lunes, 19 de octubre de 2015

Million Veteran Program (MVP): A Mega-Biobank to Study Genetic Influences On Health and Disease. - PubMed - NCBI

2015 Oct 3. pii: S0895-4356(15)00444-8. doi: 10.1016/j.jclinepi.2015.09.016. [Epub ahead of print]

Million Veteran Program (MVP): A Mega-Biobank to Study Genetic Influences On Health and Disease.

Gaziano JM1, Concato J2, Brophy M3, Fiore L3, Pyarajan S4, Breeling J4, Whitbourne S4, Deen J4, Shannon C4, Humphries D4, Guarino P5, Aslan M5,Anderson D6, LaFleur R6, Hammond T7, Schaa K7, Moser J7, Huang G7, Muralidhar S7, Przygodzki R7, O'Leary TJ7.

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Abstract

OBJECTIVE:

To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) healthcare system.

STUDY DESIGN AND SETTING:

Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses.

RESULTS:

Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of 3 August 2015, and with a steady-state of ≈50 recruiting sites nationwide, N=397,104 Veterans have been enrolled. Among N=199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). Based on self-reported race, white (77.2%) and African-American (13.5%) populations are well represented.

CONCLUSIONS:

By helping to promote the future integration of genetic testing in health care delivery, including clinical decision-making, the Million Veteran Program is designed to contribute to the development of precision medicine.