miércoles, 28 de febrero de 2018

Researchers discover 50 new gene regions that increase risk of schizophrenia

Researchers discover 50 new gene regions that increase risk of schizophrenia

News-Medical

Researchers discover 50 new gene regions that increase risk of schizophrenia

Researchers at the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University have discovered 50 new gene regions that increase the risk of developing schizophrenia. They have also used state-of-the-art information about brain development to accurately pinpoint new genes and biological pathways implicated in this disorder.
The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.
Professor Sir Mike Owen, who leads the MRC Centre at Cardiff University, said: "These findings are another important step on the long road to new treatments for schizophrenia and will be crucial for identifying potential new drugs, which will become an increasing focus of our work in the coming years."
Another significant and unexpected finding was that the genes linked to schizophrenia risk are mostly crucial to normal development and therefore typically do not contain harmful mutations. This discovery will help researchers narrow down their search for the mechanisms of the disorder as these genes, commonly called 'loss-of-function intolerant', only account for around 15% of all the genes in the human genome.
Dr Antonio Pardiñas, first author of the study, said: "We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia."
The findings also explain a mystery that has puzzled psychiatrists and evolutionary geneticists alike: if people with schizophrenia have, on average, fewer children than people without the disorder, why does schizophrenia still affect so many people?
Dr James Walters, from Cardiff University, who led the study, explains: "Many of the genetic variants that confer risk to schizophrenia are relatively common in the population, and many scientists would have expected them to be selected against by natural selection, become rare and eventually disappear from the population.
"Many theories have emerged to explain this. One of these is that genetic risk for schizophrenia must have, or have had in the past, a positive effect to balance against the negative ones. We did not find any evidence for a so-called 'positive selection' but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place. Also, most of them do not have individually serious effects, and this makes them less likely to be selected, either for or against."
Professor Sir Mike Owen, said: "The MRC Centre will be working closely with colleagues in Cardiff's Neuroscience and Mental Health Research Institute and the recently established Medicines Discovery Institute, as well as external collaborators, to use these genetic discoveries as the basis for new approaches to treatment."
Dr Rachael Panizzo, Program Manager for Mental Health and Addiction at the Medical Research Council, added: "This large study provides further evidence of the complex genetics underlying schizophrenia. Advances in our understanding of the biological pathways and mechanisms involved will help uncover new targets for treatment, which could one day translate into better, more personalized care for people living with schizophrenia."

3 comentarios:

  1. I was diagnose with hpv virus for 5years i broke up with my boyfriend because i contracted the virus from him, luckily i found a herbalist name Dr. onokun everyone testify good of his natural treatment i picked up his address and contacted him. he truly treated me with natural herbs in a week and i got cured. i share this post because ever since i got this treatment I'm perfectly ok with my health. i contacted him through this email.. dronokunherbalcure@gmail.com

    ResponderEliminar
  2. 5 years ago I had warts, I was treated with some liquid applied to the warts they continued to grow and spread... The next 2 doctors did laser surgery to remove them. 1 year after the surgery, they grew back close to where the 1st ones were' so I was finally told it was hpv. I have had it for very long time, I contract it from my cheated boyfriend and I found out he was also infected and I end up the relationship between us. the warts was so embarrasses because it started spreading all over I have be dealing with this things for very long time the last treatment I take was About 2 years ago I applied natural treatment from Dr onokun herbal cure, a week after applying the treatment all the warts was gone. it's now 2 years and some months I don't have single wart or any symptoms of hpv. wow"" it's great, Dr onokun has finally cured me. Anyone living with hpv contact Dr onokun for natural treatment.
    His email address: dronokunherbalcure@gm‎ail.com

    ResponderEliminar
  3. Dearest Esteems,

    We are Offering best Global Financial Service rendered to the general public with maximum satisfaction,maximum risk free. Do not miss this opportunity. Join the most trusted financial institution and secure a legitimate financial empowerment to add meaning to your life/business.

    Contact Dr. James Eric Firm via
    Email: fastloanoffer34@gmail.com
    https://urgentloanoffer22.blogspot.com/
    Whatsapp +918929509036
    Best Regards,
    Dr. James Eric.
    Executive Investment
    Consultant./Mediator/Facilitator

    ResponderEliminar