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Featured research: A tissue metabolomics signature to predict patient survival in pancreatic adenocarcinoma

A high-resolution magnetic spectroscopy technique was applied to intact tissue samples from pancreatic adenocarcinoma patients with the goal to compare the metabolomics profiles of pancreatic parenchyma and pancreatic adenocarcinoma. Metabolomics analysis revealed a unique signature specific to tumour tissue and identified ethanolamine as a potential biomarker for patient survival. Due to the minimal sample processing required, this technique could be used to guide clinical decisions in the context of surgery. Further validation studies are warranted to define its potential for clinical application.

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Featured minireview: Successes and failures of recent first-line immunotherapy trials in non-small cell lung cancer

Immune checkpoint inhibitors have proven to be viable therapeutic options for advanced non-small cell lung cancer (NSCLC) resistant to the standard chemotherapy with platinum-based compounds. Success in the second-line setting has encouraged evaluation of immunotherapeutics as the first-line treatment, also; Jordi Remon, Benjamin Besse and Jean-Charles Soria discuss contradictory results of recent phase III trials assessing first-line immunotherapy in NSCLC, looking at reasons for discrepancy and remaining open questions.

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1. RESEARCH ARTICLE

   Can incontinence be cured? A systematic review of cure rates

   Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande, Jos Kleijnen and Ian Milsom

   Published on: 24 March 2017
2. RESEARCH ARTICLE

   Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility

   Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis and Andrei P. Drabovich

   Published on: 23 March 2017
3. RESEARCH ARTICLE

   Allopurinol and the risk of ventricular arrhythmias in the elderly: a study using US Medicare data

   Jasvinder A. Singh and John Cleveland

   Published on: 22 March 2017
4. RESEARCH ARTICLE

   Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: a prospective cohort

   Stephen D. Lawn, Andrew D. Kerkhoff, Rosie Burton, Charlotte Schutz, Andrew Boulle, Monica Vogt, Ankur Gupta-Wright, Mark P. Nicol and Graeme Meintjes

   Published on: 21 March 2017
5. RESEARCH ARTICLE

   Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors’ conclusions

   G. Michael Allan, Caitlin R. Finley, James McCormack, Vivek Kumar, Simon Kwong, Emelie Braschi, Christina Korownyk, Michael R. Kolber, Adriennne J. Lindblad, Oksana Babenko and Scott Garrison

   Published on: 20 March 2017

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