Hereditary Breast and Ovarian Cancer: Is it time for Population Screening for BRCA Mutations? - February 17, 2015

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Breast & Ovarian Cancer

Hereditary Breast and Ovarian Cancer: Is it time for Population Screening for BRCA Mutations? - February 17, 2015

A never-ending genetic quest. Mary-Claire King?s Pioneering gene work, from breast cancer to human rights, New York Times, Feb 9

Precision medicine meets public health: population screening for BRCA1 and BRCA2.
Levy-Lahad Ephrat et al. J. Natl. Cancer Inst. 2015 Jan (1) 420

Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2.
Gabai-Kapara Efrat et al. Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 30. (39) 14205-10

Lasker Award winner Mary-Claire King.
King Mary-Claire et al. Nat. Med. 2014 Oct (10) 1124-5

Population-based screening for BRCA1 and BRCA2: 2014 Lasker Award.
King Mary-Claire et al. JAMA 2014 Sep 17. (11) 1091-2

Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing.
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 380

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial.
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 379

Ovarian Cancer: Recent Genomic Insights - January 20, 2015

Identification of six new susceptibility loci for invasive epithelial ovarian cancer 
Karoline B Kuchenbaecker et al. Nature Genetics, January 12, 2015

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer.
Candido Dos Reis FJ, Clin Cancer Res. 2014 Nov 14

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An ovarian tumour tissue analysis consortium study.
Köbel M, et al. Br J Cancer. 2014 Dec 9;111(12):2297-307

New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.
Liu J, et al. Clin Cancer Res. 2014 Oct 15;20(20):5150-6

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.
Emmanuel C, et al. Clin Cancer Res. 2014 Dec 15;20(24):6618-30.

Knowledge-driven genomic interactions: an application in ovarian cancer.
Kim D, Li R, et al. BioData Min. 2014 Sep 9;7:20

Ovarian cancer biomarkers: current state and future implications from high-throughput technologies.
Leung F, et al. Adv Clin Chem. 2014;66:25-77.

BRCA Testing in Action: Personal Stories - December 30, 2014

Feature: Peering into my genome, by Jennifer Couzin-Frankel, Science Magazine, Dec 4

CDC blog post: Knowing BRCA changed my life, Debbie Wasserman Schultz (June, 2014)

The REAL story of Mary-Claire King, by andrea, Brave Bosom Blog Post, Nov 20

Public Health Genomics in Action: Hereditary Breast and Ovarian Cancer - December 4, 2014

Hereditary breast and ovarian cancer in public health, Genetic Alliance, webinar, Nov 21

CDC Know:BRCA Tool

Recent insights

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial. 
Ranjit Manchanda, et al. JNCI, January, 2015

'Screen more' for cancer risk genes,  by James Gallagher, BBC, Nov 30

Celebrities: Genetics and Breast Cancer - November 6, 2014

'Angelina Jolie effect': BRCA testing doubles, by Zosia Chustecka, Medscape, Sept 3

Cancer information seeking in the digital age: Effects of Angelina Jolie's prophylactic mastectomy announcement 
Noar SM, et al. Med Decis Making 2014 Oct

Celebrity disclosures and information seeking: the case of Angelina Jolie 
Juthe RH, et al. Genet Med 2014 Oct

The Angelina effect: immediate reach, grasp, and impact of going public. 
Borzekowski DL et al. Genet Med. 2014 Jul;16(7):516-21.

Angelina Jolie's faulty gene: newspaper coverage of a celebrity's preventive bilateral mastectomy in Canada, the United States, and the United Kingdom. 
Kamenova K et al. Genet Med. 2014 Jul;16(7):522-8.

Breast Cancer: Genomics in Prediction and Stratified Screening - October 30, 2014

The role of genome sequencing in personalized breast cancer prevention. 
Weiva Sieh, et al. Cancer Epidemiology Biomarkers and Prevention, October 23, 2014

Cancer genomics: Using big data to advance breast cancer risk prediction, by Srivani Ravoori, AACR blog post, Oct 23

Genomic sequencing more efficient in predicting breast cancer risk than previously thought,AACR, Oct 23

CDC blog post: How can we use genetic testing for stratified screening for common diseases such as breast cancer?

Breast and Ovarian Cancer Genetics: Clinical and Public Health Approaches - October 16, 2014

New CDC podcast: CDC Medscape Expert Commentary:Genetics and BRCA in Primary Care. Katherine Kolor, October 13, 2014

CDC awards grant to FORCE for breast cancer in young women,  [PDF 428.18 KB] October 10, 2014

CDC information: Does breast or ovarian cancer run in your family?

CDC BRCA assessment tool for women: The Know:BRCA Assessment can help you assess your risk of having a BRCA mutation. Learning your risk can help you and your doctor make important decisions for your health

CDC BRCA assessment tool for clinicians: Help women Know:BRCA

Assessing the genetic risk for BRCA-related breast or ovarian cancer in women: Recommendations from the U.S. Preventive Services Task Force 
Ann Intern Med. 2014;160(4):I-16. doi:10.7326/P14-9008 

CDC Public health genomics implementation tool kit for health departments- check out BRCA section