viernes, 3 de mayo de 2019

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland | BMC Cancer | Full Text

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland | BMC Cancer | Full Text

BMC Cancer

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

BMC Cancer201919:417
  • Received: 11 October 2018
  • Accepted: 24 April 2019
  • Published: 
Open Peer Review reports

Abstracts

Background

Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC.

Methods

One hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint.

Results

A total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant (p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis.

Conclusion

The IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.

Keywords

  • Intraparotid node
  • Parotid cancer
  • Mucoepidermoid carcinoma
  • Recurrence
  • Prognosis

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