"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource.

Kurnit KC1, Bailey AM2, Zeng J2, Johnson AM2, Shufean MA2, Brusco L2, Litzenburger BC2, Sánchez NS2, Khotskaya YB2, Holla V2, Simpson A2, Mills GB2,3, Mendelsohn J2,4, Bernstam E5, Shaw K2, Meric-Bernstam F6,7,8.

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Abstract

High-throughput genomic and molecular profiling of tumors is emerging as an important clinical approach. Molecular profiling is increasingly being used to guide cancer patient care, especially in advanced and incurable cancers. However, navigating the scientific literature to make evidence-based clinical decisions based on molecular profiling results is overwhelming for many oncology clinicians and researchers. The Personalized Cancer Therapy website (www.personalizedcancertherapy.org) was created to provide an online resource for clinicians and researchers to facilitate navigation of available data. Specifically, this resource can be used to help identify potential therapy options for patients harboring oncogenic genomic alterations. Herein, we describe how content on www.personalizedcancertherapy.org is generated and maintained. We end with case scenarios to illustrate the clinical utility of the website. The goal of this publicly available resource is to provide easily accessible information to a broad oncology audience, as this may help ease the information retrieval burden facing participants in the precision oncology field. Cancer Res; 77(21); e123-6. ©2017 AACR.