domingo, 7 de octubre de 2018

Genetics of breast cancer in African populations: a literature review. - PubMed - NCBI

Genetics of breast cancer in African populations: a literature review. - PubMed - NCBI

 2018 May 11;3:e8. doi: 10.1017/gheg.2018.8. eCollection 2018.

Genetics of breast cancer in African populations: a literature review.

Abstract

Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide. We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk. Data were provided on mutations and polymorphisms associated with BC without fixing a specific date. Case-only studies and clinical trials were excluded. Our study revealed that the majority of African BC genetic studies remain restricted to the investigation of BRCA1 and BRCA2 genes and differences in their mutations spectrum. Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.

KEYWORDS:

Africa; breast cancer; genetic variability; genetics

PMID:
 
30263132
 
PMCID:
 
PMC6152487
 
DOI:
 
10.1017/gheg.2018.8

No hay comentarios:

Publicar un comentario