domingo, 25 de junio de 2017

Do online prognostication tools represent a valid alternative to genomic profiling in the context of adjuvant treatment of early breast cancer? A s... - PubMed - NCBI

Do online prognostication tools represent a valid alternative to genomic profiling in the context of adjuvant treatment of early breast cancer? A s... - PubMed - NCBI



 2017 Jun 3. pii: S0002-9610(17)30531-7. doi: 10.1016/j.amjsurg.2017.05.006. [Epub ahead of print]

Do online prognostication tools represent a valid alternative to genomic profiling in the context of adjuvant treatment of early breast cancer? A systematic review of the literature.

Abstract

INTRODUCTION:

Decision-making regarding adjuvant chemotherapy has been based on clinical and pathological features. However, such decisions are seldom consistent. Web-based predictive models have been developed using data from cancer registries to help determine the need for adjuvant therapy. More recently, with the recognition of the heterogenous nature of breast cancer, genomic assays have been developed to aid in the therapeutic decision-making.

METHODS:

We have carried out a comprehensive literature review regarding online prognostication tools and genomic assays to assess whether online tools could be used as valid alternatives to genomic profiling in decision-making regarding adjuvant therapy in early breast cancer.

RESULTS AND CONCLUSIONS:

Breast cancer has been recently recognized as a heterogenous disease based on variations in molecular characteristics. Online tools are valuable in guiding adjuvant treatment, especially in resource constrained countries. However, in the era of personalized therapy, molecular profiling appears to be superior in predicting clinical outcome and guiding therapy.

KEYWORDS:

Adjuvant; Breast cancer; Genetic testing; Genomics; Prognosis

PMID:
 
28622841
 
DOI:
 
10.1016/j.amjsurg.2017.05.006

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