Added text to state that an analysis of 2,655 patients enrolled in GOG-0182, only cytoreduction to node-visible disease that is R0 (i.e., complete surgical resection) had an independent effect on survival (cited Horowitz et al. as reference 5).
Added text to state that although more toxic, the weekly paclitaxel regimen did not adversely affect quality of life when compared with the intermittent schedule (cited Harano et al. as reference 25).
Added text to state that two phase III studies compared the outcome of standard primary cytoreductive surgery (PCS) with that of neoadjuvant chemotherapy followed by interval cytoreductive surgery; both studies demonstrated that progression-free survival and overall survival were noninferior with PCS (cited Kehoe et al. as reference 50).
Added text to state that between 2004 and 2010, a group of 87 hospitals in the United Kingdom and New Zealand enrolled 550 women with stage III or IV ovarian epithelial cancer and randomly assigned them to undergo PCS followed by six cycles of chemotherapy or to receive primary (neoadjuvant) chemotherapy for three cycles, followed by surgery and three additional cycles of chemotherapy (cited level of evidence 1iiA).
Added text to state that these studies and additional observational and partially published phase III studies have led to the publication of a Clinical Practice Guideline on behalf of the Society of Gynecologic Oncology and the American Society of Clinical Oncology (cited Wright et al. as reference 51).
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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