CIENCIASMEDICASNEWS: Ahead of Print - Comparative Analysis of Whole-Genome Sequence of African Swine Fever Virus Belgium 2018/1 - Volume 25, Number 6—June 2019 - Emerging Infectious Diseases journal

sábado, 11 de mayo de 2019

Ahead of Print - Comparative Analysis of Whole-Genome Sequence of African Swine Fever Virus Belgium 2018/1 - Volume 25, Number 6—June 2019 - Emerging Infectious Diseases journal - CDC

Comparative Analysis of Whole-Genome Sequence of African Swine Fever Virus Belgium 2018/1

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Jan H. Forth, Marylène Tignon, Ann Brigitte Cay, Leonie F. Forth, Dirk Höper, Sandra Blome, and Martin Beer

Author affiliations: Friedrich-Loeffler-Institut, Greifswald, Germany (J.H. Forth, L.F. Forth, D. Höper, S. Blome, M. Beer); Sciensano, Brussels, Belgium (M. Tignon, A.B. Cay)

Abstract

We analyzed the whole-genome sequence of African swine fever virus Belgium 2018/1. The strain fits into the European genotype II (>99.98% identity). The high-coverage sequence revealed 15 differences compared with an improved virus African swine fever virus Georgia 2007/1 sequence. However, in the absence of genetic markers, no spatial or temporal correlations could be defined.

African swine fever (ASF) is one of the most pathogenic viral diseases of swine leading to clinical and pathomorphological signs of a viral hemorrhagic fever (1). In 2007, ASF was introduced into Georgia (2) and thereafter into numerous eastern European and European Union (EU) countries (3), as well as Asia (China, Mongolia, and Vietnam) (World Organization for Animal Health–World Animal Health Information database, http://www.oie.int/wahis_2/public/wahid.php/Wahidhome/Home/indexcontent, 2019 Feb 21).

In September 2018, the African swine fever virus (ASFV) was introduced into Belgium (3,4); as of March 19, 2019, 687 cases have been reported by Belgium’s Federal Agency for the Safety of the Food Chain (http://www.afsca.be/ppa/actualite/belgique).