Opioid Use: Public Health and Genomic Insights - January 23, 2015

Genomics|Features|Opioid

Opioid Use

Opioid Use: Public Health and Genomic Insights - January 23, 2015

CDC MMWR article: Opioid Prescription Claims Among Women of Reproductive Age — United States, 2008–2012 
MMWR January 23, 2015 / 64(02);37-41

CDC information: Opioid pain medications used early in pregnancy might increase risk of some birth defects

Genome-wide association study of copy number variations (CNVs) with opioid dependence.
Li D, et al. Neuropsychopharmacology. 2014 Sep 27.

Genetics of opioid dependence: A review of the genetic contribution to opioid dependence.
Mistry CJ, et al. Curr Psychiatry Rev. 2014 May;10(2):156-167.

Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study.
Samaan Z, et al. Neuropsychiatr Dis Treat. 2014 Aug 19;10:1503-8

PharmGKB summary: tramadol pathway.
Gong L, et al. Pharmacogenet Genomics. 2014 Jul;24(7):374-80

Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.
Dennis BB, et al. PLoS One. 2014 Jan 29;9(1):e86114

The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction.
Clarke TK, et al. Ann Hum Genet. 2014 Jan;78(1):33-9.

Moving toward personalized medicine in the methadone maintenance treatment program: a pilot study on the evaluation of treatment responses in Taiwan.
Lee HY,et al. Biomed Res Int. 2013;2013:741403.

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
Gelernter J, et al. Biol Psychiatry. 2014 Jul 1;76(1):66-74

Genetic factors involved in risk for methamphetamine intake and sensitization.
Belknap JK, et al. Mamm Genome. 2013 Dec;24(11-12):446-58

Opioid medication prescribing to women of reproductive age, by Jennifer N. Lind, CDC Expert Commentary, Medscape, Jan 23