domingo, 15 de septiembre de 2019

Journal of Experimental & Clinical Cancer Research | Articles

Journal of Experimental & Clinical Cancer Research | Articles

  • New Content Item
  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Regina Elena NCI
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy
  1. Research

    Colon cancer is the second leading cancer worldwide. Recurrent disease and chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. ATP-citrate lyase (ACLY), the first-step rate-...
    Authors:Jun Wen, Xuejie Min, Mengqin Shen, Qian Hua, Yuan Han, Li Zhao, Liu Liu, Gang Huang, Jianjun Liu and Xiaoping Zhao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:401
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  2. Content Type:Research

    Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumou...
    Authors:Ping Jiang, Mao Huang, Weiwei Qi, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao and Xia Yang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:400
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  3. Content Type:Research

    Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...
    Authors:So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Ji-Won Kim, Ji-Young Kim and Jeong-Seok Nam
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:399
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  4. Content Type:Research

    Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts.
    Authors:Jiansheng Chen, Taoliang Chen, Yubo Zhu, Yan Li, Yuxuan Zhang, Yun Wang, Xiao Li, Xiaomi Xie, Jihui Wang, Min Huang, Xinlin Sun and Yiquan Ke
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:398
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  5. Content Type:Research

    Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...
    Authors:Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben and David Schrama
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:397
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  6. Content Type:Review

    Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% o...
    Authors:Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:396
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  7. Content Type:Research

    Long non-coding RNA plays a crucial role in the occurrence and progression of glioma. We aimed to explore the function of LINC00174 in cell proliferation, apoptosis, migration, invasion and glycolysis of gliom...
    Authors:Jian Shi, Yang Zhang, Bing Qin, Yongjie Wang and Xiangdong Zhu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:395
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  8. Content Type:Research

    FAM92A1–289(abbreviated FAM289) is recognized as one of the newly-discovered putative oncogenes. However, its role and molecular mechanisms in promoting cancer progression has not yet been elucidated. This stu...
    Authors:Xing Rong Guo, Mu Yu Wu, Long Jun Dai, Yu Huang, Meng Ye Shan, Shi Nan Ma, Jue Wang, Hao Peng, Yan Ding, Qiu Fang Zhang, Jun Ming Tang, Xu Zhi Ruan and Dong Sheng Li
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:394
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  9. Content Type:Research

    m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including...
    Authors:Wen Peng, Jie Li, Ranran Chen, Qiou Gu, Peng Yang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Zhiyuan Zhang, Junwei Tang and Yueming Sun
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:393
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  10. Content Type:Research

    Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulat...
    Authors:Annapurna Pranatharthi, Pavana Thomas, Avinash H. Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R. Ross and Sweta Srivastava
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:392
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  11. Content Type:Research

    Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple c...
    Authors:Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren and Xinsheng Peng
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:391
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  12. Content Type:Research

    Dysregulation of microRNAs (miRNAs) play critical roles in cancerous processes. Although miR-3064 was reported to be an important tumor suppressor in ovarian cancer, the cellular impact of miR-3064 on pancreat...
    Authors:Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:390
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  13. Content Type:Research

    In cancer progression, hypoxia, or low oxygen tension, is a major regulator of tumor aggressiveness and metastasis. However, how cancer cells adapt to the hypoxia and communicate with other mesenchymal cells i...
    Authors:Yu Mao, Yimin Wang, Lixin Dong, Yunjie Zhang, Yanqiu Zhang, Chao Wang, Qiang Zhang, Sen Yang, Liyan Cao, Xinyuan Zhang, Xin Li and Zhanzhao Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:389
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  14. Content Type:Research

    Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in cancer progression and hypo...
    Authors:Shasha Ren, Jiuzhou Liu, Yun Feng, Zhenyu Li, Liang He, Leilei Li, Xiaozhong Cao, Zhenghua Wang and Yanwu Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:388
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  15. Content Type:Correction

    In the original publication of this article [1], the Fig. 7 is wrong, but does not affect discussions and conclusions drawn in the article.
    Authors:Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:387
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:263
  16. Content Type:Research

    Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely incurable. Our limited understanding of key molecular mechanisms underlying RCC invasion and metastasis has hampered efforts to iden...
    Authors:Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu and Dan Yue
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:386
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  17. Content Type:Correction

    In the original publication of this article [1], there are mistakes in Fig. 3A and Fig. 3D.
    Authors:Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:385
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:68
  18. Content Type:Research

    Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood. RING finger protein...
    Authors:Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu and Chao Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:384
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  19. Content Type:Research

    Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Proteolysis targeting chimeric (PROTAC) are novel compounds that promote protein degradation by bindi...
    Authors:María del Mar Noblejas-López, Cristina Nieto-Jimenez, Miguel Burgos, Mónica Gómez-Juárez, Juan Carlos Montero, Azucena Esparís-Ogando, Atanasio Pandiella, Eva M. Galán-Moya and Alberto Ocaña
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:383
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  20. Content Type:Research

    Ovarian carcinomas are the deadliest gynecological malignancies owing to their high rate of recurrence and high resistance to platinum-based chemotherapy. Recent studies have shown platinum-dependent enrichmen...
    Authors:Syed S. Islam and Abdelilah Aboussekhra
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:382
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  21. Content Type:Research

    High rates of recurrence and metastasis are the major cause of the poor outcomes for patients with lung cancer. In previous research, we have demonstrated that Tac2-N promotes tumor growth by suppressing p53 s...
    Authors:Xianglin Hao, Li-yun Gao, Ning Zhang, Hongqiang Chen, Xiao Jiang, Wenbin Liu, Lin Ao, Jia Cao, Fei Han and Jinyi Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:319
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  22. Content Type:Research

    Anti-angiogenesis remains an attractive strategy for cancer therapy. Some anti-angiogenic reagents have bell-shape dose-response curves with higher than the effective doses yielding lower anti-angiogenic effec...
    Authors:Jialiang Hu, Wenjing Wang, Chen Liu, Mengwei Li, Edouard Nice and Hanmei Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:381
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  23. Content Type:Research

    Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma. Equally important, However, tumorigenic functions of lncRNA ...
    Authors:Zhenzhe Li, Jixing Zhang, Hongshan Zheng, Chenlong Li, Jinsheng Xiong, Weiliang Wang, Hongbo Bao, Hua Jin and Peng Liang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:380
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  24. Content Type:Research

    TP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-...
    Authors:Yuechao Zhao, Yiran Li, Jie Sheng, Fan Wu, Kai Li, Rong Huang, Xiaojuan Wang, Tao Jiao, Xin Guan, Yan Lu, Xiao Chen, Zhiwen Luo, Yanchi Zhou, Hanjie Hu, Wenjie Liu, Boyu Du…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:379
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  25. Content Type:Research

    Cripto-1 (CR-1) has been reported to be involved in the development of several human cancers. The potential role of CR-1 in clear cell renal cell carcinoma (ccRCC) is still not clear.
    Authors:Yi-Jun Xue, Song-Ning Chen, Wei-Guang Chen, Geng-Qing Wu, Yun-Feng Liao, Jian-Bin Xu, Hao Tang, Shui-Hua Yang, Shui-Yong He, Yun-Fei Luo, Zhi-Hui Wu and Hai-Wen Huang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:378
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  26. Content Type:Research

    Cardamonin, a chalcone isolated from Alpiniae katsumadai, has anti-inflammatory and anti-tumor activities. However, the molecular mechanism by which cardamonin inhibits breast cancer progression largely remains t...
    Authors:Jinmei Jin, Shuiping Qiu, Ping Wang, Xiaohui Liang, Fei Huang, Hui Wu, Beibei Zhang, Weidong Zhang, Xinhui Tian, Ren Xu, Hailian Shi and Xiaojun Wu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:377
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  27. Content Type:Research

    Metformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer. But there are few reports on the roles of Yap1, the key molecule of Hipp...
    Authors:Yanju Wu, Qianqian Zheng, Yan Li, Guang Wang, Shuting Gao, Xiaodong Zhang, Xu Yan, Xinwen Zhang, Jisheng Xie, Yuanyuan Wang, Xun Sun, Xin Meng, Bo Yin and Biao Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:376
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  28. Content Type:Research

    An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) play pivotal roles in cancer onset and development. LncRNA AFAP1-AS1 has been validated to be abnormally upregulated and pl...
    Authors:Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang and Zengwu Shao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:375
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  29. Content Type:Correction

    In the original publication of this article [1], there is an error in Fig. 4A.
    Authors:Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li and Jiayuh Lin
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:374
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:63
  30. Content Type:Research

    An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour...
    Authors:Isabella Orienti, Valentina Salvati, Giovanni Sette, Massimo Zucchetti, Lucilla Bongiorno-Borbone, Angelo Peschiaroli, Lello Zolla, Federica Francescangeli, Mariella Ferrari, Cristina Matteo, Ezia Bello, Antonio Di Virgilio, Mario Falchi, Maria Laura De Angelis, Marta Baiocchi, Gerry Melino…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:373
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  31. Content Type:Research

    The interaction between tumor cells and their immunosuppressive microenvironment promotes tumor progression and drug resistance. Thus, simultaneously targeting tumor cells and stromal cells is expected to have...
    Authors:Xia Peng, Pengcong Hou, Yi Chen, Yang Dai, Yinchun Ji, Yanyan Shen, Yi Su, Bo Liu, Yueliang Wang, Deqiao Sun, Yuchen Jiang, Chuantao Zha, Zuoquan Xie, Jian Ding, Meiyu Geng and Jing Ai
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:372
    Published on: 
  32. Content Type:Research

    Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, the...
    Authors:Chenlong Wang, Yaxin Chen, Yang Wang, Xiaoxiao Liu, Yanzhuo Liu, Ying Li, Honglei Chen, Chengpeng Fan, Dongfang Wu and Jing Yang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:371
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  33. Content Type:Research

    Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemother...
    Authors:Jiafei Liu, Like Qu, Lin Meng and Chengchao Shou
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:370
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  34. Content Type:Research

    Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to disc...
    Authors:Yan Liu, Yingru Zhi, Haizhu Song, Mingzhu Zong, Jun Yi, Guoxin Mao, Longbang Chen and Guichun Huang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:369
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  35. Content Type:Review

    Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of surv...
    Authors:Fengzhi Li, Ieman Aljahdali and Xiang Ling
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:368
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  36. Content Type:Correction

    In the publication of this article [1], there is an error in Fig. 5C (panel 4, group of InmiR-26a + silinc01296 in SW620). The revised Fig. 5 which includes 5C has now been included in this correction.
    Authors:Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu and Li Jia
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:367
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:316
  37. Content Type:Research

    The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood.
    Authors:Erbao Bian, Xueran Chen, Yadi Xu, Xinghu Ji, Meng Cheng, Hongliang Wang, Zhiyou Fang and Bing Zhao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:366
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  38. Content Type:Research

    The lncRNA LINC00460 plays crucial roles in several epithelial cancers, although its mechanisms of action differ greatly in different cellular contexts. In this study, we aimed to determine the potential clini...
    Authors:Yingying Jiang, Wei Cao, Kun Wu, Xing Qin, Xiaoning Wang, Yan Li, Binbin Yu, Zhen Zhang, Xu Wang, Ming Yan, Qin Xu, Jianjun Zhang and Wantao Chen
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:365
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  39. Content Type:Research

    Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to exa...
    Authors:Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz de Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos and Georgios D. Ayiomamitis
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:364
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  40. Content Type:Research

    In order to develop a new immunotherapeutic agent targeting metastatic breast cancers, we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14, a specific prognosis marker for ER ...
    Authors:Ki Yeon Kim, Minsang Yoon, Youngkyung Cho, Kwang-Hoon Lee, Sora Park, Se-ra Lee, So-Young Choi, Deokjae Lee, Chansik Yang, Eun Hye Cho, Sangjun Davie Jeon, Seok-Hyung Kim, Chungho Kim and Moon Gyo Kim
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:363
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  41. Content Type:Research

    Tumor targeting small molecular inhibitors are the most popular treatments for many malignant diseases, including cancer. However, the lower clinical response and drug resistance still limit their clinical eff...
    Authors:Xiaoge Gao, Pin Jiang, Qian Zhang, Qian Liu, Shuangshuang Jiang, Ling Liu, Maomao Guo, Qian Cheng, Junnian Zheng and Hong Yao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:362
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  42. Content Type:Research

    Triple Negative Breast cancer (TNBC) is incurable cancer with higher rates of relapse and shorter overall survival compared with other subtypes of breast cancer. Cellular retinoic acid binding protein 2 (CRABP...
    Authors:Xuefei Feng, Miao Zhang, Bo Wang, Can Zhou, Yudong Mu, Juan Li, Xiaoxu Liu, Yaochun Wang, Zhangjun Song and Peijun Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:361
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  43. Content Type:Research

    A major limitation in the treatment for malignant mesothelioma is related to serious side effects caused by chemotherapeutics and to the development of cancer-resistance. Advances in cancer therapies have been...
    Authors:Francesco Di Meo, Stefania Filosa, Michele Madonna, Gerarda Giello, Alba Di Pardo, Vittorio Maglione, Alfonso Baldi and Stefania Crispi
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:360
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  44. Content Type:Research

    MicroRNAs (miRNAs) play crucial roles in tumor initiation and development. Previously, we indicated that miR-504 is downregulated and suppresses tumor proliferation in glioblastoma (GBM). However, the regulati...
    Authors:Qiang Liu, Yanlei Guan, Zhenhang Li, Yao Wang, Yu Liu, Run Cui and Yunjie Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:358
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  45. Content Type:Correction

    In the original publication of this article [1], there is a mistake in Fig. 4E.
    Authors:Qianqian Liu, Hongye Ma, Xiuhua Sun, Bing Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Weijie Dong and Li Jia
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:357
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:199
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