Plasmodium vivax recurrences help maintain malaria transmission. They are caused by recrudescence, reinfection or relapse, which are not easily differentiated.
A longitudinal observational study took place in Turbo municipality, Colombia. Participants with uncomplicated P. vivax infection received supervised concomitantly treatment with chloroquine 25 mg/Kg and primaquine 0.25 mg/Kg/day for 14 days. Incidence of recurrence was assessed over 180 days. Samples were genotyped and origins of recurrences were established.
134 participants were enrolled between February 2012 and July 2013, and 87 were followed for 180 days in which 29 recurrences were detected. Cumulative incidence of first recurrence was 24.1% (21/87) (CI 95% 14.6 to 33.7) and 86% (18/21) of them occurred between days 51 and 110. High genetic diversity of P. vivax was found and 12.5% (16/128) of the infections were polyclonal. Among detected recurrences 93.1% were genotyped as genetically identical to the one from the previous episode and 65.5% (19/29) were classified as relapses.
Our results indicate that there is a high incidence of P. vivax malaria recurrence after treatment in Turbo municipality, Colombia, a large majority of which are likely relapses from the previous infection. We attribute this to the primaquine regimen currently used in Colombia, which may be insufficient to eliminate hypnozoites.
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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