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ANC: Neuroscience of Disease

Featured video: Researchers hone in on Zika's neural target

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  Featured video: Researchers hone in on Zika's neural target
• Researchers at the University of Glasgow compare the susceptibility of central and peripheral nervous cells to Zika virus infection.

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1. RESEARCH

   The chronically inflamed central nervous system provides niches for long-lived plasma cells

   Karolin Pollok, Ronja Mothes, Carolin Ulbricht, Alina Liebheit, Jan David Gerken, Sylvia Uhlmann, Friedemann Paul, Raluca Niesner, Helena Radbruch and Anja Erika Hauser

   Published on: 25 November 2017
2. RESEARCH

   Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

   Marcello Rossi, Daniela Saverioni, Michele Di Bari, Simone Baiardi, Afina Willemina Lemstra, Laura Pirisinu, Sabina Capellari, Annemieke Rozemuller, Romolo Nonno and Piero Parchi

   Published on: 23 November 2017
3. RESEARCH

   Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

   Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly and Andrew B. West

   Published on: 22 November 2017
4. METHODOLOGY ARTICLE

   A novel vector for transgenesis in the rat CNS

   T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson and Stanley B. Prusiner

   Published on: 21 November 2017
5. RESEARCH

   α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

   Ashley S. Harms, Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite and Andrew B. West

   Published on: 21 November 2017

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Featured article: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Professor Zhang et al investigate the mechanism of extracellular vesicle transmission across the blood-brain barrier as it relates to Parkinson's Disease.

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Featured article: Novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Dr. Finkelstein et al report the preclinical characterization of PBT434, a novel quinazolinone compound bearing a moderate affinity metal-binding motif, which is in development for Parkinsonian conditions.  

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