lunes, 27 de marzo de 2017

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia. - PubMed - NCBI

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia. - PubMed - NCBI



 2017 Mar;23(3):491-495. doi: 10.3201/eid2303.161034.

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.

Abstract

Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.

KEYWORDS:

Georgia; South Africa; bacteria; drug resistance; pyrazinamide; sequencing; tuberculosis; tuberculosis and other mycobacteria

PMID:
 
28221108
 
DOI:
 
10.3201/eid2303.161034
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Last Posted: Mar 23, 2017


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