PRECISION ONCOLOGY DECISION SUPPORT: CURRENT APPROACHES AND STRATEGIES FOR THE FUTURE. - PubMed - NCBI
Clin Cancer Res. 2018 Feb 2. pii: clincanres.2494.2017. doi: 10.1158/1078-0432.CCR-17-2494. [Epub ahead of print]
PRECISION ONCOLOGY DECISION SUPPORT: CURRENT APPROACHES AND STRATEGIES FOR THE FUTURE.
Kurnit KC1,
Ileana Dumbrava EE2,
Litzenburger BC3,
Khotskaya YB4,
Johnson A5,
Yap TA6,
Rodon J7,
Zeng J8,
Shufean MA8,
Bailey A5,
Sánchez N9,
Holla VR10,
Mendelsohn J11,
Shaw KRM12,
Bernstam EV13,
Mills GB14,
Meric-Bernstam F15.
Abstract
With the increasing availability of genomics, routine analysis of advanced cancers is now feasible. Treatment selection is frequently guided by the molecular characteristics of a patient's tumor, and an increasing number of trials are genomically-selected. Furthermore, multiple studies have demonstrated the benefit of therapies that are chosen based upon the molecular profile of a tumor. However, the rapid evolution of genomic testing platforms and emergence of new technologies makes interpreting molecular testing reports more challenging. More sophisticated precision oncology decision support services are essential. This review outlines existing tools available for health care providers and precision oncology teams, and highlights strategies for optimizing decision support. Specific attention is given to the assays currently available for molecular testing, as well as considerations for interpreting alteration information. This article also discusses strategies for identifying and matching patients to clinical trials, current challenges, and proposals for future development of precision oncology decision support.
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