CIENCIASMEDICASNEWS: Medical News | Medical Articles: Sodium Bisulfite Conversion of DNA

jueves, 16 de mayo de 2019

Medical News | Medical Articles: Sodium Bisulfite Conversion of DNA

	May 16, 2019
	Genetics
	The latest Genetics news from News Medical

Sodium BisulfiteConversion of DNA

When DNA is treated with sodium bisulfite, cytosine residues in the DNA are deaminated to uracil leaving 5-mC residues intact. This alteration in the DNA sequence gives more information about the degree of methylation within a region of DNA to a resolution of a single nucleotide when the bisulfite conversion is followed by sequencing analysis.

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			'Eye-in-a-dish' model reveals genetic variants that may contribute to AMD Age-related macular degeneration (AMD) is one of the most common causes of vision loss in people over age 65. The exact cause is unknown, but the fact that a family history of AMD increases a person's risk for the condition suggests genetics play an important role. Using stem cells derived from six people, University of California San Diego School of Medicine researchers recapitulated retinal cells in the lab. This "eye-in-a-dish" model allowed them to look for genetic variants that might contribute to AMD.

			Genomics study reveals five genes linked to treatment resistance in prostate cancer A new genomics study has found that men are three times more likely to die from prostate cancer if they possess mutations the retinoblastoma 1 (RB1) gene. The researchers also found that men with the mutation were seven times more likely to relapse than men without the mutation.

	Cause of cancer is 'written' in our DNA as unique 'fingerprints' Scientists have discovered that the cause of cancer is “written” within the DNA of tumors, a finding that could help doctors to decide on the best treatment for a patient. Previously, the roots of many cancer have been unclear, with doctors unable to attribute the disease to any particular culprit among the myriad of carcinogens encountered by people every day in air pollution, pesticides, cigarette smoke, and sunlight, for example.

	DNA Repair and Transcription: A Balancing Act Transcription is the process by which DNA is converted into messenger RNA in preparation for translation into a functional product. Extrinsic agents, such as ionizing radiation or chemical mutagen and intrinsic processes, for example, replication fork collapse, may result in cellular double-stranded breaks (DSBs) leading to global genomic instability.

	Genetic test for low birth weight on the horizon Researchers from the University of Queensland in collaboration with The University of Exeter, University of Oxford and Cambridge University, have successfully identified 190 genetic factors associated with a low birth weight. The results of the study titled, “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors” were published in the latest issue of the journal Nature Genetics.

	Researchers identify genetic component involved in development of familial sarcoidosis Working with their colleagues from the University of Lyon, researchers from MedUni Vienna's Center for Pathobiochemistry and Genetics have discovered mutations in genes that regulate the metabolic sensor mTOR in patients with familial sarcoidosis.

	Researchers reveal ebb and flow of gene expression that may awaken neural stem cells The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells -- neurons -- have limited ability to regenerate.