Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. - PubMed - NCBI
Nat Rev Urol. 2017 Oct 31. doi: 10.1038/nrurol.2017.163. [Epub ahead of print]
Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol.
van den Heuvel-Eibrink MM1,
Hol JA1,
Pritchard-Jones K2,
van Tinteren H3,
Furtwängler R4,
Verschuur AC5,
Vujanic GM6,
Leuschner I7,
Brok J2,
Rübe C8,
Smets AM9,
Janssens GO1,10,
Godzinski J11,12,
Ramírez-Villar GL13,
de Camargo B14,
Segers H15,
Collini P16,
Gessler M17,
Bergeron C18,
Spreafico F16,
Graf N4;
International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG).
Abstract
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.
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