Evaluating novel diagnostics in an outbreak setting: lessons learned from Ebola. - PubMed - NCBI

Evaluating novel diagnostics in an outbreak setting: lessons learned from Ebola. - PubMed - NCBI

J Clin Microbiol. 2017 Mar 1. pii: JCM.00053-17. doi: 10.1128/JCM.00053-17. [Epub ahead of print]

Evaluating novel diagnostics in an outbreak setting: lessons learned from Ebola.

Pollock NR1, Wonderly B2.

Author information

Abstract

Inadequate access to rapid testing for Ebola virus disease during the 2014-16 outbreak led to an explosion in the development of diagnostics that could be performed at or near the point-of-care and by less experienced operators, leading in turn to an acute need for novel test evaluation. Here, we present the challenges to novel diagnostic development and evaluation in an emergency setting, and suggestions for potential new "global emergency standards" to address them.

Copyright © 2017 American Society for Microbiology.

PMID:

  

28250002

  

DOI:

  

10.1128/JCM.00053-17

 
 
 

Last Posted: Mar 15, 2017

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• Evaluating novel diagnostics in an outbreak setting: lessons learned from Ebola.  
  Pollock Nira R et al. Journal of clinical microbiology 2017 Mar
• West African Ebola Virus Strains: Unstable and Ready to Invade?  
  Basler Christopher F et al. Cell host & microbe 2017 Mar (3) 316-318
• Ebola Virus RNA in Semen from an HIV-Positive Survivor of Ebola.  
  Purpura Lawrence J et al. Emerging infectious diseases 2017 Apr (4)
• Ebola Virus RNA in Semen from an HIV-Positive Survivor of Ebola 
  LJ Purpura et al, EID, Apri 2017
• A polymorphism within the internal fusion loop of the Ebola virus glycoprotein modulates host cell entry.  
  Hoffmann Markus et al. Journal of virology 2017 Feb
• Spatial and temporal dynamics of superspreading events in the 2014-2015 West Africa Ebola epidemic.  
  Lau Max S Y et al. Proceedings of the National Academy of Sciences of the United States of America 2017 Feb
• Ultrasensitive Ebola Virus Detection Based on Electroluminescent Nanospheres and Immunomagnetic Separation.  
  Wu Zhen et al. Analytical chemistry 2017 Feb (3) 2039-2048
• Ebola viruses need very few mutations to cause disease in new host species  
  Science Magazine, February 15, 2017
• Changes associated with Ebola virus adaptation to novel species  
  Pappalardo M, et al. Bionformatics, Feb 15, 2017.
• Sequencing of Ebola Virus Genomes Using Nanopore Technology.  
  Hoenen Thomas et al. Bio-protocol 2016 Nov (21)
• Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus.  
  Liu Xuan et al. Genome biology 2017 Jan (1) 4
• Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient.  
  Biava Mirella et al. PLoS pathogens 2017 Jan (1) e1006065
• Human transmission of Ebola virus.  
  Lawrence Philip et al. Current opinion in virology 2016 Dec 51-58
• Scientists announce new Ebola vaccine  
  NPR News, December 23, 2016
• Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child.  
  Sissoko Daouda et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Dec
• Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system.  
  Guito Jonathan C et al. Virology 2016 Dec 501147-165

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