Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women — United States, 2008 and 2016

Weekly / April 19, 2019 / 68(15);337–343

Nancy M. McClung, PhD1,2; Julia W. Gargano, PhD2; Ina U. Park, MD3; Erin Whitney, MPH4; Nasreen Abdullah, MD5; Sara Ehlers, MPH5; Nancy M. Bennett, MD6; Mary Scahill6; Linda M. Niccolai, PhD7; Monica Brackney, MS7; Marie R. Griffin, MD8; Manideepthi Pemmaraju, MBBS8; Troy D. Querec, PhD9; Angela A. Cleveland, MPH2; Elizabeth R. Unger, MD, PhD9; Lauri E. Markowitz, MD2; HPV-IMPACT Working Group (View author affiliations)

Summary

What is already known about this topic?

Cervical cancer is the most common human papillomavirus (HPV)-associated cancer in women, and high-grade cervical lesions (CIN2+) have been used to monitor HPV vaccine impact.

What is added by this report?

During 2008–2016, CIN2+ rates in a population-based surveillance system declined in women aged 18–24 years. The estimated numbers of U.S. CIN2+ cases were 216,000 (2008) and 196,000 (2016), with an estimated 76% attributable to 9-valent HPV vaccine types.

What are the implications for public health practice?

Cervical cancer prevention strategies include both HPV vaccination and screening. The reduction in CIN2+ attributable to vaccine types in young women demonstrates impact of the HPV vaccination program. Continued efforts to increase coverage and encourage vaccination at the routine ages (11–12 years) can increase vaccine impact on cervical disease in the United States.