CIENCIASMEDICASNEWS: Cancer & Metabolism

jueves, 5 de julio de 2018

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Cancer & Metabolism

Articles

Content Type:Research
| 28 June 2018
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
Authors:Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai and Harvey R. Herschman
Content Type:Research
| 11 June 2018
Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
Authors:Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto and Ulrike Kämmerer
Content Type:Research
| 31 May 2018
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
Authors:Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks
Content Type:Research
| 17 April 2018
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Authors:Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins…
Content Type:Research
| 3 April 2018
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
Authors:Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen