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BMC Microbiology

Featured review: Structure, Genetics and Worldwide Spread of NDM-1: a threat to public health

The emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised a major public health concern. NDM-1 hydrolyses a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria.This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe. 

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