Sensory integration–based approaches improved sensory and motor skills relative to other interventions.
Environmental enrichment improved nonverbal cognitive skills compared with standard care.
Massage (vs. no massage) improved ASD symptom severity and sensory challenges.
Auditory integration–based approaches did not improve language outcomes.
Future research should focus on which children may benefit from interventions and how long treatment effects last.
To evaluate the effectiveness and safety of interventions targeting sensory challenges in children with autism spectrum disorder (ASD).
We searched MEDLINE®, Embase®, the Cumulative Index of Nursing and Allied Health Literature®, and PsycINFO® from January 2010 to September 2016.
We included studies comparing interventions incorporating sensory-focused modalities with alternative treatments or no treatment. Studies had to include at least 10 children with ASD ages 2–12 years. Two investigators independently screened studies and rated risk of bias. We extracted and summarized data qualitatively because of the significant heterogeneity. We also assessed strength of the evidence (SOE).
We identified 24 unique comparative studies (17 newly published studies and 7 studies addressed in our 2011 review of therapies for children with ASD). Studies included 20 randomized controlled trials (RCTs), 1 nonrandomized trial, and 3 retrospective cohort studies (3 low, 10 moderate, and 11 high risk of bias [ROB]). Populations, intervention approaches, and outcomes assessed varied across studies. Relative to usual care or other interventions, sensory integration–based approaches improved measures related to sensory and motor skills in the short term (3 RCTs with high, moderate, and low ROB and 1 high ROB retrospective cohort study). Environmental enrichment improved nonverbal cognitive skills in treated children compared with standard care in two small RCTs (low and moderate ROB). Four small RCTs (2 moderate and 2 high ROB) of auditory integration–based approaches reported mixed results. Studies of music therapy (4 RCTs—1 low, 2 moderate, and 1 high ROB—and 1 high ROB nonrandomized trial) used different protocols and addressed different outcomes, precluding synthesis. Massage improved ASD symptom severity and sensory challenges versus a waitlist control condition (7 studies, 5 with likely overlapping participants, 3 moderate and 4 high ROB). Additional RCTs (moderate and high ROB) of interventions with sensory-related components (tactile stimulation exercises, weighted blankets) reported few significant differences between treatment groups.
Weitlauf AS, Sathe NA, McPheeters ML, Warren Z. Interventions Targeting Sensory Challenges in Children With Autism Spectrum Disorder—An Update. Comparative Effectiveness Review No. 186. (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2015-00003-I.) AHRQ Publication No. 17-EHC004-EF. Rockville, MD: Agency for Healthcare Research and Quality; May 2017. www.effectivehealthcare.ahrq.gov/reports/final.cfm. doi: https://doi.org/10.23970/AHRQEPCCER186.
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