miércoles, 4 de febrero de 2015

Antibiotic Resistance Solutions Initiative | Antibiotic/Antimicrobial Resistance | CDC

Antibiotic Resistance Solutions Initiative | Antibiotic/Antimicrobial Resistance | CDC

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Antibiotic Resistance Solutions Initiative



CDC’s AR Solutions Initiative



Antibiotic Resistance Solutions Initiative
$264M: A Comprehensive Response

Antibiotic resistance is one of the most pressing health threats facing the world today. The FY 2016 Budget submission calls for critical increases for CDC programs. For CDC, the FY 16 budget proposal would support prevention programs, outbreak surveillance, antibiotic use and resistance monitoring, and antibiotic stewardship programs to address this threat.

The FY 16 budget proposal would support full implementation of the activities in National Strategy for Combating Antibiotic-Resistant Bacteria (CARB)[PDF - 37 pages] and the President’s Council of Advisors on Science and Technology report.

The problem

Antibiotic resistance, when bacteria don’t respond to the drugs designed to kill them, threatens to return us to the time when simple infections were often fatal. To address this threat, CDC and public health partners must fully implement the National Strategy for Combating Antibiotic-Resistant Bacteria .
 Antimicrobial Resistance estimated minimum number of illnesses image

The action

The national strategy identifies five core actions:
  • Slow the Development of Resistant Bacteria and Prevent the Spread of Resistant Infections
  • Strengthen National One-Health Surveillance Efforts to Combat Resistance
  • Advance Development and Use of Rapid and Innovative Diagnostic Tests for Identification and Characterization of Resistant Bacteria
  • Accelerate Basic and Applied Research and Development for New Antibiotics, Other Therapeutics, and Vaccines
  • Improve International Collaboration and Capacities for Antibiotic Resistance Prevention, Surveillance, Control, and Antibiotic Research and Development

The results

The FY16 AR Solution Initiative fully implements the National Strategy for Combating Antibiotic-Resistant Bacteria.
• Comprehensive Tracking
• Rapid Detection
• Faster Outbreak Response
• Insights for Research Innovation
• Better Patient Care
• Improved Prescribing
• 10x More Susceptibility Testing
• Nationwide Implementation of CDC Core Elements of Hospital Antibiotic Stewardship
• Global Partnerships for Prevention and Detection
 reduction rate graphic element

The details

Stop Spread; Protect People

Action in every state

  • Establish State AR Prevention Programs (“Protect Programs”), groups of healthcare facilities in communities around the country that  work together to better track outbreaks, improve prescribing, and prevent infections
  • Detect and respond rapidly to reduce spread of multidrug-resistant gonorrhea (GC) and better treatment of GC
  • Identify critical new interventions against multidrug-resistant tuberculosis (TB) and expand pre-migration TB screening beyond immigrants and refugees
  • Support development of next generation rapid susceptibility tests for drug-resistant pathogens
  • Identify new ways to prevent human infections caused by resistant bacteria (such asSalmonella) from food animals using the National Antimicrobial Resistance Monitoring System (NARMS)

Track Superbugs; Measure Impact

Accelerate outbreak detection and prevention innovation

  • New Detect Network of AR Regional Labs to improve response to outbreaks of urgent, serious, or concerning threats; know faster which antibiotics work; and use cutting edge methods to track and get ahead of spread
  • New AR Isolate Bank to provide a complete collection of current resistant threats; help keep pace with mutations; and provide information for FDA-approval of products and for companies/researchers’ new tests and antibiotics
  • Measure impact of antibiotics on human microbiome to learn if a healthy microbiome protects people and to learn if antibiotics given to infants and elderly lead to health problems or higher risk of drug-resistant infection
  • Double number of CDC’s Emerging Infections Program (EIP) sites to expand tracking to urgent and serious threats; track evolving AR threats better; and improve understanding of who is at risk
  • Enhance global partnerships for prevention and detection to combat AR internationally

Track and Improve Prescribing

Improve antibiotic use and reduce antibiotic resistance

  • Provide real-time data about antibiotic use and trends in healthcare in specific facilities and across regions using the National Healthcare Safety Network (NHSN); set the standard for how facilities, communities, states, and the nation can improve antibiotic use and reduce resistance
  • Improve antibiotic prescribing practices in healthcare (antibiotic stewardship) by ensuring all hospitals have effective stewardship programs and evaluating state-to-state variations in antibiotic use to improve prescribing outside of hospitals
  • Provide real-time data about antibiotic use and trends for outpatient care to better understand prescribing practices and set national goals for improving antibiotic use
  • Measure the impact of antibiotic use on human and animal health and greatly scale up rapid detection of AR infections commonly transmitted through food to humans by collaborating with FDA and USDA to expand the National Antimicrobial Resistance Monitoring System (NARMS)
To learn more, read the White House fact sheet reviewing the President’s 2016 budget proposing historic investment to combat antibiotic resistance bacteria to protect the public health.  

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