martes, 30 de octubre de 2018

Broadly neutralizing antibodies (bnAbs) against HIV

Broadly neutralizing antibodies (bnAbs) against HIV

Broadly neutralizing antibodies (bnAbs) against HIV

A review collection published in Retrovirology
Edited by Rogier Sanders and Marit van Gils.​​​​​​​
Since the discovery of HIV-1 as the causative virus of AIDS over 35 years ago, scientists have tried to stop the virus spreading through the human population by generating a protective vaccine. Early optimism that a vaccine would be available within 10 years soon changed into frustration and disappointment. However, the discovery of broadly neutralizing antibodies (bNAbs) fueled new optimism. The isolation and characterization of many new bNAbs over the last decade has changed the field by guiding the design of novel vaccine immunogens using bNAbs as templates and therapeutic approaches by exploiting the bNAbs themselves.HIV_envelope_glycoprotein_bNAbs_Alba Torrents​​​​​​​

This thematic series in Retrovirology contains a collection of review articles that describe bNAb development after HIV-1 infection, the application of bNAbs as therapeutics and the attempts to elicit bNAbs by vaccination.  
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.
  1. Content Type:Review

    A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and described, particularly in the last decade. This continually expanding array of bnAbs has crucially led to the identi...
    Authors:Laura E. McCoy
    Citation:Retrovirology 2018 15:70
    Published on: 
  2. Content Type:Review

    As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse ...
    Authors:Neal N. Padte, Jian Yu, Yaoxing Huang and David D. Ho
    Citation:Retrovirology 2018 15:60
    Published on: 
  3. Content Type:Review

    HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus a...
    Authors:Jérémy Dufloo, Timothée Bruel and Olivier Schwartz
    Citation:Retrovirology 2018 15:51
    Published on: 

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