domingo, 21 de mayo de 2017

Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing. - PubMed - NCBI

Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing. - PubMed - NCBI



 2017 May 11;8(5):e92. doi: 10.1038/ctg.2017.19.

Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing.

Abstract

Colorectal cancer affects 1 in 20 men and women in their lifetime. About 30% of these cases have been shown to be familial while only about 5% are associated with a highly penetrant hereditary colon cancer syndrome. In many familial cases, however, no mutation in the commonly implicated CRC genes is found. With the development of next-generation sequencing, testing laboratories are now able to offer hereditary gastrointestinal panel testing, which allows for the simultaneous sequencing of a much broader set of genes associated with CRC. We discuss the advantages and disadvantages of such testing to inform best clinical practice.

PMID:
 
28492537
 
DOI:
 
10.1038/ctg.2017.19

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