Review series: New technologies

Written by renowned experts in the field, this collection of open access Review articles explores the use of RNA sequencing, cytometry, metabolomics and next-generation DNA sequencing in rheumatic disease.

New technologies

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process. The Editors-in-Chief declare no competing interests.

Content Type:Review
Response to peripheral immune stimulation within the brain: magnetic resonance imaging perspective of treatment success
Chronic peripheral inflammation in diseases such as rheumatoid arthritis leads to alterations in central pain processing and consequently to mood disorders resulting from sensitization within the central nervo...
Authors:Marina Sergeeva, Jürgen Rech, Georg Schett and Andreas Hess
Citation:Arthritis Research & Therapy 2015 17:268
Published on: 19 October 2015
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Content Type:Review
Fatigue in chronic inflammation - a link to pain pathways
Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in pa...
Authors:Karine Louati and Francis Berenbaum
Citation:Arthritis Research & Therapy 2015 17:254
Published on: 5 October 2015
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Content Type:Review
Use of RNA sequencing to evaluate rheumatic disease patients
Studying the factors that control gene expression is of substantial importance for rheumatic diseases with poorly understood etiopathogenesis. In the past, gene expression microarrays have been used to measure...
Authors:Eugenia G Giannopoulou, Olivier Elemento and Lionel B Ivashkiv
Citation:Arthritis Research & Therapy 2015 17:167
Published on: 1 July 2015
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Content Type:Review
Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy
The development of biomarkers for autoimmune diseases has been hampered by a lack of understanding of disease etiopathogenesis and of the mechanisms underlying the induction and maintenance of inflammation, wh...
Authors:Nitya Nair, Henrik E Mei, Shih-Yu Chen, Matthew Hale, Garry P Nolan, Holden T Maecker, Mark Genovese, C Garrison Fathman and Chan C Whiting
Citation:Arthritis Research & Therapy 2015 17:127
Published on: 18 May 2015
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Content Type:Review
Polychromatic flow cytometry in evaluating rheumatic disease patients
B cells are central players in multiple autoimmune rheumatic diseases as a result of the imbalance between pathogenic and protective B-cell functions, which are presumably mediated by distinct populations. Yet...
Authors:Chungwen Wei, Scott Jenks and Iñaki Sanz
Citation:Arthritis Research & Therapy 2015 17:46
Published on: 5 March 2015
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Content Type:Review
T-cell metabolism in autoimmune disease
Cancer cells have long been known to fuel their pathogenic growth habits by sustaining a high glycolytic flux, first described almost 90 years ago as the so-called Warburg effect. Immune cells utilize a simila...
Authors:Zhen Yang, Eric L Matteson, Jörg J Goronzy and Cornelia M Weyand
Citation:Arthritis Research & Therapy 2015 17:29
Published on: 11 February 2015
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Content Type:Review
Use of next-generation DNA sequencing to analyze genetic variants in rheumatic disease
Next-generation DNA sequencing has revolutionized the field of genetics and genomics, providing researchers with the tools to efficiently identify novel rare and low frequency risk variants, which was not prac...
Authors:Graham B Wiley, Jennifer A Kelly and Patrick M Gaffney
Citation:Arthritis Research & Therapy 2014 16:490
Published on: 22 November 2014
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