, small victories and the quiet determination to keep going.
Visuomotor processing in the superior colliculus Elí Lezama [1] , Mario Treviño* [1]
https://www.academia.edu/academia-neuroscience-and-brain-research/1/2/10.20935/AcadNeurosci8046
The superior colliculus (SC) is an evolutionarily conserved midbrain structure that maintains a consistent laminar organization across most mammalian species. This architecture reflects shared functional requirements for visual processing, attentional control, and motor coordination. Physiological studies confirm that the SC can process visual information independently of the primary visual cortex (V1), sustaining visuomotor behaviors through subcortical networks following V1 lesion or inactivation. This capacity illustrates how alternative neural pathways can maintain essential survival-related functions without cortical involvement. Comparative approaches reveal both conserved operational principles and species-specific adaptations. In rodents, SC activity guides attentional allocation, perceptual selection, and adaptive decision-making based on visual cues. In primates, its extensive connectivity with cortical and subcortical structures supports target selection, saccade generation, and sensorimotor integration. Collectively, these findings establish the SC as a fundamental substrate for adaptive signal processing that links perception with action across diverse behavioral contexts. This review synthesizes current understanding of the mammalian SC, focusing on its roles in visual processing, attention, and motor coordination. By synthesizing evidence across species, we describe how conserved neural architecture contributes to adaptive perception and behavior, and how the SC complements cortical pathways in shaping visually guided actions.
The launch of Academia Neuroscience and Brain Research
Roberto Ciccocioppo
Volume 1, Issue 1
https://www.academia.edu/journals/academia-neuroscience-and-brain-research/articles?source=journal-top-nav
Cognitive speed training over weeks may delay the diagnosis of dementia over decades
Cognitive speed training over weeks may delay the diagnosis of dementia over decades
NIH-funded effort finds positive outcomes with strategies that engaged mostly unconscious, rather than conscious, thinking.
https://www.nih.gov/news-events/news-releases/cognitive-speed-training-over-weeks-may-delay-diagnosis-dementia-over-decades
A National Institutes of Health (NIH)-funded study that followed adults age 65 and older over 20 years has linked a specific cognitive training regimen to reduced diagnoses of Alzheimer disease and related dementias (ADRD). While the authors assessed three different kinds of training, only one, which challenged participants with rapid object detection tasks, was associated with a 25% lower rate of dementia diagnosis, as indicated by Medicare claims data.
Case 6: De-Differentiated Endometrial Cancer e-Tumor Board Case Discussions are developed independently. ++
https://www.medscape.com/etumor/endometrial-cancer-s01/e06
Case 5: Multiply Recurrent Stage II Endometrial Cancer
e-Tumor Board Case Discussions are developed independently.
https://www.medscape.com/etumor/endometrial-cancer-s01/e05
Sensory nerves play role in bone fracture healing
Sensory nerves play role in bone fracture healing
At a Glance
A study in mice found that after a bone fracture, the nerves that sense pain also promote healing by signaling for bone repair and wound healing.
The findings could lead to new treatments that stimulate bone repair and might be used to drive bone formation in bone disorders such as osteoporosis.
https://www.nih.gov/news-events/nih-research-matters/sensory-nerves-play-role-bone-fracture-healing
Understanding obesity-induced inflammation
Understanding obesity-induced inflammation
At a Glance
NIH-funded researchers detailed a chain of events through which obesity promotes harmful inflammation.
The findings point to potential new pathways for treating obesity-related illnesses.
https://www.nih.gov/news-events/nih-research-matters/understanding-obesity-induced-inflammation
People with dementia prescribed risky drugs
People with dementia prescribed risky drugs
At a Glance
Researchers found that many older adults with dementia were prescribed medications that can increase the risk of confusion, falls, and hospitalization.
Reducing such unnecessary prescriptions could improve the quality of care for older adults.
https://www.nih.gov/news-events/nih-research-matters/people-dementia-prescribed-risky-drugs
NIH scientists develop "digital twin" of eye cells to understand and treat age-related macular degeneration
NIH scientists develop "digital twin" of eye cells to understand and treat age-related macular degeneration
Breakthrough modeling technology reveals how cells lose their organization in leading cause of vision loss.
https://www.nih.gov/news-events/news-releases/nih-scientists-develop-digital-twin-eye-cells-understand-treat-age-related-macular-degeneration
: A digital 3D image showing a polarized iRPE cell. It is very colorful with the cell border in magenta, the nuclei in cyan and the mitochondria in yellow.
Representative image of a polarized iRPE cell. Phalloidin staining shows cell borders (magenta), Hoechst labels nuclei (cyan), while TOMM20 tagged with mEGFP was used to visualize mitochondria (yellow).
National Institutes of Health (NIH) researchers have developed a digital replica of crucial eye cells, providing a new tool for studying how the cells organize themselves when they are healthy and affected by diseases. The platform opens a new door for therapeutic discovery for blinding diseases such as age-related macular degeneration (AMD), a leading cause of vision loss in people over 50.
The Lancet Summit: shaping the future of diabetes prevention Nov 30–Dec 2, 2026 | Sitges, Spain + ++... ++
The Lancet Summit: shaping the future of diabetes prevention
Nov 30–Dec 2, 2026 | Sitges, Spain
https://thelancetsummit.com/diabetes-prevention/index.html?utm_campaign=update-lanpub&utm_medium=email&_hsenc=p2ANqtz-9RHLVXOhfK9L3hTtEqNYmkH28N8s3Py3uMJTBdwib4o_8c5pihyepwexHbPuENxKVIvNrNo8nIhX6wd-br0tdow1qs7g&_hsmi=402955683&utm_content=402666425&utm_source=hs_email
Abstracts invited for short talks and posters
Submit by Jun 12, 2026
Commercialisation and care sufficiency: the privatisation of children's homes in England
Benjamin Goodair, DPhila b.goodair@lse.ac.uk ∙ François Schoenberger, PhDb,c ∙ Anders Bach-Mortensen, DPhil
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00279-8/fulltext?dgcid=hubspot_update_feature_updatealerts_lanpub&utm_campaign=update-lanpub&utm_medium=email&_hsenc=p2ANqtz-_YG8ZT1eATJ00vI0qJIy7vbdSdBXpyiLzVPFkkTu8Uci_LF06rIyOZBKm0IFIJMV-rzZSLVWePomjDWGJvDlapqPuPBw&_hsmi=402955683&utm_content=402666425&utm_source=hs_email
Editorial
e69
Strengthening cardiovascular disease prevention in Europe
The Lancet Public Health
https://www.thelancet.com/journals/lanpub/issue/vol11no2/PIIS2468-2667(26)X2001-1
Uptake and performance of self-collection offered through primary care to all eligible participants in a national cervical screening programme in Australia: a retrospective cohort study
Farhana Sultana, PhDa ∙ Megan Smith, PhDb ∙ Prof Marion Saville, MBChBc,d ∙ Prof Deborah Bateson, MB BSf ∙ Prof David Roder, DDScg ∙ Vivienne Milch, MHPolh,i ∙ et al.
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00304-4/fulltext?dgcid=hubspot_update_feature_updatealerts_lanpub&utm_campaign=update-lanpub&utm_medium=email&_hsenc=p2ANqtz-9mVLdOpUrtgrzT65IUdydEK2dotTCDkVO0htibpyTnIqWY--2xAZ4XGaciXYCXnzpANgpL8oFCgFJLc2bcQUulwcKxFw&_hsmi=402955683&utm_content=402666425&utm_source=hs_email
The potential effect of a geographically focused intervention against tuberculosis in the USA: a simulation modelling study
Mathilda Regan, PhDa mathildaregan@hsph.harvard.edu ∙ Hening Cui, MSa ∙ Nicole A Swartwood, MSPHa ∙ Yunfei Li, ScDa ∙ Suzanne M Marks, MPHb ∙ Terrika Barham, PhDc ∙ Awal Khan, PhDb ∙ Carla A Winston, PhDb ∙ Prof Ted Cohen, DPHd ∙ Prof C Robert Horsburgh, Jr, MDe ∙ Prof Joshua A Salomon, PhDf ∙ Nicolas A Menzies, PhDa
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00306-8/fulltext?dgcid=hubspot_update_feature_updatealerts_lanpub&utm_campaign=update-lanpub&utm_medium=email&_hsenc=p2ANqtz-8vho989B16Y0AkchQBtq93dgvsTVD8v39AcK1BZh2h8IrbADYIksli-g_PjNazYTsFooOG4D_XYD3p-zKhbWmJNCQt1Q&_hsmi=402955683&utm_content=402666425&utm_source=hs_email
Suscribirse a:
Comentarios (Atom)
