Acta Neuropathologica Communications | Home page

Acta Neuropathologica Communications | Home page

Acta Neuropathologica Communications

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1. Content Type:Research

     |  13 April 2018

   Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

   Authors:Matthew D. Cykowski, Suzanne Z. Powell, Joan W. Appel, Anithachristy S. Arumanayagam, Andreana L. Rivera and Stanley H. Appel
2. Content Type:Research

     |  11 April 2018

   Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

   Authors:Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno and Dariusz C. Górecki
3. Content Type:Research

     |  3 April 2018

   Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

   Authors:Gaëlle Dominguez, Marie-Lise Maddelein, Mélanie Pucelle, Yvan Nicaise, Claude-Alain Maurage, Charles Duyckaerts, Olivier Cuvillier and Marie-Bernadette Delisle
4. Content Type:Research

     |  3 April 2018

   Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

   Authors:Alejandro Ruiz-Riquelme, Heather H. C. Lau, Erica Stuart, Adrienn N. Goczi, Zhilan Wang, Gerold Schmitt-Ulms and Joel C. Watts
5. Content Type:Letter To The Editor

     |  15 March 2018

   BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma

   Authors:Drew Pratt, Sandra Camelo-Piragua, Kathryn McFadden, Denise Leung, Rajen Mody, Arul Chinnaiyan, Carl Koschmann and Sriram Venneti

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Featured article: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Professor Zhang et al investigate the mechanism of extracellular vesicle transmission across the blood-brain barrier as it relates to Parkinson's Disease.

Featured article: Novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Dr. Finkelstein et al report the preclinical characterization of PBT434, a novel quinazolinone compound bearing a moderate affinity metal-binding motif, which is in development for Parkinsonian conditions.