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Featured article: Microparticles mediate immune evasion

Jaiswal et al_CC

Microparticles shed by multidrug resistant breast cancer cells can incapacitate macrophages so that they can be destroyed by engulfment. This mechanism may ensure the survival of cancer cells and allow their distant spread, by providing a permissive environment for secondary tumour colonisation.

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Featured review: Molecular chess, hallmarks of anti-cancer drug resistance

Cree and Charlton_CC

The development of resistance to anti-cancer drugs is an ongoing problem which makes relapse inevitable for many cancer patients. Ian Cree and Peter Charlton review the known mechanisms leading to the acquisition of resistance, and discuss the importance of developing personalised therapeutic strategies to overcome it.

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1. RESEARCH ARTICLE

   Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design

   Matthias Kröz, Marcus Reif, Augustina Glinz, Bettina Berger, Andreas Nikolaou, Roland Zerm, Benno Brinkhaus, Matthias Girke, Arndt Büssing and Christoph Gutenbrunner

   Published on: 2 March 2017
2. RESEARCH ARTICLE

   Cancer-related health behaviours of young people not in education, employment or training (‘NEET’): a cross-sectional study

   Catherine H. Stewart, Philip Berry, Dunja Przulj and Charlene Treanor

   Published on: 2 March 2017
3. RESEARCH ARTICLE

   A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

   Joyce Y. Cheng, Taylor C. Brown, Timothy D. Murtha, Adam Stenman, C. Christofer Juhlin, Catharina Larsson, James M. Healy, Manju L. Prasad, Wolfram T. Knoefel, Andreas Krieg, Ute I. Scholl, Reju Korah and Tobias Carling

   Published on: 1 March 2017
4. RESEARCH ARTICLE

   The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation

   D. J. Lundon, A. Boland, M. Prencipe, G. Hurley, A O’Neill, E. Kay, S. T. Aherne, P. Doolan, S. F. Madden, M. Clynes, C. Morrissey, J. M. Fitzpatrick and R. W. Watson

   Published on: 1 March 2017
5. RESEARCH ARTICLE

   In search of druggable targets for GBM amino acid metabolism

   Eduard H. Panosyan, Henry J. Lin, Jan Koster and Joseph L. Lasky

   Published on: 28 February 2017

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