CIENCIASMEDICASNEWS: Polypharmacology: the future of drug discovery?

miércoles, 3 de abril de 2019

Polypharmacology: the future of drug discovery?

	April 3, 2019
	Drug Discovery and Production
	The latest drug discovery news from News Medical

Monitoring Ambient Environmental Conditions in the Lab

Monitoring ambient environmental conditions in drug discovery labs, including temperature, pressure, humidity and light levels, is a crucial necessity. For example, in the pharmaceutical industry, the WHO offer guidance for the storage and transport of time- and temperature-sensitive pharmaceutical products, which necessitates monitoring and alarming for temperature and humidity.

			Polypharmacology: The Future of Drug Discovery? Polypharmacology involves the pharmaceutical compounds that exert an effect on multiple targets in the body. There is currently significant interest in this area of research for drug discovery in the future, due to the projected ability to improve efficacy and reduce drug resistance.

			Metabolomics in Pharmacology Metabolomics is the holistic study of metabolism. The application of metabolomics in pharmacology gives rise to a new field called “pharmacometabolomics.” The basic tenet of pharmacometabolomics is to determine the effects of drug treatment on the body’s metabolic scenario. It is also used to identify specific metabolic pathways that are responsible for drug-mediated outcomes.

	“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery In this interview, News-Medical speaks to Dr. Richard Eglen from Corning Life Sciences about the use of organoids in the drug discovery workflow, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

	How are Host Cell Proteins Removed from Biopharmaceuticals? Host cell proteins (HCPs) are cell-derived impurities that contaminate therapeutic proteins. Removing host cell proteins is crucial, as these proteins are immunogenic and can thus compromise the integrity of the final product.

	Small Molecule Microarrays for Drug Discovery Small molecule microarrays allow screening of biomolecules such as peptides and carbohydrates. By immobilizing these small molecules on a microarray, interactions can be quickly assessed through a high throughput process.

	Drug Repurposing: Biomedical Tools and Research Techniques Most drugs are develooped with a specific indication, without ever investigating the efficacy against other diseases. This article describes the benefits of drug repurposing over traditional drug development, and the scientific methods used to identify new uses of a drug.

	Pharmaceutical Applications of Supercritical Fluid Chromatography Although supercritical fluids were used as eluents for chromatographic separations in 1962, the term supercritical fluid chromatography (SFC) was first used only five years later. Since then, the technique has come a long way, particularly in the pharmaceutical industry