Precision Medicine: Genomic Profiles to Individualize Therapy. - PubMed - NCBI

Precision Medicine: Genomic Profiles to Individualize Therapy. - PubMed - NCBI

Otolaryngol Clin North Am. 2017 May 17. pii: S0030-6665(17)30060-9. doi: 10.1016/j.otc.2017.03.012. [Epub ahead of print]

Precision Medicine: Genomic Profiles to Individualize Therapy.

Streeter OE Jr1, Beron PJ2, Iyer PN3.

Author information

Abstract

Precision medicine is the application of genotypic and Omics biomarkers to determine the most appropriate, outcome-driven therapy for individual patients. To determine the best choice of therapy, institutions use significant information technology-enabled data from imaging, electronic medical records, sensors in the clinic/hospitals, and wearable sensors to determine treatment response. With genomic profiling, targets to affect a disease course are continuing to be developed. As clonal mutational prevalence continues to be understood, information can be communicated to patients to inform them that resistance is common, requiring collection of more genetic mutations from patients with further biopsies or blood collection.

Copyright © 2017 Elsevier Inc. All rights reserved.

KEYWORDS:

Big data; Checkpoint inhibitors; Genomic profiling; Hyperthermia; Immunotherapy; Machine learning; Precision medicine; Radiogenomics

PMID:

 

28527522

 

DOI:

 

10.1016/j.otc.2017.03.012