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Public Health Genomics Knowledge Base (v1.0)

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Lynch Syndrome Screening: Current Challenges

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CDC Resources
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- CDC-Authored Genomics Publications (4)
Discoveries and Insights
- Hot Topics (62)
- Health Impact Scan (14)
- Relevant Resources (2)
Epidemiology
- Human Genome Epidemiology (275)
- Relevant Resources (1)
Translational Research
- Health Impact Scan (92)
Evidence Synthesis
- Guidelines (17)
- Evidence Classification (11)
- Health Impact Scan (38)
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Practice and Implementation
- Implementation (38)
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Listen to a CDC podcast about Genetic Testing for Lynch syndrome (Time Posted: Sep-04-2015 9AM)
Colorectal Cancer Awareness (Time Posted: Sep-04-2015 9AM)
Genetic Testing for Hereditary Colorectal Cancer (Time Posted: Sep-04-2015 9AM)

Universal Screening of Colorectal Cancers for Lynch Syndrome: Challenges and Opportunities. Vindigni Stephen M et al. Digestive diseases and sciences 2015 Nov (Time Posted: Dec-02-2015 9AM)
Universal Screening of Colorectal Cancers for Lynch Syndrome: Challenges and Opportunities. Vindigni Stephen M et al. Digestive diseases and sciences 2015 Nov (Time Posted: Nov-29-2015 10PM)
Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer. Kastrinos Fay et al. Journal of the National Cancer Institute 2016 Feb (2) (Time Posted: Nov-29-2015 10PM)
Limiting Lynch Syndrome Screening in Endometrial Cancers May Be Harmful Gynecologic Cancer Advisor, November 9, 2015 (Time Posted: Nov-11-2015 11AM)
Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study. Goodfellow Paul J et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Nov (Time Posted: Nov-11-2015 11AM)

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Contribution of rare germline copy number variations and common susceptibility loci in Lynch Syndrome patients negative for mutations in the mismatch repair genes. International journal of cancer. Journal international du cancer 2015 Dec . Villacis Rolando A R, Miranda Priscila M, Gomy Israel, Santos Erika M M, Carraro Dirce M, Achatz Maria I, Rossi Benedito M, Rogatto Silvia
Lynch syndrome and cervical cancer. International journal of cancer. Journal international du cancer 2015 Dec 137 (11): 2757-61. Antill Yoland C, Dowty James G, Win Aung Ko, Thompson Tina, Walsh Michael D, Cummings Margaret C, Gallinger Steven, Lindor Noralane M, Le Marchand Loïc, Hopper John L, Newcomb Polly A, Haile Robert W, Church James, Tucker Katherine M, Buchanan Daniel D, Young Joanne P, Winship Ingrid M, Jenkins Mark
[Challenges for Urologists in the Care of Patients with Lynch Syndrome: Example of A Patient with Muir-Torre Syndrome, A Subtype of Lynch Syndrome]. Aktuelle Urologie 2015 Oct . Löhmann C, Kächele V, Martinschek A, Sparwasser
Identification of germline genetic mutations in patients with pancreatic cancer. Cancer 2015 Oct . Salo-Mullen Erin E, O'Reilly Eileen M, Kelsen David P, Ashraf Asad M, Lowery Maeve A, Yu Kenneth H, Reidy Diane L, Epstein Andrew S, Lincoln Anne, Saldia Amethyst, Jacobs Lauren M, Rau-Murthy Rohini, Zhang Liying, Kurtz Robert C, Saltz Leonard, Offit Kenneth, Robson Mark E, Stadler Zsofia
Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal? Oncotarget 2015 Oct . Maccaroni Elena, Bracci Raffaella, Giampieri Riccardo, Bianchi Francesca, Belvederesi Laura, Brugiati Cristiana, Pagliaretta Silvia, Del Prete Michela, Scartozzi Mario, Cascinu Stefa

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Publication	Product Type
Prognostic Factors for Distress After Genetic Testing for Hereditary Cancer. Voorwinden Jan S, et al. Journal of genetic counseling 2015 10 0.	Original Studies
Initial Results of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome. Howarth Dt R, et al. The American surgeon 2015 10 0. (10) 941-4	Original Studies
Genetic testing for Lynch syndrome: family communication and motivation. Leenen Celine H M, et al. Familial cancer 2015 10 0.	Original Studies
Population-Based Lynch Syndrome Screening by Microsatellite Instability in Patients ≤50: Prevalence, Testing Determinants, and Result Availability Prior to Colon Surgery. Karlitz Jordan J, et al. The American journal of gastroenterology 2015 7 0. (7) 948-55	Original Studies
Lynch Syndrome Patients with Limited Family History Identified in a Laboratory Setting: A Descriptive Study. Landon Michelle, et al. Oncology 2015 0 0. (4) 221-6	Original Studies

Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D). Published 2014 (EU-Consortium Care for CMMR-D (C4CMMR-D))
Committee opinion no. 634: hereditary cancer syndromes and risk assessment. Published 2015 (American College of Obstetricians and Gynecologists (ACOG) - Committee on Genetics )
Lynch Syndrome: AGA Patient Guideline Summary. Published 2015 (American Gastroenterological Association )
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Published 2014 (U.S. Multi-Society Task Force on Colorectal Cancer)
American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome. Published 2015 (American Gastroenterological Association (AGA) Institute - Clinical Guidelines Committee )

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Lynch Syndrome: For the General Public [Disease: Lynch syndrome; Type: Education\|Program; State: Illinois]
Lynch Syndrome: For Health Care Professionals [Disease: Lynch syndrome; Type: Education\|Program; State: Illinois]
GeorgiaCancerInfo.org [Disease: Lynch syndrome\|Breast Cancer\|Ovarian Cancer; Type: Education\|Program\|General Information; State: Georgia]
Georgia CORE (Center for Oncology Research and Education) [Disease: Breast Cancer\|Lynch syndrome\|Ovarian Cancer; Type: Program\|General Information; State: Georgia]