CIENCIASMEDICASNEWS: Medical News | Medical Articles - Pharmacy / Pharmacology

viernes, 26 de octubre de 2018

Medical News | Medical Articles - Pharmacy / Pharmacology - Oct 26, 2018 Edition

	October 26, 2018
	Pharmacy / Pharmacology
	The latest pharmacy / pharmacology news from News Medical

Antibody Screening Tools; Improving Workflows

New therapeutic antibodies are constantly needed for immunotherapies, Thomas Duensing from Intellicyt, part of the Sartorius Group, discusses how the Intellicyt® iQue Screener Plus platform enables multiplexed antibody screening, which increases the rate that these screens can be performed to thousands per hour.

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Developing Better Treatments With Small Molecules

Focussing in on neurological conditions, small molecules have been instrumental in helping to treat brain diseases much more effectively. The discovery of small molecules that could cross the blood-brain barrier was key to strategies that targeted pharmacological therapy for neurological and psychological illnesses.

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Modeling Non-Numerical Data in Systems Biology

An interview with Dr. Eshan Mitra, discussing the importance of computer models in biology and the development of a more accurate model of the RAF phosphorylation pathway.

	What are PARP inhibitors? Poly ADP-ribose polymerase (PARP) inhibitors are pharmaceutical drugs that can be used to treat many different forms of cancer, including ovarian and breast cancer. They manipulate DNA repair pathways, causing the death of cancerous cells.

	Machine Learning in Drug Development Drug development is a costly and often fruitless process. Many of the drugs initially investigated are not brought to clinical trial, and many after that are not approved by the FDA or other similar boards.

	Researchers find opportunity to control salt-sensitive hypertension without exercising Hypertension researchers at The University of Toledo have shown that by increasing the body's supply of beta hydroxybutyrate, a chemical produced predominantly by the liver, it is possible to regulate high blood pressure without reducing sodium intake or increasing exercise.

	Study highlights existence of barriers to early clinical trial access for adolescents and young adults Young cancer patients at the crossroads of childhood and adulthood seem to be stuck in a treatment impasse. A study to be presented at the ESMO 2018 Congress in Munich, has highlighted the existence of barriers to the inclusion of 12 to 25-year-olds in both adult and pediatric early phase clinical trials, suggesting a need for more tailored approaches to give this patient population better access to therapeutic innovation.

	Bioengineering scientists propose new paradigm for research into cardiovascular diseases Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease--a condition responsible for 17 million deaths per annum globally.