martes, 30 de octubre de 2018

Measuring HIV-1 persistence in vivo

Measuring HIV-1 persistence in vivo

Measuring HIV-1 persistence in vivo

New Content ItemEdited by Ben Berkhout and Alexander Pasternak
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. HIV-1 forms a reservoir that persists despite prolonged therapy and is considered the main barrier to an HIV cure. Being able to accurately measure HIV persistence in ART-treated individuals is necessary for monitoring the response to ART, as well as the effectiveness of curative interventions aimed at HIV remission. This thematic series in Retrovirology contains a collection of review articles that describe traditional and novel methods of quantitation of HIV persistence in vivo.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer review process. The Editors declare no competing interests.
  1. Content Type:Review

    Among the different markers of HIV persistence in infected cells, total HIV DNA is to date the most widely used. It allows an overall quantification of all viral forms of HIV DNA in infected cells, each playin...
    Authors:Christine Rouzioux and Véronique Avettand-Fenoël
    Citation:Retrovirology 2018 15:30
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  2. Content Type:Review

    Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses. Measuring persistent HIV-1 is challenging, as ...
    Authors:Zheng Wang, Francesco R. Simonetti, Robert F. Siliciano and Gregory M. Laird
    Citation:Retrovirology 2018 15:21
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  3. Content Type:Review

    Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA molecules can be found in acutely...
    Authors:Javier Martinez-Picado, Ryan Zurakowski, María José Buzón and Mario Stevenson
    Citation:Retrovirology 2018 15:15
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  4. Content Type:Review

    Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART) provides insights into the mechanisms that maintain the viral reservoir during ART. This review describes common methods u...
    Authors:Gert van Zyl, Michael J. Bale and Mary F. Kearney
    Citation:Retrovirology 2018 15:14
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  5. Content Type:Review

    Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reserv...
    Authors:Sofie Rutsaert, Kobus Bosman, Wim Trypsteen, Monique Nijhuis and Linos Vandekerckhove
    Citation:Retrovirology 2018 15:16
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  6. Content Type:Review

    Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. Th...
    Authors:Alexander O. Pasternak and Ben Berkhout
    Citation:Retrovirology 2018 15:13
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  7. Content Type:Review

    The development of increasingly safe and effective antiretroviral treatments for human immunodeficiency virus (HIV) over the past several decades has led to vastly improved patient survival when treatment is a...
    Authors:Claire Deleage, Chi N. Chan, Kathleen Busman-Sahay and Jacob D. Estes
    Citation:Retrovirology 2018 15:4
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  8. Content Type:Review

    A robust measure of the size of the latent HIV reservoir is essential to quantifying the effect of interventions designed to deplete the pool of reactivatable, replication competent proviruses. In addition to ...
    Authors:Nicholas J. Norton, Axel Fun, Mikaila Bandara, Mark R. Wills, Hoi Ping Mok and Andrew M. L. Lever
    Citation:Retrovirology 2017 14:58
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