Cancer Epidemiol Biomarkers Prev. 2018 Jul 17. pii: cebp.0503.2018. doi: 10.1158/1055-9965.EPI-18-0503. [Epub ahead of print]
BORDERLINE OVARIAN TUMORS SHARE FAMILIAL RISKS WITH ITSELF AND INVASIVE CANCERS.
Borderline ovarian tumors (BOTs) are a subgroup of ovarian malignancies with low malignant potential. Very limited earlier data are available on familial clustering of BOTs with other cancers. We aim to explore histology-specific familial associations among BOTs and associations between BOT and any invasive cancers.
Based on 16.1 million individuals in the Swedish Family-Cancer Database, we estimated familial risks for overall or histology-specific BOT patients considering both BOT and any invasive cancers in first-degree relatives (parents or siblings), as well as familial risks for invasive cancers considering family history of BOTs.
A total of 4199 BOT cases were found in the offspring generation; among them, 34 (0.8%) cases had first-degree relatives diagnosed with any BOT, and 2489 (59.3%) cases with any invasive cancers. A family history of BOT was associated with risks for all BOTs (RR=2.20, p<0.001). Papillary BOT in first-degree relatives was associated with the increased risk of having the same type of BOT (RR=10.10, p<0.001). BOTs showed familial associations with some invasive cancers, most consistently with colorectal, ovarian, pancreatic, lung and bone cancers, and with leukemia. In histological analyses, associations of BOT with even rare cancers of the anus, thyroid and endocrine glands were noted.
BOTs may share susceptibility with itself and a number of invasive cancers.
These results provide insight into familial associations of BOT for the first time which may help with the etiologic mechanism and preventive strategy of BOTs as well as the genetic counseling for BOT patients.
Copyright ©2018, American Association for Cancer Research.