martes, 27 de febrero de 2018

Molecule halts herpes of the eye | National Institutes of Health (NIH)

Molecule halts herpes of the eye | National Institutes of Health (NIH)

National Institutes of Health (NIH) - Turning Discovery into Health

Molecule halts herpes of the eye

At a Glance

  • Scientists identified a small molecule that prevents herpes simplex-1 virus from making viral proteins in human cornea cell lines and mouse models of ocular herpes.
  • The findings suggest a new class of molecule that may be useful for developing antiviral treatments.
Herpes simplex virus-1 capsidThe herpes simplex virus-1, which causes most cases of ocular herpes. Bernard Heymann, Ph.D., NIAMS Laboratory of Structural Biology Research
Herpes of the eye, or ocular herpes, is a recurring viral infection that’s usually caused by the herpes simplex virus-1 (HSV-1). This is the same virus that causes cold sores. Ocular herpes can also be caused by herpes simplex virus-2, which is the main cause of genital herpes.
Ocular herpes can produce sores on the eyelid or surface of the cornea. Recurrences can lead to complications like blindness or meningoencephalitis, a lethal infection of the brain. There’s no cure for ocular herpes, but it can be controlled with antiviral drugs.
The main class of antiviral drugs used to treat ocular herpes blocks the virus’ ability to replicate (make copies of itself). The drugs are nucleoside analogs, which look similar to DNA nucleotides but have a modification that interferes with DNA replication. Some people have viruses that develop resistance to these antivirals and would benefit from other types of treatments.
A team led by Dr. Deepak Shukla of the University of Illinois at Chicago investigated the antiviral properties of a molecule called BX795 in cell lines and mouse models of ocular herpes. The research was supported by NIH’s National Eye Institute (NEI). Results were published in Science Translational Medicine on February 14, 2018.
The researchers were initially testing BX795 in cells infected with HSV-1 to better understand aspects of the host cells’ defense system. BX795 is known to block a molecule called TANK-binding kinase 1 (TBK1), which cells produce to protect themselves after an infection. The scientists expected that blocking this molecule would increase the amount of virus in the cell. They were surprised to find that the drug reduced herpes infections.
The team compared BX795 with an antiviral currently prescribed for herpes, called TFT (trifluridine or trifluorothymidine), in a human corneal epithelial cell line infected with HSV-1. They found that both treatments reduced HSV-1 infections in the cells to a similar degree. They saw similar results when they compared the two drugs in a mouse model of ocular herpes.
When BX795 and TFT were applied to human corneal epithelial cells together, they did not show synergistic effects. The researchers also compared BX795 with several other herpes antivirals, including acyclovir, famciclovir, ganciclovir, and penciclovir. BX795 was similar or better at suppressing herpes infections in human corneal epithelial cells than any of the other antivirals—and at lower doses. 
Using protein and gene analysis, the team discovered that BX795 works by blocking viral protein synthesis through Akt, a host cell molecule required to start protein synthesis. BX795 also reduced HSV-1 protein levels in primary human corneal cells and human cornea buttons that the researchers secured from tissue banks.
“We have needed alternative drugs that work on new targets for a very long time because patients who develop resistance to nucleoside analogs have very few good options for treating their infection,” Shukla says. “We have found a molecule that works in a totally novel fashion. Instead of working on the virus, it works in the host cells and helps them to clear the virus.”
Given that BX795 targets a common viral replication process, it may be useful against other viruses as well. However, more studies are needed to determine its effects on other viruses and to understand its effects in people.
—by Tianna Hicklin, Ph.D.

Related Links

References: An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. Jaishankar D, Yakoub AM, Yadavalli T, Agelidis A, Thakkar N, Hadigal S, Ames J, Shukla D. Sci Transl Med. 2018 Feb 14;10(428). pii: eaan5861. doi: 10.1126/scitranslmed.aan5861. PMID: 29444978.
Funding: NIH’s National Eye Institute (NEI).

15 comentarios:

  1. HSV CURE
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    Respuestas
    1. Hello, everyone! I,m here to explore blogs and forum about the wonderful and most safe cure for (Herpes Virus).I was positive to the deadly virus called herpes and i lost hope because i was out casted and rejected even by my closet friends.i searched on-line to know and enquirer about cure for Herpes and i read someone testimony on how he was cured from Herpes so i decided to contact the same herbalist because i know that nature has the power to heal everything.i contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days!i used the med as he instructed me (MORNING and EVENING) and i was cured!its really like a dream but i am so happy!thats the reason i decided to also add more comment of Him so that more can be saved just like me!and if you need his help, you can email him on nativehealthclinic@gmail.com, Instagram IG: @dremmanuel2 or whatsapp +2348140073965 I,m neme amber and you can get in touch with me via nemeamber@gmail.com..Contact him for help at Herpes virus HIV/AIDS CANCER COPD BRAIN TUMOR All kind of virus and disease

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    2. I believed God has sent dr ododo to help people out from this horrible virus. i was diagnosis with herpes for 3 years, few months ago a friend introduced me to dr ododo and i only took his natural treatment for a week & 3 days, and i totally got cured with his herbal treatment. if you are suffering from genital herpes, you don't have to be roaming round dr ododo email is been attached to contact him.{drododoherbalhome1@gmail.com }or whats-app {+2348079954368} GOOD LUCK  

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    3. I believed God has sent dr ododo to help people out from this horrible virus. i was diagnosis with herpes for 3 years, few months ago a friend introduced me to dr ododo and i only took his natural treatment for a week & 3 days, and i totally got cured with his herbal treatment. if you are suffering from genital herpes, you don't have to be roaming round dr ododo email is been attached to contact him.{drododoherbalhome1@gmail.com }or whats-app {+2348079954368} GOOD LUCK  

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      I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few months ago i came on search on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr ODODO and she drop the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. ODODO telling him about my (HERPES Virus) well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me. I am now here to testify that i am not longer a herpes patient, I have experience a total transformation in my life,for all herpes patients get your herbal medicine to cure your sickness. And there has being rapid improvement in my health, I no longer feel pains and I wake up each morning feeling revived. So friends my advise is if you have such sickness or any other at all,you can contact him. via whatsapp +234 807 995 4368},  {DRODODOHERBALHOME1@gmail.com}, Wbesite: http://DRODODOHERBALHOME1.WORDPRESS.COM  CANCER

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  2. Having Herpes is a Terrible Experience and my Experience will help some hsv patients beware of Herbs from online doc.
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  6. I'm 15 years old. I was born with HIV my mother passed away because of the HIV infection And I regret why i never met Dr Itua he could have cured my mum for me because as a single mother it was very hard for my mother I came across Dr itua healing words online about how he cure different disease in different races diseases like HIV/Aids Herpes,Parkison,Asthma,Copd,Epilepsy,Shingles,Cold Sore,Infertility, Chronic Fatigues Syndrome,Fibromyalgia, Diabetes Hepatitis even Cancer I was so excited but frighten at same time because I haven't come across such thing article online then I contacted Dr Itua on Mail drituaherbalcenter@gmail.com I also chat with him on what's app +2348149277967 he tells me how it works then I tell him I want to proceed I paid him so swiftly Colorado post office I receive my herbal medicine within 4/5 working days he gave me guild lines to follow and here am I living healthy again can imagine how god use men to manifest his works am I writing in all articles online to spread the god work of Dr Itua Herbal Medicine,He's a Great Man.

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  7. I am so Happy to be writing this article in here, i am here to explore blogs forum about the wonderful and most safe cure for HERPES SIMPLEX VIRUS.I was positive to the Virus called HERPES and i lost hope completely because i was rejected even by my closet friends. i searched online to know and inquire about cure for HERPES and i saw testimony about DR Ebhota online on how he cured so many persons from Herpes Disease so i decided to contact the great herbalist because i know that nature has the power to heal everything. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via FEDEX or DHL and it got to me after 4 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i'm so happy! that's the reason i decided to also add more comment of Him so that more people can be saved just like me! and if you need his help,contact his Email: (drebhotasoltion@gmail.com) You can contact him on WhatsApp +2348089535482 He also have the herb to cure difference cure for any sickness (1) HERPES,
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    (5) HEPATITIS B,
    (6) IMPOTENCE,
    (7) BARENESS/INFERTILITY
    (8) DIARRHEA
    (9) ASTHMA.. 

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  8. Hello, everyone! I,m here to explore blogs and forum about the wonderful and most safe cure for (Herpes Virus).I was positive to the deadly virus called herpes and i lost hope because i was out casted and rejected even by my closet friends.i searched on-line to know and enquirer about cure for Herpes and i read someone testimony on how he was cured from Herpes so i decided to contact the same herbalist because i know that nature has the power to heal everything.i contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days!i used the med as he instructed me (MORNING and EVENING) and i was cured!its really like a dream but i am so happy!thats the reason i decided to also add more comment of Him so that more can be saved just like me!and if you need his help, you can email him on nativehealthclinic@gmail.com, Instagram IG: @dremmanuel2 or whatsapp +2348140073965 I,m neme amber and you can get in touch with me via nemeamber@gmail.com..Contact him for help at Herpes virus HIV/AIDS CANCER COPD BRAIN TUMOR All kind of virus and disease

    ResponderEliminar
  9. I believed God has sent dr ododo to help people out from this horrible virus. i was diagnosis with herpes for 3 years, few months ago a friend introduced me to dr ododo and i only took his natural treatment for a week & 3 days, and i totally got cured with his herbal treatment. if you are suffering from genital herpes, you don't have to be roaming round dr ododo email is been attached to contact him.{drododoherbalhome1@gmail.com }or whats-app {+2348079954368} GOOD LUCK  

    ResponderEliminar
  10. I believed God has sent dr ododo to help people out from this horrible virus. i was diagnosis with herpes for 3 years, few months ago a friend introduced me to dr ododo and i only took his natural treatment for a week & 3 days, and i totally got cured with his herbal treatment. if you are suffering from genital herpes, you don't have to be roaming round dr ododo email is been attached to contact him.{drododoherbalhome1@gmail.com }or whats-app {+2348079954368} GOOD LUCK  

    ResponderEliminar
  11. Dr. ODODO has really made me so much believe in him by getting me cured with his herbal treatment. i really appreciate you Dr.ODODO for bringing back happiness to my life again. thanks you so much,friends join me to thank him for what he has actually done for me i pray to you all for a good life and good health, and most especially to you Dr. Sam THANKS.

    I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few months ago i came on search on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr ODODO and she drop the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. ODODO telling him about my (HERPES Virus) well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me. I am now here to testify that i am not longer a herpes patient, I have experience a total transformation in my life,for all herpes patients get your herbal medicine to cure your sickness. And there has being rapid improvement in my health, I no longer feel pains and I wake up each morning feeling revived. So friends my advise is if you have such sickness or any other at all,you can contact him. via whatsapp +234 807 995 4368},  {DRODODOHERBALHOME1@gmail.com}, Wbesite: http://DRODODOHERBALHOME1.WORDPRESS.COM  CANCER
    EPILEPSY.
    GENPILENCIN.
    HIV AIDS.
    COPD
    DIABETICS
    STROKE.
    EXPANDS OF PENIS BREAST
    H.P.V TYPE 1 TYPE 2 TYPE 3 AND TYPE 4. TYPE 5.
    HUMAN PAPAILOMA VIRUS.
    HERPES.
    SYPHILIS.
    HEPATITIS A B and C.

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