domingo, 29 de mayo de 2016

Familial skin cancer syndromes: Increased melanoma risk. - PubMed - NCBI

Familial skin cancer syndromes: Increased melanoma risk. - PubMed - NCBI



 2016 Mar;74(3):423-34. doi: 10.1016/j.jaad.2015.09.070.

Familial skin cancer syndromes: Increased melanoma risk.

Abstract

Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.
Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

genetic syndromes; genetics; inherited cancer risk; melanoma; oncogenes; skin cancer; tumor suppressor

PMID:
 
26892652
 
[PubMed - in process]

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