Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression | Molecular Cancer | Full Text

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression | Molecular Cancer | Full Text

Molecular Cancer

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

• Ju-Ha Kim, 
• Jisung Hwang, 
• Ji Hoon Jung, 
• Hyo-Jung Lee, 
• Dae Young Lee & 
• Sung-Hoon Kim 

Molecular Cancer volume 18, Article number: 180 (2019) Cite this article

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Abstract

Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.