Cabut/dTIEG associates with the transcription factor Yorkie for growth control | EMBOr
Abstract
The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co‐activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co‐localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down‐regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up‐regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co‐activator in growth control.
Synopsis
The transcription factor Cbt associates with Yki, a key effector of growth control in the Hippo pathway. Up‐regulation of Cbt promotes cell proliferation, while down‐regulation suppresses Yki‐dependent overgrowth in Drosophila.
- Cbt co‐localizes with Yki on common gene promoters.
- Cbt is required for Yki activity in wing and eye development.
- Cbt acts as a modulator of Yki activity in tissue growth control.
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